KEGG   Bos taurus (cow): 538598Help
Entry
538598            CDS       T01008                                 

Gene name
IRS1
Definition
insulin receptor substrate 1
Orthology
K16172  
insulin receptor substrate 1
Organism
bta  Bos taurus (cow)
Pathway
FoxO signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
Neurotrophin signaling pathway
Insulin signaling pathway
Adipocytokine signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
MicroRNAs in cancer
Class
Environmental Information Processing; Signal transduction; FoxO signaling pathway [PATH:bta04068]
Environmental Information Processing; Signal transduction; PI3K-Akt signaling pathway [PATH:bta04151]
Environmental Information Processing; Signal transduction; mTOR signaling pathway [PATH:bta04150]
Organismal Systems; Endocrine system; Insulin signaling pathway [PATH:bta04910]
Organismal Systems; Endocrine system; Adipocytokine signaling pathway [PATH:bta04920]
Organismal Systems; Excretory system; Aldosterone-regulated sodium reabsorption [PATH:bta04960]
Organismal Systems; Nervous system; Neurotrophin signaling pathway [PATH:bta04722]
Human Diseases; Cancers; MicroRNAs in cancer [PATH:bta05206]
Human Diseases; Endocrine and metabolic diseases; Type II diabetes mellitus [PATH:bta04930]
Human Diseases; Endocrine and metabolic diseases; Non-alcoholic fatty liver disease (NAFLD) [PATH:bta04932]
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
BGD-bta: 
UniProt: 
Position
2
AA seq 1237 aa AA seqDB search
MASPPETDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP
KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGH
HDGAAAPGAGGGGGSCSGSSGLGEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLI
GIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQV
DDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLT
RRSRTESITATSPASLVGGKQGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHR
GSSRLHPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSP
SDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGASTLTAPN
GHYILPRGGNGHRYVPAAGLGTSPALPGEEAAGAADLDNRFRKRTHSAGTSPTISHQKTP
SQSSVASIEEYTEMMPAYPPGGGSGGRVPSYRHSAFVPTHSYPEEGLEMHPLERRGGHHR
PDTSSLHTDDGYMPMSPGVAPVPGSRKGSGDYMPMSPKSVSAPQQIINPIRRHPQRVDPN
GYMMMSPSGSCSPDIGGGPSSGGSSSGAAPSGSSYGKLWTNGVGGHHSHALPHPKLPVES
GSGKLLSCTGDYMNMSPVGDSNTSSPSDCYYGPEDPQHKPVLSYYSLPRSFKHTQRPGEL
EEPRHHQHLRLSSSSGRLLYTAAAEDSSSSTSSDSLGGGYCGARPEPGLPHLHHQVLQAH
LPRKVDTAAQTNNRLARPTRLSLGDPKASTLPRAREQQPPPPLLLPPEPKSPGEYVNIEF
GSDQPGYLSGPVASHSSPSIRCPSQLQPAPREEDTGAEEYMNMDLGPGRRATWQKSVGVQ
PGRVGPAPPGAASVCRPTRAVPSSCGDYMTMQMGGPRQSYVDTSPVAPISYADMRTGVVV
EDASLPRATAAAPSSSSTASVSSTAPPPGTGELAARSALLGGPSAFTRVNLSPNRNQSAK
VIRADPQGCRRRHSSETFSSTPSATRVGNTMPFGAGAAVGGSGGGSSSSAEDVKRHSSAS
FENVWLRPGELGGAPKELAQVCGAAGGLENGLNYIDLDLVKDFKQRPQECPPQPQPPPLP
APHQPLASSQSGPTSRSSEDLSAYASITFQKQPEDLQ
NT seq 3714 nt NT seq  +upstreamnt  +downstreamnt
atggcgagccctccggagactgacggcttctcggacgtgcgcaaggtgggctacctgcgc
aaacccaagagcatgcacaaacgattcttcgtgctgcgggcggccagcgaggctgggggc
ccggcgcgcctcgagtactacgagaacgagaagaagtggcggcacaagtctagcgccccc
aaacgctcgatccccctggagagctgcttcaacatcaacaagcgggcggactccaagaac
aagcacctggtggccctctacacccgggacgagcactttgccatcgcggcagacagcgag
gccgagcaggacagctggtaccaggccctcctgcagctgcacaaccgtgccaagggccac
cacgacggggccgcggcgcctggggcgggaggcggcgggggcagctgcagtggcagctcc
ggcctcggggaggccggtgaggacttgagctacggggacgtgcccccaggacccgccttc
