KEGG   Bos taurus (cow): 100138040Help
Entry
100138040         CDS       T01008                                 

Gene name
SOS2
Definition
(RefSeq) SOS Ras/Rho guanine nucleotide exchange factor 2
  KO
K03099  
son of sevenless
Organism
bta  Bos taurus (cow)
Pathway
EGFR tyrosine kinase inhibitor resistance
MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Chemokine signaling pathway
FoxO signaling pathway
Phospholipase D signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
Dorso-ventral axis formation
Focal adhesion
Gap junction
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Neurotrophin signaling pathway
Regulation of actin cytoskeleton
Insulin signaling pathway
GnRH signaling pathway
Estrogen signaling pathway
Prolactin signaling pathway
Alcoholism
Hepatitis C
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Renal cell carcinoma
Endometrial cancer
Glioma
Prostate cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:bta00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    100138040 (SOS2)
   04010 MAPK signaling pathway
    100138040 (SOS2)
   04012 ErbB signaling pathway
    100138040 (SOS2)
   04630 Jak-STAT signaling pathway
    100138040 (SOS2)
   04068 FoxO signaling pathway
    100138040 (SOS2)
   04072 Phospholipase D signaling pathway
    100138040 (SOS2)
   04151 PI3K-Akt signaling pathway
    100138040 (SOS2)
   04150 mTOR signaling pathway
    100138040 (SOS2)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    100138040 (SOS2)
  Cellular commiunity
   04510 Focal adhesion
    100138040 (SOS2)
   04540 Gap junction
    100138040 (SOS2)
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    100138040 (SOS2)
   04660 T cell receptor signaling pathway
    100138040 (SOS2)
   04662 B cell receptor signaling pathway
    100138040 (SOS2)
   04664 Fc epsilon RI signaling pathway
    100138040 (SOS2)
   04062 Chemokine signaling pathway
    100138040 (SOS2)
  Endocrine system
   04910 Insulin signaling pathway
    100138040 (SOS2)
   04912 GnRH signaling pathway
    100138040 (SOS2)
   04915 Estrogen signaling pathway
    100138040 (SOS2)
   04917 Prolactin signaling pathway
    100138040 (SOS2)
  Nervous system
   04722 Neurotrophin signaling pathway
    100138040 (SOS2)
  Development
   04320 Dorso-ventral axis formation
    100138040 (SOS2)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    100138040 (SOS2)
   05231 Choline metabolism in cancer
    100138040 (SOS2)
   05206 MicroRNAs in cancer
    100138040 (SOS2)
   05205 Proteoglycans in cancer
    100138040 (SOS2)
   05214 Glioma
    100138040 (SOS2)
   05221 Acute myeloid leukemia
    100138040 (SOS2)
   05220 Chronic myeloid leukemia
    100138040 (SOS2)
   05211 Renal cell carcinoma
    100138040 (SOS2)
