KEGG   Ailuropoda melanoleuca (giant panda): 100481360
Entry
100481360         CDS       T01329                                 
Symbol
JAK2
Name
(RefSeq) tyrosine-protein kinase JAK2 isoform X1
  KO
K04447  Janus kinase 2 [EC:2.7.10.2]
Organism
aml  Ailuropoda melanoleuca (giant panda)
Pathway
aml01521  EGFR tyrosine kinase inhibitor resistance
aml04062  Chemokine signaling pathway
aml04148  Efferocytosis
aml04151  PI3K-Akt signaling pathway
aml04217  Necroptosis
aml04550  Signaling pathways regulating pluripotency of stem cells
aml04630  JAK-STAT signaling pathway
aml04658  Th1 and Th2 cell differentiation
aml04659  Th17 cell differentiation
aml04725  Cholinergic synapse
aml04917  Prolactin signaling pathway
aml04920  Adipocytokine signaling pathway
aml04933  AGE-RAGE signaling pathway in diabetic complications
aml04935  Growth hormone synthesis, secretion and action
aml05140  Leishmaniasis
aml05145  Toxoplasmosis
aml05152  Tuberculosis
aml05161  Hepatitis B
aml05164  Influenza A
aml05167  Kaposi sarcoma-associated herpesvirus infection
aml05168  Herpes simplex virus 1 infection
aml05200  Pathways in cancer
aml05207  Chemical carcinogenesis - receptor activation
aml05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
aml05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:aml00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    100481360 (JAK2)
   04151 PI3K-Akt signaling pathway
    100481360 (JAK2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    100481360 (JAK2)
  09143 Cell growth and death
   04217 Necroptosis
    100481360 (JAK2)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    100481360 (JAK2)
 09150 Organismal Systems
  09151 Immune system
   04658 Th1 and Th2 cell differentiation
    100481360 (JAK2)
   04659 Th17 cell differentiation
    100481360 (JAK2)
   04062 Chemokine signaling pathway
    100481360 (JAK2)
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    100481360 (JAK2)
   04917 Prolactin signaling pathway
    100481360 (JAK2)
   04935 Growth hormone synthesis, secretion and action
    100481360 (JAK2)
  09156 Nervous system
   04725 Cholinergic synapse
    100481360 (JAK2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100481360 (JAK2)
   05207 Chemical carcinogenesis - receptor activation
    100481360 (JAK2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100481360 (JAK2)
  09172 Infectious disease: viral
   05161 Hepatitis B
    100481360 (JAK2)
   05164 Influenza A
    100481360 (JAK2)
   05168 Herpes simplex virus 1 infection
    100481360 (JAK2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100481360 (JAK2)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    100481360 (JAK2)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    100481360 (JAK2)
   05140 Leishmaniasis
    100481360 (JAK2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100481360 (JAK2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    100481360 (JAK2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100481360 (JAK2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:aml01001]
    100481360 (JAK2)
Enzymes [BR:aml01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     100481360 (JAK2)
Protein kinases [BR:aml01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   100481360 (JAK2)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase FERM_F2 FERM_F1 Jak1_Phl SH2 ABC1 FERM_C_FAK1 RIO1 Kinase-like FERM_M
Other DBs
NCBI-GeneID: 100481360
NCBI-ProteinID: XP_034503039
Ensembl: ENSAMEG00000009661
Position
17:complement(19378990..19500783)
AA seq 1132 aa
MGMACLTMTEMEGTSVSPVHQNGDIPGNANPMKDIDPLLQVYLYHSLEKAEGEYLKFPTG
EYVAEEICVAASKACGITPVYHSMFALMSETERIWYPPNHVFHIDESTRQNVLYRIRFYF
PYWYCNGSNRTYRHGISRGAEAPLLDDFVMAYLFAQWRHDFLHGWIKIPVTHETQEECLG
MAVLDMMRLAKEKDQTPLDIYSSISYKTFLPKCVRAKIQDYHILTRKRIRYRFRRFIEQF
SHCKATARNLKLKYLINLETLQSAFYTEQFEVKEPGSGPSGEEIFATIIITGNGGIQWSR
GKHKESETLTEQDLQLYCDFPDIIDVTIKQASQEGSNESRIVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPMVLENIQSNCHGPILMDFAISKLKKAGNQT
GLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENGEYNLSGTKKNFSNLKDLLNC
YQMETVRSDSIIFQFTKCCPPKLKDKSNLLVFRTNGISDVPTSPTLQRHNNVNQMVFHKI
RNEDLMFNESLGQGTFTKIFKGIRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM
MSQLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINILWKLEVAKQLAWA
MHFLEEKALIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWTEL
ANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRD
PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE
ILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQI
CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW
YAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIE
LLKNNGRLPRPDGCPDEIYLIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
NT seq 3399 nt   +upstreamnt  +downstreamnt
atgggaatggcttgccttacaatgacagaaatggaaggaacatctgtatctcctgtacat
cagaatggtgatattcccggaaacgctaatcccatgaaggacatagatccactcctacag
gtgtatctttatcattctcttgagaaagctgaaggagagtatctgaagtttccaactggg
gagtatgttgcggaagaaatttgtgttgctgcttctaaagcttgtggaatcacacctgtg
tatcatagtatgtttgctttaatgagtgaaacagaaaggatctggtatccacccaaccat
gtcttccatatagatgaatcaaccagacaaaatgtactctacagaataagattttacttt
ccttactggtattgtaatggcagcaacagaacctatcggcatggaatatctcgaggtgct
gaagctcctcttcttgacgactttgtcatggcttacctttttgctcagtggcggcatgat
tttttacatggatggataaaaatacctgtgacccatgaaacacaggaagaatgtcttgga
atggctgtgttagatatgatgagactagccaaagagaaggatcaaaccccactggacatc
tatagttctatcagctacaagacattcttaccaaaatgtgttcgagcaaagatccaagac
tatcatattttgacaaggaaacgaataaggtacaggtttcgcagatttattgagcaattc
agccattgcaaagccactgccagaaacttgaaacttaagtatcttataaatctggaaact
cttcagtctgccttctacacagagcagtttgaagtaaaagaacctggaagtggtccttca
ggtgaggagatttttgcaaccattataataactggaaacggtggaattcagtggtcaaga
gggaaacataaagaaagtgagacactgacagaacaggatttacagttatattgtgacttt
cctgatattattgatgttactattaagcaagcaagccaagaaggctcaaatgaaagtaga
attgtaactatccataagcaagatggtaaaaacctggaaattgaacttagctcattaaga
gaagctttgtcctttgtgtcattaattgatggctattatagattaaccgcagatgcacat
cattacctctgtaaagaagtagcacctccaatggtccttgaaaatatacaaagcaactgt
catggcccaattttaatggatttcgccatcagtaaactaaagaaagcaggtaatcagact
ggactctatgtacttcgatgcagtcctaaggactttaataagtattttctgacttttgct
gtcgagcgagaaaatgtcattgaatataagcactgtttgattacaaaaaatgagaatgga
gaatacaacctcagtgggaccaagaagaacttcagtaatcttaaagatcttttgaattgc
taccaaatggaaactgttcgctcagacagtataattttccagtttactaaatgctgtccc
ccaaagttgaaagataaatcaaaccttctagtcttcagaaccaatggtatttctgatgtt
ccaacatcaccgacattacagaggcataataatgtgaaccaaatggtgtttcacaaaatc
agaaatgaagatttgatgtttaatgaaagccttggtcaaggcacttttacaaaaattttt
aaaggtataagaagagaagtaggagactatggtcaactccatgaaacagaagttctttta
aaagttctggataaagcacacagaaactactcagagtctttctttgaagcagcaagcatg
atgagccagctttctcacaagcatctggttttaaattatggagtatgtgtctgtggggag
gagaatattctggttcaagagtttgtaaaatttggatcattagatacatatctgaaaaag
aataaaaattctataaatatattatggaaacttgaagtggctaaacagttggcatgggcc
atgcattttctagaagaaaaagcacttattcatggaaatgtgtgtgccaaaaatattctg
cttatcagagaagaagacaggaagacaggaaatcctcctttcatcaaacttagtgatcct
ggcattagtattacagttttgccaaaggacattcttcaggagagaataccatgggtacca
cctgaatgcatcgaaaatcctaaaaatctaaatttggcaacagacaaatggagttttggt
accactttgtgggaaatctgcagtggaggagataagcctctgagtgctttggattctcaa
agaaagctacagttttatgaagataggcaccagcttcctgcaccaaagtggacagaatta
gcaaatcttattaataattgtatggattatgaaccagattttagaccttctttcagagcc
atcatacgagatcttaatagtttgtttactccagattatgaactattaacagaaaatgac
atgttaccaaatatgagaataggtgccctagggttttctggtgcttttgaagaccgagac
cctacacagtttgaagagagacacttgaaatttctacagcaacttggcaagggtaatttt
ggcagtgtggagatgtgccggtatgaccctctgcaagacaacactggggaggtggtggct
gtgaagaagctccagcacagtactgaagagcacctgcgagactttgaaagggaaattgaa
atcctcaaatcgctgcagcatgacaacattgtgaagtacaagggagtgtgctacagtgct
ggtcggcgtaatctaagattaattatggaatatttaccatatggaagtttacgagactat
ctccaaaaacataaagaacggatagatcataaaaaacttctgcagtatacatctcagata
tgcaagggcatggagtatcttggtacaaaaaggtatatccacagggatctggcaacaagg
aatatattggtggaaaacgaaaacagagttaaaattggagattttgggttaaccaaagtc
ttgccacaagacaaagaatactacaaagtaaaagaacctggtgaaagtcccatattctgg
tatgctccagaatcactgacggagagcaagttttctgtggcttcagatgtctggagcttt
ggagtggttctgtatgaacttttcacgtatattgagaagagtaaaagtcccccagcggaa
tttatgcgtatgattggcaatgacaaacaaggacagatgattgtgtttcatttgatagaa
ctcctaaagaataatggaagattaccaagaccagatggatgcccagatgagatttatttg
atcatgacagaatgctggaacaataatgtcaatcaacgcccctcttttagagacctagct
cttcgagttgatcaaataagggacaacatggctggatga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (25)   
   KEGG PATHWAY (25)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (14)   
   KEGG ORTHOLOGY (1)   
   RefGene (9)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (5)   
   RefSeq(pep) (5)   
DNA sequence (7)   
   RefSeq(nuc) (7)   
Protein domain (11)   
   Pfam (11)   
All databases (67)   

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