KEGG T01822: RAM

Amycolatopsis mediterranei S699: RAM_45590

Entry

RAM_45590 CDS T01822

Definition

2-isopropylmalate synthase

Orthology

K01649

2-isopropylmalate synthase [EC:2.3.3.13]

Organism

amn Amycolatopsis mediterranei S699

Pathway

amn00290	Valine, leucine and isoleucine biosynthesis
amn00620	Pyruvate metabolism
amn01100	Metabolic pathways
amn01110	Biosynthesis of secondary metabolites
amn01210	2-Oxocarboxylic acid metabolism
amn01230	Biosynthesis of amino acids

Module

amn_M00432

Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate

Class

Metabolism; Carbohydrate metabolism; Pyruvate metabolism [PATH:amn00620]
Metabolism; Amino acid metabolism; Valine, leucine and isoleucine biosynthesis [PATH:amn00290]

SSDB

Motif

Pfam:

HMGL-like LeuA_dimer

Other DBs

NCBI-GI:

384154224

NCBI-GeneID:

12125827

UniProt:

G0FKP2

Position

9738610..9740295

AA seq 561 aa
MPVHRYRPWYDVVENIDLPDRTWPEKRIDRAPLWCAVDLRDGNQALIDPMSPARKRKFFD
LLVRMGYKEIEVGFPAASQTDFDFVREIIEEHAIPDDVSIQVLTQCRPELIERTFKSLEG
APRAIVHIYNSTSILQRRVVFREEREGIKKIATQAAEMVVELAAKQPDTDFRFQYSPESY
TGTELSYALEVCNAVTEIWQPTPEKPVILNLPATVEMATPNVYADSIEWMSRNLDRRDSV
ILSLHPHNDRGTGIAAAELGYQAGADRIEGCLFGNGERTGNVDLVALGMNLYSQGIDPQI
DFSDMDEIKRTVEYCNQLPVGERSPWGGDLVFTAFSGSHQDAINKGLDALKDAADKAGVP
IDEYPWEVPYLPIDPKDVGRMYEAVIRVNSQSGKGGVAYIMKAEHQLDLPRRLQIEFSKV
IQRYTDTEGGEVDPATMYNAFSAEYLELKTPLELVRQHVRDNGDGEYDITATVKVEGDEH
EVTGRGNGPIAAFFDALSTVGFDLRLLDYNEHTLSPGDDARAASYIECAISDRVFWGIGI
DPSIVTASLRAVVSAVNRANR

NT seq 1686 nt +upstreamnt +downstreamnt
atgccggtccaccgctaccgcccctggtacgacgtggtcgagaacatcgacctgcccgac
cgcacctggcccgagaagcgcatcgaccgcgcgccgctgtggtgcgccgtcgacctgcgg
gacggcaaccaggccctgatcgacccgatgtcgcccgcgcgcaagcgcaagttcttcgac
ctgctggtccgcatggggtacaaggagatcgaggtcggcttcccggccgcgtcccagacc
gacttcgacttcgtccgcgagatcatcgaagagcacgccatcccggacgacgtcagcatc
caggtgctgacccagtgccgtcccgagctgatcgaacgcaccttcaagtcgctcgaaggc
gcgccgcgggcgatcgtccacatctacaactcgacgtcgatcctgcagcgccgcgtggtc
ttccgcgaggagcgcgagggcatcaagaagatcgcgacgcaggccgcggaaatggtcgtc
gagctggccgcgaagcagccggacaccgacttccgcttccagtactcgccggagtcctac
accggcaccgagctgtcctacgcgctcgaggtctgcaacgccgtcaccgagatctggcag
ccgacgccggagaagccggtgatcctgaacctgccggcgaccgtcgagatggcgacgccg
aacgtctacgccgactcgatcgagtggatgtcccggaacctggaccgccgcgactcggtg
atcctgtcgctgcacccgcacaacgaccgcggcaccggcatcgccgccgccgagctgggc
taccaggccggcgccgaccggatcgagggctgcctgttcggcaacggggagcgcaccggc
aacgtcgacctggtcgcgctgggcatgaacctctacagccagggcatcgacccgcagatc
gacttctccgacatggacgagatcaagcggacggtcgagtactgcaaccagctgccggtc
ggcgagcgctcgccgtggggcggcgacctggtgttcaccgcgttctcgggcagccaccag
gacgcgatcaacaagggcctcgacgcgctgaaggacgccgccgacaaggccggcgtcccg
atcgacgagtacccgtgggaggtcccgtacctgccgatcgacccgaaggacgtcggccgg
atgtacgaggccgtgatccgggtgaactcgcagtccggcaagggcggcgtcgcctacatc
atgaaggccgagcaccagctcgacctgccgcggcggctgcagatcgagttctcgaaggtc
atccagcgctacaccgacaccgagggcggcgaggtcgacccggccaccatgtacaacgcc
ttctcggccgagtacctggagctgaagacgccgctggagctggtccgccagcacgtgcgc
gacaacggcgacggcgagtacgacatcaccgcgaccgtgaaggtggagggtgacgagcac
gaggtcaccggccgcggcaacggcccgatcgcggcgttcttcgacgcgctgtcgacggtg
ggcttcgacctgcgcctgctggactacaacgaacacacgctctcgccgggcgacgacgcg
cgcgccgcgtcgtacatcgagtgcgcgatctcggaccgggtgttctggggcatcggcatc
gacccgtcgatcgtcacggcgtcactgcgcgcggtcgtctcggcggtgaaccgcgccaac
cgctag

All links

Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (1)   
   OC (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
Protein domain (2)   
   Pfam (2)   
All databases (23)   

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