KEGG   Ailuropoda melanoleuca (giant panda): 100465232Help
Entry
100465232         CDS       T01329                                 

Gene name
PLCB3
Definition
phospholipase C, beta 3 (phosphatidylinositol-specific)
Orthology
K05858  
phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
aml  Ailuropoda melanoleuca (giant panda)
Pathway
Inositol phosphate metabolism
Metabolic pathways
Rap1 signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
Phosphatidylinositol signaling system
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Wnt signaling pathway
Gap junction
Platelet activation
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Dopaminergic synapse
Long-term depression
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Alzheimer's disease
Huntington's disease
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Amoebiasis
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:aml00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100465232 (PLCB3)
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    100465232 (PLCB3)
   04310 Wnt signaling pathway
    100465232 (PLCB3)
   04020 Calcium signaling pathway
    100465232 (PLCB3)
   04070 Phosphatidylinositol signaling system
    100465232 (PLCB3)
   04022 cGMP - PKG signaling pathway
    100465232 (PLCB3)
 Cellular Processes
  Cell communication
   04540 Gap junction
    100465232 (PLCB3)
 Organismal Systems
  Immune system
   04611 Platelet activation
    100465232 (PLCB3)
   04062 Chemokine signaling pathway
    100465232 (PLCB3)
  Endocrine system
   04911 Insulin secretion
    100465232 (PLCB3)
   04912 GnRH signaling pathway
    100465232 (PLCB3)
   04915 Estrogen signaling pathway
    100465232 (PLCB3)
   04921 Oxytocin signaling pathway
    100465232 (PLCB3)
   04918 Thyroid hormone synthesis
    100465232 (PLCB3)
   04919 Thyroid hormone signaling pathway
    100465232 (PLCB3)
   04916 Melanogenesis
    100465232 (PLCB3)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100465232 (PLCB3)
   04270 Vascular smooth muscle contraction
    100465232 (PLCB3)
  Digestive system
   04970 Salivary secretion
    100465232 (PLCB3)
   04971 Gastric acid secretion
    100465232 (PLCB3)
   04972 Pancreatic secretion
    100465232 (PLCB3)
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    100465232 (PLCB3)
  Nervous system
   04724 Glutamatergic synapse
    100465232 (PLCB3)
   04725 Cholinergic synapse
    100465232 (PLCB3)
   04728 Dopaminergic synapse
    100465232 (PLCB3)
   04726 Serotonergic synapse
    100465232 (PLCB3)
   04720 Long-term potentiation
    100465232 (PLCB3)
   04730 Long-term depression
    100465232 (PLCB3)
   04723 Retrograde endocannabinoid signaling
    100465232 (PLCB3)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100465232 (PLCB3)
  Environmental adaptation
