KEGG   Ailuropoda melanoleuca (giant panda): 100471122Help
Entry
100471122         CDS       T01329                                 

Gene name
MTOR
Definition
mechanistic target of rapamycin (serine/threonine kinase)
Orthology
K07203  
FKBP12-rapamycin complex-associated protein
Organism
aml  Ailuropoda melanoleuca (giant panda)
Pathway
ErbB signaling pathway
HIF-1 signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Insulin signaling pathway
Thyroid hormone signaling pathway
Adipocytokine signaling pathway
Type II diabetes mellitus
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Glioma
Prostate cancer
Acute myeloid leukemia
Brite
KEGG Orthology (KO) [BR:aml00001]
 Environmental Information Processing
  Signal transduction
   04012 ErbB signaling pathway
    100471122 (MTOR)
   04066 HIF-1 signaling pathway
    100471122 (MTOR)
   04151 PI3K-Akt signaling pathway
    100471122 (MTOR)
   04152 AMPK signaling pathway
    100471122 (MTOR)
   04150 mTOR signaling pathway
    100471122 (MTOR)
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    100471122 (MTOR)
   04920 Adipocytokine signaling pathway
    100471122 (MTOR)
   04919 Thyroid hormone signaling pathway
    100471122 (MTOR)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    100471122 (MTOR)
   05206 MicroRNAs in cancer
    100471122 (MTOR)
   05205 Proteoglycans in cancer
    100471122 (MTOR)
   05214 Glioma
    100471122 (MTOR)
   05221 Acute myeloid leukemia
    100471122 (MTOR)
   05215 Prostate cancer
    100471122 (MTOR)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    100471122 (MTOR)
Protein kinases [BR:aml01001]
 Serine/threonine protein kinases: Atypical group
  PIKK family [OT]
   100471122 (MTOR)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Ensembl: 
UniProt: 
Position
Un
AA seq 2544 aa AA seqDB search
MLGTGPTAATAATTTSSNVSVLQQFASGLKSRNEETRAKAAKELQHYVTMELREMSQEES
TRFYDQLNHHIFELVSSSDANERKGGILAIASLIGVEGGNATRIGRFANYLRNLLPSNDP
VVMEMASKAIGRLAMAGDTFTAEYVEFEVKRALEWLGADRNEGRRHAAVLVLRELAISVP
TFFFQQVQPFFDNIFVAVWDPKQAIREGAVAALRACLILTTQREPKEMQKPQWYRHTFEE
AEKGFDETLAKEKGMNRDDRIHGALLILNELVRISSMEGERLREEMEEITQQQLVHDKYC
KDLMGFGTKPRHITPFTSFQAVQPPQSNALVGLLGYSSHQGLMGFGASPSPAKSTLVESR
CCRDLMEEKFDQVCQWVLKCRNSKNSLIQMTILNLLPRLAAFRPSAFTDTQYLQDTMNHV
LSCVKKEKERTAAFQALGLLSVAVRSEFKVYLPRVLDIIRAALPPKDFAHKRQKAMQVDA
TVFTCISMLARAMGPGIQQDIKELLEPMLAVGLSPALTAVLYDLSRQIPQLKKDIQDGLL
KMLSLVLMHKPLRHPGMPKGLAHQLASPGLTALPEASDVGSITLALRTLGSFEFEGHSLT
QFVRHCADHFLNSEHKEIRMEAARTCSRLLTPSVHLISGHAHVVSQTAVQVVADVLSKLL
VVGITDPDPDIRYCVLASLDERFDAHLAQAENLQALFVALNDQVFEIRELAICTVGRLSS
MNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALI
LKLKDPDPDPNPGVINNVLATIGELAQVSGLEMRKWVDELFIIIMDMLQDSSLLAKRQVA
LWTLGQLVASTGYVVEPYRKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHK
VNIGMIDQSRDASAVSLSESKSSQDSSDYSTSEMLVNMGNLPLDEFYPAVSMVALMRIFR
DQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNVIRVCDGAIREFLFQQLGMLV
SFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIILLIEQIVVALGGEFKLYLPQLIPHMLR
VFMHDNSPGRIVSIKLLAAIQLFGANLDDYLHLLLPPIVKLFDAPEVPLPSRKAALETVD
RLTESLDFTDYASRIIHPIVRTLDQSPELRPTAMDTLSSLVFQLGKKYQIFIPMVNKVLV
