KEGG   Ailuropoda melanoleuca (giant panda): 100464435Help
Entry
100464435         CDS       T01329                                 

Gene name
DOT1L
Definition
DOT1-like, histone H3 methyltransferase (S. cerevisiae)
Orthology
K11427  
histone-lysine N-methyltransferase, H3 lysine-79 specific [EC:2.1.1.43]
Organism
aml  Ailuropoda melanoleuca (giant panda)
Pathway
Lysine degradation
Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:aml00001]
 Metabolism
  Amino acid metabolism
   00310 Lysine degradation
    100464435 (DOT1L)
 Human Diseases
  Cancers
   05202 Transcriptional misregulation in cancers
    100464435 (DOT1L)
Enzymes [BR:aml01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.43  histone-lysine N-methyltransferase
     100464435 (DOT1L)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 
Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Position
Un
AA seq 1666 aa AA seqDB search
MSGSGFCKVWGQLAAQTPDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVLIDYDTKSFE
SMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSNGLLRHILQQVYNHSVTDPEKLNNYE
PFSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCKHHYGVEKAD
IPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFVNNFAFGPEV
DHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLKGSVSWTGKP
VSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRESKSTTTTPTKVPESKAAVPAD
TPMDSGAEEEKAGATAIKKPSPSKARKKKLNKKGRKMAGRKRGRPKKMSTANPERKPKKS
QTALDLLHAQAAAQTAAPSPQDAYKSPHSPFYQLPPSVQRHPPDQLLLAPTPPALQKLLE
SFKIQYLQFLAYTKTAQYKASLQQLLDQEKEKNARLLGAAQQLFGHCQAQKEEIKRLFQQ
KLDELGVKALTYNDLIQAQKEISAHNQQLREQTEQLQKDNRELRSQSLQLLKARCEELKL
DWSTLSLENLLKEKQALRTQISEKQRHCLELQISIVELEKSQRQQELLQLKSCVPPDDAL
AAHLRGKGSLGRELEADAGRLHLDLDCSKFSLPHFSSASPELSINGHAASYEVCSALSRP
SSKQNTPQYLASPLDQEVVPCTPSHSSRSRLEKMSGLALPDYTRLSPAKLVLRRHLSQDH
AASGKTAAGELHPRAEHAKENGLPYQSPGIANGIKLSPQDPRPSSPVALQMTGERGGEKG
LKERAYASSGEAITSLPVSIPLSTVQPSKLPVSIPLASVVLPSRAEKVRSTPSPVPQTRE
SSSALEKQMGTNAHSAGSKSLAPAPAGFYTGSVAVSGALAGSPAPLAPGAESSAFDEVSG
SGSLFASVGSCSSTPQHPPLLPQSRGSGTASPAHPLCASPRLSSATQGPLPEASKGDFPS
ETGFSDPEGEAKRRIVFTISAGGSGAKQSPPSKPSPLPTGARGDSGQGHGSDSRKRGRRK
RAAAGTPSLSSSVSPKRRALPSVAGLFTQSSGSPLNLNSMVSNINQPLEITAISSPESLK
SSPVPYQDNDQPPVLKKEKPLSQTNGAHYSPLTSDEEQGSEDEPGSARIERKIATISLES
KSPPKTLESGGSLAGRKPTPAGEPANSSKWKSTFSPISDLGLAKCADSPLQAGSALSQNS
LFTFRPPLEEPGLADAKLAAHPRKSFPGALSGAGGLSPSSNPPNGFAFSGGLAADLSLHS
FSDGASLSHKVPEAASLGAPLSFPAPRGKEGSATEPGAFVNKRQLDGLGGPKGREAGELG
LPACGPPDKVSLTHSKPGKGRDREPDLKNGHNLFISAATVPPGGLLSGPGLATVASSTVS
AAPSAQTHRPFLGTFAPGPQFALGPMSLQANLGSSVLQSLFSSVPAAAGLVHVSSAATRL
TNSHAMGSFSSGVAGGAVGGVFNHAVPSASAHPFGASFGSGAACRSATLSLTPLQAVASA
PASSFQSEPVLLQNLASLPANQAFLPASSAASLRPANASLSIKLASLPHKAPRPSFTVHH
