KEGG   Bos taurus (cow): 538598Help
Entry
538598            CDS       T01008                                 

Gene name
IRS1
Definition
insulin receptor substrate 1
Orthology
K16172  
insulin receptor substrate 1
Organism
bta  Bos taurus (cow)
Pathway
cGMP-PKG signaling pathway
FoxO signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Neurotrophin signaling pathway
Insulin signaling pathway
Adipocytokine signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
MicroRNAs in cancer
Brite
KEGG Orthology (KO) [BR:bta00001]
 Environmental Information Processing
  Signal transduction
   04068 FoxO signaling pathway
    538598 (IRS1)
   04022 cGMP - PKG signaling pathway
    538598 (IRS1)
   04151 PI3K-Akt signaling pathway
    538598 (IRS1)
   04152 AMPK signaling pathway
    538598 (IRS1)
   04150 mTOR signaling pathway
    538598 (IRS1)
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    538598 (IRS1)
   04920 Adipocytokine signaling pathway
    538598 (IRS1)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    538598 (IRS1)
  Nervous system
   04722 Neurotrophin signaling pathway
    538598 (IRS1)
 Human Diseases
  Cancers
   05206 MicroRNAs in cancer
    538598 (IRS1)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    538598 (IRS1)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    538598 (IRS1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
BGD-bta: 
UniProt: 
Position
2
AA seq 1237 aa AA seqDB search
MASPPETDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP
KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGH
HDGAAAPGAGGGGGSCSGSSGLGEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLI
GIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQV
DDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLT
RRSRTESITATSPASLVGGKQGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHR
GSSRLHPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSP
SDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGASTLTAPN
GHYILPRGGNGHRYVPAAGLGTSPALPGEEAAGAADLDNRFRKRTHSAGTSPTISHQKTP
SQSSVASIEEYTEMMPAYPPGGGSGGRVPSYRHSAFVPTHSYPEEGLEMHPLERRGGHHR
PDTSSLHTDDGYMPMSPGVAPVPGSRKGSGDYMPMSPKSVSAPQQIINPIRRHPQRVDPN
GYMMMSPSGSCSPDIGGGPSSGGSSSGAAPSGSSYGKLWTNGVGGHHSHALPHPKLPVES
GSGKLLSCTGDYMNMSPVGDSNTSSPSDCYYGPEDPQHKPVLSYYSLPRSFKHTQRPGEL
EEPRHHQHLRLSSSSGRLLYTAAAEDSSSSTSSDSLGGGYCGARPEPGLPHLHHQVLQAH
LPRKVDTAAQTNNRLARPTRLSLGDPKASTLPRAREQQPPPPLLLPPEPKSPGEYVNIEF
GSDQPGYLSGPVASHSSPSIRCPSQLQPAPREEDTGAEEYMNMDLGPGRRATWQKSVGVQ
PGRVGPAPPGAASVCRPTRAVPSSCGDYMTMQMGGPRQSYVDTSPVAPISYADMRTGVVV
EDASLPRATAAAPSSSSTASVSSTAPPPGTGELAARSALLGGPSAFTRVNLSPNRNQSAK
VIRADPQGCRRRHSSETFSSTPSATRVGNTMPFGAGAAVGGSGGGSSSSAEDVKRHSSAS
FENVWLRPGELGGAPKELAQVCGAAGGLENGLNYIDLDLVKDFKQRPQECPPQPQPPPLP
APHQPLASSQSGPTSRSSEDLSAYASITFQKQPEDLQ
NT seq 3714 nt NT seq  +upstreamnt  +downstreamnt
atggcgagccctccggagactgacggcttctcggacgtgcgcaaggtgggctacctgcgc
aaacccaagagcatgcacaaacgattcttcgtgctgcgggcggccagcgaggctgggggc
ccggcgcgcctcgagtactacgagaacgagaagaagtggcggcacaagtctagcgccccc
aaacgctcgatccccctggagagctgcttcaacatcaacaagcgggcggactccaagaac
aagcacctggtggccctctacacccgggacgagcactttgccatcgcggcagacagcgag
gccgagcaggacagctggtaccaggccctcctgcagctgcacaaccgtgccaagggccac
cacgacggggccgcggcgcctggggcgggaggcggcgggggcagctgcagtggcagctcc
ggcctcggggaggccggtgaggacttgagctacggggacgtgcccccaggacccgccttc
