KEGG   Bos taurus (cow): 510442
Entry
510442            CDS       T01008                                 
Symbol
DOT1L
Name
(RefSeq) histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X7
  KO
K11427  [histone H3]-lysine79 N-trimethyltransferase [EC:2.1.1.360]
Organism
bta  Bos taurus (cow)
Pathway
bta00310  Lysine degradation
bta01100  Metabolic pathways
bta05202  Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:bta00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    510442 (DOT1L)
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    510442 (DOT1L)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:bta03036]
    510442 (DOT1L)
Enzymes [BR:bta01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.360  [histone H3]-lysine79 N-trimethyltransferase
     510442 (DOT1L)
Chromosome and associated proteins [BR:bta03036]
 Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     510442 (DOT1L)
   HMT complexes
    Dot1-containing complex
     510442 (DOT1L)
SSDB
Motif
Pfam: DOT1 HALZ
Other DBs
NCBI-GeneID: 510442
NCBI-ProteinID: XP_003586321
Ensembl: ENSBTAG00000009996
VGNC: 50607
UniProt: E1BGK8
Position
7:21334365..21388810
AA seq 1523 aa
MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVL
IDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSTGLLRHILQQVYNHSVT
DPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCK
HHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVVFV
NNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLK
GSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRENKSNTTTPTKVP
ESKAAVPADTPVDSGAEEEKAGTATVKKPSPSKARKKKLNKKGRKMVGRKRGRPKKMSAT
NPERKPKKTQSSLDLLHAQTASRAASPLPQDAHRPPHSPFYQLPPSVQRPTPEQLLLAPT
PPALHRLLESFRIQYLQFLAYTKTPQYKASLQQLLDQEKEKNARLLGAAQQLFGHCQAQK
EEIKRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQTEQLEKGNWELRSQSLRLL
KARCEELKLDWSTLSLENLLKEKQALKSQISEKQRHCLELQISIVELEKSQRQQELLQLK
SCVPPDEALALQLRGKPEAEPSRLHLELDCARFSLPPFSSLSPELSMNGHAAGYELCSAL
GRPSPKQNTPQYLASPLDQEVVPCTPSHSGRPRLEKLSSLALPDYTRLSPAKLVLRRHLS
QDHAASGKAAASELHPRAEHAKENGLPYQSPGITNGIKLSPQDPRPSSPTALQMGEKGPE
KGVKERAYASSGEAITSLPVSIPLSTVQPSKLPVSIPLASVVLPSRAEKARSTPSPGPPA
RESSSTLEKQVAANTHGAGGNAAGSKSLALAPTGFAYAGSVAISGALAGSPAPLAPGAEP
PALDESSSSGSLFATVGSRSSTPQHPPLLTQPRTCGSASPAPQLCSSPRLGALGPLPDSG
KGDLPCEASFSDPESEAKRRIVFTISAGASSAKQSPSSKHSPLPSGARGDGGQGHGPDGR
KRGRRKRASAGTPSLSSSVSPKRRALPSVAGLFTQSSGSPLNLNSMVSNINQPLEITAIS
SPESSLKSSPVPYQDNDQPPVLKKEKPLSQTNGAHYSPLTSDEEPGSEDEPGSARIERKI
ATISLESKSPPKTLENAGGSLAGRKAPLASEPVNSSKWKSTFSPISDLGLAKAADSPLQA
ASALSHNSLFAFRPGLEEPSAADAKLATHSRKSFPGTLPGAGGLSPSSLPASGFALGGGL
AADLSLHSFSDGASLSHKAPEAAGLGAPLSFPGPRGKEGGAAESGPFVNKRQLDGLGPKG
EGGLPTCGPPDKASTAHSKAGKGREREPDVKNGHNLFMAAATAPPAGLLSGPGLAPAASS
