KEGG   Bos taurus (cow): 327672Help
Entry
327672            CDS       T01008                                 

Gene name
MAPK1, ERK2
Definition
mitogen-activated protein kinase 1 (EC:2.7.11.24)
Orthology
K04371  
mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
Organism
bta  Bos taurus (cow)
Pathway
MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Oocyte meiosis
mTOR signaling pathway
PI3K-Akt signaling pathway
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Dorso-ventral axis formation
TGF-beta signaling pathway
Axon guidance
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Adherens junction
Gap junction
Signaling pathways regulating pluripotency of stem cells
Platelet activation
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Circadian entrainment
Long-term potentiation
Neurotrophin signaling pathway
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Long-term depression
Regulation of actin cytoskeleton
Insulin signaling pathway
GnRH signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Melanogenesis
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Aldosterone-regulated sodium reabsorption
Alzheimer's disease
Prion diseases
Alcoholism
Salmonella infection
Pertussis
Leishmaniasis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Tuberculosis
Hepatitis C
Hepatitis B
Influenza A
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Thyroid cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Central carbon metabolism in cancer
Brite
KEGG Orthology (KO) [BR:bta00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    327672 (MAPK1)
   04015 Rap1 signaling pathway
    327672 (MAPK1)
   04010 MAPK signaling pathway
    327672 (MAPK1)
   04012 ErbB signaling pathway
    327672 (MAPK1)
   04350 TGF-beta signaling pathway
    327672 (MAPK1)
   04370 VEGF signaling pathway
    327672 (MAPK1)
   04668 TNF signaling pathway
    327672 (MAPK1)
   04066 HIF-1 signaling pathway
    327672 (MAPK1)
   04068 FoxO signaling pathway
    327672 (MAPK1)
   04024 cAMP signaling pathway
    327672 (MAPK1)
   04022 cGMP - PKG signaling pathway
    327672 (MAPK1)
   04151 PI3K-Akt signaling pathway
    327672 (MAPK1)
   04150 mTOR signaling pathway
    327672 (MAPK1)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    327672 (MAPK1)
  Cell growth and death
   04114 Oocyte meiosis
    327672 (MAPK1)
  Cellular commiunity
   04510 Focal adhesion
    327672 (MAPK1)
   04520 Adherens junction
    327672 (MAPK1)
   04540 Gap junction
    327672 (MAPK1)
   04550 Signaling pathways regulating pluripotency of stem cells
    327672 (MAPK1)
 Organismal Systems
  Immune system
   04611 Platelet activation
    327672 (MAPK1)
   04620 Toll-like receptor signaling pathway
    327672 (MAPK1)
   04621 NOD-like receptor signaling pathway
    327672 (MAPK1)
   04650 Natural killer cell mediated cytotoxicity
    327672 (MAPK1)
   04660 T cell receptor signaling pathway
    327672 (MAPK1)
   04662 B cell receptor signaling pathway
    327672 (MAPK1)
   04664 Fc epsilon RI signaling pathway
    327672 (MAPK1)
   04666 Fc gamma R-mediated phagocytosis
    327672 (MAPK1)
   04062 Chemokine signaling pathway
    327672 (MAPK1)
  Endocrine system
   04910 Insulin signaling pathway
    327672 (MAPK1)
   04912 GnRH signaling pathway
    327672 (MAPK1)
   04915 Estrogen signaling pathway
    327672 (MAPK1)
   04914 Progesterone-mediated oocyte maturation
    327672 (MAPK1)
   04917 Prolactin signaling pathway
    327672 (MAPK1)
   04921 Oxytocin signaling pathway
    327672 (MAPK1)
   04919 Thyroid hormone signaling pathway
    327672 (MAPK1)
   04916 Melanogenesis
    327672 (MAPK1)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    327672 (MAPK1)
   04270 Vascular smooth muscle contraction
    327672 (MAPK1)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    327672 (MAPK1)
