KEGG   Bos taurus (cow): 338037
Entry
338037            CDS       T01008                                 
Symbol
MYLK
Name
(RefSeq) myosin light chain kinase, smooth muscle isoform 1
  KO
K00907  myosin-light-chain kinase [EC:2.7.11.18]
Organism
bta  Bos taurus (cow)
Pathway
bta04020  Calcium signaling pathway
bta04022  cGMP-PKG signaling pathway
bta04270  Vascular smooth muscle contraction
bta04371  Apelin signaling pathway
bta04510  Focal adhesion
bta04611  Platelet activation
bta04810  Regulation of actin cytoskeleton
bta04921  Oxytocin signaling pathway
bta04971  Gastric acid secretion
Brite
KEGG Orthology (KO) [BR:bta00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    338037 (MYLK)
   04020 Calcium signaling pathway
    338037 (MYLK)
   04022 cGMP-PKG signaling pathway
    338037 (MYLK)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    338037 (MYLK)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    338037 (MYLK)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    338037 (MYLK)
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    338037 (MYLK)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    338037 (MYLK)
  09154 Digestive system
   04971 Gastric acid secretion
    338037 (MYLK)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:bta01001]
    338037 (MYLK)
Enzymes [BR:bta01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.18  myosin-light-chain kinase
     338037 (MYLK)
Protein kinases [BR:bta01001]
 Serine/threonine kinases: CAMK group
  MLCK family
   338037 (MYLK)
SSDB
Motif
Pfam: Pkinase I-set Ig_3 PK_Tyr_Ser-Thr ig Ig_2 fn3 V-set C2-set_2 ABC1 Kinase-like Ig_C17orf99 Kdo RIO1 DUF5898 AvrM_N Ig_4 Tissue_fac Pur_ac_phosph_N
Other DBs
NCBI-GeneID: 338037
NCBI-ProteinID: NP_788809
BGD-bta: BT26108
Ensembl: ENSBTAG00000014567
UniProt: Q28824
Position
1:complement(67980544..68260061)
AA seq 1176 aa
MDFRANLQRQVKPKTLSEEERKVHGPQQVDFRSVLAKKGTPKTPVPEKVPPPKPATPDFR
SVLGSKKKLPTENGSNNTEALNAKAAEGLKPVGNAQPSGFLKPVGNAKLADTPKPLSSTK
PAETPKPLGNVKPAETPKPLGSTKPAETPKPLGSTKPAETPKPLGNVKPAETPKPLGNIK
PTETPKPLGSTKPAETPKPLGSTKPAETPKPLGNVKPAETPKPLGNVKPAETPKPLGNVK
PAETPKPVSNAKPAETLKPVGNAKPAETPKPLSNVKPAETPKLVGNAKPAETSKPLDNAK
PAEAPKPLGNAKPAEIPKPTGKEELKKEIKNDVNCKKGHAGATDSEKRPESRGTAPTFEE
KLQDLHVAEGQKLLLQCRVSSDPPATITWTLNGKTLKTTKFIVLSQEGSLCSVSIEKALP
EDRGLYKCVAKNSAGQAESSCQVTVDVPDAPTSENAKAPEMKARRPKSSLPPVLGTESDA
TVKKKPAPKTPPKAAMPPQIIQFPEDQKVRAGESVELFGKVAGTQPITCTWMKFRKQIQD
SEHIKVENSEQGSKLTIRAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCA
SDIRSSSLTLSWYGSSYDGGSAVQSYSVEIWDSVDKTWKELATCRSTSFNVQDLLPDREY
KFRVRAINVYGTSEPSQESELTALGEKPEEEPKDEVEVSDDDEKEPEVDYRTVTVNTEQK
VSDFYDIEERLGSGKFGQVFRLVEKKTGKIWAGKFFKAYSAKEKENIRQEISIMNCLHHP
KLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMKQISEGVEYIHKQ
GIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIG
YATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNL
LKKDMKNRLNCTQCLQHPWLMKDTKNMEAKKLSKDRMKKYMARRKWQKTGNAVRAIGRLS
SMAMISGLSGRKSSTGSPTSPLNAEKLESEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEV
VEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKY
TCKAVNSLGEATCTAELIVETMEEGEGEGGEEEEEE
NT seq 3531 nt   +upstreamnt  +downstreamnt
atggatttccgcgccaacctgcagcggcaggtgaagccgaagaccctgtcagaggaggag
aggaaagtgcatggcccccagcaggtggacttccgctctgtcctagccaagaaggggact
cccaagacccctgtgcctgagaaggtaccccctccaaaaccggccacgccagattttcgc
tcagtgttgggcagtaagaaaaaattaccaacagagaatggtagcaataacactgaggcc
ttgaatgccaaggcagcagaaggtctcaagcctgtgggcaatgcccagccttcagggttc
ctgaaacccgtgggcaacgccaagctggctgatacccccaaacccttgagcagcaccaag
ccagcagagacccccaaacccttgggtaatgtcaagccagctgagacccccaaacccttg
ggcagcaccaagccagcagaaacccccaaacccttgggcagcaccaagccagcagagacc
