KEGG   Bos taurus (cow): 287026Help
Entry
287026            CDS       T01008                                 

Gene name
PLCB1
Definition
phospholipase C, beta 1 (phosphoinositide-specific) (EC:3.1.4.11)
Orthology
K05858  
phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
bta  Bos taurus (cow)
Pathway
Inositol phosphate metabolism
Metabolic pathways
Rap1 signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
Phosphatidylinositol signaling system
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Wnt signaling pathway
Gap junction
Platelet activation
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Dopaminergic synapse
Long-term depression
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Alzheimer's disease
Huntington's disease
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Amoebiasis
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:bta00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    287026 (PLCB1)
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    287026 (PLCB1)
   04310 Wnt signaling pathway
    287026 (PLCB1)
   04020 Calcium signaling pathway
    287026 (PLCB1)
   04070 Phosphatidylinositol signaling system
    287026 (PLCB1)
   04022 cGMP - PKG signaling pathway
    287026 (PLCB1)
 Cellular Processes
  Cellular commiunity
   04540 Gap junction
    287026 (PLCB1)
 Organismal Systems
  Immune system
   04611 Platelet activation
    287026 (PLCB1)
   04062 Chemokine signaling pathway
    287026 (PLCB1)
  Endocrine system
   04911 Insulin secretion
    287026 (PLCB1)
   04912 GnRH signaling pathway
    287026 (PLCB1)
   04915 Estrogen signaling pathway
    287026 (PLCB1)
   04921 Oxytocin signaling pathway
    287026 (PLCB1)
   04918 Thyroid hormone synthesis
    287026 (PLCB1)
   04919 Thyroid hormone signaling pathway
    287026 (PLCB1)
   04916 Melanogenesis
    287026 (PLCB1)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    287026 (PLCB1)
   04270 Vascular smooth muscle contraction
    287026 (PLCB1)
  Digestive system
   04970 Salivary secretion
    287026 (PLCB1)
   04971 Gastric acid secretion
    287026 (PLCB1)
   04972 Pancreatic secretion
    287026 (PLCB1)
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    287026 (PLCB1)
  Nervous system
   04724 Glutamatergic synapse
    287026 (PLCB1)
   04725 Cholinergic synapse
    287026 (PLCB1)
   04728 Dopaminergic synapse
    287026 (PLCB1)
   04726 Serotonergic synapse
    287026 (PLCB1)
   04720 Long-term potentiation
    287026 (PLCB1)
   04730 Long-term depression
    287026 (PLCB1)
   04723 Retrograde endocannabinoid signaling
    287026 (PLCB1)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    287026 (PLCB1)
  Environmental adaptation
   04713 Circadian entrainment
    287026 (PLCB1)
 Human Diseases
  Neurodegenerative diseases
   05010 Alzheimer's disease
    287026 (PLCB1)
   05016 Huntington's disease
    287026 (PLCB1)
  Infectious diseases
   05146 Amoebiasis
    287026 (PLCB1)
   05142 Chagas disease (American trypanosomiasis)
    287026 (PLCB1)
   05143 African trypanosomiasis
    287026 (PLCB1)
Enzymes [BR:bta01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     287026 (PLCB1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
BGD-bta: 
Ensembl: 
UniProt: 
Position
13
AA seq 1216 aa AA seqDB search
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWEDDSTVVTPIILRTDPQGFFFYWTDQNKE
TELLDLSLVKDARCGKHAKAPKDPKLRELLDVGNIGRLEHRMITVVYGPDLVNISHLNLV
AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA
DRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL
TVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLAKKGQISVDGFMRYLS
GEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV
ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ
QAKMAEYCRLIFGDALLMEPLDKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKK
KLSEQASNTYSDSSSVFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEM
SNLVNYIQPVKFESFEISKKRNRSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK
GTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK
HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQG
NAVNPIWEEEPIVFKKVVLPSLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNER
NQPLMLPALFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK
