KEGG   Ailuropoda melanoleuca (giant panda): 100465232Help
Entry
100465232         CDS       T01329                                 

Gene name
PLCB3
Definition
(RefSeq) phospholipase C beta 3
  KO
K05858  
phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
aml  Ailuropoda melanoleuca (giant panda)
Pathway
Inositol phosphate metabolism
Metabolic pathways
Rap1 signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
Phosphatidylinositol signaling system
Sphingolipid signaling pathway
Phospholipase D signaling pathway
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Wnt signaling pathway
Apelin signaling pathway
Gap junction
Platelet activation
NOD-like receptor signaling pathway
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Dopaminergic synapse
Long-term depression
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Glucagon signaling pathway
Renin secretion
Aldosterone synthesis and secretion
AGE-RAGE signaling pathway in diabetic complications
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Alzheimer's disease
Huntington's disease
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Amoebiasis
Pathways in cancer
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:aml00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100465232 (PLCB3)
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    100465232 (PLCB3)
   04310 Wnt signaling pathway
    100465232 (PLCB3)
   04371 Apelin signaling pathway
    100465232 (PLCB3)
   04020 Calcium signaling pathway
    100465232 (PLCB3)
   04070 Phosphatidylinositol signaling system
    100465232 (PLCB3)
   04072 Phospholipase D signaling pathway
    100465232 (PLCB3)
   04071 Sphingolipid signaling pathway
    100465232 (PLCB3)
   04022 cGMP - PKG signaling pathway
    100465232 (PLCB3)
 Cellular Processes
  Cellular community - eukaryotes
   04540 Gap junction
    100465232 (PLCB3)
 Organismal Systems
  Immune system
   04611 Platelet activation
    100465232 (PLCB3)
   04621 NOD-like receptor signaling pathway
    100465232 (PLCB3)
   04062 Chemokine signaling pathway
    100465232 (PLCB3)
  Endocrine system
   04911 Insulin secretion
    100465232 (PLCB3)
   04922 Glucagon signaling pathway
    100465232 (PLCB3)
   04912 GnRH signaling pathway
    100465232 (PLCB3)
   04915 Estrogen signaling pathway
    100465232 (PLCB3)
   04921 Oxytocin signaling pathway
    100465232 (PLCB3)
   04918 Thyroid hormone synthesis
    100465232 (PLCB3)
   04919 Thyroid hormone signaling pathway
    100465232 (PLCB3)
   04916 Melanogenesis
    100465232 (PLCB3)
   04924 Renin secretion
    100465232 (PLCB3)
   04925 Aldosterone synthesis and secretion
    100465232 (PLCB3)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100465232 (PLCB3)
   04270 Vascular smooth muscle contraction
    100465232 (PLCB3)
  Digestive system
   04970 Salivary secretion
    100465232 (PLCB3)
   04971 Gastric acid secretion
    100465232 (PLCB3)
   04972 Pancreatic secretion
    100465232 (PLCB3)
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    100465232 (PLCB3)
  Nervous system
   04724 Glutamatergic synapse
    100465232 (PLCB3)
   04725 Cholinergic synapse
    100465232 (PLCB3)
   04728 Dopaminergic synapse
    100465232 (PLCB3)
   04726 Serotonergic synapse
