KEGG   Bos mutus (wild yak): 102287266
Entry
102287266         CDS       T02919                                 
Symbol
TYK2
Name
(RefSeq) tyrosine kinase 2
  KO
K11219  non-receptor tyrosine-protein kinase TYK2 [EC:2.7.10.2]
Organism
bom  Bos mutus (wild yak)
Pathway
bom04217  Necroptosis
bom04380  Osteoclast differentiation
bom04620  Toll-like receptor signaling pathway
bom04621  NOD-like receptor signaling pathway
bom04630  JAK-STAT signaling pathway
bom04658  Th1 and Th2 cell differentiation
bom04659  Th17 cell differentiation
bom05145  Toxoplasmosis
bom05160  Hepatitis C
bom05161  Hepatitis B
bom05162  Measles
bom05164  Influenza A
bom05165  Human papillomavirus infection
bom05167  Kaposi sarcoma-associated herpesvirus infection
bom05168  Herpes simplex virus 1 infection
bom05169  Epstein-Barr virus infection
bom05171  Coronavirus disease - COVID-19
Brite
KEGG Orthology (KO) [BR:bom00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    102287266 (TYK2)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    102287266 (TYK2)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    102287266 (TYK2)
   04621 NOD-like receptor signaling pathway
    102287266 (TYK2)
   04658 Th1 and Th2 cell differentiation
    102287266 (TYK2)
   04659 Th17 cell differentiation
    102287266 (TYK2)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    102287266 (TYK2)
 09160 Human Diseases
  09172 Infectious disease: viral
   05161 Hepatitis B
    102287266 (TYK2)
   05160 Hepatitis C
    102287266 (TYK2)
   05171 Coronavirus disease - COVID-19
    102287266 (TYK2)
   05164 Influenza A
    102287266 (TYK2)
   05162 Measles
    102287266 (TYK2)
   05168 Herpes simplex virus 1 infection
    102287266 (TYK2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102287266 (TYK2)
   05169 Epstein-Barr virus infection
    102287266 (TYK2)
   05165 Human papillomavirus infection
    102287266 (TYK2)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    102287266 (TYK2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:bom01001]
    102287266 (TYK2)
Enzymes [BR:bom01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     102287266 (TYK2)
Protein kinases [BR:bom01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   102287266 (TYK2)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase Jak1_Phl FERM_F2 FERM_F1 Kinase-like Kdo FERM_C_FAK1 ABC1
Other DBs
NCBI-GeneID: 102287266
NCBI-ProteinID: XP_005902973
Position
Un
AA seq 1185 aa
MPLCQWRATTRGRKPSGDGAQPMATREGLKVLLHWAGPSGGEPWVTFTEPTLTAEDVCIH
VAHKVGITPPCFNLFALFDAQAQVWLPPNHILDTSRDSSLTLYFRMRFYFRNWHGTNPQE
PAVYRCGPPGAETSSEQAEQGVQLLDPASFEYLFEQGKHEFVNDVASLWELSSEEEIHHF
QNESLGMALLHLCHLALRNGVPLEKVAKKTSFKDCIPRSFRRQMRQHNALTRLRQRSIFR
KFLRAFQPGCLSQQVVMVKYLATLERLAPCFGTERVPVCHLELLSQADGEPCYIRDGGQA
PPDPGSESAVGPPTHEVLVSGTEGIRWRLVPAEGPADGGAGGGSRMPDADPSGKKMKAEE
VGSEPVDRPRESPWSYFCDFQDITHMVLKERHVSIHCQDNKCLELTLPSRAAALSLVSLV
DGYFRLTADSNHYLCHEVAPPRLLMSIQDGIHGPLLEPFVLAKLKPEAGLYLIHWSTSHL
HRLILTVAQRDQAPGTKGLRLRKFPIELQAGTVMLEGWGRSFPSVRDLRAALQDCSLRAG
NDCFSLRRCCLPRPGEISNLIVTRGPQASTRPLNLSHLSFYRVRQEDITQLSHLGQGTRT
NVYEGLLRVGGGGPEEDKADGEEPPTPAGDRGQELRVVLKVLDPSHHDIALAFYETASLM
SQVSHVHLAFVHGVFVHGSENIMVTEYVEHGPLDVWLRRERGRVPLAWKLAVAQQLASAL
SYLEDKSLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLSALSREERVERIPWTAPE
CLSGGANSLSTAADKWGFGATLLEICFDGEAPLQGRSPSEKERFYQKQHKLPEPSCPELA
TLTSQCLTYEPAQRPSFRTILRDFTQLQPQNLADVLSVSPDSLASDPTVFHKRYLKKIRD
LGEGHFGKVSLYCYDPTNDGTGEMVAVKALKAGCGPQLRTGWRREIDILRTLYHKHIVKY
KGCCEDQGEKSIQLVMEYMPLGSLRDYLPRHNVGLVQLLLFSLQICEGMAYLHTQHYVHR
DLAARNVLLDNNRLVKIGDFGLTKAVPEGHEYYCVREDGDSPVFWYAPECLKECKFYYAS
DVWSFGVLMYELLTYCDSSQSPPSKFIELIGLTQGQMTVLRLTELLERGERLPQPEKCPS
EIYCLMKDCWKAEASFRPTFQNLVPILRSYHEKYQGQAPSVFSVC
NT seq 3558 nt   +upstreamnt  +downstreamnt
atgcctctgtgccaatggagggccaccaccaggggcaggaagcccagtggggacggagct
