KEGG   Bos taurus (cow): 281987Help
Entry
281987            CDS       T01008                                 

Gene name
PLCG1
Definition
phospholipase C, gamma 1 (EC:3.1.4.11)
Orthology
K01116  
phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Organism
bta  Bos taurus (cow)
Pathway
Inositol phosphate metabolism
Metabolic pathways
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
NF-kappa B signaling pathway
HIF-1 signaling pathway
Phosphatidylinositol signaling system
VEGF signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Inflammatory mediator regulation of TRP channels
Thyroid hormone signaling pathway
Epstein-Barr virus infection
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Glioma
Non-small cell lung cancer
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:bta00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    281987 (PLCG1)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    281987 (PLCG1)
   04015 Rap1 signaling pathway
    281987 (PLCG1)
   04012 ErbB signaling pathway
    281987 (PLCG1)
   04370 VEGF signaling pathway
    281987 (PLCG1)
   04064 NF-kappa B signaling pathway
    281987 (PLCG1)
   04066 HIF-1 signaling pathway
    281987 (PLCG1)
   04020 Calcium signaling pathway
    281987 (PLCG1)
   04070 Phosphatidylinositol signaling system
    281987 (PLCG1)
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    281987 (PLCG1)
   04660 T cell receptor signaling pathway
    281987 (PLCG1)
   04664 Fc epsilon RI signaling pathway
    281987 (PLCG1)
   04666 Fc gamma R-mediated phagocytosis
    281987 (PLCG1)
   04670 Leukocyte transendothelial migration
    281987 (PLCG1)
  Endocrine system
   04919 Thyroid hormone signaling pathway
    281987 (PLCG1)
  Nervous system
   04722 Neurotrophin signaling pathway
    281987 (PLCG1)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    281987 (PLCG1)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    281987 (PLCG1)
   05206 MicroRNAs in cancer
    281987 (PLCG1)
   05205 Proteoglycans in cancer
    281987 (PLCG1)
   05214 Glioma
    281987 (PLCG1)
   05223 Non-small cell lung cancer
    281987 (PLCG1)
  Infectious diseases
   05169 Epstein-Barr virus infection
    281987 (PLCG1)
Enzymes [BR:bta01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     281987 (PLCG1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
BGD-bta: 
Ensembl: 
UniProt: 
Structure
PDB: 

