Valine, leucine and isoleucine biosynthesis

Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:bfr00290]

Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:bfr00290]

Isoleucine biosynthesis, pyruvate => 2-oxobutanoate [PATH:bfr00290]

Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:bfr00290]

2-isopropylmalate synthase; K09011 D-citramalate synthase [EC:2.3.1.182] [KO:K09011] [EC:2.3.1.182]

isopropylmalate isomerase large subunit; K01703 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit [EC:4.2.1.33 4.2.1.35] [KO:K01703] [EC:4.2.1.35 4.2.1.33]

3-isopropylmalate dehydratase small subunit; K01704 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit [EC:4.2.1.33 4.2.1.35] [KO:K01704] [EC:4.2.1.35 4.2.1.33]

3-isopropylmalate dehydrogenase; K00052 3-isopropylmalate dehydrogenase [EC:1.1.1.85] [KO:K00052] [EC:1.1.1.85]

acetolactate synthase large subunit; K01652 acetolactate synthase I/II/III large subunit [EC:2.2.1.6] [KO:K01652] [EC:2.2.1.6]

acetohydroxyacid synthase small subunit; K01653 acetolactate synthase I/III small subunit [EC:2.2.1.6] [KO:K01653] [EC:2.2.1.6]

ketol-acid reductoisomerase; K00053 ketol-acid reductoisomerase [EC:1.1.1.86] [KO:K00053] [EC:1.1.1.86]

dihydroxy-acid dehydratase; K01687 dihydroxy-acid dehydratase [EC:4.2.1.9] [KO:K01687] [EC:4.2.1.9]

branched-chain amino acid aminotransferase; K00826 branched-chain amino acid aminotransferase [EC:2.6.1.42] [KO:K00826] [EC:2.6.1.42]

2-isopropylmalate synthase; K01649 2-isopropylmalate synthase [EC:2.3.3.13] [KO:K01649] [EC:2.3.3.13]

Pyruvate

Acetyl-CoA

2-Oxobutanoate

L-Leucine

3-Methyl-2-oxobutanoic acid

L-Valine

L-Threonine

4-Methyl-2-oxopentanoate

L-Isoleucine

(S)-3-Methyl-2-oxopentanoic acid

2-Methylmaleate

alpha-Isopropylmalate

(R)-2-Methylmalate

2-Isopropylmaleate

3-Hydroxy-3-methyl-2-oxobutanoic acid

(2S)-2-Isopropyl-3-oxosuccinate

(R)-2,3-Dihydroxy-3-methylbutanoate

(2R,3S)-3-Isopropylmalate

(S)-2-Aceto-2-hydroxybutanoate

(R)-2,3-Dihydroxy-3-methylpentanoate

(S)-2-Acetolactate

D-erythro-3-Methylmalate

(R)-3-Hydroxy-3-methyl-2-oxopentanoate