   05215 Prostate cancer
    100138040 (SOS2)
   05213 Endometrial cancer
    100138040 (SOS2)
   05223 Non-small cell lung cancer
    100138040 (SOS2)
  Substance dependence
   05034 Alcoholism
    100138040 (SOS2)
  Infectious diseases
   05160 Hepatitis C
    100138040 (SOS2)
  Antineoplastic resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    100138040 (SOS2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-ProteinID: 
NCBI-GeneID: 
BGD-bta: 
Position
10
AA seq 1192 aa AA seqDB search
VRFSDFCLISIILLILKLRTFFFKVQEQVHPNLSANEESLYYIEELIFQLLNKLCMAQPR
TVQDVEERVQKTFPHPIDKWAIADAQSAIEKRKRRNPLLLPVDKIHPSLKEVLGYKVDYH
VSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMFDQDDIGLVS
LCEDEPSSSGELNYYDLVRTEIAEERQYLRELNMIIKVFREAFLSDRKLFKPSDIEKIFS
NILDIHELTVKLLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYETLSQDILSPKF
NENFSKLMARPAVALHFQSIADGFKEAVRYVLPRLMLVPVYHCWHYFELLKFVMRKIQIC
DKEDTCECKHAFELVSKDENSIIYAAKSAEEKNNWMAALISLQYRSTLDRMLDSVLLKEE
NEQPLRLPSPEVYRFVVKDSEENIVFEDNLQSRSGIPIIKGGTVVKLIERLTYHMYADPN
FVRTFLTTYRSFCKPQELLSLLIERFEIPEPEPTEADKLALEKGEQPISTDLKRFRKEYV
QPVQLRVLNVFRHWVEHHFYDFERDLELLERLESFISSVRGKAMKKWVESIAKIIKRKKQ
AQANGISHNITFESPPPPIEWHISRPGQFETFDLMTLHPIEIARQLTLLESDLYRKVQPS
ELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEERVAILSRIIEILQVF
QDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRKILDDAVELSQDHFKKYLVKLKSI
NPPCVPFFGIYLTNILKTEEGNNDFXKKKGKDLINFSKRRKVAEITGEIQQYQNQPYCLR
IEPEMRRFFENLNPMGCASEKEFTDYLFNKSLEIEPRNCKQPPRFPRKSAFSLKSPGIRP
NTGRHGSTSGTLRGHPTPLEREPCKISFSRIAETELESTVSAPTSPNTPSTPPVSASSDL
SVFLDVDLNSSCGSNSIFAPVLLPHSKSFFSSCGSLHKLSEEPLIPPPLPPRKKFDQDAS
NSKGTMKSDDDPPAIPPRQPPPPKVKPRVPAPAGPFDGPLHSPPPPPPRDPLPDTPPPVP
LRPPEHFINCPFTLQPPPLGHLHRDPDWFRDVSTCPNSPNTPPSTPSPRVPRRCYVLSSS
QNNLAHPQAPPVPPRQNSSPHLPKLPPKTYKRELSHPPVYRLPLLENAETPQ
NT seq 3579 nt NT seq  +upstreamnt  +downstreamnt
gtaagattctcagacttttgtttaataagtatcattttgcttatacttaaattgagaact
tttttttttaaggttcaggagcaagtacatcccaatctctcagctaatgaagagtctctc
tattacattgaagagctgatttttcagctgcttaataaattatgcatggcccaaccaagg
actgttcaagatgtggaggaacgagttcaaaagacctttcctcatccaattgataaatgg
gctattgctgatgcacagtctgccatagagaaacgaaaaagaagaaatcctctcttactg
cctgtggacaaaatccatccttcattgaaggaagttttagggtacaaagtggactaccat
gtatccctgtatattgtggctgtgctggagtatatctcagctgatattttgaaattggct
ggtaattatgtttttaatatccgacattatgaaatatctcaacaagacattaaagtgtca
atgtgtgcagataaggttttgatggacatgtttgatcaggatgacataggcttggtttct
ctttgtgaagatgaacctagttcttcaggcgaattaaactactatgaccttgttagaact
gaaattgcagaagaaagacagtatctacgggaactaaatatgatcataaaagtgtttcga
gaagcttttctttctgacagaaagctgtttaaaccttctgatattgaaaagattttcagt
aacattttagatatacatgaattgactgtgaaacttttaggtttaattgaagacacagtt
gaaatgactgatgaaagtagccctcatcccttagctggcagctgttttgaagatctggca
gaggagcaagcatttgatccttatgaaacattatcccaggatattctttcaccaaagttt
