KEGG   Bos taurus (cow): 282306Help
Entry
282306            CDS       T01008                                 

Gene name
PIK3CA
Definition
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (EC:2.7.11.1 2.7.1.153)
Orthology
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
Organism
bta  Bos taurus (cow)
Pathway
Inositol phosphate metabolism
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Signaling pathways regulating pluripotency of stem cells
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Bacterial invasion of epithelial cells
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Hepatitis C
Hepatitis B
Measles
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Brite
KEGG Orthology (KO) [BR:bta00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    282306 (PIK3CA)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    282306 (PIK3CA)
   04015 Rap1 signaling pathway
    282306 (PIK3CA)
   04012 ErbB signaling pathway
    282306 (PIK3CA)
   04370 VEGF signaling pathway
    282306 (PIK3CA)
   04630 Jak-STAT signaling pathway
    282306 (PIK3CA)
   04668 TNF signaling pathway
    282306 (PIK3CA)
   04066 HIF-1 signaling pathway
    282306 (PIK3CA)
   04068 FoxO signaling pathway
    282306 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    282306 (PIK3CA)
   04024 cAMP signaling pathway
    282306 (PIK3CA)
   04022 cGMP - PKG signaling pathway
    282306 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    282306 (PIK3CA)
   04152 AMPK signaling pathway
    282306 (PIK3CA)
   04150 mTOR signaling pathway
    282306 (PIK3CA)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    282306 (PIK3CA)
  Cell growth and death
   04210 Apoptosis
    282306 (PIK3CA)
  Cellular commiunity
   04510 Focal adhesion
    282306 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    282306 (PIK3CA)
 Organismal Systems
  Immune system
   04611 Platelet activation
    282306 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    282306 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    282306 (PIK3CA)
   04660 T cell receptor signaling pathway
    282306 (PIK3CA)
   04662 B cell receptor signaling pathway
    282306 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    282306 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    282306 (PIK3CA)
   04670 Leukocyte transendothelial migration
    282306 (PIK3CA)
   04062 Chemokine signaling pathway
    282306 (PIK3CA)
  Endocrine system
   04910 Insulin signaling pathway
    282306 (PIK3CA)
   04915 Estrogen signaling pathway
    282306 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    282306 (PIK3CA)
   04917 Prolactin signaling pathway
    282306 (PIK3CA)
   04921 Oxytocin signaling pathway
    282306 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    282306 (PIK3CA)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    282306 (PIK3CA)
  Digestive system
   04973 Carbohydrate digestion and absorption
    282306 (PIK3CA)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    282306 (PIK3CA)
  Nervous system
   04725 Cholinergic synapse
    282306 (PIK3CA)
   04722 Neurotrophin signaling pathway
    282306 (PIK3CA)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    282306 (PIK3CA)
  Development
   04380 Osteoclast differentiation
    282306 (PIK3CA)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    282306 (PIK3CA)
   05205 Proteoglycans in cancer
    282306 (PIK3CA)
   05203 Viral carcinogenesis
    282306 (PIK3CA)
   05210 Colorectal cancer
    282306 (PIK3CA)
   05212 Pancreatic cancer
    282306 (PIK3CA)
   05214 Glioma
    282306 (PIK3CA)
   05221 Acute myeloid leukemia
    282306 (PIK3CA)
   05220 Chronic myeloid leukemia
    282306 (PIK3CA)
   05218 Melanoma
    282306 (PIK3CA)
   05211 Renal cell carcinoma
    282306 (PIK3CA)
   05215 Prostate cancer
    282306 (PIK3CA)
   05213 Endometrial cancer
    282306 (PIK3CA)
   05222 Small cell lung cancer
    282306 (PIK3CA)
   05223 Non-small cell lung cancer
    282306 (PIK3CA)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    282306 (PIK3CA)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    282306 (PIK3CA)
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    282306 (PIK3CA)
   05166 HTLV-I infection
    282306 (PIK3CA)
   05162 Measles
    282306 (PIK3CA)
   05164 Influenza A
    282306 (PIK3CA)
   05161 Hepatitis B
    282306 (PIK3CA)
   05160 Hepatitis C
    282306 (PIK3CA)
   05169 Epstein-Barr virus infection
    282306 (PIK3CA)
   05146 Amoebiasis
    282306 (PIK3CA)
   05145 Toxoplasmosis
    282306 (PIK3CA)
   05142 Chagas disease (American trypanosomiasis)
    282306 (PIK3CA)
Enzymes [BR:bta01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     282306 (PIK3CA)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Ensembl: 
UniProt: 
Structure
PDB: 

