KEGG   Bos taurus (cow): 100139219Help
Entry
100139219         CDS       T01008                                 

Gene name
MTOR
Definition
mechanistic target of rapamycin (serine/threonine kinase)
Orthology
K07203  
FKBP12-rapamycin complex-associated protein
Organism
bta  Bos taurus (cow)
Pathway
ErbB signaling pathway
HIF-1 signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Insulin signaling pathway
Thyroid hormone signaling pathway
Adipocytokine signaling pathway
Type II diabetes mellitus
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Glioma
Prostate cancer
Acute myeloid leukemia
Brite
KEGG Orthology (KO) [BR:bta00001]
 Environmental Information Processing
  Signal transduction
   04012 ErbB signaling pathway
    100139219 (MTOR)
   04066 HIF-1 signaling pathway
    100139219 (MTOR)
   04151 PI3K-Akt signaling pathway
    100139219 (MTOR)
   04152 AMPK signaling pathway
    100139219 (MTOR)
   04150 mTOR signaling pathway
    100139219 (MTOR)
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    100139219 (MTOR)
   04920 Adipocytokine signaling pathway
    100139219 (MTOR)
   04919 Thyroid hormone signaling pathway
    100139219 (MTOR)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    100139219 (MTOR)
   05206 MicroRNAs in cancer
    100139219 (MTOR)
   05205 Proteoglycans in cancer
    100139219 (MTOR)
   05214 Glioma
    100139219 (MTOR)
   05221 Acute myeloid leukemia
    100139219 (MTOR)
   05215 Prostate cancer
    100139219 (MTOR)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    100139219 (MTOR)
Protein kinases [BR:bta01001]
 Serine/threonine protein kinases: Atypical group
  PIKK family [OT]
   100139219 (MTOR)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
BGD-bta: 
Ensembl: 
Position
16
AA seq 2550 aa AA seqDB search
MLGTGPAAATTAATTSSNVSVLQQFASGLKSRNEETRAKAAKELQHYVTMELREMSQEES
TRFYDQLNHHIFELVSSSDANERKGGILAIASLIGVEGGNATRIGRFANYLRNLLPSNDP
VVMEMASKAIGRLAMAGDTFTAEYVEFEVKRALEWLGADRNEGRRHAAVLVLRELAISVP
TFFFQQVQPFFDNIFVAVWDPKQAIREGAVAALRACLILTTQREPKEMQKPQWYRHTFEE
AEKGFDETLAKEKGMNRDDRIHGALLILNELVRISSMEGERLREEMEEITQQQLVHDKYC
KDLMGFGTKPRHITPFTSFQSVQPQQSNALVGLLGYSSHQGLMGFGASPSPAKSMLVESR
CCRDLMEEKFDQVCQWVLKCRNSKNSLIQMTILNLLPRLAAFRPSAFTDTQYLQDTMNHV
LSCVKKEKERTAAFQALGLLSVAVRSEFKVYLPRVLDIIRAALPPKDFAHKRQKAMQVDA
TVFTCISMLARAMGPGIQQDIKELLEPMLAVGLSPALTAVLYDLSRQIPQLKKDIQDGLL
KMLSLVLMHKPLRHPGMPKGLAHQLASPGLTTLPEASDVGSITLALRTLGSFEFEGHSLT
QFVRHCADHFLNSEHKEIRMEAARTCSRLLTPSVHLISGHAHVVSQTAVQVVADVLSKLL
VVGITDPDPDIRYCVLASLDERFDAHLAQAENLQALFVALNDQVFEIRELAICTVGRLSS
MNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALI
LKLKDPDPDPNPGVINNVLATIGELAQVSGLEMRKWVDELFIIIMDMLQDSSLLAKRQVA
LWTLGQLVASTGYVVEPYRKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHK
VNIGMIDQSRDASAVSLSESKSSQDSSDYSTSEMLVNMGNLPLDEFYPAVSMVALMRIFR
DQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNVIRVCDGAIREFLFQQLGMLV
SFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIILLIEQIVVALGGEFKLYLPQLIPHMLR
VFMHDNSSGRIVSIKLLAAIQLFGANLDDYLHLLLPPIVKLFDAPEAPLPSRKAALETVD
RLTESLDFTDYASRIIHPIVRTLDQSPELRSTAMDTLSSLVFQLGKKYQIFIPMVNKVLV
