KEGG   Bos taurus (cow): 510442Help
Entry
510442            CDS       T01008                                 

Gene name
DOT1L
Definition
DOT1-like histone H3K79 methyltransferase
Orthology
K11427  
histone-lysine N-methyltransferase, H3 lysine-79 specific [EC:2.1.1.43]
Organism
bta  Bos taurus (cow)
Pathway
Lysine degradation
Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:bta00001]
 Metabolism
  Amino acid metabolism
   00310 Lysine degradation
    510442 (DOT1L)
 Human Diseases
  Cancers
   05202 Transcriptional misregulation in cancers
    510442 (DOT1L)
Enzymes [BR:bta01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.43  histone-lysine N-methyltransferase
     510442 (DOT1L)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 
Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Ensembl: 
UniProt: 
Position
7
AA seq 1713 aa AA seqDB search
MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVL
IDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSTGLLRHILQQVYNHSVT
DPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCK
HHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVVFV
NNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLK
GSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRENKSNTTTPTKVP
ESKAAVPADTPVDSGAEEEKAGTATVKKPSPSKARKKKLNKKGRKMVGRKRGRPKKMSAT
NPERKPKKTQSSLDLLHAQTASRAASPLPQDAHRPPHSPFYQLPPSVQRPTPEQLLLAPT
PPALHRLLESFRIQYLQFLAYTKTPQYKASLQQLLDQEKEKNARLLGAAQQLFGHCQAQK
EEIKRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQTEQLEKGNWELRSQSLRLL
KARCEELKLDWSTLSLENLLKEKQALKSQISEKQRHCLELQISIVELEKSQRQQELLQLK
SCVPPDEALALQLRGKPEAEPSRLHLELDCARFSLPPFSSLSPELSMNGHAAGYELCSAL
GRPSPKQNTPQYLASPLDQEVVPCTPSHSGRPRLEKLSSLALPDYTRLSPAKLVLRRHLS
QDHAASGKAAASELHPRAEHAKENGLPYQSPGITNGIKLSPQDPRPSSPTALQMGEKGPE
KGVKERAYASSGEAITSLPVSIPLSTVQPSKLPVSIPLASVVLPSRAEKARSTPSPGPPA
RESSSTLEKQVAANTHGAGGNAAGSKSLALAPTGFAYAGSVAISGALAGSPAPLAPGAEP
PALDESSSSGSLFATVGSRSSTPQHPPLLTQPRTCGSASPAPQLCSSPRLGALGPLPDSG
KGDLPCEASFSDPESEAKRRIVFTISAGASSAKQSPSSKHSPLPSGARGDGGQGHGPDGR
KRGRRKRASAGTPSLSSSVSPKRRALPSVAGLFTQSSGSPLNLNSMVSNINQPLEITAIS
SPESSLKSSPVPYQDNDQPPVLKKEKPLSQTNGAHYSPLTSDEEPGSEDEPGSARIERKI
ATISLESKSPPKTLENGGSLAGRKAPLASEPVNSSKWKSTFSPISDLGLAKAADSPLQAA
SALSHNSLFAFRPGLEEPSAADAKLATHSRKSFPGTLPGAGGLSPSSLPASGFALGGGLA
ADLSLHSFSDGASLSHKAPEAAGLGAPLSFPGPRGKEGGAAESGPFVNKRQLDGLGPKGE
GGLPTCGPPDKASTAHSKAGKGREREPDVKNGHNLFMAAATAPPAGLLSGPGLAPAASSA
GGAAPSVQTHRPFLGAFAPGPQFALGPMSLQANLGPSVLQSLFSSVPAAGLVHVSTAATR
LTNSHAMGSFSSGVAGGAVGGVFNHAVPPASAHPFGASFGSGAACRSATLSLTPLQAVAS
TPASSFQAPSSAEPRPPPPPPHLGRPPPGQPALHAPPHPNATLPPPPALLPANSEPVLLQ
NLVSLPANQAFLPASSAASLPPANASLSIKLASLPHKVSRPSLTVHHQPLPGLALAQAAP
VNPQASSTGPPAVWVSLGMPPPYAARLAGVKPR