Jmol
Position
1
AA seq 1068 aa AA seqDB search
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt NT seq  +upstreamnt  +downstreamnt
atgcctccaagaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatgggatgatagtgactttagaatgcctccgtgaggct
acgttaataacgataaagcatgaactatttaaagaagcaagaaaataccctctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacaagacgactttgtgaccttcggctttttcaaccctttttaaaa
gtaattgaaccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggttttgct
atcggcatgccagtgtgtgaattcgatatggttaaagatccagaagtacaggacttccga
agaaatattctcaatgtttgtaaagaagctgtggatcttagggatcttaattcacctcat
agtagagcaatgtatgtttatcctccaaatgtagaatcttcaccagaactgccaaagcac
atatataataaattggataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgacaaacagaagtatactctgaaaatcaaccatgactgtgtgccagaacaagta
attgctgaagcaatcaggaaaaaaactcgaagtatgttgctatcatctgaacaactaaaa
ctctgtgttttagaatatcagggcaagtatattttaaaagtgtgtggatgtgatgaatac
ttcctagaaaaatatcctctgagtcagtataagtatataagaagctgtataatgcttggg
aggatgcccaatttgatgctgatggctaaagaaagcctctattctcaactgccaatggac
tgttttacaatgccatcatattccagacgcatctccacagctacgccatatatgaatgga
gaaacatctacaaaatccctttgggttataaatagtgcactcagaataaaaattctttgt
gcaacctatgtgaatgtaaatattcgagacattgacaagatttatgttcgaacaggtatc
taccatggaggagaacccttatgtgataatgtgaacactcaaagagtaccttgttccaat
cccaggtggaatgaatggctgaattacgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttccatttgttctgttaaaggccgaaagggtgctaaagaggaacactgt
ccattggcctggggaaatataaacttgtttgattacacagatactctagtatctggaaaa
atggctttgaatctttggccagtacctcatggactagaagatttgctgaaccctattggt
gttactggatcaaatccaaataaagaaactccatgtttagagttggagtttgactggttc
agcagtgtggtaaagtttccagatatgtcagtgattgaagagcatgccaattggtctgta
tcccgtgaagcaggatttagttattcccatgcaggactgagtaacagactagctagagac
aatgaattaagagaaaatgataaagaacagctccgagcaatttgtacacgagatcctcta
tctgaaatcactgagcaagagaaagattttctgtggagccacagacactattgtgtaact
atccccgaaattctacccaaattgcttctgtctgttaaatggaactctagagatgaagta
gctcagatgtactgcttggtaaaagattggcctccaatcaagcctgaacaggctatggag
cttctggactgcaattacccagatcctatggttcgaggttttgctgttcggtgcttagaa
aaatatttaacagatgacaaactttctcagtacctaattcagctagtacaggtactaaaa
tatgaacagtatttggataacctgcttgtgagatttttactcaaaaaagcgttaactaat
caaaggatcggtcactttttcttttggcatttaaaatctgagatgcacaataaaacagtt
agtcagaggtttggcctgcttttggagtcctattgccgtgcatgtgggatgtatctgaag
caccttaataggcaagttgaggctatggaaaagctcattaacttgactgacattctcaaa
caagagaagaaggatgaaacacaaaaggtacagatgaagtttttagttgagcaaatgcgg
cgaccagatttcatggatgctctccagggctttctgtctcctctaaaccctgctcatcag
ctgggaaatctcaggcttgaagagtgtcgaattatgtcttctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagaattactctttcagaacaatgagatcatc
tttaaaaatggggatgatttacggcaagatatgctaacccttcagattattcgcattatg
gaaaatatctggcaaaatcaaggtcttgatcttcgaatgttaccttatggatgtctgtca
atcggtgactgtgtgggacttatcgaggtggtgagaaattctcacactataatgcagatt
cagtgtaaaggaggcctgaaaggtgcactgcagtttaacagccacacactccatcagtgg
ctcaaagacaagaacaagggggaaatatatgatgcggccatcgatttgtttacacgatca
tgtgctggatattgtgttgccaccttcattttgggaattggagatcgtcacaatagtaat
atcatggttaaagatgatggacaactgtttcatatagattttggacactttttggatcac
aagaagaaaaaatttggttataaacgagagcgcgtgccgtttgttttgacacaagatttc
ttaatagtgattagtaaaggagcccaagaatgcacaaagacaagagaatttgagaggttt
caggagatgtgttacaaggcttatctagctattcggcagcatgccaatctcttcataaat
cttttctcaatgatgcttggctctggaatgccagaactgcaatcttttgatgatattgca
tacattcgaaagaccctagctttagataaaactgagcaagaggctttggagtatttcatg
aaacaaatgaatgatgcacaccatggtggctggacaacaaaaatggattggatcttccac
acaattaagcagcatgctttgaactga

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