aaggaggtctggcaggtgatcctgaaacccaagggcctgggtcagacaaagaacctgatt
ggcatctaccgcctctgcctgaccagcaagaccatcagcttcgtgaagctgaactcggag
gctgcggccgtggtgctgcagctgatgaacatcaggcgctgcggccactcagagaacttc
ttcttcatcgaagtgggccgttccgcagtgacgggccccggggagttctggatgcaggtg
gacgactccgtggtggcccagaacatgcacgagacaatcctggaggccatgcgggccatg
agcgatgagttccgccctagaagcaagagccagtcctcctccaactgctccaaccccatc
agtgtgcccctgcggaggcaccacctcaacaaccctccacccagccaggtggggctgacc
cgccgctcgcgcaccgagagcatcacagccacctccccggccagcttggtgggcgggaag
cagggctccttccgcgtgcgtgcctccagtgatggcgaaggcaccatgtctcgccccgcc
tcagtggacggcagtcctgtgagtcctagcaccaacaggacccacgcccaccgccatcga
ggcagctcccggctgcacccgcctctcaaccacagccgctccatccccatgccttcttct
cgctgctcgccttccgccaccagccccgtcagtctgtcgtccagcagcacgagtggccat
ggctccacctcagactgcctcttcccgcggcggtctagtgcttctgtgtctggttccccc
agtgatggcggcttcatctcctccgatgagtatggctccagtccctgcgatttccgaagt
tccttccgcagcgtcaccccagattccctgggccacaccccgcccgcccggggtgaggag
gagctaagcaactacatctgcatgggaggcaagggggcctccaccctcactgcccccaat
ggtcactacattttgccccggggtggcaatggtcaccgctacgtgccagccgccggcttg
ggcacgagcccagccctgccaggagaagaagcagccggtgcggcagatctggataatcgg
ttccgaaaacggactcactctgcgggcacttcgcctaccatttcccaccagaaaaccccg
tctcagtcctctgtggcttccattgaggaatataccgaaatgatgcccgcttacccacca
ggaggtggcagtggaggccgagtacccagctaccggcactccgccttcgtgcccacccac
tcctacccagaggagggtctggaaatgcaccccttggagcggcgtgggggccaccaccgc
ccagacacctccagccttcacactgatgatggctacatgcccatgtccccaggggtggcc
ccagtgcccggcagccggaaaggcagtggggactacatgcccatgagccccaagagcgtg
tctgccccgcagcagatcatcaaccccatcagacgccatccccagagagtggaccccaac
ggctacatgatgatgtccccaagcggcagctgctctcctgacattggaggtgggcccagc
agcggtggcagcagcagcggtgccgccccttctgggagcagctatggcaagctttggaca
aacggggtagggggccaccactctcacgccctgccacaccccaaacttccggtggagagc
ggtagtggcaaactcttgtcttgtacaggtgactacatgaacatgtcgcccgtcggggac
tccaacaccagcagcccctccgactgctattatggccccgaggacccccagcacaagccc
gtcctctcctactactcattgccaaggtcctttaagcacacccagcgtcctggggagctg
gaggagccccggcaccaccagcacctccgcctttcctcaagttccggtcgactcctctac
actgcggccgcagaagattcctcttcgtccaccagcagcgacagcctgggcgggggatac
tgtggggctcggccggagcccggcctcccgcatctccatcatcaggtcctgcaggcccat
ctgcctcgaaaggtggacacagctgcccagaccaacaaccgcctggctcggcccacgagg
ctgtctctgggggatcccaaggccagcaccttacctcgggcccgagagcagcagccaccg
ccccccttgctgctccctccggagcccaagagcccaggggagtatgtgaatattgaattt
gggagcgatcagccaggctacttatcgggcccggtggcgtcccacagctcgccttccatc
aggtgtccgtcccagctccagccagctcccagagaggaggatacgggcgcagaagagtat
atgaacatggacctggggccgggccggagggccacctggcagaagagcgtgggggtccag
cccggcagggtgggcccggcgccccctggagctgctagcgtgtgcaggccgactagggca
gtgcccagcagctgcggcgactacatgaccatgcagatgggtggtccccggcagagctac
gtggacacctcacctgtcgcgcccatcagctacgccgacatgcggacgggcgtcgttgtg
gaggatgccagcttgcccagggccaccgcggccgctccctcctcatcttcgacagcctct
gtttcctccactgcgcctcctccgggaacaggggagctggcggcccgctcggccctcctg
gggggcccgagcgccttcacgcgggtgaacctcagtcccaaccgcaaccagagtgccaaa
gtgatccgtgccgaccctcaagggtgcaggaggcggcacagctccgagaccttctcctct
acgcccagtgccacccgggtgggcaacacgatgcccttcggagctggggctgccgtcggg
ggcagcggtggcggcagcagcagcagcgccgaggatgtcaaacgccacagctctgcttcc
ttcgagaacgtgtggctgaggcctggggagctcgggggagcccccaaggagctggcccaa
gtgtgcggggccgctgggggtttggagaatggtcttaactacatagacctggatttggtc
aaggacttcaaacagcgccctcaagagtgcccacctcaaccgcagcctcctccactcccg
gcccctcatcagcctctggccagtagtcagagcggccccaccagccgctccagcgaggat
ctaagcgcctatgccagcatcactttccagaagcagccagaggacctccagtag

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