KEGG   Ailuropoda melanoleuca (giant panda): 100481755Help
Entry
100481755         CDS       T01329                                 

Gene name
PLCB1
Definition
(RefSeq) phospholipase C, beta 1 (phosphoinositide-specific)
  KO
K05858  
phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
aml  Ailuropoda melanoleuca (giant panda)
Pathway
Inositol phosphate metabolism
Metabolic pathways
Rap1 signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
Phosphatidylinositol signaling system
Sphingolipid signaling pathway
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Wnt signaling pathway
Gap junction
Platelet activation
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Dopaminergic synapse
Long-term depression
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Glucagon signaling pathway
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Alzheimer's disease
Huntington's disease
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Amoebiasis
Pathways in cancer
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:aml00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100481755 (PLCB1)
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    100481755 (PLCB1)
   04310 Wnt signaling pathway
    100481755 (PLCB1)
   04020 Calcium signaling pathway
    100481755 (PLCB1)
   04070 Phosphatidylinositol signaling system
    100481755 (PLCB1)
   04071 Sphingolipid signaling pathway
    100481755 (PLCB1)
   04022 cGMP - PKG signaling pathway
    100481755 (PLCB1)
 Cellular Processes
  Cellular commiunity
   04540 Gap junction
    100481755 (PLCB1)
 Organismal Systems
  Immune system
   04611 Platelet activation
    100481755 (PLCB1)
   04062 Chemokine signaling pathway
    100481755 (PLCB1)
  Endocrine system
   04911 Insulin secretion
    100481755 (PLCB1)
   04922 Glucagon signaling pathway
    100481755 (PLCB1)
   04912 GnRH signaling pathway
    100481755 (PLCB1)
   04915 Estrogen signaling pathway
    100481755 (PLCB1)
   04921 Oxytocin signaling pathway
    100481755 (PLCB1)
   04918 Thyroid hormone synthesis
    100481755 (PLCB1)
   04919 Thyroid hormone signaling pathway
    100481755 (PLCB1)
   04916 Melanogenesis
    100481755 (PLCB1)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100481755 (PLCB1)
   04270 Vascular smooth muscle contraction
    100481755 (PLCB1)
  Digestive system
   04970 Salivary secretion
    100481755 (PLCB1)
   04971 Gastric acid secretion
    100481755 (PLCB1)
   04972 Pancreatic secretion
    100481755 (PLCB1)
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    100481755 (PLCB1)
  Nervous system
   04724 Glutamatergic synapse
    100481755 (PLCB1)
   04725 Cholinergic synapse
    100481755 (PLCB1)
   04728 Dopaminergic synapse
    100481755 (PLCB1)
   04726 Serotonergic synapse
    100481755 (PLCB1)
   04720 Long-term potentiation
    100481755 (PLCB1)
   04730 Long-term depression
    100481755 (PLCB1)
   04723 Retrograde endocannabinoid signaling
    100481755 (PLCB1)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100481755 (PLCB1)
  Environmental adaptation
   04713 Circadian entrainment
    100481755 (PLCB1)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    100481755 (PLCB1)
  Neurodegenerative diseases
   05010 Alzheimer's disease
    100481755 (PLCB1)
   05016 Huntington's disease
    100481755 (PLCB1)
  Infectious diseases
   05146 Amoebiasis
    100481755 (PLCB1)
   05142 Chagas disease (American trypanosomiasis)
    100481755 (PLCB1)
   05143 African trypanosomiasis
    100481755 (PLCB1)
Enzymes [BR:aml01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     100481755 (PLCB1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Ensembl: 
Position
Un
AA seq 1072 aa AA seqDB search
MITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKL
QVTPEGRIPLKNIYRLFSADRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCP
RPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPN
NSLAKKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLA
GNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFK
TSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYK
ILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSVFEPSSPGAGEADTESDDDDDDDDCK