RHRINHQRYDVLICRIVKGYTLADEEEDPLIYQHRMLRSGQGDALASGPVETGPMKKLHV
STINLQKAWGAARRVSKDDWLEWLRRLSLELLKDSSSPSLRSCWALAQAYNPMARDLFNA
AFVSCWSELNEDQQDELIRSIELALTSQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGI
VLLGERAAKCRAYAKALHYKELEFQKGPTPAILESLISINNKLQQPEAAAGVLEYAMKHF
GELEIQATWYEKLHEWEDALVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEK
WTLVNDETQAKMARMAAAAAWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLA
QQCIDKARDLLDAELTAMAGESYSRAYGAMVSCHMLSELEEVIQYKLVPERREIIRQIWW
ERLQGCQRIVEDWQKILMVRSLVVSPHEDMRTWLKYASLCGKSGRLALAHKTLVLLLGVD
PSRQLDHPLPTVHPQVTYAYMKNMWKSARKIDAFQHMQHFVQTMQQQAQHAIATEDQQHK
QELHKLMARCFLKLGEWQLNLQGINESTIPKVLQYYSAATEHDRSWYKAWHAWAVMNFEA
VLHYKHQNQARDEKKKLRHASGANITNAATAATTAATATATTTSTEGSNSESEAESTENS
PTPSPLQKKVTEDLSKTLLMYTVPAVQGFFRSISLSRGNNLQDTLRVLTLWFDYGHWPDV
NEALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVA
SKSTTTARHNAANKILKNMCEHSNTLVQQAMMVSEELIRVAILWHEMWHEGLEEASRLYF
GERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQ
AWDLYYHVFRRISKQLPQLTSLELQYVSPKLLMCRDLELAVPGTYDPNQPIIRIQSIAPS
LQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKN
LSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDYDHLT
LMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDR
HPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRIT
CHTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKGNKRSRTRTDSYSAGQSVEILD
GVELGEPAHKKTGTTVPESIHSFIGDGLVKPEALNKKAIQIINRVRDKLTGRDFSHDETL
DVPTQVELLIKQATSHENLCQCYIGWCPFW
NT seq 7653 nt NT seq  +upstreamnt  +downstreamnt
atgcttggaaccggccctgctgctgccaccacagctgccaccacatccagcaatgtgagc
gtcctgcagcagtttgccagcggcctgaagagccggaatgaagagactagggccaaagct
gccaaggagctccagcactacgtcaccatggagctccgagagatgagtcaagaggagtct
actcgcttctatgatcagctgaaccatcacatctttgaactggtgtccagctcagatgcc
aatgagaggaaaggtggcattttggccatagccagcctcataggagtggaaggtgggaat
gccactcgaattggaagatttgctaactaccttcggaacctccttccctccaacgaccca
gttgtcatggaaatggcatccaaggccatcggtcggctcgccatggcaggggacactttc
actgctgagtatgtggagtttgaggtgaagcgagccctggaatggctgggtgctgaccgc
aatgagggccggagacacgcggctgtcctggtgctccgtgagctggccatcagcgtcccc
accttcttcttccagcaagtgcagcccttctttgataatatttttgtggccgtgtgggac
cccaaacaggccatccgggaaggagctgtcgccgcccttcgtgcctgtctgatcctcacc
acccagcgggagccaaaagagatgcagaagccgcagtggtacaggcacacgtttgaagaa
gcagagaaagggtttgatgagaccttggccaaggagaagggcatgaatcgggatgaccgg
atccatggagccctgcttatcctcaatgagctggtccggatcagtagcatggagggagag
cgcctgagagaagaaatggaagaaatcacacagcagcagttggtccatgacaagtactgc
aaggatctcatgggttttggaacgaaaccccgtcacatcacccccttcaccagtttccag
tccgtgcagccccagcagtcaaatgccttggtggggctgctggggtacagctctcaccaa
ggcctcatgggctttggggcctcccccagcccagcaaagtccatgctggtggaaagtcgc
tgctgcagggacttgatggaggagaaatttgatcaggtgtgccagtgggtgctgaagtgc
aggaatagcaagaactcgctgatccaaatgacaatccttaatttgttgccccgcttggct
gccttccgaccttctgccttcacagatacccagtacctccaggataccatgaaccatgtc
ctgagctgcgtcaagaaggagaaggaacggacagcagcctttcaagccctggggctactt
tctgtggctgtgaggtctgagttcaaggtctatttacctcgtgtgctggacatcatccga
gcagccctgccccctaaggacttcgcccataagagacagaaggctatgcaagtggatgcc
acagtgttcacctgcatcagcatgctggcccgagccatggggccaggcatccaacaggac
atcaaggagctgctggagcccatgctggcggtgggcctgagccctgccctcacagctgtg
ctctatgacctgagccgtcagattccacagctgaaaaaggacatccaagacgggctcctg
