KEGG   Ailuropoda melanoleuca (giant panda): 100479294Help
Entry
100479294         CDS       T01329                                 

Definition
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like
Orthology
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
Organism
aml  Ailuropoda melanoleuca (giant panda)
Pathway
Inositol phosphate metabolism
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Bacterial invasion of epithelial cells
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Hepatitis C
Hepatitis B
Measles
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Brite
KEGG Orthology (KO) [BR:aml00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100479294
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    100479294
   04015 Rap1 signaling pathway
    100479294
   04012 ErbB signaling pathway
    100479294
   04370 VEGF signaling pathway
    100479294
   04630 Jak-STAT signaling pathway
    100479294
   04668 TNF signaling pathway
    100479294
   04066 HIF-1 signaling pathway
    100479294
   04068 FoxO signaling pathway
    100479294
   04070 Phosphatidylinositol signaling system
    100479294
   04022 cGMP - PKG signaling pathway
    100479294
   04151 PI3K-Akt signaling pathway
    100479294
   04152 AMPK signaling pathway
    100479294
   04150 mTOR signaling pathway
    100479294
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    100479294
  Cell growth and death
   04210 Apoptosis
    100479294
  Cell communication
   04510 Focal adhesion
    100479294
 Organismal Systems
  Immune system
   04611 Platelet activation
    100479294
   04620 Toll-like receptor signaling pathway
    100479294
   04650 Natural killer cell mediated cytotoxicity
    100479294
   04660 T cell receptor signaling pathway
    100479294
   04662 B cell receptor signaling pathway
    100479294
   04664 Fc epsilon RI signaling pathway
    100479294
   04666 Fc gamma R-mediated phagocytosis
    100479294
   04670 Leukocyte transendothelial migration
    100479294
   04062 Chemokine signaling pathway
    100479294
  Endocrine system
   04910 Insulin signaling pathway
    100479294
   04915 Estrogen signaling pathway
    100479294
   04914 Progesterone-mediated oocyte maturation
    100479294
   04917 Prolactin signaling pathway
    100479294
   04921 Oxytocin signaling pathway
    100479294
   04919 Thyroid hormone signaling pathway
    100479294
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100479294
  Digestive system
   04973 Carbohydrate digestion and absorption
    100479294
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100479294
  Nervous system
   04725 Cholinergic synapse
    100479294
   04722 Neurotrophin signaling pathway
    100479294
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100479294
  Development
   04380 Osteoclast differentiation
    100479294
 Human Diseases
  Cancers
   05200 Pathways in cancer
    100479294
   05205 Proteoglycans in cancer
    100479294
   05203 Viral carcinogenesis
    100479294
   05210 Colorectal cancer
    100479294
   05212 Pancreatic cancer
    100479294
   05214 Glioma
    100479294
   05221 Acute myeloid leukemia
    100479294
   05220 Chronic myeloid leukemia
    100479294
   05218 Melanoma
    100479294
   05211 Renal cell carcinoma
    100479294
   05215 Prostate cancer
    100479294
   05213 Endometrial cancer
    100479294
   05222 Small cell lung cancer
    100479294
   05223 Non-small cell lung cancer
    100479294
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    100479294
   04932 Non-alcoholic fatty liver disease (NAFLD)
    100479294
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    100479294
   05166 HTLV-I infection
    100479294
   05162 Measles
    100479294
   05164 Influenza A
    100479294
   05161 Hepatitis B
