KEGG   Ailuropoda melanoleuca (giant panda): 100481755Help
Entry
100481755         CDS       T01329                                 

Gene name
PLCB1
Definition
phospholipase C, beta 1 (phosphoinositide-specific)
Orthology
K05858  
phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
aml  Ailuropoda melanoleuca (giant panda)
Pathway
Inositol phosphate metabolism
Metabolic pathways
Rap1 signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
Phosphatidylinositol signaling system
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Wnt signaling pathway
Gap junction
Platelet activation
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Dopaminergic synapse
Long-term depression
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Alzheimer's disease
Huntington's disease
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Amoebiasis
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:aml00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100481755 (PLCB1)
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    100481755 (PLCB1)
   04310 Wnt signaling pathway
    100481755 (PLCB1)
   04020 Calcium signaling pathway
    100481755 (PLCB1)
   04070 Phosphatidylinositol signaling system
    100481755 (PLCB1)
   04022 cGMP - PKG signaling pathway
    100481755 (PLCB1)
 Cellular Processes
  Cell communication
   04540 Gap junction
    100481755 (PLCB1)
 Organismal Systems
  Immune system
   04611 Platelet activation
    100481755 (PLCB1)
   04062 Chemokine signaling pathway
    100481755 (PLCB1)
  Endocrine system
   04911 Insulin secretion
    100481755 (PLCB1)
   04912 GnRH signaling pathway
    100481755 (PLCB1)
   04915 Estrogen signaling pathway
    100481755 (PLCB1)
   04921 Oxytocin signaling pathway
    100481755 (PLCB1)
   04918 Thyroid hormone synthesis
    100481755 (PLCB1)
   04919 Thyroid hormone signaling pathway
    100481755 (PLCB1)
   04916 Melanogenesis
    100481755 (PLCB1)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100481755 (PLCB1)
   04270 Vascular smooth muscle contraction
    100481755 (PLCB1)
  Digestive system
   04970 Salivary secretion
    100481755 (PLCB1)
   04971 Gastric acid secretion
    100481755 (PLCB1)
   04972 Pancreatic secretion
    100481755 (PLCB1)
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    100481755 (PLCB1)
  Nervous system
   04724 Glutamatergic synapse
    100481755 (PLCB1)
   04725 Cholinergic synapse
    100481755 (PLCB1)
   04728 Dopaminergic synapse
    100481755 (PLCB1)
   04726 Serotonergic synapse
    100481755 (PLCB1)
   04720 Long-term potentiation
    100481755 (PLCB1)
   04730 Long-term depression
    100481755 (PLCB1)
   04723 Retrograde endocannabinoid signaling
    100481755 (PLCB1)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100481755 (PLCB1)
  Environmental adaptation
   04713 Circadian entrainment
    100481755 (PLCB1)
 Human Diseases
  Neurodegenerative diseases
   05010 Alzheimer's disease
    100481755 (PLCB1)
   05016 Huntington's disease
    100481755 (PLCB1)
  Infectious diseases
   05146 Amoebiasis
    100481755 (PLCB1)
   05142 Chagas disease (American trypanosomiasis)
    100481755 (PLCB1)
   05143 African trypanosomiasis
    100481755 (PLCB1)
Enzymes [BR:aml01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     100481755 (PLCB1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Position
Un
AA seq 1169 aa AA seqDB search
MVQRQMIPLLIYKQVGGSPMLCHNDCVIDLTLSHQDPKLRELLDVGNIGRLEHRMITVVY
GPDLVNISHLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEG
RIPLKNIYRLFSADRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDN
IFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLAKK
GQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVE
MYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPI
LLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNK
KKSHKSSEGSGKKKLSEQASNTYSDSSSVFEPSSPGAGEADTESDDDDDDDDCKKSSMDE
GTAGSEAMATEEMSNLVNYIQPVKFESFEISKKRNRSFEMSSFVETKGLEQLTKSPVEFV
EYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYEYNGKSG
YRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVD
TRRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPSLACLRIAVYEEGGKFIGHRILPVQAI
RPGYHYICLRNERNQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQL
AALTLEDEEEVKKEADPGETPSEAPSEARTTPAENGVNHTTSLAPKPPSQALHSQPAPGS
VKAPAKTEDLIQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHRKTTDLIKE
HTTKYNEIQNDYLRRRAALEKTAKKDSKKKSDPSSPDHGSSTIEQDLAALDAEMTQKLID
LKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKE
LKKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEK
HKEIRQQILDEKPKLQTDLEQEYQDKFKRLPLEILEFVQEAMKGKINEDSNHSSAPPSLA
SEPGKMNHKPPSSEELEGDNPGKEFDTPL
NT seq 3510 nt NT seq  +upstreamnt  +downstreamnt
atggtccagaggcagatgatccccctcctgatctacaaacaggtcggtggtagcccaatg
ctgtgtcacaatgactgtgtcattgacctcactttatctcatcaggaccccaaattacgt
gaacttttggatgtggggaacatcgggcgcctggagcatcgcatgataacagtggtgtat
gggcctgacttggttaacatctcccacttgaatctcgtggctttccaagaagaagtggcc
aaggaatggacaaatgaggttttcagtttggcaacaaacctgctggcccaaaacatgtca
agagacgcatttctggaaaaagcctatactaagcttaagctgcaagtcactccagaaggg
cgcattcctctcaaaaacatataccgcttgttctcagcagaccggaagcgagttgaaact
gctttagaggcttgtagtcttccatcttcaaggaacgattcaatacctcaagaagatttc
actccagaagtgtacagagttttcctgaacaatctttgccctcgacctgaaattgataac
atcttttccgaatttggtgccaaaagcaaaccataccttaccgttgatcagatgatggac
tttatcaatcttaagcagagagatccccggctaaatgaaatactttatccacctctaaag
caagaacaagtccaagtattgattgagaagtatgaacccaacaatagcctcgccaaaaaa
ggacagatatcagtggatggctttatgcgctatctaagtggagaagaaaatggagtcgtt
tcgcctgagaaactggatttgaatgaagatatgtctcagcccctttctcactatttcatc
aattcctcacacaacacctacctcacagctggccagttggctggaaactcctctgttgag
atgtatcgccaagtgctcctgtctggttgtcgctgtgtggagttggactgctggaaggga
cggactgctgaagaggaaccagtcatcacccatgggttcaccatgacaactgaaatatcc
ttcaaggaagtgatagaagcaatcgctgagtgtgcatttaagacatcaccttttccaatt
ctgctttcatttgagaaccacgtagattctccaaagcagcaagccaagatggcggagtat
tgccgactgatctttggagatgctcttctcatggaaccactggaaaaatacccactggaa
tctggagttcctcttccaagccctatggatttaatgtacaaaattttggtgaaaaataag
aagaaatcgcacaagtcatcagaaggaagtggcaaaaagaagctctcggaacaagcctcc
aacacgtacagtgactcctccagcgtgtttgaaccctcgtctccaggagccggggaagct
gataccgagagtgatgatgatgatgatgatgatgactgtaaaaaatcttcaatggatgag
gggactgccgggagcgaggccatggccaccgaagagatgtctaacctggtgaactatatt
cagccagtcaagtttgagtcatttgaaatttcaaaaaaaagaaatagaagttttgaaatg
tcttccttcgtggaaaccaaaggtctcgagcagctgacgaaatcgccagtggaatttgta
gaatacaacaaaatgcagcttagcaggatatatccaaaaggaacccgtgtggattcatct
aactacatgcctcagctcttctggaatgcgggttgccaaatggttgcacttaattttcaa
actgtggacctggctatgcaaataaatatggggatgtacgaatacaatgggaaaagtggc
tacagattaaagccagagttcatgaggagacctgacaagcattttgatccattcaccgaa
ggcatcgtggatgggatagtggccaacactttatctgtcaagattatttcaggtcagttt
ctttctgataagaaagtcgggacttatgtggaagtggatatgtttggtttgcctgtggac
acgaggaggaaggcgtttaagaccaaaacatcacaaggaaatgctgtaaatcctgtctgg
gaagaggagcccattgtgttcaaaaaggtggttcttccttctctggcctgtttgaggata
gcagtttatgaagaagggggtaaatttatcggtcaccggatcttgccagtacaggcgatt
cggccaggctatcactacatctgtctgaggaatgagaggaaccagcctctgacgctccca
gctgtctttgtctacatagaggtgaaagactatgtcccagatacatatgcagatgtgatt
gaagctttgtcaaatccaatacgatatgtgaatctgatggagcaaagagctaaacagttg
gctgctttaacactggaagatgaggaagaagtaaagaaagaggctgatcctggggaaaca
ccgtcagaagctccaagtgaagccaggacaactccagcagaaaatggagtgaatcacact
acgtccctggcacccaaaccaccttcccaggctctccacagccaaccagctccaggttct
gtaaaggcacctgccaaaacagaagatcttattcagagtgttttaacagaagtggaagcc
cagaccatcgaagagctaaagcagcagaaatcgtttgtgaaacttcaaaagaaacactac
aaagaaatgaaagacctggttaaaagacaccacaggaaaaccactgaccttatcaaggaa
cacactacaaaatataatgaaattcagaatgactacttgagaaggagggcagctttggag
aagacagccaaaaaggatagtaagaaaaaatcagatcctagcagtcctgaccatggttcg
tcaacaattgagcaagatcttgctgccctagatgctgaaatgacccaaaagttaatagac
ttgaaggacaaacaacagcagcagctgcttaatcttcgacaagagcagtattatagtgaa
aagtaccagaagcgagagcatattaaactgcttattcaaaagttgacggatgttgctgaa
gaatgtcagaacaatcagctgaagaagctcaaagaaatctgtgagaaagagaagaaggaa
ttaaagaagaagatggacaaaaaaaggcaggagaagataacagaagctaaatccaaagac
aaaagtcaaatggaagaggaaaagacagagatgatccggtcatacatccaggaggtggtg
cagtacatcaagaggttagaagaggcccaaagtaaacggcaagaaaaacttgtagagaaa
cacaaggagatacgtcaacagatactggacgaaaagcccaagctgcagacggacctggag
caagagtaccaagacaagttcaaaagactgcccctggagatcctggagttcgtgcaggaa
gccatgaaagggaagatcaacgaagacagcaatcacagttctgcccctccctccctggcc
tcagagcctggaaaaatgaaccacaagcctccctccagtgaggagctagaaggagacaac
ccaggaaaagagttcgatacgcctctgtga

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