NT seq 5142 nt NT seq  +upstreamnt  +downstreamnt
atgggggagaagctggagctgaggctcaagtcgcccgtgggggccgagcccgccgtctac
ccgtggccgctgccggtctacgacaaacaccacgatgctgctcatgaaatcatcgagacc
atcagatgggtctgtgaagaaatcccggatctcaagcttgctatggagaattacgtttta
attgactacgataccaaaagctttgagagtatgcagaggctctgtgacaagtacaaccgg
gccatcgacagcatccaccagctgtggaagggcaccacacagcccatgaagctgaacaca
cggccatccacggggctcctgcggcacatcctgcagcaggtctacaaccactcagtgacc
gaccctgagaagctcaacaactacgagcccttctccccagaggtgtatggggagacctcc
ttcgacctggtcgcccagatgatcgatgagatcaagatgaccgaagatgacctgttcgtg
gacctgggcagtggagtgggccaggttgtgctgcaggttgccgcggccaccaactgcaaa
catcactacggtgtagagaaagctgacatcccagccaagtacgcggagaccatggaccga
gagttcaggaagtggatgaaatggtatggaaaaaagcatgcagaatacacactggagagg
ggggacttcctctcggaggagtggagagaacggattgctaacacaagtgttgtatttgtg
aataactttgcctttggtcctgaggtggatcaccagctgaaggagcggtttgcaaacatg
aaggaaggtggcagaatcgtgtcctcgaagccctttgcgcctctgaacttcagaataaac
agtagaaacttgagtgacatcggcaccatcatgcgcgtcgtggagctgtcgccgctaaaa
ggctcggtgtcatggacggggaagccagtctcctactacctgcacaccatcgaccgcacc
atacttgaaaactatttttctagtctaaaaaatccaaaactcagggaggaacaagaggca
gctcggcgccggcagcagcgggagaacaagagcaacacaaccacgcccaccaaggtgccc
gagagcaaggcagctgtgccggcggacacccccgtggactctggtgctgaggaggagaaa
gccgggacggccactgtcaagaagccatctccctccaaggcccggaagaagaagctgaac
aagaagggccggaagatggtgggtcggaagcgtgggcgccccaagaagatgagtgccacc
aaccccgagcgcaagcccaagaagacccagagctcactggacctgctgcacgcccagacc
gcgtcacgagcggcctcccccttgccgcaggacgcgcacaggccacctcacagcccattc
taccagctacctcccagcgtgcagcggcctacccccgagcagctgctgctggcacccacc
ccgcccgcactgcacaggctgctagagtccttcaggattcagtacctacagttcctggca
tacacgaagacccctcagtacaaggccagcctgcagcagctcctggaccaggagaaggag
aagaatgcccggttgctaggcgcagcgcagcagctatttggccactgccaagctcagaag
gaggagatcaagaggctcttccagcagaaactggacgagctgggagtgaaggcgctgacc
tacaacgacctgatccaagcgcagaaggagatctcggctcacaaccagcagttgagggag
cagacggagcagctggagaagggcaactgggagctgaggagccagagcctgaggctgctc
aaggcacgatgcgaggagctgaagctggactggtccacgctgtcgctggagaatctgctg
aaggagaagcaggccctgaagagccagatctcagagaagcagaggcactgcctggagctg
cagatcagcatcgtggagctggagaagagccagcggcagcaggagttgctgcagctcaag
tcctgcgtgccgcctgatgaggcactggctctgcagcttcgtgggaagccagaggctgag
cctagccggctgcacttggagctggactgcgcccgcttctccctgccacccttcagcagc
ttgagccccgagctctctatgaatggccacgcagccggctatgagctctgcagcgcactg
ggtcggccctcgcccaagcagaacaccccccagtacctggcctccccgctagaccaggag
gtcgtgccctgcacccctagccacagcggccggccacggctagagaagctgtccagcctg
gccctgcctgactacaccaggctatcccctgccaagctggtgctgcggcgccacctgagc
caggaccacgcggccagtggcaaggcagctgccagtgagctgcacccacgagccgagcat
gccaaggagaatgggctcccttaccagagccctggcatcactaatggcatcaagctgagc
ccacaagacccccgaccttcatcccccacggctttacagatgggagagaagggccccgag
aagggtgtgaaggagcgtgcctacgccagcagtggggaggccatcaccagcctgcccgtc
