KEGG   Bos taurus (cow): 508888Help
Entry
508888            CDS       T01008                                 

Gene name
PLCB2
Definition
phospholipase C, beta 2
Orthology
K05858  
phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
bta  Bos taurus (cow)
Pathway
Inositol phosphate metabolism
Metabolic pathways
Rap1 signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
Phosphatidylinositol signaling system
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Wnt signaling pathway
Gap junction
Platelet activation
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Dopaminergic synapse
Long-term depression
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Alzheimer's disease
Huntington's disease
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Amoebiasis
Pathways in cancer
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:bta00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    508888 (PLCB2)
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    508888 (PLCB2)
   04310 Wnt signaling pathway
    508888 (PLCB2)
   04020 Calcium signaling pathway
    508888 (PLCB2)
   04070 Phosphatidylinositol signaling system
    508888 (PLCB2)
   04022 cGMP - PKG signaling pathway
    508888 (PLCB2)
 Cellular Processes
  Cellular commiunity
   04540 Gap junction
    508888 (PLCB2)
 Organismal Systems
  Immune system
   04611 Platelet activation
    508888 (PLCB2)
   04062 Chemokine signaling pathway
    508888 (PLCB2)
  Endocrine system
   04911 Insulin secretion
    508888 (PLCB2)
   04912 GnRH signaling pathway
    508888 (PLCB2)
   04915 Estrogen signaling pathway
    508888 (PLCB2)
   04921 Oxytocin signaling pathway
    508888 (PLCB2)
   04918 Thyroid hormone synthesis
    508888 (PLCB2)
   04919 Thyroid hormone signaling pathway
    508888 (PLCB2)
   04916 Melanogenesis
    508888 (PLCB2)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    508888 (PLCB2)
   04270 Vascular smooth muscle contraction
    508888 (PLCB2)
  Digestive system
   04970 Salivary secretion
    508888 (PLCB2)
   04971 Gastric acid secretion
    508888 (PLCB2)
   04972 Pancreatic secretion
    508888 (PLCB2)
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    508888 (PLCB2)
  Nervous system
   04724 Glutamatergic synapse
    508888 (PLCB2)
   04725 Cholinergic synapse
    508888 (PLCB2)
   04728 Dopaminergic synapse
    508888 (PLCB2)
   04726 Serotonergic synapse
    508888 (PLCB2)
   04720 Long-term potentiation
    508888 (PLCB2)
   04730 Long-term depression
    508888 (PLCB2)
   04723 Retrograde endocannabinoid signaling
    508888 (PLCB2)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    508888 (PLCB2)
  Environmental adaptation
   04713 Circadian entrainment
    508888 (PLCB2)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    508888 (PLCB2)
