KEGG   Bos taurus (cow): 515669Help
Entry
515669            CDS       T01008                                 

Gene name
PLCB3
Definition
phospholipase C, beta 3 (phosphatidylinositol-specific) (EC:3.1.4.11)
Orthology
K05858  
phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
bta  Bos taurus (cow)
Pathway
Inositol phosphate metabolism
Metabolic pathways
Rap1 signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
Phosphatidylinositol signaling system
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Wnt signaling pathway
Gap junction
Platelet activation
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Dopaminergic synapse
Long-term depression
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Alzheimer's disease
Huntington's disease
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Amoebiasis
Pathways in cancer
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:bta00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    515669 (PLCB3)
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    515669 (PLCB3)
   04310 Wnt signaling pathway
    515669 (PLCB3)
   04020 Calcium signaling pathway
    515669 (PLCB3)
   04070 Phosphatidylinositol signaling system
    515669 (PLCB3)
   04022 cGMP - PKG signaling pathway
    515669 (PLCB3)
 Cellular Processes
  Cellular commiunity
   04540 Gap junction
    515669 (PLCB3)
 Organismal Systems
  Immune system
   04611 Platelet activation
    515669 (PLCB3)
   04062 Chemokine signaling pathway
    515669 (PLCB3)
  Endocrine system
   04911 Insulin secretion
    515669 (PLCB3)
   04912 GnRH signaling pathway
    515669 (PLCB3)
   04915 Estrogen signaling pathway
    515669 (PLCB3)
   04921 Oxytocin signaling pathway
    515669 (PLCB3)
   04918 Thyroid hormone synthesis
    515669 (PLCB3)
   04919 Thyroid hormone signaling pathway
    515669 (PLCB3)
   04916 Melanogenesis
    515669 (PLCB3)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    515669 (PLCB3)
   04270 Vascular smooth muscle contraction
    515669 (PLCB3)
  Digestive system
   04970 Salivary secretion
    515669 (PLCB3)
   04971 Gastric acid secretion
    515669 (PLCB3)
   04972 Pancreatic secretion
    515669 (PLCB3)
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    515669 (PLCB3)
  Nervous system
   04724 Glutamatergic synapse
    515669 (PLCB3)
   04725 Cholinergic synapse
    515669 (PLCB3)
   04728 Dopaminergic synapse
    515669 (PLCB3)
   04726 Serotonergic synapse
    515669 (PLCB3)
   04720 Long-term potentiation
    515669 (PLCB3)
   04730 Long-term depression
    515669 (PLCB3)
   04723 Retrograde endocannabinoid signaling
    515669 (PLCB3)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    515669 (PLCB3)
  Environmental adaptation
   04713 Circadian entrainment
    515669 (PLCB3)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    515669 (PLCB3)
  Neurodegenerative diseases
   05010 Alzheimer's disease
    515669 (PLCB3)
   05016 Huntington's disease
    515669 (PLCB3)
  Infectious diseases
   05146 Amoebiasis
    515669 (PLCB3)
   05142 Chagas disease (American trypanosomiasis)
    515669 (PLCB3)
   05143 African trypanosomiasis
    515669 (PLCB3)
Enzymes [BR:bta01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     515669 (PLCB3)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Ensembl: 
UniProt: 
Position
29
AA seq 1234 aa AA seqDB search
MAGARPGVHALQLEPPTVVETLRRGSKFIKWDEEASSRNLVTLRVDSNGFFLYWTGPNME
VDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDARLEEKLMTVVAGPDPVNTTFLNF
MAVQDDTAKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFS
ADKKRVETALESCGLNFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPY
LTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNKQFLERDQMSMEGFSRYL
GGEENGILPLEALDLSTDMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRC
VELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAK
QQAKMAEYCRSIFGDALLIDPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHRLGSGVPDS
SVRKRPLEQSNSALSESSATTEPSSPQLGSPSSDSCPGLSNGEEVGLEKPSLEPRKSLGE
EGLQRGPDVLGPAYREDEEEDEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVNYIEPV
KFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYM
PQLFWNVGCQLVALNFQTLDVPMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIV
DGIVANAVRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEP
FDFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYICLRNEANQPLCLPALLI
YTEASDYIPDDHQDYAEALINPIKHVSLMDQRAKQLAALIGESEAQSGPETSQETQTQQL
GCQLNPHPTPSPLDASPRRPPGPATSPTSSSISSSISSPGQRDDLIASILSEVAPAPLDE
LRGHKALVKLRSRQERDFRELYKKHQRKAVALTRRLLDNLAQARAGSRCRQRPGVLSGED
ERAEEEEVSRYQEFQKKQVQCLLELREAQVDTEADRRLEHLQQAQLKLREVVLDAHMTQL
KKLKEINEREKKELQKILDRKRHNSISEAKTREKHKKEAELTEINRRHITESVNSIRRLE
EAQKQRQERLVAGQQQILQQLAEEEPKLLAQLVQDCQEQRERLPQEIRWSLLGETQEGLG
DGHLVACASNGHAPGSSGHLPGADSESQEETTKL
NT seq 3705 nt NT seq  +upstreamnt  +downstreamnt
atggcgggcgccaggcccggcgtccacgcgctgcagctagagccgcccaccgtcgtggag
accctgcggcgcgggagtaagttcatcaaatgggacgaggaggcctccagtcggaacctg
gtaaccctgcgagtggactccaatggcttcttcctgtactggacgggacccaacatggag
gtggacacactcgacatcagttccatcagggacaccaggacgggccgttatgcccgcctg
cccaaggaccccaagatccgggaggtgttgggctttgggggccctgatgcccggttggag
gagaagctgatgacagtggtggccgggccagacccggtgaatacaacattcttgaacttc
atggccgtgcaggatgatacagccaaggtctggtccgaggagctcttcaagttggctatg
aacatcctggctcagaacgcctcccggaacaccttcttgcgcaaagcatacacgaagctg
aagctgcaggtaaaccaggatggacggattccagtcaagaacatcctgaagatgttctca
gcagacaagaagcgggtagaaactgcactggaatcctgtggcctcaatttcaaccgaagc
gagtccatccggcctgacgagttttccttggaaatctttgagcggttcctgaacaagctg
tgtctgcggccagacattgataagatcctgctggagataggtgccaagggcaaaccttac
ctgacgctggagcagctcatggatttcattaaccagaagcagcgggacccgcggctcaac
gaagtgctgtacccacctctgcggccctcccaggcccgactgctcatcgagaagtacgaa
cccaacaagcagttcctggagcgagaccagatgtccatggagggcttcagccgctacctg
ggaggtgaggagaatggcattctgccgcttgaggccttggatctgagcacagacatgacc
cagccgctcagcgcctacttcatcaattcctcgcacaacacctatctcacggcggggcag
ctggccggaacctcgtcggtggagatgtaccggcaggcgctgttgtggggctgccgctgt
gtggagctggacgtgtggaaggggcggccgcccgaggaggagccgttcatcacgcacggc
ttcaccatgaccacggaggtgccgctgagagacgtgcttgaggccatcgcggagacggcc
ttcaagacttcgccctaccccgtcatcctctcctttgagaaccacgtggactcggcgaaa
cagcaggccaagatggctgagtactgccgctccatctttggggatgctctgctcatcgac
cccctggacaagtacccgctggccccaggcgtccccctgcccagcccccaggacctgatg
ggccgcatcctggtgaagaacaagaagcggcaccgactcggcagcggcgtccccgacagc
tccgtgcgcaagcggccactggagcagagcaactcggccctgagcgagagctccgccacc
accgagccctcctcgccccagctcgggtcccccagctctgacagctgcccaggcctgagc
aatggggaggaggtgggcctcgagaagcccagcctggagcctcggaagtctctgggggag
gagggtttgcagcggggccctgatgttcttggacctgcctaccgggaggatgaggaagag
gacgaggaagaggaggaacaaacggaccccaaaaagccgaccacggatgagggcactgcc
agcagtgaggtcaacgccactgaggaaatgtccacactcgtcaactatatcgagcctgtc
aagttcaagtccttcgaggctgctcgaaagaggaacaagtgcttcgagatgtcgtccttc
gtggagaccaaggccatggagcaactgaccaagagccccatggagtttgtggaatacaac
aagcagcagctcagccgcatctaccccaagggcacccgcgtggactcgtccaactacatg
ccccagctcttctggaacgtgggctgccagctcgttgcactcaactttcagaccctggat
gtgccaatgcagctcaacgccggcgtgtttgagtacaacgggcgcagcggctacctactc
aagcctgagttcatgcggcggccggacaagtcctttgaccccttcaccgaagtcatagtg
gacggcatcgtggccaatgccgtgcgggtcaaggtgatctcggggcagttcctgtccgac
aggaaggtgggaatctacgtggaggtagacatgttcgggcttcctgttgacacgcggcgc
aagtaccgcacacggacctcacaggggaactcgttcaaccctgtgtgggatgaggagcca
ttcgacttccccaaggtggtgctgcccacactggcttcgctgcgcatcgcggcctttgag
gaggggggcaagttcgtggggcaccggatcctgcctgtctctgctatccgctcagggtac
cattacatctgcctgcggaatgaggccaaccagccgctgtgcctgccagccctgctcatc
tacaccgaggcctccgactacatccccgacgaccaccaggactatgcagaggccctgatc
aaccccatcaagcatgtcagcctgatggaccagagggccaagcagctggctgccctcatt
ggggagagcgaggctcagtctggcccggagacgagccaggagacccagactcagcagctg
gggtgccagctgaacccacacccgacgcccagcccgctggacgcctccccgcgccggccc
ccaggccccgccacctccccgaccagctcctccatcagctcctccatcagcagcccaggt
cagcgcgatgatcttatcgccagcatcctctcagaggtggccccggccccgctggacgag
ctccgaggccacaaggccctagtgaagctccggagccggcaagagcgagacttccgggag
ctgtacaagaaacatcagcggaaggccgttgccctcacgcgccggttgctcgacaacctg
gcccaggcccgtgcggggagcaggtgccgacagcggcctggtgtcctaagcggggaggac
gagagggcagaagaggaagaggttagcaggtatcaagagttccagaagaaacaggtgcag
tgtctgctggagctgagggaggcccaggtggacacagaggcggatcggaggctggagcac
ctgcagcaggctcagctgaagctcagggaggttgtcctggacgctcacatgactcagttg
aagaaactgaaggagataaacgagagggagaagaaggagctgcagaagatcctggacagg
aaacgccacaacagcatctcagaggccaagaccagggagaaacataagaaagaggcggaa
ctgacagagattaaccgtcggcacatcactgagtcagtcaactccatccgtcggctggag
gaggcccagaagcagcggcaggaacgccttgtggccggacagcagcagatcctccaacag
ctggcggaagaggagcccaagctgctggcccagctggtccaggactgtcaggagcagcgg
gagaggctgccccaggagatccgctggagcctgctgggcgagacacaggagggactgggg
gacgggcatctggtcgcctgtgccagcaacggtcacgcgcctgggagcagcgggcacctg
cccggcgctgactcagagagccaggaggagactacaaagctctga

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