RHRINHQRYDVLICRIVKGYTLADEEEDPLIYQHRMLRSGQGDALASGPVETGPMKKLHV
STINLQKAWGAARRVSKDDWLEWLRRLSLELLKDSSSPSLRSCWALAQAYNPMARDLFNA
AFVSCWSELNEDQQDELIRSIELALTSQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGI
VLLGERAAKCRAYAKALHYKELEFQKGPTPAILESLISINNKLQQPEAAAGVLEYAMKHF
GELEIQATWYEKLHEWEDALVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEK
WTLVNDETQAKMARMAAAAAWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLA
QQCIDKARDLLDAELTAMAGESYSRAYGAMVSCHMLSELEEVIQYKLVPERREIIRQIWW
ERLQGCQRIVEDWQKILMVRSLVVSPHEDMRTWLKYASLCGKSGRLALAHKTLVLLLGVD
PSRQLDHPLPTVHPQVTYAYMKNMWKSARKIDAFQHMQHFVQTVQQQAQHAIATEDQQHK
QELHKLMARCFLKLGEWQLNLQGINESTIPKVLQYYSAATEHDRSWYKAWHAWAVMNFEA
VLHYKHQNQARDEKKKLRHASGANITSTSTAATTAATATATSTEGSNSESEAESTENSPT
PSPLQKKVTEDLSKTLLMYTVPAVQGFFRSISLSRGNNLQDTLRVLTLWFDYGHWPDVNE
ALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVASK
STTTARHNAANKILKNMCEHSNTLVQQAMMVSEELIRVAILWHEMWHEGLEEASRLYFGE
RNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAW
DLYYHVFRRISKQLPQLTSLELQYVSPKLLMCRDLELAVPGTYDPNQPIIRIQSIAPSLQ
VITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNLS
IQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDYDHLTLM
QKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRHP
SNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRITCH
TVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKGNKRSRTRTDSYSAGQSVEILDGV
ELGEPAHKKTGTTVPESIHSFIGDGLVKPEALNKKAIQIINRVRDKLTGRDFSHDETLDV
PTQVELLIKQATSHENLCQCYIGW
NT seq 7635 nt NT seq  +upstreamnt  +downstreamnt
atgctgggaactggacccactgccgccaccgcagctaccaccacgtccagcaacgtgagc
gtcctgcagcagttcgccagtggcctgaagagccggaatgaggagaccagggccaaagct
gccaaggagctccagcactatgtcaccatggagcttcgagagatgagtcaagaggagtct
actcgattctatgatcagctgaaccatcacatttttgaactggtttccagctcagatgcc
aatgagaggaaaggtggcatcttggccatagccagccttataggagtggaaggcgggaat
gccactcggattggaagattcgctaactatcttcggaacctcctcccctcgaatgaccca
gttgtcatggagatggcatccaaggccattggccgcctcgccatggcaggggacactttt
acggctgagtatgtggagtttgaggtgaagcgagccttggagtggctgggtgctgaccgc
aacgagggccggagacacgccgctgttctggttctccgtgagctggccatcagcgtcccc
accttcttcttccagcaagtgcagcccttctttgacaacatttttgtggccgtgtgggac
cccaaacaggccatccgtgagggagccgtggccgcccttcgtgcctgcctgattctcacc
acgcagcgtgagccgaaggagatgcagaagcctcagtggtaccggcacacgtttgaagaa
gcagagaaagggtttgatgagacattggccaaggagaaaggcatgaatcgggatgatcgc
atccacggagccttgctgatcctcaacgagttggtccgaatcagcagcatggagggagag
cgcctgagagaagaaatggaagaaatcacacagcagcagctcgtgcacgacaagtactgc
aaggacctcatgggcttcgggacgaaacctcgccacatcacccccttcaccagtttccag
gccgtccagcccccgcagtccaatgccttggtgggactgctggggtacagctctcaccaa
ggcctcatggggttcggggcttcccccagcccagcgaagtccaccctggtggagagtcgg
tgttgcagagacctgatggaggagaaatttgatcaggtgtgccagtgggtgctgaaatgc
aggaacagcaagaactcactgatccagatgacaatccttaatctgttgccccgcctggcc
gcgtttcgaccttctgccttcacagatacccagtacctccaagataccatgaaccatgtc
ttaagctgtgtcaagaaggagaaggaacgtacagcagccttccaagccctggggctgctt
tctgtggctgtgagatctgagtttaaggtctatttacctcgtgtgctggacatcatccgt
gcagccctaccccctaaggactttgcccataagagacagaaggccatgcaggtggatgcc
acagtgttcacctgcatcagcatgctggcccgggcaatggggccaggcatccaacaggat
atcaaggagctgctggagcccatgctggcagtgggactgagccctgccctcactgctgtg