ccaaaacccttgggtaacgtcaagccagctgagacccccaaacccttgggtaacatcaag
ccaactgagacccccaaacccttgggcagcaccaagccagcagaaacccccaaacccttg
ggcagcaccaagccagcagagaccccaaaacccttgggtaatgtcaagccagccgagacc
cccaaacccttgggtaatgtcaagccagctgagacccccaaacccttgggtaatgtcaag
ccagctgagacccctaaacctgtgagcaatgccaagccagccgaaaccctcaaacctgtg
ggcaacgccaagccagctgagacccccaaacccttgagtaacgtcaagccagctgaaacc
cccaaacttgtgggcaatgccaagccagctgagacctctaaacccttggataacgccaag
ccagctgaggcccccaaacccttgggcaatgccaagccggctgaaatcccaaaacccact
gggaaagaagaacttaagaaggagattaagaatgatgtgaactgcaagaagggccatgca
ggggccacagatagtgaaaagagaccagagagccgagggacagccccgaccttcgaggag
aaactacaagatctccatgtggcagagggtcagaagctgctgctccagtgccgggtgtcc
tctgaccccccagccaccatcacttggacactgaatggaaagacgctcaagaccaccaag
ttcatcgtcctctcccaagaaggctccttgtgctccgtctccatcgagaaggcactgccc
gaggacagaggcttatacaagtgtgtagccaagaacagtgccggccaggctgagtcctcc
tgccaagtcaccgtggacgttccagatgcccccaccagtgaaaatgccaaggccccggag
atgaaagcccggaggccgaagagctctcttcctccagtgctaggaacagaaagtgacgca
actgtgaaaaagaaacctgcccccaagacacctccgaaggcagccatgccgcctcagatc
atccagtttcctgaggaccagaaggtgcgagcaggagagtctgtggagctctttggtaag
gtggccggcacccagcccatcacctgcacctggatgaagttccgaaagcagatccaggac
agcgagcacatcaaggtggagaacagcgagcagggcagcaagctcaccatccgggcggca
cgccaggagcactgtggctgctacaccctgctggtggagaacaaactgggcagcaggcag
gcccaagtcaacctcaccgtggtggacaagccagaccccccagccggtacaccttgtgcc
tctgacatccgaagctcctcactgaccttgtcctggtatggctcctcgtatgatgggggc
agcgccgtacagtcatacagtgtcgagatctgggactcagtggacaagacgtggaaggaa
ctagccacgtgccgcagcacttctttcaacgtccaggacctgctgcctgaccgagaatat
aagttccgtgtgcgtgcaatcaatgtctatggaaccagtgagccaagccaggagtctgaa
ctcacagccttgggagagaaacctgaagaagagccgaaggacgaagtggaggtgtcagat
gatgatgagaaggagcctgaggtcgactaccggaccgtcacggtcaatactgagcagaaa
gtgtccgacttctacgacatcgaagagagactaggatctgggaaatttggacaggtcttt
cgacttgtagaaaagaaaactggaaaaatctgggcagggaaattcttcaaggcgtattcg
gccaaggagaaagagaacatccggcaggagatcagcatcatgaactgcctgcaccacccc
aagctggtccagtgtgtggacgccttcgaagagaaggccaacatcgtcatggtcctggag
atcgtgtccgggggtgagctgttcgagcgcatcattgatgaggactttgagctgacggag
cgggagtgcatcaagtacatgaagcagatctcagagggggtggagtacatccacaagcag
ggcatcgtccacctggacctcaagcccgagaacatcatgtgtgtcaacaagacaggcacc
aggatcaagctcatcgacttcggtctggccaggaggttggagaatgcggggtctctgaag
gtcctctttggcaccccggagttcgtcgcacccgaagtgatcaactatgagcccattggc
tatgccacggacatgtggagcatcggggtcatctgctacatcctggtcagtggactgtcc
cccttcatgggtgacaatgacaacgaaaccttagccaacgttacctcagccacctgggac
tttgacgacgaggccttcgacgagatctccgatgacgccaaggattttatcagcaacttg
ctgaagaaggatatgaaaaaccgcctgaactgcacccagtgccttcagcatccatggcta
atgaaagacaccaagaacatggaggccaagaaactctccaaggaccggatgaagaagtac
atggcaagaaggaaatggcagaaaacgggcaatgctgtgagagccatcggaagactgtcc
tctatggcaatgatctcagggctcagtggcaggaaatcctcaacagggtcaccaaccagc
ccgctcaatgcagaaaaactagaatctgaagatgtctcccaagctttcctggaggctgtc
gctgaggagaagccccatgtaaaaccctacttttccaagaccattcgtgacttagaagtt
gtggagggaagtgctgctagatttgactgcaagattgaaggatacccggaccctgaagtc
gtctggttcaaagatgaccaatcaatccgggagtcccgccacttccagatagactacgat
gaggatgggaactgctctttaatcattagtgatgtctgcggggatgatgatgccaagtac
acctgcaaggctgtcaacagtcttggagaagccacctgcacagcagagctcatcgtggaa
accatggaggaaggagaaggagaagggggagaagaggaggaggaagagtga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (9)   
   KEGG PATHWAY (9)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (49)   
   KEGG ORTHOLOGY (1)   
   RefGene (43)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   BGD-BTA (1)   
   OC (1)   
Protein sequence (11)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (9)   
DNA sequence (11)   
   RefSeq(nuc) (9)   
   GenBank (1)   
   EMBL (1)   
Protein domain (19)   
   Pfam (19)   
All databases (104)   

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