KEGG   Bos mutus (wild yak): 102274553Help
Entry
102274553         CDS       T02919                                 

Gene name
PIK3CA
Definition
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Orthology
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
Organism
bom  Bos mutus (wild yak)
Pathway
Inositol phosphate metabolism
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Signaling pathways regulating pluripotency of stem cells
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Bacterial invasion of epithelial cells
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Hepatitis C
Hepatitis B
Measles
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Central carbon metabolism in cancer
Choline metabolism in cancer
Module
PI3K-Akt signaling
Brite
KEGG Orthology (KO) [BR:bom00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    102274553 (PIK3CA)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    102274553 (PIK3CA)
   04015 Rap1 signaling pathway
    102274553 (PIK3CA)
   04012 ErbB signaling pathway
    102274553 (PIK3CA)
   04370 VEGF signaling pathway
    102274553 (PIK3CA)
   04630 Jak-STAT signaling pathway
    102274553 (PIK3CA)
   04668 TNF signaling pathway
    102274553 (PIK3CA)
   04066 HIF-1 signaling pathway
    102274553 (PIK3CA)
   04068 FoxO signaling pathway
    102274553 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    102274553 (PIK3CA)
   04024 cAMP signaling pathway
    102274553 (PIK3CA)
   04022 cGMP - PKG signaling pathway
    102274553 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    102274553 (PIK3CA)
   04152 AMPK signaling pathway
    102274553 (PIK3CA)
   04150 mTOR signaling pathway
    102274553 (PIK3CA)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    102274553 (PIK3CA)
  Cell growth and death
   04210 Apoptosis
    102274553 (PIK3CA)
  Cellular commiunity
   04510 Focal adhesion
    102274553 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    102274553 (PIK3CA)
 Organismal Systems
  Immune system
   04611 Platelet activation
    102274553 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    102274553 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    102274553 (PIK3CA)
   04660 T cell receptor signaling pathway
    102274553 (PIK3CA)
   04662 B cell receptor signaling pathway
    102274553 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    102274553 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    102274553 (PIK3CA)
   04670 Leukocyte transendothelial migration
    102274553 (PIK3CA)
   04062 Chemokine signaling pathway
    102274553 (PIK3CA)
  Endocrine system
   04910 Insulin signaling pathway
    102274553 (PIK3CA)
   04915 Estrogen signaling pathway
    102274553 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    102274553 (PIK3CA)
   04917 Prolactin signaling pathway
    102274553 (PIK3CA)
   04921 Oxytocin signaling pathway
    102274553 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    102274553 (PIK3CA)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    102274553 (PIK3CA)
  Digestive system
   04973 Carbohydrate digestion and absorption
    102274553 (PIK3CA)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    102274553 (PIK3CA)
  Nervous system
   04725 Cholinergic synapse
    102274553 (PIK3CA)
   04722 Neurotrophin signaling pathway
    102274553 (PIK3CA)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    102274553 (PIK3CA)
  Development
   04380 Osteoclast differentiation
    102274553 (PIK3CA)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    102274553 (PIK3CA)
   05230 Central carbon metabolism in cancer
    102274553 (PIK3CA)
   05231 Choline metabolism in cancer
    102274553 (PIK3CA)
   05205 Proteoglycans in cancer
    102274553 (PIK3CA)
   05203 Viral carcinogenesis
    102274553 (PIK3CA)
   05210 Colorectal cancer
    102274553 (PIK3CA)
   05212 Pancreatic cancer
    102274553 (PIK3CA)
   05214 Glioma
    102274553 (PIK3CA)
   05221 Acute myeloid leukemia
    102274553 (PIK3CA)
   05220 Chronic myeloid leukemia
    102274553 (PIK3CA)
   05218 Melanoma
    102274553 (PIK3CA)
   05211 Renal cell carcinoma
    102274553 (PIK3CA)
   05215 Prostate cancer
    102274553 (PIK3CA)
   05213 Endometrial cancer
    102274553 (PIK3CA)
   05222 Small cell lung cancer
    102274553 (PIK3CA)
   05223 Non-small cell lung cancer
    102274553 (PIK3CA)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    102274553 (PIK3CA)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    102274553 (PIK3CA)
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    102274553 (PIK3CA)
   05166 HTLV-I infection
