KEGG   Ailuropoda melanoleuca (giant panda): 100471078
Entry
100471078         CDS       T01329                                 
Symbol
ARHGEF12
Name
(RefSeq) rho guanine nucleotide exchange factor 12 isoform X1
  KO
K07532  Rho guanine nucleotide exchange factor 12
Organism
aml  Ailuropoda melanoleuca (giant panda)
Pathway
aml04270  Vascular smooth muscle contraction
aml04360  Axon guidance
aml04611  Platelet activation
aml04625  C-type lectin receptor signaling pathway
aml04810  Regulation of actin cytoskeleton
aml05135  Yersinia infection
aml05152  Tuberculosis
aml05163  Human cytomegalovirus infection
aml05200  Pathways in cancer
aml05205  Proteoglycans in cancer
Brite
KEGG Orthology (KO) [BR:aml00001]
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100471078 (ARHGEF12)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100471078 (ARHGEF12)
   04625 C-type lectin receptor signaling pathway
    100471078 (ARHGEF12)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    100471078 (ARHGEF12)
  09158 Development and regeneration
   04360 Axon guidance
    100471078 (ARHGEF12)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100471078 (ARHGEF12)
   05205 Proteoglycans in cancer
    100471078 (ARHGEF12)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    100471078 (ARHGEF12)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    100471078 (ARHGEF12)
   05152 Tuberculosis
    100471078 (ARHGEF12)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:aml04131]
    100471078 (ARHGEF12)
Membrane trafficking [BR:aml04131]
 Others
  Rho GTPase associated proteins
   Rho guanine nucleotide exchange factors (GEFs)
    100471078 (ARHGEF12)
SSDB
Motif
Pfam: RGS-like PH_16 RhoGEF PDZ PDZ_6 PH_13 PDZ_2 COS Tricorn_PDZ AAA_23
Other DBs
NCBI-GeneID: 100471078
NCBI-ProteinID: XP_011215116
Ensembl: ENSAMEG00000008026
UniProt: G1LN95
Position
8:15923227..16077682
AA seq 1543 aa
MSGTQSTITDRFPLKKPIRHGSILNRESPTDKKQKVERSASHDFDPTDSSSKKTKSSSEE
SRSEIYGLVQRCVIIQKDDNGFGLTVSGDNPVFVQSVKEDGAAMRAGVQTGDRIIKVNGT
LVTHSNHLEVVKLIKSGSYVALTVQGRPPGSPQIPLADSEVEPSVIGHMSPIMTSPHSPG
ASGNMERITSPVLMGEENNVVHNQKVEILRKMLQKEQERLQLLQEDYNRTPAQRLLKEIQ
EAKKHIPQLQEQLSKATGSAQDGAAVTSSKPLGDALTVSEVEADPGDGLSRIDSSSGDAS
RPSSDSADSPKSALKERIYLEENPEKSEVIQDTDTQSLIGSPSPRIAPHIIGAEDDDFGT
EHEQINGQCSCFQSIELLKSRPAHLAVFLHHVVSQFDPATLLCYLYSDLYKQTNSKETRR
VFLEFHQFFLDRSAHLKVSVPDEISVDLEKRRPELIPEDLHRHYIQTMQERVHPEVQRHL
EDFRQKRSMGLTLAESELTKLDAERDKDRVTLEKERACAEQIVAKIEEVLMTAQAVEEDK
SSTMQYVILMYMKHLGVKVKEPRNLEHKRGRIGFLPKIKQSMKKDREGEEKGKRRGFPSI
LGPPRRPSRHDNSAIGRAMELQKQRHPKHLPTPSSVSPEPQDPAKLRQSGLAGEGTDVGY
LPANSMSSVASGATLSQEGGKENDTGSKQLGETPASGDCVDSTPRTPNTVFDFPPPPLDQ
VQEEEWEVERVTEHGTPKPFRKFDSIAFGESQSEDEQFENDLETDPPNWQQLVSREVLLG
LKPSEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILSPSELRKIFSNLEDILQ
LHIGLNEQMKAVRKRNETSVIDQIGEDLLTWFSGPGEDKLKHAAATFCSNQPFALEMIKS
RQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKYPLLLDNIAKYTEWPMEREKV
KKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLDTSNLKLSEYPNVEELRNLDLTKRKM
IHEGPLVWKVNRDKTIDLYTLLLEDILVLLQKQDDRLVLRCHSKILASTADSKHTFSPVI
KLNTVLVRQVATDNKALFVISMSDNGAQIYELVAQTVSEKTVWQDLICRMAASVKEQSAK
PIPLPQSPPCEGDNDEEAAPKLKVGHHSISVPGLQSPDRDLGLESPLMSSKPQSHSLGTS
GKSEVDDLFVAERQFAKEQHADGTLQEAGASYQIPIPDPHLPASEERWALDALRNLGLLK
QLLVQQLGLTEKSTQEDWPHFPRYRTASSGVQTNGGAQNSENSKACPPGEGQMPFRTGTG
DIATCYSPRTSAESSAPRDSVVLAFQDSQASNILVMDHVIMTPEMPPAEPEGSLDESGEH
FFDAREAHSDDNPSEGDGAVQKEEDVTLRISGNYLILDGYEAVQESSTDEDVASLLPPPP
PAGIPSTDSARPHQHSPQRAHSDGAASPFTPEFLLQQRWGAMEDSCFEIQSPPSCADSQS
QIMEYIRKIEADLEHLKKVEESYSMLCQRLAGSALTDKHSDKS
NT seq 4632 nt   +upstreamnt  +downstreamnt
atgagtggcacacagtctactatcaccgacaggtttcccctcaaaaaacctataaggcat
gggagtattttgaaccgagagtcaccaacagataagaagcagaaagttgagcgcagtgca
tcacatgattttgatcctacagatagctcctccaagaagacaaagtctagttcagaggag
agtagatccgagatatatggtcttgttcagcgttgtgtgatcatccagaaggatgacaat
ggatttgggctgacggtcagtggagacaatccagtcttcgtacagtctgtcaaagaagat
ggagcagccatgcgggctggggtacagacaggtgatcgaatcatcaaggtgaatggaact
ctggtgactcattcaaaccatttggaagtggtgaagctaatcaaatctggttcctatgta
gctctcactgttcagggacgcccacctgggtcgccccagattccactcgccgattctgaa
gtagagccatcagtcattggacatatgtctcccatcatgacatcccctcattcacctgga
gcatctgggaacatggagagaattactagtcctgtgcttatgggggaggaaaacaatgtg
gttcataaccagaaagtagaaattctgagaaaaatgttacagaaagaacaggaacggctg
cagttattgcaggaagattacaaccgaacacctgcccaaagattgctaaaagagatccaa
gaggccaagaaacacattcctcagctgcaagagcagttatccaaagccacgggctctgct
caggatggagctgcagttacctcctccaagcctttaggtgacgcactgacagtcagtgag
gtggaagctgatcctggtgatggactaagcagaattgactccagcagtggagacgcttct
cggcccagtagtgacagcgcagacagtcccaagagtgccctgaaagagaggatttatcta
gaggaaaacccagagaaaagtgaagtgattcaggacactgatactcagtcactcatcggg
agtccctctccccgtatagcacctcatattattggagcagaggatgatgattttggtact
gaacatgaacagatcaatgggcagtgcagctgtttccagagcatcgagctgctgaaatct
cgccctgctcacctggctgttttcttacaccacgtggtctcacaatttgaccccgcaacg
ctgctctgttatctctattcagacctgtacaagcagaccaattccaaggagactcgtcgt
gtcttccttgagtttcatcagttcttcctggatcgatctgcacacctgaaagtttctgtg
cctgatgaaatatcagtagatctagaaaaaagaagacctgagcttatacccgaggatctg
caccgccactatatccaaactatgcaggaaagagtccacccagaagttcagaggcacttg
gaagattttcggcagaagcgtagcatggggctgaccttggctgaaagtgaactgactaaa
ctcgacgcagagcgagacaaggaccgggtcactttggagaaggaacgggcatgtgcagaa
cagatcgttgccaaaattgaagaagtgttgatgactgctcaggctgtagaagaagataag
agttcaacaatgcagtatgttatccttatgtacatgaagcatttgggggtaaaagtgaaa
gaacctcgaaatttggagcacaagcggggtcggattggattccttccaaaaatcaagcag
agtatgaagaaagatcgagaaggcgaagaaaaagggaagcgcagaggattccccagcatc
ctgggacccccaaggagaccaagccgtcatgacaacagtgcaattggcagggccatggag
ctacagaaacagcggcacccaaagcacttacccacaccctcttctgtgagtccagagcct
caggaccctgctaagttgcgccagagtgggttagcaggtgaaggaacagacgtcggatac
ctgccagccaattccatgtcctctgtggcttcaggggccactctttcccaggaaggaggg
aaagagaatgatacaggatcaaagcaacttggagaaacaccagcatctggagactgcgta
gatagcacccctcggactccgaatactgtctttgatttcccacctcctcctttagaccaa
gtgcaggaggaggaatgggaagtggaaagggtgactgaacatgggacaccaaagcccttt