aagatgctgtccctggtccttatgcacaaacccctccggcaccccggcatgcccaagggc
ctggcccatcagctggcttcccctggtctcacgaccctccctgaggccagtgatgtgggc
agcatcacccttgctctccgaactctcggcagttttgaatttgaaggccactctctgacc
cagtttgtccgccactgtgcggatcacttcctgaacagcgagcacaaggagatccgtatg
gaggccgcccgcacctgctcccgcctgctcacaccctctgtccacctcatcagtggccac
gctcatgtggtcagccagactgcagtgcaagtggtggcagatgtgctcagcaaactgctc
gtggttgggataaccgatcctgaccccgacatccgctactgtgtcttggcgtccctggac
gagcgctttgatgcacacctggcccaggcggagaacctgcaggccctgtttgtggctctg
aatgaccaggtgtttgagatccgggagctggccatctgcactgtgggccggctcagcagc
atgaacccagccttcgtcatgcccttcctgcgcaagatgctcatccagattctcacagag
ctggagcacagcggcattggaagaatcaaggagcagagtgcccgcatgctgggccacctg
gtctccaacgccccgcggctcatccgcccctacatggagcctattctgaaggctttaatt
ttgaaactgaaagatccagaccctgatccaaacccaggtgtgatcaataatgtcttggct
acgataggagagttggctcaggttagtggccttgaaatgaggaaatgggttgatgaactt
tttattatcatcatggacatgctccaagactcctctctgttggccaaaaggcaggtggct
ctgtggaccttggggcagttggtggccagcactggctacgtggtagagccctacaggaag
taccccacattgctggaggtgctgctgaactttctgaagactgagcaaaaccagggtaca
cggcgggaggctatccgtgtgttggggctcctaggggcattggatccctacaagcacaaa
gtgaacattggcatgatcgaccagtcccgggacgcttctgccgtcagcctgtcagagtcc
aagtcaagtcaggattcttctgactacagcaccagcgagatgctggtcaacatggggaac
ctgcctctagacgagttctacccggccgtgtccatggtggccctgatgcgcatcttccga
gaccagtccctctctcaccaccacaccatggttgtccaggctatcaccttcatcttcaag
tccctggggctcaagtgcgtgcagttcctgccccaggtcatgcccacattcctgaatgtc
attcgggtttgtgacggggccatccgggaatttctgttccagcagctgggaatgttagtg
tcctttgtgaagagccacatcagaccttacatggatgagatagtcacgctcatgagagaa
ttctgggtcatgaacacctccatccagagcacaatcattctcctcattgagcagattgtg
gtagccctcgggggtgaatttaagctctacctgccccagctgattccacacatgcttcgt
gtcttcatgcatgacaatagctcaggccgcatcgtctccatcaagttgctggctgcaatc
cagctgttcggtgccaacctggatgactatctgcatttgttgctgcccccgatcgtgaag
ttatttgacgcccccgaagccccattgccttctcgaaaggccgcgctagagactgtggac
cgtctgacagagtctctggatttcacggactatgcctctcggatcattcatccgattgta
cgcacactggaccagagcccagaactccgttccacagcaatggacacgttgtcttcactc
gtctttcagctgggaaagaagtaccaaattttcattccaatggtgaacaaagttctggtg
agacaccgaatcaaccatcagcgctacgatgtcctcatctgcaggatagtcaaggggtat
accctggctgacgaggaggaggaccctctgatttaccagcatcgaatgctgaggagcggc
caaggtgatgccttagccagtggaccagtggaaacggggcccatgaagaaactgcacgtc
agcaccatcaacctccaaaaggcctggggagctgccagaagggtttccaaagatgattgg
ttggaatggctgcggcggctgagcctggagctgctgaaggactcctcgtcaccctccctg
cgctcctgctgggccctggcacaggcctacaacccgatggccagggatctctttaacgct
gcgtttgtgtcctgctggtctgagctgaatgaggaccagcaggatgagctcatcagaagc
atcgagttggccctcacctcccaggacatcgcagaagtcacgcaaaccctcttaaatttg
gctgaattcatggaacacagtgacaagggccccctgcctttgagagatgacaatggcatt
gtcctgctgggcgagagagctgccaagtgccgagcatatgccaaagcgctgcactacaaa
gaactggagttccagaaaggtcccacccctgccattctcgagtctctcatcagcattaat
aataagctgcagcagccagaggcagctgctggggtgttggagtatgccatgaagcacttt
ggagagctggagatccaggctacctggtatgagaagctgcacgagtgggaagatgctctc
gtggcctatgataagaaaatggacaccaacaaggacgacccagagctgatgctgggccgc
atgcgctgcctcgaggccttgggggaatgggggcagcttcaccagcagtgctgtgaaaaa
tggactctggttaatgatgagacccaagccaagatggcccgcatggctgctgcagctgca
tggggtttaggtcagtgggacagcatggaagagtacacgtgtatgatccctcgggacacc
cacgacggggcattttatagagctgtgctggcgctacatcaggacctcttctccttggca