EADPGETPSEAPSEARPTPAENGVNHTTSLTPKPPSQALHSQPAPGSVKAPAKTEDLIQS
VLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYL
RRRAALEKTAKKDNKKKSEPSSPDHVSSTIEQDLAALDAEMTQKLVDLKDKQQQQLLNLR
QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKI
TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKP
KLQVELEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHSSAPPLMTSDSGKLNQKPPSS
EELEGENPGKEFDTPL
NT seq 3651 nt NT seq  +upstreamnt  +downstreamnt
atggccggggcacagcctggagtgcacgcgctgcaactcaagccggtgtgcgtgtccgac
agcctcaagaagggcaccaaattcgtcaagtgggaggatgactccactgttgtcactccg
attattttgaggactgaccctcagggatttttcttttactggacagatcaaaacaaggag
acggagctgttagatctcagccttgtcaaagacgccagatgtgggaaacatgccaaggcg
cccaaggaccctaaattacgtgaacttctggatgtggggaacattgggcgcctggaacat
cgcatgatcacagtggtgtatgggcctgacttagtgaacatctcccatttgaacctcgtg
gctttccaagaagaagtggccaaggaatggacaaatgaggttttcagtttggcaacaaac
ctgctggcccaaaacatgtccagggatgcatttctggaaaaggcgtatactaagcttaag
ctgcaagtcactccagaaggacgcattcctctcaaaaacatataccgcctgttctcagca
gaccggaagcgagtcgagacagctttagaggcttgtagtcttccatcttcaaggaatgat
tcgatacctcaagaagatttcactcctgaagtgtacagagttttcctgaacaacctttgt
cctcgacctgaaattgataacatcttttccgaatttggtgccaaaagcaaaccatacctt
acagttgatcagatgatggattttatcaacctcaagcagcgagatccccggctaaatgaa
atactttacccacctttaaagcaagagcaagtccaagtgttgattgagaagtatgaacct
aacaacagcctcgccaaaaaaggacagatatcagtggatggatttatgcgctatctgagt
ggagaagaaaatggagtcgtttcacctgagaaactggatttgaatgaagatatgtctcag
cccctttctcactatttcattaattcctcacacaacacctacctcacagctggccagctg
gctggaaactcctccgttgagatgtatcgccaagtgctcctgtctggttgtcgctgtgtg
gagctggactgctggaagggacgaactgcagaagaggagccagtcatcacccatgggttc
accatgaccacagaaatatccttcaaggaagtgattgaagccattgctgaatgtgcattt
aagacttcaccttttccaattctgctttcatttgagaaccatgtggactcgccgaagcag
caagccaagatggcggagtactgcagactcatcttcggcgacgccctcctcatggagccg
ctggacaagtacccgttggaatctggagttccccttccaagtcctatggatttaatgtac
aaaattttggtgaaaaataagaagaaatcacacaagtcgtcagaaggaagtggcaagaag
aagctctcagaacaagcttccaacacgtacagcgactcctccagtgtgtttgagccctcg
tccccaggagccggagaagctgatacagagagtgacgatgatgacgatgatgatgactgt
aaaaagtcttcaatggatgaggggaccgcagggagcgaggccatggccacagaagagatg
tctaatctggtgaactatatccagccagtcaagttcgagtcatttgaaatttcaaaaaaa
agaaatagaagcttcgagatgtcttcctttgtggaaaccaaaggtcttgagcaacttaca
aagtctccggtggaatttgtagaatataacaaaatgcagcttagcaggatatatccaaag
ggaacacgcgtggattcatctaactatatgcctcagctcttctggaatgcaggctgccaa
atggttgctcttaatttccaaacagtggacctggctatgcagataaacatggggatgtat
gaatataatgggaagagtggctacaggctgaagccggagttcatgaggagacctgacaag
cactttgatccattcacagaaggcatcgtggacggcatagtggccaacactttatctgtt
aagattatttcaggtcagtttctctctgataagaaagtcgggacttatgtggaagtggat
atgtttggtttgcctgtggacacaaggaggaaggcatttaagaccaaaacatcacaagga
aacgctgtaaatcccatctgggaagaagaacccattgtattcaaaaaggtggtccttcct
tcgctagcctgtttgaggatagcagtttatgaagaaggaggtaaatttattggtcaccga
atcttgccagtacaagcaattcggccaggctatcactacatctgtctgaggaatgagagg
aaccagcctctcatgctgccagcgctctttgtctacatagaggtgaaggactatgtccca
gacacatatgcagatgtgattgaagctttgtcaaatccaatccgatatgtgaatctgatg
gagcagagagctaaacaactggctgctttgacactggaagatgaagaagaagtgaagaaa
gaggctgatcctggggaaacaccatcagaagctccgagtgaagccaggccaactccagca
gaaaacggggtgaatcacacaacgtccctgacacccaaaccaccctcccaggctctgcac
agccagccagctccaggttctgtaaaggcacctgccaaaacagaagatcttattcagagt
gttttaacagaagtagaagcgcagacgattgaagagctaaagcagcagaagtcgtttgtg
aaacttcaaaagaagcactacaaggaaatgaaggacctggttaagagacaccacaagaaa
accaccgacctcatcaaagagcacactacaaaatacaatgaaatccagaatgactacttg
agaaggagagcagctctggaaaagacagccaaaaaggacaataagaaaaaatcagaaccc
agtagccctgaccacgtctcatcaacaattgagcaagaccttgctgccctggatgccgag
atgacccaaaagttagtagatctgaaggacaaacagcagcagcagctgcttaatcttcga
caagagcaatactatagcgaaaaataccagaaacgagaacacattaaactgcttattcaa
aaattgactgatgttgctgaagaatgtcagaataatcagttaaagaagctcaaagaaatc
tgtgagaaagagaagaaggaattaaagaagaaaatggataaaaagaggcaggagaagata
acagaagcaaaatccaaagacaaaagccagatggaggaggaaaagacagagatgatccgg
tcatacatccaggaggtggtgcagtacatcaagaggttagaagaggcgcaaagtaaacgg
caagaaaaactcgtagagaaacacaaagaaatccgccagcagatcctggatgaaaagccc
aagctacaggtggaactggagcaggaataccaagacaagttcaaaaggctgcccctggag
attttggaatttgtgcaggaagccatgaaagggaagattagtgaagacagcaatcacagc
tctgcccctcccctgatgacctcagactctggaaaactaaaccagaagcctccttccagt
gaagaattggaaggagaaaacccaggaaaagagtttgatacccctctgtga

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