KEGG   Bos taurus (cow): 281985Help
Entry
281985            CDS       T01008                                 

Gene name
PLCB4
Definition
phospholipase C, beta 4 (EC:3.1.4.11)
Orthology
K05858  
phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
bta  Bos taurus (cow)
Pathway
Inositol phosphate metabolism
Metabolic pathways
Rap1 signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
Phosphatidylinositol signaling system
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Wnt signaling pathway
Gap junction
Platelet activation
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Dopaminergic synapse
Long-term depression
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Alzheimer's disease
Huntington's disease
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Amoebiasis
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:bta00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    281985 (PLCB4)
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    281985 (PLCB4)
   04310 Wnt signaling pathway
    281985 (PLCB4)
   04020 Calcium signaling pathway
    281985 (PLCB4)
   04070 Phosphatidylinositol signaling system
    281985 (PLCB4)
   04022 cGMP - PKG signaling pathway
    281985 (PLCB4)
 Cellular Processes
  Cell communication
   04540 Gap junction
    281985 (PLCB4)
 Organismal Systems
  Immune system
   04611 Platelet activation
    281985 (PLCB4)
   04062 Chemokine signaling pathway
    281985 (PLCB4)
  Endocrine system
   04911 Insulin secretion
    281985 (PLCB4)
   04912 GnRH signaling pathway
    281985 (PLCB4)
   04915 Estrogen signaling pathway
    281985 (PLCB4)
   04921 Oxytocin signaling pathway
    281985 (PLCB4)
   04918 Thyroid hormone synthesis
    281985 (PLCB4)
   04919 Thyroid hormone signaling pathway
    281985 (PLCB4)
   04916 Melanogenesis
    281985 (PLCB4)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    281985 (PLCB4)
   04270 Vascular smooth muscle contraction
    281985 (PLCB4)
  Digestive system
   04970 Salivary secretion
    281985 (PLCB4)
   04971 Gastric acid secretion
    281985 (PLCB4)
   04972 Pancreatic secretion
    281985 (PLCB4)
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    281985 (PLCB4)
  Nervous system
   04724 Glutamatergic synapse
    281985 (PLCB4)
   04725 Cholinergic synapse
    281985 (PLCB4)
   04728 Dopaminergic synapse
    281985 (PLCB4)
   04726 Serotonergic synapse
    281985 (PLCB4)
   04720 Long-term potentiation
    281985 (PLCB4)
   04730 Long-term depression
    281985 (PLCB4)
   04723 Retrograde endocannabinoid signaling
    281985 (PLCB4)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    281985 (PLCB4)
  Environmental adaptation
   04713 Circadian entrainment
    281985 (PLCB4)
 Human Diseases
  Neurodegenerative diseases
   05010 Alzheimer's disease
    281985 (PLCB4)
   05016 Huntington's disease
    281985 (PLCB4)
  Infectious diseases
   05146 Amoebiasis
    281985 (PLCB4)
   05142 Chagas disease (American trypanosomiasis)
    281985 (PLCB4)
   05143 African trypanosomiasis
    281985 (PLCB4)
Enzymes [BR:bta01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     281985 (PLCB4)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
BGD-bta: 
Ensembl: 
Position
13
AA seq 1194 aa AA seqDB search
MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVL
ECSLINSVRLGATPKDPKILAALEALGKSENDLEGRIVCVCSGADLVNISFTYMVAENPE
ITKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKQGLISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
SKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEKKQLEALKSM
MEAGESAAPVNILEDDNEEEIESAEQEEEAHPEYKYGSELSADDLGHKEAIANSVKKGLV
TVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVG
LGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQL
NQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGT
YVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRIAVYDDNNK
LIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKK
FLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKANVTPQSSSELRPTTTAA
LGAGLEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELSSLKKKHAKEHSTMQKLHCTQ
VDKIVAQYDKEKLTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSDHKSKVKEIVAQH
TKEWSDMINTHSAEEQEIRDLHLSQQCELLRKLLISAHEQQTQQLKLSHDRESKEMRAHQ
AKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQSKEMDQLKKVQ
LEHLEFLEKQNEQLLKSCHAVSQTQGEGDAADGEIGSRDGPQTSNSCVKLQDTN
NT seq 3585 nt NT seq  +upstreamnt  +downstreamnt
atggccaaaccttatgaatttaattggcagaaggaagttccttcctttttgcaagaagga
gcagtttttgacagatatgaagaggaatcctttgtgtttgaacccaactgcctcttcaaa
gtagatgaatttggcttctttctgacctggagaagtgaaggcaaggaaggccaagtgcta
gaatgctccctcatcaacagtgttcggctgggagccacaccgaaggatcccaaaattttg
gctgctcttgaagctcttggcaaatcagaaaatgatctggaagggcggatagtttgcgtc
tgcagtggtgcagatctggtgaacatcagtttcacgtacatggtggctgaaaatccagaa
ataactaagcaatgggtcgaaggcctgagatccatcattcacaacttcagggccaacaac
gtcagcccgatgacgtgcctcaagaagcactggatgaaattggcatttatgaccaacaca
aatgggaaaattccagttaggagtattactagaacctttgcatcggggaaaacagaaaag
gtgatctttcaagcactcaaggagctaggtcttcccagtggaaagaatgatgaaattgag
cctgccgcatttacttatgaaaagttctatgaactgacacaaaagatttgtcctcggaca
gatatagaggatcttttcaaaaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaatgaacatcaacgagatcctcgactgaatgaaattttattc
ccattttatgatgctaaaagggcaatgcagatcattgagatgtatgagcccgatgaagat
ttgaagaaacaaggcctcatatcaagtgatgggttttgcagatacctgatgtcagatgaa
aacgcccccgtcttcctagatcgtctagagctgtaccaagaaatggaccaccctctggct
cactacttcatcagctcttcccacaacacctatctcactggcagacagtttggtgggaaa
tcttcagtagaaatgtacagacaggtcctcctggctggttgcagatgtgttgaacttgac
tgttgggatggaaaaggtgaggaccaggaaccgataataactcacgggaaagcaatgtgc
acagatatcctttttaaggatgttattcaagccatcaaggaaactgcctttgtcacatcg
gaatatcctgtaattctctcctttgaaaatcactgcagcaaatatcaacagtacaagatg
tccaaatactgtgaagatctatttggagatctcctgttgaaacaagcacttgaatcacat
ccactggaaccaggcagacccttgccatccccaaatgacctcaaaagaaaaatactcatc
aaaaacaaacgactgaaacccgaggttgaaaaaaaacagcttgaagctttgaaaagcatg
atggaagccggagaatccgctgccccggtgaacatcttagaggatgataatgaagaggaa
atagaaagtgctgagcaagaggaggaagcccaccctgaatacaaatatggaagtgaactt
tctgcagatgacttgggtcacaaggaagctattgccaatagtgtcaagaagggcctggtt
accgtagaagatgagcaggcgtggatggcatcttataaatatgtgggtgctaccactaat
atccatccgtatttgtccacaatgatcaactatgcacagcctgtaaagtttcaaggtttc
catgtggctgaagaacgcaatattcattataacatgtcttcctttaatgagtcagtcggt
ctaggctacttgaagacacacgccattgaatttgtgaattataataaacggcaaatgagt
cgcatttaccccaagggaggccgagtggactccagtaattacatgcctcagattttctgg
aacgctggctgccagatggtttcgctgaactatcaaaccccagatttagcgatgcagttg
aatcaggggaaatttgagtataatggatcgtgtgggtaccttctcaaaccagatttcatg
agacggcctgatcgaacatttgatcctttctctgaaacgcctgttgatggggttattgca
gccacttgctccgtgcaggtcatatcaggtcagttcttatcagataagaaaattggcaca
tatgtagaagtggatatgtatgggctgcccacggacactatccggaaggagttccgcact
cgcatggtgatgaacaacggactcaatccagtttacaatgaagaatcatttgtgtttcgg
aaggtgatcctccccgacctggctgtcttgaggatcgccgtgtatgacgacaacaacaag
ctgatcggccagaggattctgcccctggatggcctccaagcaggctatcgacacatatcc
ctccggaatgagggaaataaacctttatcactgccaaccattttctgcaatattgtccta
aaaacatatgtgcctgatggattcggagatattgtggatgctttatcagatccaaagaaa
tttctttccattacggaaaagagagcggatcaaatgagagctatgggcattgaaactagt
gacatcgccgatgtgcccagtgacacttcaaagaacgacaagaaagggaaagccaacaca
gccaaagcgaatgtgacccctcagagcagctcggagctcaggccaaccaccacagctgcc
ctgggggctggcctggaggccaagaaaggtattgaactgatccctcaagtgaggatagaa
gatttaaagcagatgaaggcttacttgaagcatttaaagaaacaacagaaagagctcagt
tctttaaagaagaaacatgcaaaggagcacagtaccatgcagaaactccattgcactcaa
gttgacaagattgtggcacagtacgacaaggagaaattgactcacgagaaaatcctagag
aaggcaatgaagaagaaagggggaagtaattgtcttgaaatgaagaaagaaacagaaatt
aaaattcagacgctgacatcagatcacaaatctaaggtcaaggagattgtggcacagcac
acaaaggagtggtcagacatgatcaacacccacagtgcggaggagcaggagatccgggac
ctgcacctcagccagcagtgcgagctgctcagaaagctcctgatcagcgcccacgagcag
cagacccagcagctgaaactgtcccatgacagggaaagcaaagagatgcgagcacaccaa
gctaagatttctatggaaaatagcaaagccatcagccaagataaatccatcaagaataaa
gcagaacgggaaaggagagtcagggagttaaacagcagcaacactaaaaagtttctggaa
gaaagaaagcgactcgccatgaagcagtccaaagaaatggatcagttgaaaaaagtccag
cttgagcacctcgaattcctagagaaacagaatgagcagcttttgaaatcctgtcacgca
gtgtcccaaacgcaaggcgaaggagatgcagcagatggtgaaattggaagccgagatgga
ccgcagaccagcaacagttgtgtgaaactccaggacacaaactga

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