QPLPGLALAQAAPVIPQASSTGPSAVWVSLGMPPPYAARLAGVKPR
NT seq 5001 nt NT seq  +upstreamnt  +downstreamnt
atgtctggttctggtttctgcaaagtctggggtcagttggctgcccagaccccagacaaa
caccacgatgctgctcatgaaatcatcgagaccatccgatgggtctgtgaagagatcccg
gacctcaagcttgcgatggagaattatgttctcatcgactacgacaccaaaagctttgaa
agcatgcagaggctctgtgacaaatacaaccgtgccatcgacagcatccaccagctgtgg
aaggggaccacgcagcccatgaaactgaacacgcggccgtccaacgggctcctgcggcac
atcctgcagcaggtctacaaccactcggtgacggaccctgagaagctcaacaactacgag
cccttctccccggaggtgtacggagagacctcctttgacttggtcgcgcagatgatcgat
gagatcaagatgaccgaggatgacctgtttgtggacctgggcagtggagtgggccaggtc
gtgctgcaggtcgccgcggcaaccaactgcaagcatcactatggcgtggagaaagccgac
atcccagccaagtacgcggagaccatggaccgagagttcaggaagtggatgaaatggtat
ggaaaaaagcatgcagaatacacactggaaagaggcgacttcctctcggaagagtggaga
gagcggattgccaacacaagtgttatatttgtgaataattttgcctttggtcctgaggtg
gatcaccagctgaaggagcggtttgcgaacatgaaggaaggtggcagaatcgtttcctcg
aagccctttgcgcctctgaacttcagaataaacagcagaaacttgagtgacatcggcacc
atcatgcgcgttgtggagctctcgcccctgaaaggctcggtgtcctggacggggaagccg
gtctcttactacctgcacaccatcgaccgcaccatacttgaaaactatttttctagtctg
aaaaacccaaaactcagggaggaacaggaggcagctcggcgcaggcagcagcgagagagc
aagagcaccacgaccactcccaccaaggtgcccgaaagcaaggctgccgtgcccgcggac
accccgatggattccggggctgaggaagaaaaggctggggcgactgccatcaaaaagccg
tccccctccaaagcccggaagaagaagctgaacaagaaggggcggaagatggccggccgg
aagcgcgggcgtcccaagaagatgagcactgcgaaccccgagcgtaagcccaagaagagc
caaactgcactggacctcctgcacgcccaggccgcggcgcagacggcagcgccctcgccg
caggatgcgtacaagtcacctcatagcccgttttaccagctacctcccagtgtgcagcgg
cacccccccgaccagctgctgctggcacccaccccgcccgcactgcagaagctgctagaa
tccttcaagattcagtacttgcagttcttggcatataccaagaccgcccagtacaaggcc
agcctgcagcagctgctggaccaggagaaggagaagaacgcgcggttgctaggcgctgcc
cagcagctgtttggccactgccaggcccagaaagaggagatcaagaggcttttccagcag
aaactggatgagctgggagtgaaggcgctgacctacaacgacctgatccaggcgcagaag
gagatctcggctcacaaccagcagctgagggagcagacggagcagctgcagaaggacaac
agggagctgaggagccagagcctgcagctgctcaaggctcggtgtgaggagctgaagctg
gactggtccacgctgtccctggagaacctgctgaaggagaagcaggccctgcggacccag
atctccgagaagcagcggcactgcctggagctgcagataagcatcgtggagctggagaag
agccagcggcagcaggagctcctgcagctcaagtcctgcgtgccgccggacgatgccctg
gcggcacacctgcgagggaaaggctccctgggccgggagctggaggccgacgccggccgg
ctgcacctcgacctggactgctccaagttctctctgccccacttcagcagcgcgagccca
gaactctccataaacggccatgcggccagctacgaggtctgcagtgcgctgagccggccc
tcgtccaagcagaacaccccccagtacctggcctcccccctggaccaggaagtcgtaccc
tgcacgcccagccacagcagccgctcgaggctcgagaagatgtcgggcctggccttgccc
gactacacccggctctccccagccaagctggtgctgaggcgtcacctgagccaggaccac
gcggccagtggcaagactgcggctggcgagctgcacccgcgagctgagcacgccaaggag
aacggccttccgtaccagagccctggcatcgcaaatggcatcaagctgagccctcaggac