cagcccatggccaccagagaaggcctgaaagtgcttctgcactgggctggccccagtggt
ggggagccctgggtcaccttcactgagcccacactgaccgcggaggatgtctgcatccac
gtcgcacacaaagtcggcatcactccaccctgcttcaatctttttgccctcttcgatgcc
caggcccaggtctggctgcctccaaatcacattctggatacctccagggactccagcctg
acgctgtacttccgcatgaggttttatttccgaaactggcatggcacgaatcctcaggag
ccagctgtgtaccgctgcgggcccccaggggccgagacttcctcagaacaggcagagcag
ggggtgcaactcctggaccctgcctcctttgagtacctctttgagcagggcaagcatgaa
tttgtaaatgacgtggcatcactatgggagctatccagcgaggaggagatccaccacttt
cagaatgagagcctgggcatggcccttttgcacctctgccacctcgctctccgcaatggt
gtcccccttgaaaaggtggccaagaagaccagcttcaaggattgcatcccacgctccttc
cggcggcagatgcggcagcacaacgctctgacacggctgcgccaacggagcatcttccgc
aagttcctgcgggccttccagccgggctgcctctcccagcaggtcgtcatggtgaagtac
ctggccacgctcgagcgactggcaccctgctttggcacagagcgtgtgcccgtgtgccac
ctggagctgctgtcccaagccgatggggagccctgctacatccgggacggtgggcaggcc
cctcctgaccccgggtctgagtctgctgtcggaccccccacccacgaggtgctggtgtca
ggcacggaaggcatccggtggcggctggtaccggcggaggggcctgctgatggtggtgct
ggtggcggcagcaggatgcctgatgctgacccatctgggaagaaaatgaaggccgaggag
gtgggcagcgagccagtggacaggcctcgggagagcccctggtcctacttctgtgacttc
caggacatcacccacatggtgctgaaggaacgccacgtcagcatccattgtcaggacaac
aagtgcctggagctgaccctgccttcccgggctgcggccctgtccttggtgtcgctggtg
gatggctacttccgcctgactgccgactcaaaccactacctgtgccacgaggtggctcct
ccacggctgctgatgagtatccaggatggtatccacggccccctgctggagccatttgtg
ctggccaagctgaagcccgaggctggcctctaccttatccactggagcaccagccacctc
caccgcctcatcctcacagtggcccagcgcgaccaggctccaggcactaagggcttgcgc
ctgcggaagttccctatcgagctccaggccgggacagtcatgctggagggctggggccgg
tctttccccagcgtgcgggacctgagggctgccctgcaggactgctcgctgcgggccggc
aacgactgcttttccctgcgtcgctgctgcctgccccggcccggagagatctccaacctc
atcgtcacacgggggcctcaggccagcaccagaccgctcaacctcagtcatctcagcttc
taccgagtccgccaggaagacatcacccagctgtcccacttaggccagggcacaaggacc
aacgtgtatgagggcctcttgcgagtggggggcggaggccccgaggaggacaaggcagat
ggcgaggaaccccccacgcccgctggggaccgtgggcaggagcttcgtgtggtgctcaag
gtgctagaccccagtcaccacgacatcgccctggccttctacgagacagccagcctcatg
agccaggtctcccacgtgcacctggccttcgtgcacggcgtcttcgtgcacggctccgag
aacatcatggtgaccgagtacgtggagcacgggcccctggacgtatggctgcggcgggag
aggggccgcgtgcccctggcctggaagttggcagtggcccagcagctggccagcgccctc
agttacctggaagacaaaagcctggttcatggcaacgtgtgtggccggaacatcctgctg
gcacggctggggctggcggagggcaccagccccttcatcaagctgagtgaccccggcgtg
ggcctgagtgccctctccagggaggagcgggtggagcggatcccctggacagcccccgag
tgcctgtctggtggagccaacagcctgagcaccgcagccgacaagtggggctttggtgcc
accctcctggagatctgcttcgacggcgaggcccccctgcagggccgtagtccctctgag
aaagagcgcttctaccagaagcagcacaaactgcctgagccctcatgcccagagctggcc
acactcaccagccagtgcctgacctacgagccagcccagcggccatccttccgcaccatc
ctgcgtgacttcactcagctacagccccagaatctcgctgatgtcttgtctgtgagcccg
gattcactggcttcagatcccacggttttccacaagcgatacttgaaaaagatccgggat
ctgggtgagggtcacttcggaaaggtcagcctgtattgctacgaccccaccaacgacggc
actggtgagatggtagccgtgaaggccctcaaggcaggctgcggtccccagctccggacg
ggctggaggcgagaaatcgacatcctacgcacgctctaccacaagcacatcgtcaagtac
aagggctgctgcgaggaccaaggcgagaagtcgatacagctggtcatggaatacatgccc
ctgggcagcctccgagactacttgccccggcacaatgtcgggctggtccagctgctgctc
ttctccctgcagatctgcgagggtatggcctacctgcacacacagcactacgtgcatcga
gacctggccgcgcgcaacgtgctgctggacaacaacaggctagtcaagatcggggacttc
ggcctcaccaaggccgtgcccgaaggccacgagtattactgcgtgcgcgaggatggggac
agtcctgtgttctggtatgccccggagtgcctgaaggagtgtaagttctactatgcatca
gacgtctggtcctttggggtcctcatgtatgagctgctgacctactgtgactccagccag
agccctccctcgaaattcatcgagctcataggcctcacccaagggcagatgactgtgctg
aggctcacagagctgctggaacgaggggagaggctgccgcaaccagagaaatgcccctct
gagatctattgcctcatgaaggactgctggaaggcagaggcctcattccgcccgaccttc
cagaacctcgtacccatcctcagatcataccacgagaaataccaaggccaggccccctcg
gtgttcagtgtctgctga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (17)   
   KEGG PATHWAY (17)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (9)   
   Pfam (9)   
All databases (37)   

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