KEGG   Bos taurus (cow): 282322Help
Entry
282322            CDS       T01008                                 

Gene name
PRKACA
Definition
protein kinase, cAMP-dependent, catalytic, alpha (EC:2.7.11.11)
Orthology
K04345  
protein kinase A [EC:2.7.11.11]
Organism
bta  Bos taurus (cow)
Pathway
MAPK signaling pathway
Ras signaling pathway
Calcium signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
Oocyte meiosis
Apoptosis
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Wnt signaling pathway
Hedgehog signaling pathway
Gap junction
Platelet activation
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
GABAergic synapse
Dopaminergic synapse
Olfactory transduction
Taste transduction
Inflammatory mediator regulation of TRP channels
Insulin signaling pathway
Insulin secretion
GnRH signaling pathway
Ovarian steroidogenesis
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Endocrine and other factor-regulated calcium reabsorption
Vasopressin-regulated water reabsorption
Salivary secretion
Gastric acid secretion
Bile secretion
Parkinson's disease
Prion diseases
Cocaine addiction
Amphetamine addiction
Morphine addiction
Amoebiasis
HTLV-I infection
Epstein-Barr virus infection
Viral carcinogenesis
Proteoglycans in cancer
Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:bta00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    282322 (PRKACA)
   04010 MAPK signaling pathway
    282322 (PRKACA)
   04310 Wnt signaling pathway
    282322 (PRKACA)
   04340 Hedgehog signaling pathway
    282322 (PRKACA)
   04020 Calcium signaling pathway
    282322 (PRKACA)
   04024 cAMP signaling pathway
    282322 (PRKACA)
 Cellular Processes
  Cell growth and death
   04114 Oocyte meiosis
    282322 (PRKACA)
   04210 Apoptosis
    282322 (PRKACA)
  Cell communication
   04540 Gap junction
    282322 (PRKACA)
 Organismal Systems
  Immune system
   04611 Platelet activation
    282322 (PRKACA)
   04062 Chemokine signaling pathway
    282322 (PRKACA)
  Endocrine system
   04911 Insulin secretion
    282322 (PRKACA)
   04910 Insulin signaling pathway
    282322 (PRKACA)
   04912 GnRH signaling pathway
    282322 (PRKACA)
   04913 Ovarian Steroidogenesis
    282322 (PRKACA)
   04915 Estrogen signaling pathway
    282322 (PRKACA)
   04914 Progesterone-mediated oocyte maturation
    282322 (PRKACA)
   04921 Oxytocin signaling pathway
    282322 (PRKACA)
   04918 Thyroid hormone synthesis
    282322 (PRKACA)
   04919 Thyroid hormone signaling pathway
    282322 (PRKACA)
   04916 Melanogenesis
    282322 (PRKACA)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    282322 (PRKACA)
   04270 Vascular smooth muscle contraction
    282322 (PRKACA)
  Digestive system
   04970 Salivary secretion
    282322 (PRKACA)
   04971 Gastric acid secretion
    282322 (PRKACA)
   04976 Bile secretion
    282322 (PRKACA)
  Excretory system
   04962 Vasopressin-regulated water reabsorption
    282322 (PRKACA)
   04961 Endocrine and other factor-regulated calcium reabsorption
    282322 (PRKACA)
  Nervous system
   04724 Glutamatergic synapse
    282322 (PRKACA)
   04727 GABAergic synapse
    282322 (PRKACA)
   04725 Cholinergic synapse
    282322 (PRKACA)
   04728 Dopaminergic synapse
    282322 (PRKACA)
   04726 Serotonergic synapse
    282322 (PRKACA)
   04720 Long-term potentiation
    282322 (PRKACA)
   04723 Retrograde endocannabinoid signaling
    282322 (PRKACA)
  Sensory system
   04740 Olfactory transduction
    282322 (PRKACA)
   04742 Taste transduction
    282322 (PRKACA)
   04750 Inflammatory mediator regulation of TRP channels
    282322 (PRKACA)
  Environmental adaptation
   04713 Circadian entrainment
    282322 (PRKACA)
 Human Diseases
  Cancers
   05205 Proteoglycans in cancer
    282322 (PRKACA)
   05203 Viral carcinogenesis
    282322 (PRKACA)
  Neurodegenerative diseases
   05012 Parkinson's disease
    282322 (PRKACA)
   05020 Prion diseases
    282322 (PRKACA)
  Substance dependence
   05030 Cocaine addiction
    282322 (PRKACA)
   05031 Amphetamine addiction
    282322 (PRKACA)
   05032 Morphine addiction
    282322 (PRKACA)
  Cardiovascular diseases
   05414 Dilated cardiomyopathy (DCM)
    282322 (PRKACA)
  Infectious diseases
   05166 HTLV-I infection
    282322 (PRKACA)
   05169 Epstein-Barr virus infection
    282322 (PRKACA)
   05146 Amoebiasis
    282322 (PRKACA)
Enzymes [BR:bta01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.11  cAMP-dependent protein kinase
     282322 (PRKACA)
Protein kinases [BR:bta01001]
 Serine/threonine protein kinases: AGC group
  PKA family
   282322 (PRKACA)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
BGD-bta: 
Ensembl: 
UniProt: 
Structure
PDB: 

Jmol
Position
7
AA seq 351 aa AA seqDB search
MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVML
VKHMETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMV
MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY
IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF
ADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT
TDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF
NT seq 1056 nt NT seq  +upstreamnt  +downstreamnt
atgggcaacgccgccgccgccaagaagggcagcgagcaagaaagcgtgaaagagttctta
gccaaagccaaagaagattttcttaaaaaatgggaaaatcctgctcagaacacagcccac
ttggatcagtttgaacgaatcaagaccctgggtacgggctccttcgggcgggtgatgctg
gtgaagcacatggagaccgggaaccactacgccatgaagatcctcgacaaacagaaggtg
gtgaagctgaaacagattgagcacaccctgaatgagaagcgcatcctgcaggcggtcaac
tttccgttccttgtcaaactcgagttctccttcaaggacaactcaaatttatacatggtc
atggagtacgtgcccggtggggagatgttctcacacctgcgacggatcgggaggttcagt
gagccccacgcacgcttctacgccgcccagattgtcctgacctttgagtacctgcactcg
cttgatctcatttaccgggacctgaagccagagaacctcctcatcgaccagcagggctac
attcaggtgacagactttggtttcgccaagcgtgtgaaaggccgcacctggaccttgtgt
gggacccctgagtacttggcccccgagatcatcctgagtaaaggctacaacaaagctgtg
gactggtgggccctgggggtcctcatctacgaaatggccgcaggctacccgcccttcttt
gccgaccagcccatccagatctacgagaagattgtctctgggaaggtgcggtttccatcc
cacttcagctctgacttgaaggatctgctgcgcaacctcctacaagtggacctcaccaag
cgctttgggaacctcaagaatggggtcaatgatatcaagaaccacaagtggtttgccaca
actgactggattgccatctaccagaggaaggtggaagctcccttcataccaaagtttaaa
ggccctggggacacaagtaactttgacgactatgaggaggaagagatccgagtctctatc
aatgagaagtgtggcaaggagttttctgagttctag

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