cctcgaccttcatcccccgtggccttacagatgacaggggagaggggcggcgagaagggt
ttgaaggagcgtgcctacgccagcagcggggaggccatcaccagcctgcccgtcagcatc
ccgctcagcaccgtgcagccgagcaagctgcccgtcagcatccctctggccagtgtggtg
ctgcccagccgcgccgagaaagtgagaagcacccccagccctgtgccgcagacccgagag
tcctcgtccgcacttgaaaagcagatgggcacgaatgcccacagtgctggaagcaaaagc
ctcgccccagctcctgcaggcttctacactggctcggtggccgtcagtggggccctggca
ggcagcccggcccccctcgctcctggagccgagtccagcgcctttgacgaggtctccggc
tcaggaagcctgttcgccagcgtggggtcctgcagctctaccccacagcacccgcccctg
ctgccgcagtcccgcggctctggcacggcctcacctgcccatccactctgcgccagcccc
cggctcagcagtgccacccagggcccgctccccgaggccagcaaaggggactttccgtcc
gagaccggcttctccgaccccgagggcgaagccaagaggagaatcgtctttaccatctca
gctggcggcagtggtgccaagcagtcacctcccagcaaacccagccctctgcccacgggt
gcccgcggggacagcggccagggccacgggtcggacagtcgcaagcggggcaggaggaag
cgggcggcggccgggacccccagcctgagctccagcgtgtcgcccaagcgtcgggccctg
ccgtccgttgccggcctcttcacgcagtcgtcagggtccccactgaacctcaactcgatg
gtcagcaacattaatcagcctttggaaatcacggccatctcgtcccccgagagcctgaag
agctcccctgtcccctaccaggacaacgaccagccgcccgttctcaagaaggagaagccc
ttgagccagaccaacggggcccactactccccactgacctcagacgaggagcaaggctcc
gaggacgagccgggcagcgccagaatcgagagaaaaattgcaacaatctccttagaaagc
aaatctcctccgaaaaccttggaaagtggtggtagcctggccggcaggaagccgacccct
gccggtgagcccgccaacagcagcaagtggaaatccaccttctcgcccatctccgacctc
ggcctggccaagtgtgccgacagcccgctgcaggccggctctgccctgagccagaactcc
ctgttcactttccggccccccctagaggagcccggcttggccgatgccaagctggctgcc
caccccaggaaaagctttcccggtgcgctgtcgggggccggtgggctgagccccagcagc
aaccctcccaatggcttcgccttcagcgggggcctggccgccgacctcagtttacacagc
ttcagcgatggtgcttctctctcccacaaggttcccgaggccgccagcctgggtgccccc
ctgagcttccccgccccgcggggcaaggagggcagtgccacagagcccggcgcctttgtg
aacaagaggcagctggacggactgggaggcccaaagggcagggaggcaggcgagctgggc
ctgccggcgtgcgggcccccagacaaggtctcgctgacgcacagcaagccaggcaagggc
cgggaccgtgagcccgacttgaagaacggccacaacctcttcatttctgccgccactgtg
cctcccgggggcctcctcagtggcccgggcctcgccacggtggcgtcctcgacagtcagc
gcggccccctctgcccagactcaccgccccttcctgggcacctttgcccctggcccgcag
ttcgccctgggtcccatgtccctgcaggccaatctgggctcgtccgtgctacagtccttg
ttcagctccgtgccagccgccgccggcctggtgcacgtctcgtccgccgcgaccagactg
accaactcgcacgccatgggcagcttctcctccggggtggcaggcggcgctgttggaggt
gtctttaaccacgcggtgccttccgcctccgctcatccgtttggagccagtttcggcagc
ggggctgcgtgtcgcagcgccacgctgagcttaaccccgctgcaggcggtggccagcgcc
cccgcgtcttcctttcagtctgagcctgtgcttctgcagaacctcgcgtccctcccggct
aaccaggctttcttacccgcctcttctgccgcctctctgcggcccgctaacgcctctctg
tccattaagctcgcctccctcccgcacaaggccccccgcccctccttcacggtgcaccac
cagcccctgcccgggctggccctggcccaggccgcgcccgtgatcccgcaggccagctcc
acggggccgtctgccgtgtgggtttcccttggcatgccgcctccgtatgccgcgcgcctt
gcgggggttaagccaagataa

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