  Neurodegenerative diseases
   05010 Alzheimer's disease
    508888 (PLCB2)
   05016 Huntington's disease
    508888 (PLCB2)
  Infectious diseases
   05146 Amoebiasis
    508888 (PLCB2)
   05142 Chagas disease (American trypanosomiasis)
    508888 (PLCB2)
   05143 African trypanosomiasis
    508888 (PLCB2)
Enzymes [BR:bta01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     508888 (PLCB2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Ensembl: 
Position
10
AA seq 1185 aa AA seqDB search
MSLLNPVLLPPTVKAYLSQGERFIKWDDETTIASPVILRVDPKGYYLYWTYQSKEMELLD
ITSIRDTRFGKFAKMPKSQKLREVFNMNIRDNFLLKTLTVVSGPDMVDLTFHNFVSYKDN
VGKDWAEDVLALAKHPLTANASRSTFLDKILVKLKMQLNPEGKIPVKNFFQMFPADRKRV
EAALSACHLPKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYHSKAKPYMTKEHL
AKFINQKQRDSRLNSLLFPPARPDQVQGLIDKYEPSGINVQRGQLSPEGMVWFLCGPENS
VLAQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLAGCRCVELDCW
KGKPPDEEPIITHGFTMTTDIYFKEAIEAIAESAFKTSPYPVILSFENHVDSPRQQAKMA
EYCRTMFGDMLLTEPLEKFPLKPGIPLPSPEDLRGKILIKNKKNQFSGSASPSKELDGEA
EGSSPPNAPVGEDTVWAGEEGAELEEEEVEEEEEESGNLDEEEIKKMQSDEGTAGLEVTA
YKEMSSLVNYIQPTKFISFEFSAQKNRSYVISSFTELKAYDLLSKSSVQFVDYNKRQMSR
IYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGHLLKHEFMR
RSDKQFNPFSVDRIDVVVATTLSITXISGQFLSERSVRTYVEVELFGLPGDPKRRYRTKL
SPSTNSINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFLGHRIIPISALNSGYHHLCL
HNESNMPLTMPALFVFLEMKDYVPDTWADLTVALANPIKFFSAHDKKAVKLKEAMGGQSE
SPFPLGNHPASQINGASAPTSNGSAAAGAKREEATKETAEPQTASLEELRELKGVVKLQR
RQEKELRELGRRGVRRWEELLQRGAAQLAGLGPPGAGGSGGCRGRKLGPGKGSRKKRTLP
GEDTAGAASAEGPEGEDVRLRELRDRLELELLQLGEEQCECVMKLKEQHAAQQMTKMMEL
AREKQAAERKTLKETLEIDTKEMKKKLEAKRLERIQAMMKVTTDKMAQERLKREINNSHI
QEVVQVIKQMTENLERHQEKLEEKQAACLEQIQEMEKQFQQEAMAEYEAKMKGLEMEVKE
SVRTCLRACFPSEEEDKPERPCVVSRELCEQDTLTEQAETQESHL
NT seq 3558 nt NT seq  +upstreamnt  +downstreamnt
atgtctcttctcaaccctgtcctgctgccccccacggtgaaggcctatctgagccaaggg
gagcgcttcatcaaatgggatgatgaaacgacgatagcctctccggttatcctccgtgtg
gatcccaagggctactacttgtactggacatatcagagtaaggagatggagctcctggat
atcaccagcatccgggacacccgctttgggaagtttgccaagatgcccaagagccagaag
ctccgggaagtcttcaacatgaacatccgcgacaacttcctgctgaagacgctcacagtg
gtatccggccctgacatggtggacctcaccttccataacttcgtctcctataaggacaac
gtgggcaaggactgggctgaagacgtactggctctggccaagcacccgctgacggccaac
gcctcccgcagcaccttcctggacaagatccttgtgaagctcaagatgcagcttaaccct
gaggggaagattcccgtgaagaattttttccagatgttccctgctgaccgcaagcgggta
gaagctgccctcagtgcctgccacctccccaaaggcaagaacgatgccatcaatcctgag
gacttcccagagtccgtgtacaagagcttcctcatgagcctctgtcctcggccagaaata
gatgagatcttcacttcctaccactccaaggccaaaccctatatgactaaggagcacctg
gccaaattcatcaaccagaaacagcgcgactccaggctcaattccctgctgttcccgcca
gcgcgtcctgaccaggtgcagggcctcatcgacaagtacgagcccagcggcatcaatgtg
cagcggggccagctgtcccccgagggcatggtgtggtttctctgcgggccggagaacagt