agcatcccgctgagcaccgtgcagcccagcaagctgcccgtcagcatccccctggccagc
gtggtgctgcccagccgcgccgagaaggcgagaagcacacccagccctgggccaccggcc
cgagagtcctcatccacgctggagaagcaggtggctgctaacacccatggtgccgggggc
aacgctgctgggagcaagagcctcgccctggctcccacaggctttgcatacgccggctcg
gtggccatcagtggggccctggccggcagcccggcacccctcgcccctggagccgagccc
ccagccctggacgagtcctccagctctggaagcctctttgccaccgtggggtcccgcagc
tccaccccgcagcacccacccctgctgacgcagccacgcacctgtggctcggcctcgcca
gccccccagctctgctccagcccccggcttggcgctctgggcccactccccgactctggc
aaaggggacctgccctgcgaggccagcttctcagaccctgagagcgaagccaaaaggaga
atcgtcttcaccatctcggcgggcgccagcagcgccaagcagtcaccttccagcaaacac
agccctctgccgtcgggtgcccgcggggacggtggccagggccatgggccagacggccgc
aagcggggccggaggaagcgggcatcggcagggacccccagcctgagctcgagtgtgtcc
cccaagcgccgggccttgccatctgtcgctgggcttttcacgcagtcttcagggtccccc
ctgaacctcaactccatggtcagcaacatcaaccagcccctggagatcacagcaatctcg
tcccctgagagctccctaaagagctcacccgtcccctaccaggacaacgaccaaccaccc
gtgctcaagaaggagaagcccctgagccagaccaatggtgcccactactccccactgact
tcggacgaggaaccaggctctgaggatgagcccggcagtgccagaattgagagaaaaatt
gcaacgatctccttagaaagcaagtctccgccaaaaaccttggaaaatggtggcagccta
gcaggaaggaaggcgccgctggccagcgagccggtcaacagcagcaagtggaagtccacc
ttctcacccatctccgacctgggcctggccaaggcggccgacagcccgctgcaggctgcc
tctgctctgagccacaactctctgttcgctttccggcctggcctggaggagcccagtgcg
gccgatgccaagctggccacccactccaggaagagcttcccgggcaccctgccaggggcg
ggcgggctgagccccagtagccttcctgccagcggcttcgccctgggcgggggcctagca
gctgacctcagtttacacagcttcagtgatggtgcttctctctcccacaaggcccccgag
gcagctggcctgggtgcccccctgagcttccccggcccacggggcaaagagggtggcgct
gcagagtctggccccttcgtgaacaagcggcagctggacggactgggcccaaaaggcgag
gggggccttcccacatgcggacccccggacaaggcctccacagcgcatagcaaggcaggc
aagggccgcgagcgcgagcctgacgtcaagaacggccacaacctgttcatggccgctgcc
actgcgccccctgcaggcctcctcagcggcccaggtcttgccccagcggcatcctcggca
ggtggcgcagccccgtccgtgcagacccaccgccccttcctgggcgccttcgcccccggg
ccacagttcgcactgggccccatgtcgctacaggccaacctgggcccatctgtgctgcag
tccctgttcagttccgtgcccgccgccggcctggttcacgtctcgaccgccgccaccaga
ttgaccaactcgcacgccatgggcagcttctcctctggggtggccggcggcgcagttgga
ggtgtctttaaccacgcggtgcctcccgcctccgcccatccgtttggagccagtttcggc
agtggggctgcatgtcgcagcgccacgctgagcttaaccccgctgcaggcggtggccagc
accccggcctcttcctttcaggccccgtcctctgcggagccgaggccacccccaccccct
ccgcacctgggccggccccctccggggcagcccgccctccacgcaccccctcatcctaac
gccaccttgcctcctccccctgcgctgctcccagctaactctgagcccgtgcttctgcag
aacctcgtatccctccctgctaaccaagctttcttacccgcctcctctgccgcctctctg
ccgcctgctaacgcctctctgtccatcaagctcgcctccctcccgcacaaggtgtcccgg
ccctccttgacggtgcaccaccagcccctgcctgggctggccctggcccaggccgcgccc
gtgaacccacaggccagctccacggggccgcccgccgtgtgggtttcccttggcatgccg
cctccgtatgccgcgcgccttgcgggggttaagccgcgataa

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