   04713 Circadian entrainment
    100465232 (PLCB3)
 Human Diseases
  Neurodegenerative diseases
   05010 Alzheimer's disease
    100465232 (PLCB3)
   05016 Huntington's disease
    100465232 (PLCB3)
  Infectious diseases
   05146 Amoebiasis
    100465232 (PLCB3)
   05142 Chagas disease (American trypanosomiasis)
    100465232 (PLCB3)
   05143 African trypanosomiasis
    100465232 (PLCB3)
Enzymes [BR:aml01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     100465232 (PLCB3)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Position
Un
AA seq 1208 aa AA seqDB search
MGFEADEASSRNLVTLRVDSNGFFLYWTGPNMEVDTLDISSIRDTRTGRYARLPKDPKIR
EVLGFGGPDARLEEKLMTVVAGPDPVNTTFLNFMAVQDDTAKVWTEELFKLAMNILAQNA
SRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFSADKKRVETALESCGLNFNRSESIRPDE
FSLEIFERFLNKLCLRPDIDKILLEIGAKGKPYLTLEQLMDFINQKQRDPRLNEVLYPPL
RPSQARLLIEKYEPNQQFLERDQMSMEGFSRYLGGEENGILPLEALDLSTDMTQPLSAYF
INSSHNTYLTAGQLAGTSSVEMYRQALLWGCRCVELDVWKGRPPEEEPFITHGFTMTTEV
PLRDVLEAIAETAFKTSPYPVILSFENHVDSAKQQAKMAEYCRSIFGDALLIDPLDKYPL
APGVSLPSPQDLMGRILVKNKKRHRPSTGVPNSSVRKRPLEQSNSALSESSAATEPSSPQ
LGSPSSDSCPGLSNGEEVGPEKPSLEPQKSLGEDGLPRGPDALGSADREDEEEEEEEEEQ
TDPKKPTTDEGTASSEVNATEEMSTLVNYIEPVKFKSFEAARKRNKCFEMSSFVETKAME
QLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYMPQLFWNVGCQLVALNFQTLDVAMQLNA
GVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIVDGIVANALRVKVISGQFLSDRKVGIYV
EVDIFGLPVDTRRKYRTRTSQGNSFNPVWDEEPFDFPKVVLPTLASLRIAAFEEGGKFVG
HRILPVSAIRSGYHYICLRNEANQPLCLPALLIYTEASDYIPDDHQDYAEALINPIKHVS
LMDQRAKQLAALIGESEAQASPETCQETQSQQLGSQLTPNPTPSPLDTSPRRPPGPATSP
TSPSLSSPGQRDDLIASLLSEVAPTPLDELRGHKALVKLRSRQERELRELHKKHQRKAVA
LTRRLLDGLAQARAEGRCRQRPGVLGSSYRSGENEKEEEEEVRRYQEFQKRQVQSLLELR
EAQADTEAERRLEHLRQAQQRLREIVLDFHTTQFKRLKEMNEREKKELQKILDRKRHNSI
SEAKTREKHKKEAELTEINRRHITESVNSIRRLEEAQKQRHERLVAGQQQVLQQLAEEEP
KLLAQLAQECQEQRARLPQEIRRSLLGDTPEGLGDGHLVACASNGHAPGSGGHLSGADSE
SQEENTKL
NT seq 3627 nt NT seq  +upstreamnt  +downstreamnt
atggggtttgaggccgatgaggcctccagtcggaatctggtaaccctgcgtgtggactct
aatggcttctttctgtactggaccggacccaacatggaggtggacacactggacatcagt
tccatcagggacacgcggacggggcgttacgcccgcctgcccaaggaccccaagatccgg
gaggtgctgggctttgggggccctgacgctcggctggaggagaagttgatgacggtggtg
gccgggccagacccggtgaatacgacattcttgaacttcatggccgtgcaggatgacaca
gccaaggtctggactgaggagctgttcaagctggctatgaacatcctggctcagaatgcc
tcccggaacaccttcctgcgaaaagcgtacacaaagctgaaactgcaagtgaaccaggat
ggacggatcccggtgaagaatatcctgaagatgttttcagcagataaaaagcgagtagag
actgcactggaatcctgtggcctcaatttcaaccggagtgagtccatccggccagacgaa
ttttccttggaaatcttcgagcggttcctgaataagttgtgtctgcggccagacattgac
aagatcctgctggagataggcgccaagggcaagccgtacctgacgctggagcagctcatg
gacttcatcaaccagaagcaacgggacccgaggctcaacgaagtgctgtacccacccctg
cggccctcgcaggcccggctgctcattgagaagtatgagcccaaccagcagtttctggag
cgagaccagatgtccatggagggcttcagccgctacctgggaggtgaggagaatggcatc
ttgcctctggaggccctggatctgagcacagacatgacacagccgctgagcgcctacttc