    100465232 (PLCB3)
   04720 Long-term potentiation
    100465232 (PLCB3)
   04730 Long-term depression
    100465232 (PLCB3)
   04723 Retrograde endocannabinoid signaling
    100465232 (PLCB3)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100465232 (PLCB3)
  Environmental adaptation
   04713 Circadian entrainment
    100465232 (PLCB3)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    100465232 (PLCB3)
  Neurodegenerative diseases
   05010 Alzheimer's disease
    100465232 (PLCB3)
   05016 Huntington's disease
    100465232 (PLCB3)
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    100465232 (PLCB3)
  Infectious diseases
   05146 Amoebiasis
    100465232 (PLCB3)
   05142 Chagas disease (American trypanosomiasis)
    100465232 (PLCB3)
   05143 African trypanosomiasis
    100465232 (PLCB3)
Enzymes [BR:aml01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     100465232 (PLCB3)
Membrane trafficking [BR:aml04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    100465232 (PLCB3)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    100465232 (PLCB3)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-ProteinID: 
NCBI-GeneID: 
Ensembl: 
Position
Un
AA seq 1246 aa AA seqDB search
MRLHLHSPAETLGWMARGNRGHSPHSLTPAVPCRPQEASSRNLVTLRVDSNGFFLYWTGP
NMEVDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDARLEEKLMTVVAGPDPVNTTF
LNFMAVQDDTAKVWTEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILK
MFSADKKRVETALESCGLNFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKG
KPYLTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFS
RYLGGEENGILPLEALDLSTDMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWG
CRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVD
SAKQQAKMAEYCRSIFGDALLIDPLDKYPLAPGVSLPSPQDLMGRILVKNKKRHRPSTGV
PNSSVRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEEVGPEKPSLEPQKS
LGEDGLPRGPDALGSADREDEEEEEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVNYI
EPVKFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSS
NYMPQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTE
VIVDGIVANALRVKVISGQFLSDRKVGIYVEVDIFGLPVDTRRKYRTRTSQGNSFNPVWD
EEPFDFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYICLRNEANQPLCLPA
LLIYTEASDYIPDDHQDYAEALINPIKHVSLMDQRAKQLAALIGESEAQASPETCQETQS
QQLGSQLTPNPTPSPLDTSPRRPPGPATSPTSPSLSSPGQRDDLIASLLSEVAPTPLDEL
RGHKALVKLRSRQERELRELHKKHQRKAVALTRRLLDGLAQARAEGRCRQRPGVLSGENE
KEEEEEVRRYQEFQKRQVQSLLELREAQADTEAERRLEHLRQAQQRLREIVLDFHTTQFK
RLKEMNEREKKELQKILDRKRHNSISEAKTREKHKKEAWRRPRSSGMSALWPGSNRSYSS
WQKRSPSCWPSWPRSVRSSGQGCPRRSAGACWATRRRGWGTGIWWPVPATVMHPGAAGTC
LVLTRRAKRRIRSSELAEQEVATGWVLGGQEAKTLMLFFFFLTFYL
NT seq 3741 nt NT seq  +upstreamnt  +downstreamnt
atgaggcttcatcttcactcaccggcagaaacgctggggtggatggcccgagggaaccga
gggcacagccctcactcactgacccctgccgtcccatgccgtccccaggaggcctccagt
cggaatctggtaaccctgcgtgtggactctaatggcttctttctgtactggaccggaccc
aacatggaggtggacacactggacatcagttccatcagggacacgcggacggggcgttac
gcccgcctgcccaaggaccccaagatccgggaggtgctgggctttgggggccctgacgct
cggctggaggagaagttgatgacggtggtggccgggccagacccggtgaatacgacattc
ttgaacttcatggccgtgcaggatgacacagccaaggtctggactgaggagctgttcaag
ctggctatgaacatcctggctcagaatgcctcccggaacaccttcctgcgaaaagcgtac
acaaagctgaaactgcaagtgaaccaggatggacggatcccggtgaagaatatcctgaag
atgttttcagcagataaaaagcgagtagagactgcactggaatcctgtggcctcaatttc