KSSMDEGTAGSEAMATEEMSNLVNYIQPVKFESFEISKKRNRSFEMSSFVETKGLEQLTK
SPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYE
YNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDM
FGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPSLACLRIAVYEEGGKFIGHRI
LPVQAIRPGYHYICLRNERNQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLME
QRAKQLAALTLEDEEEVKKEADPGETPSEAPSEARTTPAENGVNHTTSLAPKPPSQALHS
QPAPGSVKAPAKTEDLIQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHRKT
TDLIKEHTTKYNEIQNDYLRRRAALEKTAKKDSKKKSDPSSPDHGSSTIEQDLAALDAEM
TQKLIDLKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEIC
EKEKKELKKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQ
EKLVEKHKEIRQQILDEKPKGDGSSSFLSETCHEDPSVSPNFTPPNPQALKW
NT seq 3219 nt NT seq  +upstreamnt  +downstreamnt
atgataacagtggtgtatgggcctgacttggttaacatctcccacttgaatctcgtggct
ttccaagaagaagtggccaaggaatggacaaatgaggttttcagtttggcaacaaacctg
ctggcccaaaacatgtcaagagacgcatttctggaaaaagcctatactaagcttaagctg
caagtcactccagaagggcgcattcctctcaaaaacatataccgcttgttctcagcagac
cggaagcgagttgaaactgctttagaggcttgtagtcttccatcttcaaggaacgattca
atacctcaagaagatttcactccagaagtgtacagagttttcctgaacaatctttgccct
cgacctgaaattgataacatcttttccgaatttggtgccaaaagcaaaccataccttacc
gttgatcagatgatggactttatcaatcttaagcagagagatccccggctaaatgaaata
ctttatccacctctaaagcaagaacaagtccaagtattgattgagaagtatgaacccaac
aatagcctcgccaaaaaaggacagatatcagtggatggctttatgcgctatctaagtgga
gaagaaaatggagtcgtttcgcctgagaaactggatttgaatgaagatatgtctcagccc
ctttctcactatttcatcaattcctcacacaacacctacctcacagctggccagttggct
ggaaactcctctgttgagatgtatcgccaagtgctcctgtctggttgtcgctgtgtggag
ttggactgctggaagggacggactgctgaagaggaaccagtcatcacccatgggttcacc
atgacaactgaaatatccttcaaggaagtgatagaagcaatcgctgagtgtgcatttaag
acatcaccttttccaattctgctttcatttgagaaccacgtagattctccaaagcagcaa
gccaagatggcggagtattgccgactgatctttggagatgctcttctcatggaaccactg
gaaaaatacccactggaatctggagttcctcttccaagccctatggatttaatgtacaaa
attttggtgaaaaataagaagaaatcgcacaagtcatcagaaggaagtggcaaaaagaag
ctctcggaacaagcctccaacacgtacagtgactcctccagcgtgtttgaaccctcgtct
ccaggagccggggaagctgataccgagagtgatgatgatgatgatgatgatgactgtaaa
aaatcttcaatggatgaggggactgccgggagcgaggccatggccaccgaagagatgtct
aacctggtgaactatattcagccagtcaagtttgagtcatttgaaatttcaaaaaaaaga
aatagaagttttgaaatgtcttccttcgtggaaaccaaaggtctcgagcagctgacgaaa
tcgccagtggaatttgtagaatacaacaaaatgcagcttagcaggatatatccaaaagga
acccgtgtggattcatctaactacatgcctcagctcttctggaatgcgggttgccaaatg
gttgcacttaattttcaaactgtggacctggctatgcaaataaatatggggatgtacgaa
tacaatgggaaaagtggctacagattaaagccagagttcatgaggagacctgacaagcat
tttgatccattcaccgaaggcatcgtggatgggatagtggccaacactttatctgtcaag
attatttcaggtcagtttctttctgataagaaagtcgggacttatgtggaagtggatatg
tttggtttgcctgtggacacgaggaggaaggcgtttaagaccaaaacatcacaaggaaat
gctgtaaatcctgtctgggaagaggagcccattgtgttcaaaaaggtggttcttccttct
ctggcctgtttgaggatagcagtttatgaagaagggggtaaatttatcggtcaccggatc
ttgccagtacaggcgattcggccaggctatcactacatctgtctgaggaatgagaggaac
cagcctctgacgctcccagctgtctttgtctacatagaggtgaaagactatgtcccagat
acatatgcagatgtgattgaagctttgtcaaatccaatacgatatgtgaatctgatggag
caaagagctaaacagttggctgctttaacactggaagatgaggaagaagtaaagaaagag
gctgatcctggggaaacaccgtcagaagctccaagtgaagccaggacaactccagcagaa
aatggagtgaatcacactacgtccctggcacccaaaccaccttcccaggctctccacagc
caaccagctccaggttctgtaaaggcacctgccaaaacagaagatcttattcagagtgtt
ttaacagaagtggaagcccagaccatcgaagagctaaagcagcagaaatcgtttgtgaaa
cttcaaaagaaacactacaaagaaatgaaagacctggttaaaagacaccacaggaaaacc
actgaccttatcaaggaacacactacaaaatataatgaaattcagaatgactacttgaga
aggagggcagctttggagaagacagccaaaaaggatagtaagaaaaaatcagatcctagc
agtcctgaccatggttcgtcaacaattgagcaagatcttgctgccctagatgctgaaatg
acccaaaagttaatagacttgaaggacaaacaacagcagcagctgcttaatcttcgacaa
gagcagtattatagtgaaaagtaccagaagcgagagcatattaaactgcttattcaaaag
ttgacggatgttgctgaagaatgtcagaacaatcagctgaagaagctcaaagaaatctgt
gagaaagagaagaaggaattaaagaagaagatggacaaaaaaaggcaggagaagataaca
gaagctaaatccaaagacaaaagtcaaatggaagaggaaaagacagagatgatccggtca
tacatccaggaggtggtgcagtacatcaagaggttagaagaggcccaaagtaaacggcaa
gaaaaacttgtagagaaacacaaggagatacgtcaacagatactggacgaaaagcccaag
ggggacggttcctcctcattcttgtcggaaacttgccatgaggatccctctgtttccccc
aactttactccccccaaccctcaagctctcaagtggtga

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