atcaactcctcacacaacacctatctcacagcggggcagctggccgggacctcgtcggtg
gagatgtaccgccaggcgctgctgtggggctgccgctgcgtggagctggatgtgtggaaa
gggcggccgcctgaggaggagcccttcatcacccacggcttcaccatgaccaccgaggtg
ccgctgcgagatgtgctcgaggccatcgcggaaaccgccttcaagacctcgccctacccc
gtcatcctctccttcgagaaccacgtggactcggcaaagcagcaggccaagatggccgag
tactgccgttccatctttggggacgcgctgctcatcgacccgctggacaagtacccgctg
gcgccaggcgtctccctgcccagcccccaggacctgatgggccgcatcctggtgaagaac
aaaaagcgacaccggcccagcactggtgtccccaacagctctgtgcgtaagcggccgctg
gagcagagcaactcggctctgagcgagagctctgccgccaccgagccctcctcacctcag
ctcgggtcccccagttctgacagctgcccaggcctgagcaatggggaagaggtgggcccg
gagaagcccagcctggagcctcaaaagtctctgggtgaggacgggctaccgaggggccct
gatgctcttgggtctgctgaccgtgaggacgaggaggaagaggaggaagaggaggaacag
acagatcccaaaaagccgaccacagatgagggcactgccagcagtgaggtcaatgccacc
gaggaaatgtcaacactcgtcaactacatcgagcctgtcaagttcaagtcctttgaggct
gctcgaaaaaggaacaaatgcttcgagatgtcatcctttgtggaaaccaaggccatggag
cagctgaccaagagccccatggagtttgtggaatacaataagcagcagctcagccggatc
taccccaagggcacccgcgtggactcatccaactacatgccccagctcttctggaacgtc
ggctgccagcttgttgcgctcaacttccagaccctggacgtggcgatgcagcttaacgca
ggtgtgttcgagtacaacgggcgcagcggctacctgctcaagcccgagttcatgcggcgg
ccagacaagtcctttgatcccttcaccgaggtcatcgtggacggcatcgtggccaatgcc
ttgcgggtcaaggtgatctcggggcagttcctgtccgacaggaaggtgggcatctacgtg
gaggtggacatatttggcctccccgtggacacacggcgcaagtaccgcactcggacctct
caggggaactccttcaatcccgtgtgggacgaggagccctttgacttccccaaggtggtg
ctgcccacactggcttcgctgcgcatcgcggcctttgaggagggaggcaagtttgtgggg
catcggattctgcctgtctctgccatccgctcaggataccactacatctgtctgcggaac
gaggccaaccagccgctctgcctgccggccctgctcatctacaccgaagcctctgactac
atccctgacgaccaccaggactacgccgaggccttgatcaaccccatcaagcacgtcagc
ctgatggaccagagagccaagcagttggccgccctcattggggagagcgaggctcaggcc
agcccagagacctgccaggagactcagtctcagcagctggggtcccagctgaccccaaac
cccacacccagcccgctggacacctccccgcgccggcccccaggccctgccacgtcccct
accagcccctcgctcagcagtccagggcagcgggacgacctcatcgccagcctcctgtca
gaggtggccccgaccccgctggacgagctccgaggccacaaggccctggtgaagctccgg
agccggcaggagcgagagctgcgggagctgcacaagaagcaccagcggaaggccgtcgcc
ctcacgcgccggctcctcgacggcctggctcaggcgcgggcggagggcaggtgccgccag
cggccgggggtcctgggctcttcctacagaagcggggaaaacgagaaggaggaggaggaa
gaggtgaggcggtatcaagagttccagaagagacaggtgcagagtctgctggagctgagg
gaggcccaggcggatacagaggctgagcggaggctggagcacctgagacaggctcagcag
cggctcagggagattgtcctggattttcacacaactcagttcaagaggctgaaggagatg
aacgagagggagaagaaggaactgcagaagattctggacaggaagcgccacaacagtatc
tcagaggccaagacaagggagaaacataagaaggaggcggaactgacagagattaaccgg
cggcatatcaccgagtcggtcaactccatccgtcggctggaggaggcccagaagcagcgg
catgagcgccttgtggccgggcagcaacaggtcctacagcagctggcagaagaggagccc
aagctgctggcccagctggcccaggagtgtcaggagcagcgggcaaggctgccccaggag
atccgccggagcctgctgggcgacacgccggaggggctgggggacgggcatctggtggcc
tgtgccagcaacggtcatgcacccgggagcggcgggcacctgtctggtgctgactcggag
agccaagaggagaatacgaagctctga

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