KEGG   Ailuropoda melanoleuca (giant panda): 100465700Help
Entry
100465700         CDS       T01329                                 

Gene name
MAP2K2
Definition
(RefSeq) mitogen-activated protein kinase kinase 2
  KO
K04369  
mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
Organism
aml  Ailuropoda melanoleuca (giant panda)
Pathway
MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Sphingolipid signaling pathway
PI3K-Akt signaling pathway
Vascular smooth muscle contraction
VEGF signaling pathway
Gap junction
Signaling pathways regulating pluripotency of stem cells
Toll-like receptor signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Long-term potentiation
Neurotrophin signaling pathway
Long-term depression
Regulation of actin cytoskeleton
Insulin signaling pathway
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Prion diseases
Hepatitis B
Influenza A
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Renal cell carcinoma
Endometrial cancer
Glioma
Prostate cancer
Thyroid cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Central carbon metabolism in cancer
Choline metabolism in cancer
Module
MAPK (ERK1/2) signaling
Brite
KEGG Orthology (KO) [BR:aml00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    100465700 (MAP2K2)
   04015 Rap1 signaling pathway
    100465700 (MAP2K2)
   04010 MAPK signaling pathway
    100465700 (MAP2K2)
   04012 ErbB signaling pathway
    100465700 (MAP2K2)
   04370 VEGF signaling pathway
    100465700 (MAP2K2)
   04066 HIF-1 signaling pathway
    100465700 (MAP2K2)
   04068 FoxO signaling pathway
    100465700 (MAP2K2)
   04071 Sphingolipid signaling pathway
    100465700 (MAP2K2)
   04024 cAMP signaling pathway
    100465700 (MAP2K2)
   04022 cGMP - PKG signaling pathway
    100465700 (MAP2K2)
   04151 PI3K-Akt signaling pathway
    100465700 (MAP2K2)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    100465700 (MAP2K2)
  Cellular commiunity
   04540 Gap junction
    100465700 (MAP2K2)
   04550 Signaling pathways regulating pluripotency of stem cells
    100465700 (MAP2K2)
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    100465700 (MAP2K2)
   04650 Natural killer cell mediated cytotoxicity
    100465700 (MAP2K2)
   04660 T cell receptor signaling pathway
    100465700 (MAP2K2)
   04662 B cell receptor signaling pathway
    100465700 (MAP2K2)
   04664 Fc epsilon RI signaling pathway
    100465700 (MAP2K2)
  Endocrine system
   04910 Insulin signaling pathway
    100465700 (MAP2K2)
   04912 GnRH signaling pathway
    100465700 (MAP2K2)
   04915 Estrogen signaling pathway
    100465700 (MAP2K2)
   04917 Prolactin signaling pathway
    100465700 (MAP2K2)
   04921 Oxytocin signaling pathway
    100465700 (MAP2K2)
   04919 Thyroid hormone signaling pathway
    100465700 (MAP2K2)
   04916 Melanogenesis
    100465700 (MAP2K2)
  Circulatory system
   04270 Vascular smooth muscle contraction
    100465700 (MAP2K2)
  Nervous system
   04720 Long-term potentiation
    100465700 (MAP2K2)
   04730 Long-term depression
    100465700 (MAP2K2)
   04722 Neurotrophin signaling pathway
    100465700 (MAP2K2)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    100465700 (MAP2K2)
   05230 Central carbon metabolism in cancer
    100465700 (MAP2K2)
   05231 Choline metabolism in cancer
    100465700 (MAP2K2)
   05206 MicroRNAs in cancer
    100465700 (MAP2K2)
   05205 Proteoglycans in cancer
    100465700 (MAP2K2)
   05214 Glioma
    100465700 (MAP2K2)
   05216 Thyroid cancer
    100465700 (MAP2K2)
   05221 Acute myeloid leukemia
    100465700 (MAP2K2)
   05220 Chronic myeloid leukemia
    100465700 (MAP2K2)
   05218 Melanoma
    100465700 (MAP2K2)
   05211 Renal cell carcinoma
    100465700 (MAP2K2)
   05219 Bladder cancer
    100465700 (MAP2K2)
   05215 Prostate cancer
    100465700 (MAP2K2)
   05213 Endometrial cancer
    100465700 (MAP2K2)
   05223 Non-small cell lung cancer
    100465700 (MAP2K2)
  Neurodegenerative diseases
   05020 Prion diseases
    100465700 (MAP2K2)
  Infectious diseases
   05164 Influenza A
    100465700 (MAP2K2)
   05161 Hepatitis B
    100465700 (MAP2K2)
Enzymes [BR:aml01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     100465700 (MAP2K2)
Protein kinases [BR:aml01001]
 Serine/threonine protein kinases: STE group
  STE7 family
   100465700 (MAP2K2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Ensembl: 
Position
Un
AA seq 390 aa AA seqDB search
ALTINPAIAEGPSPTSEGASEANLVDLQKKLAELELDEQQKKRLEAFLTQKAKVGELKDD
DFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI
VGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQI
MHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDI
WSMGLSLVELSIGRYPIPPPDAKELEAIFGRPVVDGVEGEPHSISPRPRPPGRPISGHGT
DSRPAMAIFELLDYIVNEPPPKLPSGVFTQDFQEFVNKCLIKNPAERADLKMLMSHTFIK
RSETEEVDFAGWLCNTLRLNQPSTPTRAAV
NT seq 1173 nt NT seq  +upstreamnt  +downstreamnt
gcgctcactatcaaccccgccatcgccgagggcccgtcccccaccagcgagggcgcctcc
gaagcaaacttggtggacctccaaaagaagctagcggagctagaactcgacgagcagcag
aagaagcgactggaagccttcctcacccagaaggccaaggttggggagctcaaggacgat
gacttcgaacggatctcggagctgggagccgggaacggcggggtggtcaccaaggtccag
cacagaccttccggcctcatcatggcaagaaagctgatccacctggaaatcaagccggct
atccggaaccagatcatccgcgagctgcaggtgctgcacgagtgtaactcgccgtacatc
gtgggtttctacggggccttctacagcgacggcgagatcagcatctgcatggagcacatg
gacggcggctctctggaccaggtgttgaaagaagccaagagaattcccgaggagatcctg
gggaaggtcagcattgcggttctccggggtttggcgtatctccgggaaaagcaccagatc
atgcaccgagatgtgaaaccttccaacatcctcgtcaactcccgaggggagattaagctg
tgcgattttggggtgagcggacagctcatcgactccatggccaactccttcgtgggaact
cggtcctacatgtctccagagcggttgcagggcactcactactctgtgcagtcggacatc
tggagcatgggcctgtccctggtggagctgtccatcggaaggtaccccatccccccgccg
gacgccaaggagctagaggccatatttggccggcccgtggtggacggggtagaaggagag
cctcacagcatctcaccacggccgagaccccctggacgccccatcagcggtcacgggacg
gacagccggccggccatggccatcttcgagctgctggactatatcgtgaacgagccacct
cccaagctgcccagtggcgtcttcacccaggacttccaggagtttgtaaataaatgccta
ataaagaacccagcagagcgagcggatctgaagatgctcatgagccacaccttcatcaag
cggtccgagacggaagaagtggattttgccggctggttgtgtaacacgctgcggctgaac
cagcccagcacgcccacgcgcgctgccgtgtga

DBGET integrated database retrieval system