    102274553 (PIK3CA)
   05162 Measles
    102274553 (PIK3CA)
   05164 Influenza A
    102274553 (PIK3CA)
   05161 Hepatitis B
    102274553 (PIK3CA)
   05160 Hepatitis C
    102274553 (PIK3CA)
   05169 Epstein-Barr virus infection
    102274553 (PIK3CA)
   05146 Amoebiasis
    102274553 (PIK3CA)
   05145 Toxoplasmosis
    102274553 (PIK3CA)
   05142 Chagas disease (American trypanosomiasis)
    102274553 (PIK3CA)
Enzymes [BR:bom01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     102274553 (PIK3CA)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Position
Un
AA seq 1072 aa AA seqDB search
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
XXXXXXVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICT
RDPLSEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPE
QAMELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKK
ALTNQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLT
DILKQEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAK
RPLWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPY
GCLSIGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDL
FTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVL
TQDFLIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSF
DDIAYIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3219 nt NT seq  +upstreamnt  +downstreamnt
atgcctccaagaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatgggatgatagtgactttagaatgcctccgtgaggct
acgttaataacgataaagcatgaactatttaaagaagcaagaaaataccctctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacaagacgactttgtgaccttcggctttttcaaccctttttaaaa
gtaattgaaccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggttttgct
atcggcatgccagtgtgtgaattcgatatggttaaagatccagaagtacaggacttccga
agaaatattctcaatgtttgtaaagaagctgtggatcttagggatcttaattcacctcat
agtagagcaatgtatgtttatcctccaaatgtagaatcttcaccagaactgccaaagcac
atatataataaattggataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgacaaacagaaatatactctgaaaatcaaccatgactgtgtgccagaacaagta
attgctgaagcaatcaggaaaaaaactcgaagtatgttgctatcatctgaacaactaaaa
ctctgtgttttagaatatcagggcaagtatattttaaaagtgtgtggatgtgatgaatac
ttcctagaaaaatatcctctgagtcagtataagtatataagaagctgtataatgcttggg
aggatgcccaatttgatgctgatggctaaagaaagcctctattctcaactgccaatggac
tgttttacaatgccatcatattccagacgcatctccacagctacgccatatatgaatgga
gaaacatctacaaaatccctttgggttataaatagtgcactcagaataaaaattctttgt
gcaacctatgtgaatgtaaatattcgagacattgacaagatttatgttcgaacaggtatc
taccatggaggagaacccttatgtgataatgtgaacactcaaagagtaccttgttccaat
cccaggtggaatgaatggctgaattacgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttccatttgttctgttaaaggccgaaagggtgctaaagaggaacactgt
ccattggcctggggaaatataaacttgtttgattacacagatactctagtatctggaaaa
atggctttgaatctttggccagtacctcatggactagaagatttgctgaatcctattggt
gttactggatcaaatccaaataaagaaactccatgtttagagttggagtttgactggttc
annnnnnnnnnnnnnngtgtggtaaagtttccagatatgtcagtgattgaagagcatgcc
aattggtctgtatcccgtgaagcaggatttagttattcccatgcaggactgagtaacaga
ctagctagagacaatgaattaagagaaaatgataaagaacagctccgagcaatttgtaca
cgagatcctctatctgaaatcactgagcaagagaaagattttctgtggagccacagacac
tattgtgtaactatccccgaaattctacccaaattgcttctgtctgttaagtggaactct
agagatgaagtagctcagatgtactgcttggtaaaagattggcctccaatcaagcctgaa
caggctatggagcttctggactgcaattacccagatcctatggttcgaggttttgctgtt
cggtgcttagaaaaatatttaacagatgacaaactttctcagtacctaattcagctagta
caggtactaaaatatgaacagtatttggataacctgcttgtgagatttttactcaaaaaa
gcgttaactaatcaaaggatcggtcactttttcttttggcatttaaaatctgagatgcac
aataaaacagttagtcagaggtttggcctgcttttggagtcctattgccgtgcatgtggg
atgtatctgaagcaccttaataggcaagttgaggctatggaaaagctcattaacttgact
gacattctcaaacaagagaagaaggatgaaacacaaaaggtacagatgaagtttttagtt
gagcaaatgcggcgaccagatttcatggatgctctccagggctttctgtctcctctaaac
cctgctcatcagctgggaaatctcaggcttgaagagtgtcgaattatgtcttctgcaaaa
aggccactgtggttgaattgggagaacccagacatcatgtcagaattactctttcagaac
aatgagatcatctttaaaaatggggatgatttacggcaagatatgctaacccttcagatt
attcgcattatggaaaatatctggcaaaatcaaggtcttgatcttcgaatgttaccttat
ggatgtctgtcaatcggtgactgtgtgggacttatcgaggtggtgagaaattctcacact
ataatgcagattcagtgtaaaggaggcctgaaaggtgcactgcagttcaacagccacaca
ctccatcagtggctcaaagacaagaacaagggggaaatatatgatgcagccatcgatttg
tttacacgatcatgtgctggatattgtgttgccaccttcattttgggaattggagatcgt
cacaatagtaatatcatggttaaagatgatggacaactgtttcatatagattttggacac
tttttggatcacaagaagaaaaaatttggttataaacgagagcgcgtgccgtttgttttg
acacaagatttcttaatagtgattagtaaaggagcccaagaatgcacaaagacaagagaa
tttgagaggtttcaggagatgtgttacaaggcttatctagctattcggcagcatgccaat
ctcttcataaatcttttctcaatgatgcttggctctggaatgccagaactgcaatctttt
gatgatattgcatacattcgaaagaccctagctttagataaaactgagcaagaggctttg
gagtatttcatgaaacaaatgaatgatgcacaccatggtggctggacaacaaaaatggat
tggatcttccacacaattaagcagcatgctttgaactga

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