  Nervous system
   04724 Glutamatergic synapse
    327672 (MAPK1)
   04725 Cholinergic synapse
    327672 (MAPK1)
   04726 Serotonergic synapse
    327672 (MAPK1)
   04720 Long-term potentiation
    327672 (MAPK1)
   04730 Long-term depression
    327672 (MAPK1)
   04723 Retrograde endocannabinoid signaling
    327672 (MAPK1)
   04722 Neurotrophin signaling pathway
    327672 (MAPK1)
  Development
   04320 Dorso-ventral axis formation
    327672 (MAPK1)
   04360 Axon guidance
    327672 (MAPK1)
   04380 Osteoclast differentiation
    327672 (MAPK1)
  Environmental adaptation
   04713 Circadian entrainment
    327672 (MAPK1)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    327672 (MAPK1)
   05230 Central carbon metabolism in cancer
    327672 (MAPK1)
   05205 Proteoglycans in cancer
    327672 (MAPK1)
   05203 Viral carcinogenesis
    327672 (MAPK1)
   05210 Colorectal cancer
    327672 (MAPK1)
   05212 Pancreatic cancer
    327672 (MAPK1)
   05214 Glioma
    327672 (MAPK1)
   05216 Thyroid cancer
    327672 (MAPK1)
   05221 Acute myeloid leukemia
    327672 (MAPK1)
   05220 Chronic myeloid leukemia
    327672 (MAPK1)
   05218 Melanoma
    327672 (MAPK1)
   05211 Renal cell carcinoma
    327672 (MAPK1)
   05219 Bladder cancer
    327672 (MAPK1)
   05215 Prostate cancer
    327672 (MAPK1)
   05213 Endometrial cancer
    327672 (MAPK1)
   05223 Non-small cell lung cancer
    327672 (MAPK1)
  Neurodegenerative diseases
   05010 Alzheimer's disease
    327672 (MAPK1)
   05020 Prion diseases
    327672 (MAPK1)
  Substance dependence
   05034 Alcoholism
    327672 (MAPK1)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    327672 (MAPK1)
  Infectious diseases
   05132 Salmonella infection
    327672 (MAPK1)
   05133 Pertussis
    327672 (MAPK1)
   05152 Tuberculosis
    327672 (MAPK1)
   05164 Influenza A
    327672 (MAPK1)
   05161 Hepatitis B
    327672 (MAPK1)
   05160 Hepatitis C
    327672 (MAPK1)
   05145 Toxoplasmosis
    327672 (MAPK1)
   05140 Leishmaniasis
    327672 (MAPK1)
   05142 Chagas disease (American trypanosomiasis)
    327672 (MAPK1)
Enzymes [BR:bta01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     327672 (MAPK1)
Protein kinases [BR:bta01001]
 Serine/threonine protein kinases: CMGC group
  MAPK family [OT]
   327672 (MAPK1)
Exosome [BR:bta04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   327672 (MAPK1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Ensembl: 
UniProt: 
Position
17
AA seq 360 aa AA seqDB search
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
RIEVEQALAHPYLEQYYDPSDEPVAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
NT seq 1083 nt NT seq  +upstreamnt  +downstreamnt
atggcggcggcggcggcggcgggcgcgggcccggagatggtccgcgggcaggtgttcgac
gtggggccgcgctacaccaatctctcgtacatcggcgagggcgcctacggcatggtgtgc
tctgcttatgacaatgtcaacaaagtccgagtcgccatcaagaaaatcagcccttttgag
caccagacgtactgccagagaacgctgagagagataaagatcttactgcgcttcagacat
gagaacatcatcggaatcaatgacattattcgagcaccgaccatcgagcagatgaaagat
gtgtatatagtacaggacctcatggaaacagatctctacaagctcttgaagacgcaacac
ctcagcaacgaccacatctgctattttctctaccagatcctcagagggttaaagtatatt
cattcagccaacgtgctgcaccgtgacctcaaaccttccaacctgctgctcaacaccacc
tgcgatctcaagatctgtgactttggcttggcccgtgttgcagatccagaccacgaccac
acagggttcttgacagagtacgtggccactcgctggtaccgggctccagaaatcatgttg
aattccaagggctacaccaagtccatcgacatctggtccgtcggctgcatcctcgcggag
atgctctccaacaggcccatcttccccgggaagcactaccttgaccagctgaaccacatt
ctgggtattcttggatccccgtcgcaggaagacctgaattgtataataaatttaaaagct
agaaactacctgctctctcttccacacaaaaataaggtgccatggaacaggctgttcccg
aacgcggactccaaagctctggatctactggacaaaatgttgacgttcaaccctcacaag
aggatcgaggtggagcaggctctggcccatccttacctggagcagtactacgacccgagc
gatgagcccgtcgccgaagcacccttcaagtttgacatggaattggatgacttgcccaag
gaaaagctcaaagaactcatttttgaagagactgctcgattccagccgggataccgatct
taa

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