KEGG T02044: ACPL

Actinoplanes sp. SE50/110: ACPL_7356

Entry

ACPL_7356 CDS T02044

Definition

2-isopropylmalate synthase (EC:2.3.3.13)

Orthology

K01649

2-isopropylmalate synthase [EC:2.3.3.13]

Organism

ase Actinoplanes sp. SE50/110

Pathway

ase00290	Valine, leucine and isoleucine biosynthesis
ase00620	Pyruvate metabolism
ase01100	Metabolic pathways
ase01110	Biosynthesis of secondary metabolites
ase01210	2-Oxocarboxylic acid metabolism
ase01230	Biosynthesis of amino acids

Module

ase_M00432

Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate

Class

Metabolism; Carbohydrate metabolism; Pyruvate metabolism [PATH:ase00620]
Metabolism; Amino acid metabolism; Valine, leucine and isoleucine biosynthesis [PATH:ase00290]

SSDB

Motif

Pfam:

HMGL-like LeuA_dimer

Other DBs

NCBI-GI:

386852291

NCBI-GeneID:

12824914

UniProt:

G8SL31

Position

8120792..8122366

AA seq 524 aa
MDYQVFDTTLRDGGQREGISYTVADKLAVARLLDDFGVGFIEGGWPGAMPKDTEFFARAR
TELNLRHAVLVAFGATRKAGVDVAADPQVRALLEADTPVVCVVAKSDIRHVERALRTTAE
ENLAMVRDTVRHLVANGRRAFLDCEHFFDGFRFDPEYTASVVRTAIDAGAERVIMCDTNG
GMLPSMITKAITEVVERTGVSADRLGIHCQNDTACAVANTVAAVEAGVRHFQCTANGYGE
RPGNADLFAVVSNLQLKLGLKVLPDGCLEKATRVSSALAEIANIAPDTHQAYVGAAAFAH
KAGLHASAIKVDPLLYNHVDPAVVGNDMRILVTEMAGRASIELKSRELGIDLAGHPDTLT
SVTQKVKDLEAAGWSFEAADASFELLVRSELPGEDVTRPFTLESYRVLVEHREDGKVISE
ATVKLRVKGERVIATAEGNGPVNALDEALRTALSHHHPALRSFELNDYKVRILEGSHGTN
AITRVLVETGDHNREWTTVGVHENVVEASWTALVDALTYGLGRS

NT seq 1575 nt +upstreamnt +downstreamnt
atggactaccaggtgttcgacacgacgctgcgcgacggtgggcagcgcgagggaatcagc
tacacggtcgccgacaaactcgcggtcgcacgcctgctggacgacttcggtgtcggtttc
atcgagggcggctggccgggcgcgatgcccaaggacaccgagttcttcgcccgcgccagg
accgagctgaacctccggcacgcggtgctggtcgcgttcggcgccacccgcaaggccggc
gtggacgtggcggccgacccgcaggtgcgggcgctgctggaggccgacaccccggtggtc
tgcgtggtggccaagtcggacatccggcacgtggagcgggcgctgcgcaccacggcggag
gagaacctggcgatggtccgggacacggtccggcacctggtcgccaacggccgccgggcg
ttcctcgactgtgagcacttcttcgacggcttccgtttcgacccggagtacaccgcgagc
gtggtgcggaccgcgatcgacgccggcgccgaacgcgtgatcatgtgcgacaccaacggc
ggcatgctcccctcgatgatcaccaaggcgatcaccgaggtcgtcgagcggaccggggtg
agcgccgaccggctcggcatccactgccagaacgacaccgcctgcgcggtcgcgaacacg
gtcgccgcggtcgaggccggggtgcggcacttccagtgcaccgcgaacggctacggcgag
cgccccggcaacgccgacctgttcgccgtggtcagcaacctgcaactcaagctcgggctg
aaggtcctaccggacggatgcctggagaaggcgacgcgggtctcctccgcgctcgccgag
atcgccaacatcgcccccgacacccaccaggcctatgtcggggccgcggcgttcgcccac
aaggcgggcctgcacgcgagcgcgatcaaagtggatccgctgctgtacaaccacgtcgac
ccggcggttgtcggcaacgacatgcggatcctggtgaccgagatggccggccgggccagc
atcgagctcaagagtcgcgagctcggcatcgacctggccggccatccggacacgctcacc
tcggtcacccagaaggtcaaggacctggaggcggccggctggtcgttcgaggccgccgac
gcctcgttcgagctgctggtgcgcagcgagctgccgggcgaggacgtgacccgcccgttc
accctggagtcgtaccgggtgctggtcgagcaccgcgaagacggcaaggtgatctccgag
gcgacggtgaagctgcgggtcaagggcgagcgggtgatcgccacggccgagggcaacggc
ccggtcaacgcgctggacgaggcgctgcgcaccgcgctctcccaccaccatccggcgctg
aggtcgttcgagctcaacgactacaaggtacggatcctggagggcagccacggcaccaac
gcgatcacccgggtgctggtcgagaccggcgaccacaaccgcgagtggaccaccgtcggc
gtgcacgagaacgtggtcgaggccagctggaccgccctggtcgacgcgctcacctacgga
ctcggcaggagctga

All links

Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (1)   
   OC (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
Protein domain (2)   
   Pfam (2)   
All databases (23)   

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