    100479294
   05160 Hepatitis C
    100479294
   05169 Epstein-Barr virus infection
    100479294
   05146 Amoebiasis
    100479294
   05145 Toxoplasmosis
    100479294
   05142 Chagas disease (American trypanosomiasis)
    100479294
Enzymes [BR:aml01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     100479294
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
UniProt: 
Position
Un
AA seq 1068 aa AA seqDB search
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt NT seq  +upstreamnt  +downstreamnt
atgcctccaagaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatggaatgatagtgacgttagaatgcctccgtgaggct
acattaataactataaagcatgaattatttaaagaagcaagaaagtaccctctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacaagacgactttgtgaccttcggctttttcaaccctttttaaaa
gtaattgagccagtaggcaaccgagaagaaaagatcctcaatcgagaaattggttttgct
attggcatgccagtgtgtgaatttgatatggttaaagatccagaagtacaggacttccga
agaaatattctgaatgtttgtaaagaagctgtggatcttcgggatcttaattcacctcat
agtagagcaatgtatgtctatcctccaaatgtagaatcctcaccagaactgccaaagcac
atatataataaattagataaagggcaaataatagtggtgatttgggtaatagtgtctcca
aataatgacaagcagaagtatactctgaaaatcaaccatgactgtgtgccagaacaagta
attgctgaagcaatcaggaaaaaaactagaagtatgttgctgtcatctgaacaactaaaa
ctctgtgttttagaatatcagggcaagtatattttaaaagtgtgtggatgtgatgaatac
ttccttgaaaaataccctctaagtcagtataagtacataagaagctgtataatgcttggg
aggatgcccaatttgatgctgatggctaaagaaagcctttactcccaactgccaatggac
tgtttcacaatgccttcatattccagacgcatctccacagctacaccatatatgaatgga
gaaacatctacaaaatccctttgggttataaatagtgcactcagaataaaaatcctttgt
gcaacctatgtgaatgtaaatattcgagacattgacaagatctatgttcgaacaggtatc
tatcatggaggagaacccttatgtgataatgtgaacactcaaagagtaccttgttccaat
cccaggtggaatgaatggctaaattatgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttccatttgttctgttaaaggccgaaagggtgctaaagaggaacactgt
ccattggcctggggaaatataaacttgtttgattacacagatactctagtatctggaaaa
atggctctgaatctttggccagtacctcatggattagaagatttgctgaaccctattggt
gttactgggtcaaatccaaataaagaaaccccatgcttagagttggagtttgactggttc
agcagtgtggtcaagttcccagatatgtcagtgattgaagagcatgccaactggtcggtg
tctcgggaagcaggatttagttattcccatgcaggactgagtaacagattagctagagac
aacgagttaagagaaaatgataaagaacagctccgagcaatttgtacccgagatcctcta
tctgaaatcactgagcaagagaaagattttctgtggagccacagacactattgtgtaact
atccctgaaattctacccaaattgcttctgtccgttaaatggaattctagagatgaagta
gctcagatgtactgcttagtaaaagattggcctccaatcaaacctgaacaggctatggag
cttctggactgtaattacccagatcccatggttcgaggttttgctgtccggtgcttggaa
aaatacttaacagatgacaagctttctcagtacctaattcagctagtacaggtcctaaaa
tatgaacagtatttggataacctgcttgtgagatttttactcaaaaaagcattgactaat
caaaggattgggcactttttcttttggcatttaaagtctgagatgcacaataaaaccgtt
agtcagcggtttggcctccttttggagtcctattgtcgtgcatgcgggatgtatttgaag
cacctaaataggcaagttgaggctatggaaaagctcattaacttaactgacattctcaaa
caagagaagaaggatgaaacacaaaaggtacagatgaagtttttagttgagcagatgcgg
cgaccagatttcatggatgctctacaaggttttctgtctcctctaaatcctgctcatcaa
ttaggaaatctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagagttactctttcagaacaatgagatcatc
tttaaaaatggggatgatttacggcaagatatgctaacacttcagataattcgcattatg
gaaaatatctggcaaaatcaaggtcttgatcttcgaatgttaccttatggttgtctgtca
atcggtgactgtgtgggacttattgaggtggtgcgaaactcgcacacgattatgcagatt
cagtgcaaaggtggcctgaaaggtgctctgcagttcaatagccacacactccaccagtgg
ctcaaagacaagaacaaaggagaaatatacgatgcagccattgacctgttcacacgttca
tgtgctggatattgtgttgctactttcatattgggcattggagatcgtcacaatagtaac
atcatggttaaagatgatggacaactgtttcatatagattttggacactttttggatcac
aagaagaaaaaatttggttataaacgggaacgtgtgccatttgttttgacacaagatttc
ttaatagtgattagtaaaggagcccaggaatgcacaaagacaagagaatttgagaggttt
caggagatgtgttacaaggcttatctagctattcggcagcatgccaatctcttcataaat
cttttctcaatgatgcttggctctggaatgccagaactacaatcttttgatgatattgca
tacattcgaaagaccctagctttagataaaactgaacaagaggctttggaatatttcatg
aaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttccac
acaattaagcagcatgctttgaactga

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