AGGAAPSVQTHRPFLGAFAPGPQFALGPMSLQANLGPSVLQSLFSSVPAAGLVHVSTAAT
RLTNSHAMGSFSSGVAGGAVGGN
NT seq 4572 nt   +upstreamnt  +downstreamnt
atgggggagaagctggagctgaggctcaagtcgcccgtgggggccgagcccgccgtctac
ccgtggccgctgccggtctacgacaaacaccacgatgctgctcatgaaatcatcgagacc
atcagatgggtctgtgaagaaatcccggatctcaagcttgctatggagaattacgtttta
attgactacgataccaaaagctttgagagtatgcagaggctctgtgacaagtacaaccgg
gccatcgacagcatccaccagctgtggaagggcaccacacagcccatgaagctgaacaca
cggccatccacggggctcctgcggcacatcctgcagcaggtctacaaccactcagtgacc
gaccctgagaagctcaacaactacgagcccttctccccagaggtgtatggggagacctcc
ttcgacctggtcgcccagatgatcgatgagatcaagatgaccgaagatgacctgttcgtg
gacctgggcagtggagtgggccaggttgtgctgcaggttgccgcggccaccaactgcaaa
catcactacggtgtagagaaagctgacatcccagccaagtacgcggagaccatggaccga
gagttcaggaagtggatgaaatggtatggaaaaaagcatgcagaatacacactggagagg
ggggacttcctctcggaggagtggagagaacggattgctaacacaagtgttgtatttgtg
aataactttgcctttggtcctgaggtggatcaccagctgaaggagcggtttgcaaacatg
aaggaaggtggcagaatcgtgtcctcgaagccctttgcgcctctgaacttcagaataaac
agtagaaacttgagtgacatcggcaccatcatgcgcgtcgtggagctgtcgccgctaaaa
ggctcggtgtcatggacggggaagccagtctcctactacctgcacaccatcgaccgcacc
atacttgaaaactatttttctagtctaaaaaatccaaaactcagggaggaacaagaggca
gctcggcgccggcagcagcgggagaacaagagcaacacaaccacgcccaccaaggtgccc
gagagcaaggcagctgtgccggcggacacccccgtggactctggtgctgaggaggagaaa
gccgggacggccactgtcaagaagccatctccctccaaggcccggaagaagaagctgaac
aagaagggccggaagatggtgggtcggaagcgtgggcgccccaagaagatgagtgccacc
aaccccgagcgcaagcccaagaagacccagagctcactggacctgctgcacgcccagacc
gcgtcacgagcggcctcccccttgccgcaggacgcgcacaggccacctcacagcccattc
taccagctacctcccagcgtgcagcggcctacccccgagcagctgctgctggcacccacc
ccgcccgcactgcacaggctgctagagtccttcaggattcagtacctacagttcctggca
tacacgaagacccctcagtacaaggccagcctgcagcagctcctggaccaggagaaggag
aagaatgcccggttgctaggcgcagcgcagcagctatttggccactgccaagctcagaag
gaggagatcaagaggctcttccagcagaaactggacgagctgggagtgaaggcgctgacc
tacaacgacctgatccaagcgcagaaggagatctcggctcacaaccagcagttgagggag
cagacggagcagctggagaagggcaactgggagctgaggagccagagcctgaggctgctc
aaggcacgatgcgaggagctgaagctggactggtccacgctgtcgctggagaatctgctg
aaggagaagcaggccctgaagagccagatctcagagaagcagaggcactgcctggagctg
cagatcagcatcgtggagctggagaagagccagcggcagcaggagttgctgcagctcaag
tcctgcgtgccgcctgatgaggcactggctctgcagcttcgtgggaagccagaggctgag
cctagccggctgcacttggagctggactgcgcccgcttctccctgccacccttcagcagc
ttgagccccgagctctctatgaatggccacgcagccggctatgagctctgcagcgcactg
ggtcggccctcgcccaagcagaacaccccccagtacctggcctccccgctagaccaggag
gtcgtgccctgcacccctagccacagcggccggccacggctagagaagctgtccagcctg
gccctgcctgactacaccaggctatcccctgccaagctggtgctgcggcgccacctgagc
caggaccacgcggccagtggcaaggcagctgccagtgagctgcacccacgagccgagcat
gccaaggagaatgggctcccttaccagagccctggcatcactaatggcatcaagctgagc