aaccggagtgagtccatccggccagacgaattttccttggaaatcttcgagcggttcctg
aataagttgtgtctgcggccagacattgacaagatcctgctggagataggcgccaagggc
aagccgtacctgacgctggagcagctcatggacttcatcaaccagaagcaacgggacccg
aggctcaacgaagtgctgtacccacccctgcggccctcgcaggcccggctgctcattgag
aagtatgagcccaaccagcagtttctggagcgagaccagatgtccatggagggcttcagc
cgctacctgggaggtgaggagaatggcatcttgcctctggaggccctggatctgagcaca
gacatgacacagccgctgagcgcctacttcatcaactcctcacacaacacctatctcaca
gcggggcagctggccgggacctcgtcggtggagatgtaccgccaggcgctgctgtggggc
tgccgctgcgtggagctggatgtgtggaaagggcggccgcctgaggaggagcccttcatc
acccacggcttcaccatgaccaccgaggtgccgctgcgagatgtgctcgaggccatcgcg
gaaaccgccttcaagacctcgccctaccccgtcatcctctccttcgagaaccacgtggac
tcggcaaagcagcaggccaagatggccgagtactgccgttccatctttggggacgcgctg
ctcatcgacccgctggacaagtacccgctggcgccaggcgtctccctgcccagcccccag
gacctgatgggccgcatcctggtgaagaacaaaaagcgacaccggcccagcactggtgtc
cccaacagctctgtgcgtaagcggccgctggagcagagcaactcggctctgagcgagagc
tctgccgccaccgagccctcctcacctcagctcgggtcccccagttctgacagctgccca
ggcctgagcaatggggaagaggtgggcccggagaagcccagcctggagcctcaaaagtct
ctgggtgaggacgggctaccgaggggccctgatgctcttgggtctgctgaccgtgaggac
gaggaggaagaggaggaagaggaggaacagacagatcccaaaaagccgaccacagatgag
ggcactgccagcagtgaggtcaatgccaccgaggaaatgtcaacactcgtcaactacatc
gagcctgtcaagttcaagtcctttgaggctgctcgaaaaaggaacaaatgcttcgagatg
tcatcctttgtggaaaccaaggccatggagcagctgaccaagagccccatggagtttgtg
gaatacaataagcagcagctcagccggatctaccccaagggcacccgcgtggactcatcc
aactacatgccccagctcttctggaacgtcggctgccagcttgttgcgctcaacttccag
accctggacgtggcgatgcagcttaacgcaggtgtgttcgagtacaacgggcgcagcggc
tacctgctcaagcccgagttcatgcggcggccagacaagtcctttgatcccttcaccgag
gtcatcgtggacggcatcgtggccaatgccttgcgggtcaaggtgatctcggggcagttc
ctgtccgacaggaaggtgggcatctacgtggaggtggacatatttggcctccccgtggac
acacggcgcaagtaccgcactcggacctctcaggggaactccttcaatcccgtgtgggac
gaggagccctttgacttccccaaggtggtgctgcccacactggcttcgctgcgcatcgcg
gcctttgaggagggaggcaagtttgtggggcatcggattctgcctgtctctgccatccgc
tcaggataccactacatctgtctgcggaacgaggccaaccagccgctctgcctgccggcc
ctgctcatctacaccgaagcctctgactacatccctgacgaccaccaggactacgccgag
gccttgatcaaccccatcaagcacgtcagcctgatggaccagagagccaagcagttggcc
gccctcattggggagagcgaggctcaggccagcccagagacctgccaggagactcagtct
cagcagctggggtcccagctgaccccaaaccccacacccagcccgctggacacctccccg
cgccggcccccaggccctgccacgtcccctaccagcccctcgctcagcagtccagggcag
cgggacgacctcatcgccagcctcctgtcagaggtggccccgaccccgctggacgagctc
cgaggccacaaggccctggtgaagctccggagccggcaggagcgagagctgcgggagctg
cacaagaagcaccagcggaaggccgtcgccctcacgcgccggctcctcgacggcctggct
caggcgcgggcggagggcaggtgccgccagcggccgggggtcctaagcggggaaaacgag
aaggaggaggaggaagaggtgaggcggtatcaagagttccagaagagacaggtgcagagt
ctgctggagctgagggaggcccaggcggatacagaggctgagcggaggctggagcacctg
agacaggctcagcagcggctcagggagattgtcctggattttcacacaactcagttcaag
aggctgaaggagatgaacgagagggagaagaaggaactgcagaagattctggacaggaag
cgccacaacagtatctcagaggccaagacaagggagaaacataagaaggaggcctggagg
aggcccagaagcagcggcatgagcgccttgtggccgggcagcaacaggtcctacagcagc
tggcagaagaggagcccaagctgctggcccagctggcccaggagtgtcaggagcagcggg
caaggctgccccaggagatccgccggagcctgctgggcgacacgccggaggggctggggg
acgggcatctggtggcctgtgccagcaacggtcatgcacccgggagcggcgggcacctgt
ctggtgctgactcggagagccaagaggagaatacgaagctctgaactggctgagcaagag
gtggccacaggatgggtgctgggagggcaggaagctaagacactaatgcttttttttttt
tttttaactttttatctttag

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