cgaaagtttgacagcatagcttttggagaaagtcaaagtgaggatgaacagtttgaaaat
gacttagagacagacccaccgaactggcaacagcttgttagtcgagaagtgttactggga
ctaaagccttctgagatcaaaaggcaggaagtaattaatgaattgttctacactgaaaga
gctcatgttcgaacactgaaagttcttgatcaagtattctatcagcgagtgtccagagaa
ggaattctgtcaccttcagaactacggaaaattttttcaaacttggaagatattcttcaa
cttcatattggattgaatgagcaaatgaaggctgttcgaaagaggaatgagacctcagtt
attgatcagattggggaagatttgctgacctggttcagtggaccaggagaggacaagttg
aagcacgccgctgctaccttttgcagtaaccaacctttcgccctggaaatgatcaagtct
cgtcagaaaaaggattctcgattccagacctttgtgcaagatgccgagagtaatcctcta
tgtcgtcgtctgcagctgaaggatatcattcctacccaaatgcagaggcttaccaagtac
cctcttctgttggataatattgccaaatacacagaatggccaatggaaagggagaaggtg
aagaaagctgcagatcactgtcgtcagatcttgaattatgtaaatcaggctgtcaaggag
gcagaaaacaaacagcgtttagaagactatcagcgtcgtctggatacctccaatctgaag
ttgtcggagtacccaaacgtggaagagctcaggaatttggatttaacaaaaaggaagatg
attcatgaagggccattggtctggaaggtgaaccgagataaaactattgatctatacaca
ttgctgctggaagacattcttgtattgttacaaaagcaggatgacagactggtgttaaga
tgtcatagtaagattctggcgtctaccgctgacagcaaacacacatttagccctgtcatt
aagttgaatacagtgttggttcgacaagtggcaacagataacaaagctttatttgtcatc
tccatgtcagacaatggagcccaaatttatgaactggtggcacagacagtttccgaaaag
actgtctggcaagacctaatctgtcggatggccgcatccgtgaaggaacaatccgcaaag
cccatcccgttgccacagtcaccaccttgcgaaggagacaacgatgaagaagcagctcca
aagttaaaggtgggacaccacagcatttcggtccctggtctgcagagtccagacagagat
ttgggattagagtctcccttaatgtcgtcaaaacctcagtctcattcactggggacctct
gggaaatccgaggtagatgatctgtttgtggccgagaggcagtttgctaaggagcagcat
gcagatgggactctgcaggaagccggagcaagttatcagatcccaatcccagacccacac
ttgcctgcctcggaagaacggtgggcgctggatgcactaaggaatttgggcttgctgaag
cagttgctcgtccaacagctgggtttgactgagaagagcactcaggaagactggccacat
ttcccaagatataggacagcgtcttcaggggtgcagacaaacggtggagcccagaactct
gagaatagtaaggcctgtcctcctggtgaaggacagatgccctttagaactggaactggt
gacattgcaacttgttacagtccacggacttcagctgaatcttcggctccgcgggattca
gtggtactggcattccaagatagccaggcaagtaacattttagtaatggaccacgtgatt
atgaccccagagatgcctcctgcggagccagaagggagtctcgatgagagtggagagcac
ttttttgatgcccgtgaagcacatagtgatgataacccatcagaaggtgatggagcagtt
cagaaggaagaggatgttactttgcgcatctcaggaaactatctgattcttgatggctat
gaagcggtgcaggagagctccacggatgaggacgttgcttccttgctccccccgccgccc
ccggcaggcatcccctccacagactctgcccgcccacaccagcactcgccccagcgtgcc
cattccgacggggcggcttcaccgttcacccccgaattcctgctccagcagcgctggggg
gctatggaggattcctgttttgagatccagagtcccccctcttgtgcagactctcagagc
cagattatggagtacattcggaagatcgaggctgaccttgaacacttaaagaaggtggaa
gaaagttacagcatgctttgccaaaggctggctggatcagccctcacagacaagcactca
gataaaagttag

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (10)   
   KEGG PATHWAY (10)   
Genome (1)   
   KEGG GENOME (1)   
Gene (20)   
   KEGG ORTHOLOGY (1)   
   RefGene (15)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (6)   
   UniProt (1)   
   RefSeq(pep) (5)   
DNA sequence (5)   
   RefSeq(nuc) (5)   
Protein domain (10)   
   Pfam (10)   
All databases (54)   

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