ctgtatgacctgagccgtcagattccgcagctgaagaaggacatccaggatgggctcctg
aagatgctgtccctggtcctgatgcacaaacccctccggcatccaggcatgcccaagggc
ctggcccatcagctagcttcccctggcctcacagccctgcctgaggccagcgatgtcggc
agcattactcttgccctgcgaacccttggcagctttgagtttgaaggccactctctgacc
cagttcgtccgccactgtgcggatcatttcctaaacagcgagcacaaggagatccgcatg
gaagctgcccgcacctgctcccgcctgctcacgccctctgtccacctcattagcggccac
gctcacgtggttagccagactgcagtgcaagtcgtggcagacgtgctcagcaaactgctc
gtggttgggataacagatcctgaccctgacatccgctactgtgtcttggcatccctggat
gagcgctttgatgcacacctggcccaggcagagaatttgcaggccctgtttgtggccctg
aacgaccaggtgtttgagatccgggagctggccatctgcaccgtgggccggctcagtagc
atgaacccagccttcgtcatgcctttcctgcgcaagatgcttatccagattttgacggag
ctggagcacagcggcattggaagaatcaaagagcagagtgcccgcatgctgggacacctg
gtctccaatgcaccccggctcatccgcccctacatggagcccattctgaaggctttaatt
ttgaaactgaaagatccggaccctgatccaaacccaggtgtgatcaataatgtcttggct
acaataggagaattggctcaggttagtggcctagaaatgaggaagtgggtggatgaactc
tttatcatcatcatggacatgctccaggactcctcgctgttggccaaaaggcaggtggct
ctgtggaccctgggacagttggtggccagcactggctatgtagtggagccctacaggaag
taccccactctgcttgaggtcctgctgaattttctgaagactgagcagaaccagggtaca
cggagagaggctatccgtgtgttggggcttttgggggccctggatccctacaagcacaaa
gtaaacattggcatgattgaccagtcccgcgacgcttctgctgtcagcctgtctgaatcc
aagtcaagtcaggattcctccgactacagcaccagcgagatgctggtcaacatgggcaac
ctgcccctggatgagttctaccctgccgtgtccatggtggcgctgatgcggatcttccga
gaccagtccctctcgcaccatcacaccatggttgtccaggccatcaccttcatcttcaag
tccctgggcctcaagtgtgtgcagttcctgcctcaggtcatgcccacattcctcaatgtc
attcgggtctgcgatggggccatccgggaattcctgttccagcagctgggaatgctggtg
tcctttgtgaagagccacatccgaccttacatggatgaaatagtcaccctcatgagagaa
ttctgggtcatgaacacctcgatccagagcacaatcatccttctcattgagcaaatagtg
gtagctcttgggggtgaatttaagctctacctgccccagctgatcccacacatgctacgt
gtcttcatgcatgacaacagcccaggtcgcatcgtctccatcaagctgttggccgccatc
cagctgtttggtgccaacctggatgactatctgcatttgttgttgccccctatcgtgaag
ctgtttgacgccccggaagtcccactgccatctcggaaggcagcattagagacagtggac
cgcctgacagagtccctggacttcactgactacgcctcccggatcattcatccaattgtt
cgaacgctggaccagagtccggaactgcgtcccacggccatggacacgttgtcttcgctg
gtcttccaactggggaagaagtaccagattttcattccaatggtgaacaaagtcctggtg
cgacaccgaatcaaccatcagcgctacgacgtcctcatctgcagaattgtcaagggatac
acccttgctgatgaagaagaggaccctttgatttaccagcatcgaatgctgaggagtggc
cagggggatgcattggctagtggcccagtagaaacagggcccatgaagaaactgcatgtc
agcaccatcaacctccaaaaggcctggggagctgccagaagggtgtccaaagatgactgg
ctggaatggctgaggcggctgagtctggagctcctgaaggactcctcgtcgccttccctg
cgctcgtgctgggccctggctcaggcttacaacccaatggccagggatctttttaatgcc
gcatttgtgtcctgctggtctgaactgaatgaagaccagcaggatgaactcatcagaagc
atcgagttggccctcacctcgcaggacatcgctgaagtcacgcagaccctcttaaacttg
gctgaattcatggaacacagtgacaagggccctctgccattgagagacgacaatggcatt
gtcctgctgggtgaaagggctgccaagtgccgagcatatgccaaagcactccactacaaa
gaactggagttccagaaaggtcccacccccgccatcctagagtctctcatcagcattaat
aataagctccagcagccggaggcagccgcgggggtcttagagtatgccatgaaacacttc
ggagaactggagatccaggctacctggtacgagaaactgcacgagtgggaggacgcgctc
gtggcctacgacaagaagatggacaccaacaaggatgacccggagctgatgctgggccgc
atgcgctgcctcgaggccctgggggaatggggccagctccaccagcagtgctgtgaaaag
tggaccctggttaatgatgagacccaagccaagatggcccgcatggctgccgcagctgcg
tggggtttaggtcagtgggatagcatggaggagtacacctgtatgatccctcgggacacc