ccacaagacccccgaccttcatcccccacggctttacagatgggagagaagggccccgag
aagggtgtgaaggagcgtgcctacgccagcagtggggaggccatcaccagcctgcccgtc
agcatcccgctgagcaccgtgcagcccagcaagctgcccgtcagcatccccctggccagc
gtggtgctgcccagccgcgccgagaaggcgagaagcacacccagccctgggccaccggcc
cgagagtcctcatccacgctggagaagcaggtggctgctaacacccatggtgccgggggc
aacgctgctgggagcaagagcctcgccctggctcccacaggctttgcatacgccggctcg
gtggccatcagtggggccctggccggcagcccggcacccctcgcccctggagccgagccc
ccagccctggacgagtcctccagctctggaagcctctttgccaccgtggggtcccgcagc
tccaccccgcagcacccacccctgctgacgcagccacgcacctgtggctcggcctcgcca
gccccccagctctgctccagcccccggcttggcgctctgggcccactccccgactctggc
aaaggggacctgccctgcgaggccagcttctcagaccctgagagcgaagccaaaaggaga
atcgtcttcaccatctcggcgggcgccagcagcgccaagcagtcaccttccagcaaacac
agccctctgccgtcgggtgcccgcggggacggtggccagggccatgggccagacggccgc
aagcggggccggaggaagcgggcatcggcagggacccccagcctgagctcgagtgtgtcc
cccaagcgccgggccttgccatctgtcgctgggcttttcacgcagtcttcagggtccccc
ctgaacctcaactccatggtcagcaacatcaaccagcccctggagatcacagcaatctcg
tcccctgagagctccctaaagagctcacccgtcccctaccaggacaacgaccaaccaccc
gtgctcaagaaggagaagcccctgagccagaccaatggtgcccactactccccactgact
tcggacgaggagccaggctctgaggatgagcccggcagtgccagaattgagagaaaaatt
gcaacgatctccttagaaagcaagtctccgccaaaaaccttggaaaatgcaggtggcagc
ctagcaggaaggaaggcgccgctggccagcgagccggtcaacagcagcaagtggaagtcc
accttctcacccatctccgacctgggcctggccaaggcggccgacagcccgctgcaggct
gcctctgctctgagccacaactctctgttcgctttccggcctggcctggaggagcccagt
gcggccgatgccaagctggccacccactccaggaagagcttcccgggcaccctgccaggg
gcgggcgggctgagccccagtagccttcctgccagcggcttcgccctgggcgggggccta
gcagctgacctcagtttacacagcttcagtgatggtgcttctctctcccacaaggccccc
gaggcagctggcctgggtgcccccctgagcttccccggcccacggggcaaagagggtggc
gctgcagagtctggccccttcgtgaacaagcggcagctggacggactgggcccaaaaggc
gaggggggccttcccacatgcggacccccggacaaggcctccacagcgcatagcaaggca
ggcaagggccgcgagcgcgagcctgacgtcaagaacggccacaacctgttcatggccgct
gccactgcgccccctgcaggcctcctcagcggcccaggtcttgccccagcggcatcctcg
gcaggtggcgcagccccgtccgtgcagacccaccgccccttcctgggcgccttcgccccc
gggccacagttcgcactgggccccatgtcgctacaggccaacctgggcccatctgtgctg
cagtccctgttcagttccgtgcccgccgccggcctggttcacgtctcgaccgccgccacc
agattgaccaactcgcacgccatgggcagcttctcctctggggtggccggcggcgcagtt
ggaggtaactag

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (3)   
   KEGG PATHWAY (3)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (46)   
   KEGG ORTHOLOGY (1)   
   RefGene (40)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   VGNC (1)   
Protein sequence (11)   
   UniProt (1)   
   RefSeq(pep) (10)   
DNA sequence (10)   
   RefSeq(nuc) (10)   
Protein domain (2)   
   Pfam (2)   
All databases (86)   

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