caacagtgcatcgacaaagcccgggacctactagacgcggagttaacggcgatggcggga
gagagctacagccgggcctatggggccatggtttcttgccacatgctgtctgagctggag
gaggttatccagtacaaacttgtgcccgagcgacgggagatcatccgccagatctggtgg
gagagactgcagggctgccagcgtattgtggaggactggcagaaaatcctcatggtgcgg
tcactcgtcgtcagccctcacgaggacatgaggacctggctcaagtacgcaagcctgtgt
ggcaagagtggcaggctggcacttgctcacaaaaccttagtgctgctcctgggagttgat
ccatctcggcaacttgaccatcctctgccaacggttcacccccaggtgacctacgcctac
atgaaaaatatgtggaagagcgcccgcaagattgatgccttccagcacatgcagcacttt
gttcagaccatgcagcagcaagcccagcatgccatcgccaccgaggaccagcagcacaag
caggagctgcacaagctcatggcccgatgtttcctgaaactcggggagtggcagctgaac
ctacagggcatcaacgagagcacgatccccaaagtcctgcagtactacagcgccgccaca
gagcacgaccgcagctggtacaaggcctggcatgcgtgggcagtgatgaactttgaggct
gtgctccactacaaacatcagaaccaagcccgcgacgagaagaagaagctgcgacacgcc
agtggggccaacatcactaacgcagccactgctgctaccacagcggccacggccactgcc
accaccaccagcaccgagggcagcaacagcgagagcgaggctgagagcaccgagaacagc
cctaccccgtctcctctgcagaagaaggtcactgaggatttgtccaaaaccctcttgatg
tacactgtccctgctgtccagggcttcttccgttccatctccttgtcacgaggcaacaac
ctccaggacacgctcagagtcctcaccttatggtttgattatggtcactggccagatgta
aatgaagccttagtggaaggggtgaaagcaatccagattgacacttggttacaggttata
cctcagctcattgcaagaattgatacgccaaggcccctggtgggacgtcttatccaccag
cttctcacagacattggtcggtaccacccccaggccctcatctacccactgacagtggcc
tccaagtccaccaccacagcccggcacaacgcagccaacaaaatcctgaagaacatgtgc
gaacacagcaacaccctggtgcagcaggccatgatggtgagtgaggagctgatccgagtg
gccatcctctggcacgagatgtggcatgaaggcctggaagaggcgtctcgcttgtacttt
ggggagaggaacgtgaaaggcatgttcgaggtgctggaacccctgcacgccatgatggag
cggggaccccagacactgaaggaaacatcctttaaccaggcatatggtcgagatttaatg
gaggcccaggaatggtgcaggaagtacatgaaatcagggaatgtcaaggacctcacccaa
gcctgggacctctattaccacgtattcagacgaatctccaagcagctgcctcagctcaca
tccttagagctgcagtacgtctcccccaaacttctgatgtgccgggatctggaactggct
gtgccgggaacttacgaccccaaccagcccatcattcgcattcagtccatcgcgccgtct
ctgcaagtcatcacatccaaacagaggccccggaagctgacgcttatgggcagcaacggg
cacgagtttgtcttcctcctgaagggccatgaggacttgcggcaggacgaacgggtgatg
cagctcttcggcctggtcaacacccttctggccaatgacccgacgtctcttcggaaaaac
ctcagcatccagagatacgctgtcattccattatcaaccaactcgggcctcatcggctgg
gtcccccactgtgacacactgcacgccctcatccgggactacagggagaaaaagaagatc
cttctcaacattgagcatcgcatcatgctgcggatggctccagactatgaccacctaact
ctgatgcagaaggtcgaggtgtttgagcacgccgtcaacaacacagctggggacgacctg
gccaaactgctgtggctgaagagccccagctccgaggtgtggtttgatcgaagaaccaat
tatacccgctctttagcggtcatgtctatggttgggtatattttgggcctgggcgataga
cacccatccaacctgatgctggaccggctgagtggaaagatcctgcacattgactttggg
gactgctttgaggttgctatgaccagagagaaattcccagagaaaattccatttagacta
acaagaatgctgaccaatgctatggaggtcacgggccttgatggcaactacaggatcacg
tgccacaccgtgatggaggtgctccgggagcacaaggacagcgtcatggccgtgctggaa
gccttcgtctatgaccccctgctgaactggaggctgatggacacaaataccaaaggtaac
aagcgatcacggacgaggacagattcctactctgctggccagtcagtagaaattttggat
ggtgtggaacttggggaaccagcccataagaaaacggggaccacagtgccagaatctatt
cattctttcatcggagatggtttggtgaaaccagaggccctaaataagaaagcaattcaa
attattaacagggttcgagacaagctcactggtcgggacttctctcatgacgaaaccctg
gatgtcccaacacaagtcgagctgctcatcaaacaagcgacatcccatgaaaacctctgc
cagtgctacattggctggtgtcctttctggtaa

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