Jmol
Position
13
AA seq 1291 aa AA seqDB search
MAGAASPCANGCGPSAPSDAEVVHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL
SLQATSEDEVNMWIRGLTWLMEDTLQAATPLQIERWLRKQFYSVDRNREDRISAKDLKNM
LSQVNYRVPNMRFLRERLTDLEQRTSDITYGQFAQLYRSLMYSAQKTMDLPFLEASALRA
GERPELCRVSLPEFQQFLLEYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVT
FLFSKENSIWNSQLDEVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIA
QQRNMAQYFKKVLGDTLLTKPVDIAADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSVM
YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEASG
STELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW
RNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT
NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE
GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP
GFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQEGGWWRGDYGGKKQLW
FPSNYVEEMVSPAALEPEREHLDENSPLGDLLRGVLDVPACQIAVRPEGKNNRLFVFSIS
MASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVYC
RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS
SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFLAGGHCGYVLQPSVMRDEAFDPFDKS
SLRGLEPCAICIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSIKQKTEFVVDNGLNPVW
PAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEGL
ELASLLVKIDVFPAKQENGDLSPFGGASLRERSCDASGPLFHGRAREGSFEARYQQPFED
FRISQEHLADHFDGRDRRTPRRTRVNGDNRL
NT seq 3876 nt NT seq  +upstreamnt  +downstreamnt
atggcgggcgccgcgtccccctgcgccaacggctgcgggcccagtgcgccctcggacgcc
gaggtggtgcacctctgccgcagcctcgaggtgggcaccgtcatgactttgttctactcc
aagaagtcgcagcggcccgagcggaagaccttccaggtcaagctggagacgcggcagatc
acgtggagccgaggcgccgacaagatagagggggccattgacattcgtgaaatcaaggag
atccgcccagggaagacctcacgggacttcgatcgctaccaagaggatcctgcttttcga
ccggaccagtcccactgcttcgtcatcctgtatggaatggaattccgcctgaagaccctg
agcctccaagccacgtctgaggacgaagtgaacatgtggatcaggggcctgacttggctg
atggaggacacgttgcaggcagccacacccctgcagattgagaggtggctgcggaagcag
ttctactcagtggaccggaaccgtgaggaccggatatcggccaaggacctgaagaacatg
ctgtcccaggtcaactaccgggtccccaacatgcgcttcctccgggagcggctgacggac
ctggagcagcgcaccagtgacatcacctacgggcagtttgcacagctgtaccgcagcctc
atgtacagcgcccagaagacgatggaccttcctttcctggaagccagcgccctgagggcg
ggggagcggccggagctgtgccgggtgtcccttcctgagttccagcagttcctcctcgag
taccaaggggagctgtgggcggtggaccggctccaggtgcaggagttcatgctcagcttc
ctccgagaccccttgcgagagattgaggagccttacttcttcctggacgagttcgtcacc
ttcctgttctccaaggagaacagcatatggaactcgcagctagacgaggtgtgccccgac
accatgaacaaccccctgtcccactactggatctcctcctcgcacaacacgtacctgacc
ggggaccagttctccagcgagtcctccctggaagcctacgctcgctgcctgcggatgggc
tgccgttgcattgagttggactgctgggacggcccggatgggatgccggtcatttaccat
ggacacactctgaccaccaagatcaagttctcagacgtcctgcacaccatcaaggagcac
gcctttgtggcctcagagtacccggtcatcctgtccatcgaggaccactgcagcattgcc
cagcagaggaacatggcccagtatttcaaaaaggtgcttggggacacactcctcaccaag
cccgtggatattgcagccgacgggctcccctcccccaaccagctcaagaggaagatcctt
atcaagcacaagaagttggctgagggcagtgcctacgaggaggtgccaacatcggtgatg
tactctgagaacgacatcagcaactccatcaagaatggcatcctctacctggaagaccct
gtgaaccatgagtggtacccccactacttcgtcctgaccagcagcaagatctactactcg
gaggagaccagcagcgaccagggcaacgaggatgaggaggagcccaaggaggccagtggc
agcacagagctgcactccaacgagaagtggttccacgggaagcttggggcgggccgggat
gggcggcacatcgccgagcgcctgctcacggagtactgcattgagaccggggcccccgac
ggctccttccttgtgcgcgagagcgagacctttgtgggcgactacactctgtccttctgg
cggaatggcaaagtgcagcactgccggatccactcccggcaggacgcaggcacccccaag
ttcttcctgacggacaacctcgtcttcgactccctctatgacctcatcacgcactaccag
caggtgcccctgcgctgcaacgaatttgagatgcgcctctcagagccggtcccgcagacc
aacgcgcacgagagcaaagagtggtaccacgccagcctgaccagagcgcaggccgagcac
atgctgatgcgtgtacccagggacggggccttcctggtgcggaaacggaacgagcccaac
tcctacgccatctccttccgggctgagggcaagatcaagcactgccgcgtccagcaggag
ggccagaccgtgatgctgggcaactcagagtttgacagccttgtcgacctcatcagctac
tacgagaagcacccactgtaccgcaagatgaagctgcgctaccccatcaacgaggaggct
ctggagaagatcggcacagctgagcctgactacggcgcgctgtacgagggccgcaaccct
ggcttctatgtggaggcgaaccccatgcccacgttcaagtgcgccgtcaaagctctcttc
gactacaaagcgcagcgggaggacgagctgacattcaccaagagtgccatcatccagaac
gtggagaagcaggagggaggctggtggcggggtgactacggcgggaagaagcagctgtgg
ttcccttcaaactatgtggaggaaatggtcagcccggcggccctggagcccgagagggag
cacttggacgagaacagcccactcggggacttgctccggggggtcctggatgtgccagct
tgtcagatagccgtccgtcccgagggcaagaacaaccggctgttcgtcttctccatcagc
atggcctcggtggcacactggtccctggatgtggctgccgactcgcaggaagagctgcag
gactgggtgaagaagatccgggaggtggcgcagacagcggatgccaggctcaccgagggc
aagatgatggagcggaggaagaagatcgccctagagctctcagagctcgtcgtctactgc
cggcctgtccctttcgacgaagagaagattggcaccgaacgggcctgctaccgcgacatg
tcgtccttcccggagaccaaggccgagaagtacgtgaacaaggccaaaggcaagaagttc
ctccagtacaaccgcctgcagctctcccgcatctaccctaagggccagcggctggactcc
tccaattacgaccccctgcccatgtggatctgcggcagccagcttgtggccctcaacttc
cagaccccagacaaacccatgcagatgaaccaggccctgttcctggccggcgggcactgt
ggctatgtgctgcagcccagcgtcatgcgcgatgaggccttcgatccctttgacaagagc
agcctccgcgggctggagccgtgcgccatctgcatcgaggtgctgggggcccggcacctg
ccgaagaacggccgaggcatcgtgtgtccttttgtggagatcgaggtggccggagccgag
tatgacagcatcaagcagaagacagagtttgtggtggacaatggactgaaccccgtgtgg
ccagccaagcccttccacttccagattagtaaccccgagttcgccttcctgcgcttcgtg
gtctatgaggaggacatgtttagtgaccagaacttcctagctcaggctaccttcccagtg
aagggtctgaagacaggctacagagcggtgcctctgaagaacaactacagtgagggcctg
gagctggcctccctgctcgtcaagattgacgtgttccctgccaagcaggagaacggcgac
ctcagccccttcgggggtgcgtccctgcgggagcggagctgtgacgcctcgggcccgctg
ttccacggccgggcccgggagggctcctttgaagctcgctaccagcagccctttgaggac
ttccgcatctcccaggagcatctcgcagaccattttgacggtcgggatcgcaggacccca
cgcaggactcgggtcaacggagacaaccgcctgtag

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