gtgctggcccaggacaagctgctgctgcaccacgacatgacccagccgctcaaccattac
ttcatcaactcctcccacaacacctacctgacagccggccagttctcaggcctctcctct
gctgagatgtaccgccaagtgctgctggcaggctgccgctgcgtggagctggactgctgg
aaggggaagccccccgacgaagagcccatcatcacccacggtttcaccatgaccacagac
atctatttcaaggaagcaatcgaagccattgcagaaagtgcctttaagacctccccttat
ccggtcatcctgtcatttgaaaaccacgtggactcaccccgccaacaggctaagatggcc
gagtactgccggacgatgtttggggatatgctgctcacagaacccctggagaagttcccg
ctgaaacctggcatccccctgcccagccctgaggatctccgaggcaagatcctaatcaag
aacaagaagaaccagttttctggctctgcatcccccagcaaggagctggatggggaggct
gagggtagcagcccacccaatgcccctgtgggtgaagatacagtgtgggctggtgaggaa
ggggctgagttggaggaggaggaggtagaagaggaagaggaggagtcgggaaacctggat
gaagaagagataaagaagatgcagtcagatgagggcacagcgggcctggaggtgacggcc
tacaaggagatgtccagcctggtcaattacatccagcccaccaagttcatctccttcgag
ttctctgcccaaaagaatcgaagttatgttatctcctccttcacggagctcaaggcttac
gacctgctctccaagtcctcagtgcagtttgtggactacaacaagcgccagatgagccgc
atctaccccaagggtacccgcatggactcctccaactacatgcctcagatgttctggaat
gctggttgtcagatggttgccctcaacttccagacgatggacctgcccatgcagcagaac
atggcgcttttcgagttcaacgggcagagtggccacctcctcaagcatgagttcatgcgt
cggtcggacaagcagttcaatcccttctcagtggaccgcatcgacgtggtggtagccacc
accctttccattacggngatttctgggcagttcctgtcagaacgcagcgtgcgcacctat
gtggaagtggagctgtttggccttccgggagatcccaagaggcgctatcgcaccaagcta
tcacccagtaccaactccatcaatcccgtctggaaggaggagccctttgtctttgagaag
atcttgatgcctgagctggcttccctgagagtcgctgtgatggaggaaggcaacaagttt
cttggacaccgcatcattcccatcagtgccctgaattctggataccaccatctctgtctg
cacaacgagagcaacatgccactcaccatgcctgcgctcttcgtcttcctggagatgaag
gactatgtgcctgacacctgggcagatctcactgtggccctcgccaatcctatcaagttc
ttcagtgcccatgataagaaggctgtgaagctcaaggaagccatgggaggccagtccgag
agtcccttccctcttgggaatcaccctgccagccagatcaacggggcatcggctccaaca
agcaacgggtcagcagcagccggggccaagagggaggaggccacgaaagaaactgcggaa
ccgcagaccgccagcctggaggagctgcgggagctgaagggcgtcgtgaagctgcagcgg
cgccaggagaaggagcttcgggaactggggcggcgcggcgtgcggcgctgggaggagctg
ctgcagaggggcgcggcgcagctggccgggctcgggccgccaggcgccgggggcagcggc
gggtgccggggccgcaagctcggcccgggcaagggatctcgaaaaaagaggaccctgccg
ggcgaggacaccgccggggcggcgtcggccgaaggccccgagggcgaggacgtgcgcctg
cgagagctgagggacaggctggagctggagctgctgcagctgggcgaggagcaatgcgag
tgtgtcatgaagctcaaggagcagcacgcggcccagcaaatgaccaagatgatggagctg
gctagggagaaacaggctgcagaacggaagaccctcaaggagaccttggagattgacacc
aaagagatgaagaagaagctggaggccaagaggctggagcggatccaggccatgatgaag
gtcaccacagacaagatggctcaggagaggttgaagagagagattaacaactcccacatc
caggaggtggtgcaggtgatcaagcagatgacggagaacctggagaggcaccaggagaag
ttggaggaaaagcaggcagcctgcctggaacagatccaggagatggaaaaacagttccag
caggaggcgatggcagagtacgaggccaagatgaagggcctggagatggaagtgaaggag
tcagtgaggacctgcctccgggcctgcttcccctctgaggaggaggacaagcctgagaga
ccctgcgtggtctccagggagctgtgtgagcaggacacactcacagagcaggcagagacc
caggagagccacctctga

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