cacgatggggcattttacagagccgtgctggcactgcatcaggacctcttctccttggca
cagcagtgcatcgacaaagccagagacctgctggatgccgagttaactgctatggcagga
gagagctacagtcgggcatatggggctatggtctcttgccacatgctctccgagctggag
gaggttatccagtacaaacttgtccccgagcgacgggagatcatccgccagatctggtgg
gagagactgcagggctgccagcgtattgtggaggactggcagaaaatcctgatggtgcgg
tcacttgtggtcagccctcatgaggacatgaggacctggctcaagtatgccagcctgtgc
gggaagagtggcaggctggcccttgctcacaaaaccttggtgttgctcctgggagttgat
ccatctcggcaacttgaccaccctctgccaacagttcaccctcaggtgacctacgcctac
atgaaaaacatgtggaagagcgctcgcaagatcgacgccttccagcacatgcagcacttc
gtacagaccgtgcagcagcaggcccagcacgccatcgccaccgaggaccagcagcacaag
caagagctgcacaagctcatggcccggtgcttcctgaagctcggggagtggcagctgaac
ctgcagggcatcaatgagagcaccatccccaaggtgctgcagtactacagtgcggccacg
gagcacgaccgcagctggtacaaggcctggcacgcgtgggcagtgatgaactttgaggct
gtgctgcactacaaacatcagaaccaagcccgtgatgagaagaagaagctgcggcacgcc
agtggggccaacatcaccagcacaagcactgccgccaccacagcggccactgccaccgcc
accagcaccgagggcagcaacagcgagagtgaggccgagagcaccgagaacagccccact
ccgtctcctctgcagaagaaggtcactgaggatttatccaaaaccctcttgatgtacacc
gtccctgcggtccagggcttcttccgttccatctccttgtcacgaggcaacaacctccag
gacacgctgagagtcctcaccttatggtttgactatggtcactggccagacgtaaatgaa
gccttagtggagggggtgaaagcaattcagattgacacttggttacaggttataccgcag
ctcatcgcaaggatcgatactcccaggcctttggtgggccgcctcattcaccagcttctc
acagacattggccggtaccacccgcaggccctcatctaccccctgaccgtggcctctaag
tccaccacgacggcccgccacaacgcagccaacaagattctgaagaacatgtgcgagcac
agtaataccctggtccagcaggctatgatggtgagcgaggagctaatccgcgtggccatc
ctgtggcacgagatgtggcacgaaggcctggaagaagcgtctcgtttgtactttggggaa
aggaacgtgaaaggcatgtttgaggtgctggagcccctgcatgctatgatggaacggggc
ccccagactctgaaggaaacatcttttaatcaggcgtatggtcgagacttaatggaggcc
caagagtggtgcaggaagtacatgaaatccgggaacgtcaaggacctcacccaagcctgg
gacctctattatcacgtgttcagacgaatctcgaagcagctgcctcagctcacctcctta
gaactgcagtatgtttcccccaaacttcttatgtgccgggaccttgaattggctgtgcca
gggacgtacgaccccaaccagccgatcattcgcattcagtccatagcgccgtccctgcag
gtcatcacctccaagcagaggccccggaagctgacactcatgggcagcaacgggcatgag
tttgttttcctcctgaagggccacgaagacctgcggcaggatgagcgagtgatgcagctc
tttggcctggtgaacactcttctggccaacgacccaacgtctcttcgcaagaacctcagc
atccagagatacgctgtcatccccttatcaaccaactcgggcctcatcggctgggtcccc
cactgcgacacgctgcacgccctcatccgggactacagagagaagaagaagatccttctc
aacatcgagcatcgcatcatgttgcggatggcaccagactacgatcacctgacgctgatg
cagaaggtggaggtgttcgagcacgccgtcaataacacggccggcgacgacctggccaag
ctgctgtggctgaagagccccagctccgaggtgtggtttgaccgaagaaccaactatacc
cgctctttagcggtcatgtccatggttgggtatattttgggcctgggagatcgacaccca
tccaacctaatgctggaccggctgagtgggaagatcctgcacatcgactttggggactgc
tttgaggttgctatgaccagggagaaattcccagagaagattccatttagactaacaaga
atgctgaccaatgctatggaggttactggtctggatggcaactatagaatcacgtgccac
acggtgatggaagtgcttcgggaacacaaggatagtgtcatggccgtgctggaagccttt
gtctacgaccccttgctgaactggaggctgatggacacaaataccaaaggcaacaagcgg
tcccgaacaaggacggattcctactctgctggacagtcagtagaaattttggacggtgtg
gaacttggggaacctgcccataagaaaacagggaccacagtgccagaatctattcattct
ttcattggagacggtttggtgaaaccagaggccctaaataagaaagctattcaaattatt
aacagggttcgagacaagctcactggtcgggacttttctcatgacgaaaccctggatgtc
ccaacacaggtggagctgctcatcaaacaagcaacgtcccacgagaacctctgtcaatgc
tacatcggctggtga

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