aatgaaaattttagtaagttgatggccagacctgcagtggctctacactttcagtccatc
gctgatggttttaaagaggcagttcgttatgtccttccacgccttatgctggtgccagta
tatcattgttggcactattttgaattattaaagtttgtcatgaggaaaatacaaatatgt
gataaagaagatacttgtgagtgcaaacatgcttttgaattagtatccaaagatgaaaac
agcataatatatgctgctaagtctgccgaagagaaaaataattggatggcagcacttatt
tcccttcagtatcgtagtactcttgatcgaatgctagattcagtattattgaaggaagaa
aatgaacaaccattgagattaccaagtcctgaagtgtatcgttttgtggtaaaagactct
gaggaaaacattgtttttgaagacaacttgcagagtagaagtggaatccccattattaaa
ggaggaactgtggtgaaattaattgaaaggctaacatatcatatgtacgcagatcccaat
tttgttcgtacttttcttactacatatcgttcattttgtaaaccacaggaattactaagc
ttactgattgaacgatttgaaattccagagccagaacctactgaagcagataaattggcg
ttagaaaaaggcgagcagcccatcagtacagaccttaaaaggtttcgcaaggaatacgtc
caaccagtacaacttagggtcttaaatgtgtttcggcactgggttgaacaccatttttat
gactttgaaagagacttggagctgcttgaaagactagaatccttcatttcaagtgtaaga
gggaaagctatgaagaaatgggtagagtcaattgctaagatcatcaagaggaaaaaacaa
gctcaggcaaatggtataagccataatattacctttgaaagtccacctccaccaattgaa
tggcatatcagcagaccaggacagtttgaaacatttgatctcatgacacttcatccaata
gaaattgcacgtcagctgacccttttggaatctgatctctacaggaaagttcaaccttct
gaacttgtagggagtgtatggaccaaagaagataaagaaataaattctccaaatttatta
aaaatgattcgccacaccacaaatctcaccctctggtttgaaaaatgcattgtggaggca
gaaaattttgaggaacgagtggcaatactgagtagaattatagaaattctgcaagttttt
caagatttgaataatttcaatggtgtattggagatcgtcagtgcagtaaattcagtatca
gtctatagactagatcatacctttgaggcgttgcaggaaagaaaaaggaaaattttggat
gacgctgtggaattaagtcaagatcattttaaaaaatatctagtgaaacttaagtcaatc
aatccaccctgtgtgcctttttttggaatatatttaacaaatatactgaagactgaagaa
gggaataatgattttnttaaaaagaaagggaaagatttaatcaatttcagtaagaggagg
aaagtagctgaaattactggagaaattcagcagtatcaaaatcaaccttactgtttacgg
atagaaccagaaatgaggagattctttgaaaaccttaaccccatgggatgtgcttctgaa
aaagagtttacagattatttgttcaacaagtcactagaaattgaaccccgaaattgcaaa
cagccacctcgatttcctaggaaatcagctttctccttaaaatctcctggaataaggcct
aatacaggccgacatggctctacctcaggtactttgcgaggtcacccaacaccattagaa
agagaaccgtgtaaaataagctttagtcggattgctgaaacggagcttgaatcaacagtg
tcagcaccaacctctccaaatacaccatctaccccaccagtgtctgcttcttcagacctt
agtgtgtttttagatgtggatctcaacagttcctgtggaagcaatagcatctttgctcca
gtcctcttgcctcattcaaagtctttcttcagttcgtgtggtagtttacataagctaagt
gaagagccactgattcctcctccacttccacctcgaaaaaaatttgatcaggatgcttca
aattccaagggaactatgaaatctgatgatgacccccctgctattccaccaagacaacct
cctcctccaaaggtaaaacccagagttcctgctcccgctggtccatttgacgggcctctg
cacagtccacctccaccgccgccgagagaccctcttcctgatacccctccaccggttcca
cttcggcctccagaacactttataaactgtccgtttacccttcagccacctccactggga
catcttcacagagatccagactggttcagagacgttagtacgtgtccaaattctccgaac
actcctcctagcacaccctctccaagggtacctcgtcgatgctatgtgctcagttctagt
caaaataatcttgctcatcctcaagctccccctgttccaccaaggcagaattcaagccct
catctaccaaaactgccaccaaagacttacaaacgggagctttcacaccccccagtgtat
agactgcctttgttagaaaatgcagaaactcctcaatga

DBGET integrated database retrieval system