aaggaggtctggcaggtgatcctgaaacccaagggcctgggtcagacaaagaacctgatt
ggcatctaccgcctctgcctgaccagcaagaccatcagcttcgtgaagctgaactcggag
gctgcggccgtggtgctgcagctgatgaacatcaggcgctgcggccactcagagaacttc
ttcttcatcgaagtgggccgttccgcagtgacgggccccggggagttctggatgcaggtg
gacgactccgtggtggcccagaacatgcacgagacaatcctggaggccatgcgggccatg
agcgatgagttccgccctagaagcaagagccagtcctcctccaactgctccaaccccatc
agtgtgcccctgcggaggcaccacctcaacaaccctccacccagccaggtggggctgacc
cgccgctcgcgcaccgagagcatcacagccacctccccggccagcttggtgggcgggaag
cagggctccttccgcgtgcgtgcctccagtgatggcgaaggcaccatgtctcgccccgcc
tcagtggacggcagtcctgtgagtcctagcaccaacaggacccacgcccaccgccatcga
ggcagctcccggctgcacccgcctctcaaccacagccgctccatccccatgccttcttct
cgctgctcgccttccgccaccagccccgtcagtctgtcgtccagcagcacgagtggccat
ggctccacctcagactgcctcttcccgcggcggtctagtgcttctgtgtctggttccccc
agtgatggcggcttcatctcctccgatgagtatggctccagtccctgcgatttccgaagt
tccttccgcagcgtcaccccagattccctgggccacaccccgcccgcccggggtgaggag
gagctaagcaactacatctgcatgggaggcaagggggcctccaccctcactgcccccaat
ggtcactacattttgccccggggtggcaatggtcaccgctacgtgccagccgccggcttg
ggcacgagcccagccctgccaggagaagaagcagccggtgcggcagatctggataatcgg
ttccgaaaacggactcactctgcgggcacttcgcctaccatttcccaccagaaaaccccg
tctcagtcctctgtggcttccattgaggaatataccgaaatgatgcccgcttacccacca
ggaggtggcagtggaggccgagtacccagctaccggcactccgccttcgtgcccacccac
tcctacccagaggagggtctggaaatgcaccccttggagcggcgtgggggccaccaccgc
ccagacacctccagccttcacactgatgatggctacatgcccatgtccccaggggtggcc
ccagtgcccggcagccggaaaggcagtggggactacatgcccatgagccccaagagcgtg
tctgccccgcagcagatcatcaaccccatcagacgccatccccagagagtggaccccaac
ggctacatgatgatgtccccaagcggcagctgctctcctgacattggaggtgggcccagc
agcggtggcagcagcagcggtgccgccccttctgggagcagctatggcaagctttggaca
aacggggtagggggccaccactctcacgccctgccacaccccaaacttccggtggagagc
ggtagtggcaaactcttgtcttgtacaggtgactacatgaacatgtcgcccgtcggggac
tccaacaccagcagcccctccgactgctattatggccccgaggacccccagcacaagccc
gtcctctcctactactcattgccaaggtcctttaagcacacccagcgtcctggggagctg
gaggagccccggcaccaccagcacctccgcctttcctcaagttccggtcgactcctctac
actgcggccgcagaagattcctcttcgtccaccagcagcgacagcctgggcgggggatac
tgtggggctcggccggagcccggcctcccgcatctccatcatcaggtcctgcaggcccat
ctgcctcgaaaggtggacacagctgcccagaccaacaaccgcctggctcggcccacgagg
ctgtctctgggggatcccaaggccagcaccttacctcgggcccgagagcagcagccaccg
ccccccttgctgctccctccggagcccaagagcccaggggagtatgtgaatattgaattt
gggagcgatcagccaggctacttatcgggcccggtggcgtcccacagctcgccttccatc
aggtgtccgtcccagctccagccagctcccagagaggaggatacgggcgcagaagagtat
atgaacatggacctggggccgggccggagggccacctggcagaagagcgtgggggtccag
cccggcagggtgggcccggcgccccctggagctgctagcgtgtgcaggccgactagggca
gtgcccagcagctgcggcgactacatgaccatgcagatgggtggtccccggcagagctac
gtggacacctcacctgtcgcgcccatcagctacgccgacatgcggacgggcgtcgttgtg
gaggatgccagcttgcccagggccaccgcggccgctccctcctcatcttcgacagcctct
gtttcctccactgcgcctcctccgggaacaggggagctggcggcccgctcggccctcctg
gggggcccgagcgccttcacgcgggtgaacctcagtcccaaccgcaaccagagtgccaaa
gtgatccgtgccgaccctcaagggtgcaggaggcggcacagctccgagaccttctcctct
acgcccagtgccacccgggtgggcaacacgatgcccttcggagctggggctgccgtcggg
ggcagcggtggcggcagcagcagcagcgccgaggatgtcaaacgccacagctctgcttcc
ttcgagaacgtgtggctgaggcctggggagctcgggggagcccccaaggagctggcccaa
gtgtgcggggccgctgggggtttggagaatggtcttaactacatagacctggatttggtc
aaggacttcaaacagcgccctcaagagtgcccacctcaaccgcagcctcctccactcccg
gcccctcatcagcctctggccagtagtcagagcggccccaccagccgctccagcgaggat
ctaagcgcctatgccagcatcactttccagaagcagccagaggacctccagtag

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