KEGG   Ailuropoda melanoleuca (giant panda): 100480603Help
Entry
100480603         CDS       T01329                                 

Gene name
PLCB4
Definition
phospholipase C, beta 4
Orthology
K05858  
phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
aml  Ailuropoda melanoleuca (giant panda)
Pathway
Inositol phosphate metabolism
Metabolic pathways
Rap1 signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
Phosphatidylinositol signaling system
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Wnt signaling pathway
Gap junction
Platelet activation
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Dopaminergic synapse
Long-term depression
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Alzheimer's disease
Huntington's disease
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Amoebiasis
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:aml00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100480603 (PLCB4)
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    100480603 (PLCB4)
   04310 Wnt signaling pathway
    100480603 (PLCB4)
   04020 Calcium signaling pathway
    100480603 (PLCB4)
   04070 Phosphatidylinositol signaling system
    100480603 (PLCB4)
   04022 cGMP - PKG signaling pathway
    100480603 (PLCB4)
 Cellular Processes
  Cell communication
   04540 Gap junction
    100480603 (PLCB4)
 Organismal Systems
  Immune system
   04611 Platelet activation
    100480603 (PLCB4)
   04062 Chemokine signaling pathway
    100480603 (PLCB4)
  Endocrine system
   04911 Insulin secretion
    100480603 (PLCB4)
   04912 GnRH signaling pathway
    100480603 (PLCB4)
   04915 Estrogen signaling pathway
    100480603 (PLCB4)
   04921 Oxytocin signaling pathway
    100480603 (PLCB4)
   04918 Thyroid hormone synthesis
    100480603 (PLCB4)
   04919 Thyroid hormone signaling pathway
    100480603 (PLCB4)
   04916 Melanogenesis
    100480603 (PLCB4)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100480603 (PLCB4)
   04270 Vascular smooth muscle contraction
    100480603 (PLCB4)
  Digestive system
   04970 Salivary secretion
    100480603 (PLCB4)
   04971 Gastric acid secretion
    100480603 (PLCB4)
   04972 Pancreatic secretion
    100480603 (PLCB4)
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    100480603 (PLCB4)
  Nervous system
   04724 Glutamatergic synapse
    100480603 (PLCB4)
   04725 Cholinergic synapse
    100480603 (PLCB4)
   04728 Dopaminergic synapse
    100480603 (PLCB4)
   04726 Serotonergic synapse
    100480603 (PLCB4)
   04720 Long-term potentiation
    100480603 (PLCB4)
   04730 Long-term depression
    100480603 (PLCB4)
   04723 Retrograde endocannabinoid signaling
    100480603 (PLCB4)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100480603 (PLCB4)
  Environmental adaptation
   04713 Circadian entrainment
    100480603 (PLCB4)
 Human Diseases
  Neurodegenerative diseases
   05010 Alzheimer's disease
    100480603 (PLCB4)
   05016 Huntington's disease
    100480603 (PLCB4)
  Infectious diseases
   05146 Amoebiasis
    100480603 (PLCB4)
   05142 Chagas disease (American trypanosomiasis)
    100480603 (PLCB4)
   05143 African trypanosomiasis
    100480603 (PLCB4)
Enzymes [BR:aml01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     100480603 (PLCB4)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Position
Un
AA seq 1189 aa AA seqDB search
MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVL
ECSLINSVRLGATPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPE
VTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFELFSLSSKYQQY
KMSKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEKKQLEALK
SMMEAGESTAPVSILEDDNEEEIESADQEEEAHPEYKFGNELSADDLGHKEAVANSVKKA
SDDLEHEINKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEER
NIHYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQM
VSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQ
VISGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPD
LAVLRIAVYDDNNRLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPD
GFGDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKANVT
PQSSSELRPTTTAALGSGVEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKH
AKEHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLT
SDHKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCDLLRKLLINAHEQQTQQLK
LSHDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLA
MKQSKEMDQLKKVQLEHLEFLEKQNEQAKEMQQMVKLEAEMDRRPATVV
NT seq 3570 nt NT seq  +upstreamnt  +downstreamnt
atggccaaaccttatgaatttaactggcagaaggaagttccttcctttttgcaagaagga
gccgtttttgacagatatgaagaggaatcctttgtgtttgaacccaactgcctcttcaaa
gtggatgaatttggcttctttctgacctggaggagtgaaggcaaggaaggacaagtgcta
gaatgctccctcatcaacagtgttcgcctgggagccaccccaaaggatcccaaaatcctg
gccgctcttgaagctgttggaaagtcagagaatgatctggaagggcggatagtttgtgtc
tgcagtggcacggatctggtgaacatcagcttcacatacatggtggctgaaaatccggaa
gtaactaagcaatgggtagaaggactgagatcaatcatacacaacttcagggccaacaat
gtcagtccaatgacctgcctcaagaagcactggatgaaattggcgtttatgaccaacaca
aatggtaaaattccagttaggagtattactagaacctttgcatcggggaaaacagaaaag
gtgatctttcaagcactcaaagagttaggtcttcccagtggaaagaatgatgaaattgag
cctgcagcatttacttacgaaaagttctatgaactgacacaaaagatttgtcctcggaca
gatatagaggatctttttaaaaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaatgaacatcagcgagaccctcgactgaatgaaattttattc
ccattttatgatgctaaaagggcaatgcagatcatcgagatgtatgagcctgatgaagat
ttgaagaaaaaaggcctcatatcaagcgacgggttttgcagatatctgatgtccgatgaa
aatgccccagtcttcctggatcgtttagaactttaccaagaaatggaccatcccctggcc
cattacttcatcagttcttcccacaacacctatctcacgggccgacagtttggcgggaaa
tcctcagtagaaatgtacagacaggtgctcctggctggttgcagatgtgttgaacttgac
tgttgggatggaaaaggtgaagaccaagaaccgataataactcatggaaaagcaatgtgt
acagatatcctttttaaggatgttattcaagccatcaaggaaaccgcatttgtcacatct
gaatatcctgtaattctctcttttgaattgttctctctctccagcaaatatcaacagtac
aagatgtccaaatattgcgaagatctatttggggatctcctgttgaaacaagcacttgaa
tcacatccacttgaaccaggcaggcccttaccatcccccaatgacctcaaaagaaaaata
ctcatcaaaaataaacggctgaaacctgaggttgaaaaaaaacagctcgaagctttgaaa
agcatgatggaagctggagaatccactgccccagttagcatcctagaggatgataatgaa
gaggagatagaaagtgctgaccaagaggaggaagctcaccctgaatacaaatttggaaac
gaactttctgctgatgacttgggtcacaaggaggctgttgccaatagtgtcaagaaggct
tcagatgaccttgaacatgaaatcaacaaaaagggcctggtcactgtggaagatgaacag
gcatggatggcatcgtataaatacgtaggtgctaccactaatatccatccgtatttgtct
acaatgatcaactatgcacagcctgtaaagttccaaggtttccatgtggctgaagagcgc
aatatccactataacatgtcttcttttaatgagtccgtcggtctgggctatttgaagaca
cacgcgattgaatttgtgaattataacaaacggcaaatgagccgcatttaccccaaggga
ggccgggtcgattccagtaattacatgcctcagattttctggaatgctggctgccagatg
gtttcgctgaactatcaaaccccagatttagcgatgcaattgaatcagggcaaatttgag
tataatggatcgtgcgggtacctcctcaaaccagatttcatgagacggccggatcgaaca
ttcgatcccttctctgaaactcctgttgatggggttattgcagccacttgctcagtgcag
gtcatatcaggtcagtttttatcagataagaaaattggtacatacgtagaagtggatatg
tatgggttgcccaccgacaccatacgtaaggaattccgaactcgcatggtgatgaacaac
ggactcaatccagtttacaatgaagaatcatttgtgtttcggaaggtaatcctccctgac
ctggcagtcttgagaatagcagtgtatgatgacaacaacaggctgataggccagaggatt
cttccactggatggcctccaagcaggctatcgacacatttcccttcgaaatgagggaaat
aaaccattatcactgccaacaattttctgcaatattgttcttaaaacatatgtgcctgat
ggatttggagatattgtggatgctttatcagatccaaagaaatttctttccattacggaa
aagagagcagaccaaatgagagctatgggcattgaaactagtgacatagcagatgtgccc
agtgatacttctaagaatgacaagaaaggaaaagccaacactgccaaagcaaacgtgacc
ccacagagcagctccgagctcagaccaaccaccacagcggcgctggggtctggcgtggaa
gccaagaaaggtatcgaacttatccctcaagtgaggatagaagatttaaagcagatgaag
gcttacttgaagcatttaaagaaacaacagaaggagctaaattctttaaagaagaaacat
gcaaaggagcacagcaccatgcagaagttgcactgcacgcaagttgacaaaattgtggcc
cagtatgacaaagagaagtcaacgcatgagaagatcctagagaaggcgatgaagaagaag
gggggaagtaattgtctcgaaatgaaaaaagaaacagaaattaaaattcagacactgaca
tcagatcacaaatctaaggtcaaagagatagtggcccagcacacaaaggagtggtcagaa
atgatcaacacccacagtgctgaggagcaagagatccgggacctgcacctcagccagcag
tgtgatctcctgagaaagctactgatcaatgcccacgagcagcaaacccagcagctcaaa
ctgtcccatgacagggaaagcaaggaaatgcgagcacaccaggctaagatttctatggaa
aacagcaaagccatcagccaagataaatctatcaagaataaagcagaacgggaaaggcga
gtcagggaattaaatagcagcaacaccaaaaagtttctggaagaaagaaagagactcgca
atgaaacagtccaaagaaatggatcagttaaaaaaagtccagcttgaacacctcgagttc
ctagagaaacagaatgagcaggcgaaggagatgcagcagatggtgaagttggaagccgag
atggaccgcaggccagcaacagtagtgtga

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