KEGG   PATHWAY: bwe00010Help
Entry
bwe00010                    Pathway                                

Name
Glycolysis / Gluconeogenesis - Bacillus mycoides KBAB4
Description
Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003].
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
bwe00010  Glycolysis / Gluconeogenesis
bwe00010

Ortholog table
Module
bwe_M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate [PATH:bwe00010]
bwe_M00002  Glycolysis, core module involving three-carbon compounds [PATH:bwe00010]
bwe_M00003  Gluconeogenesis, oxaloacetate => fructose-6P [PATH:bwe00010]
bwe_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:bwe00010]
bwe_M00809  PTS system, glucose-specific II component [PATH:bwe00010]
Other DBs
BSID: 62877
GO: 0006096 0006094
Organism
Bacillus mycoides KBAB4 [GN:bwe]
Gene
BcerKBAB4_4116  putative glucokinase, ROK family [KO:K00845] [EC:2.7.1.2]
BcerKBAB4_4720  Glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]
BcerKBAB4_4429  6-phosphofructokinase [KO:K00850] [EC:2.7.1.11]
BcerKBAB4_5131  fructose-1,6-bisphosphatase, class II [KO:K02446] [EC:3.1.3.11]
BcerKBAB4_4783  fructose-1,6-bisphosphatase, class II [KO:K02446] [EC:3.1.3.11]
BcerKBAB4_5133  fructose-1,6-bisphosphate aldolase, class II [KO:K01624] [EC:4.1.2.13]
BcerKBAB4_4929  Triose-phosphate isomerase [KO:K01803] [EC:5.3.1.1]
BcerKBAB4_4413  glyceraldehyde-3-phosphate dehydrogenase, type I [KO:K00134] [EC:1.2.1.12]
BcerKBAB4_4931  glyceraldehyde-3-phosphate dehydrogenase, type I [KO:K00134] [EC:1.2.1.12]
BcerKBAB4_4930  Phosphoglycerate kinase [KO:K00927] [EC:2.7.2.3]
BcerKBAB4_2293  phosphoglycerate mutase 1 family [KO:K01834] [EC:5.4.2.11]
BcerKBAB4_1926  Phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
BcerKBAB4_3514  Phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
BcerKBAB4_4794  Phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
BcerKBAB4_1619  Phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
BcerKBAB4_4928  phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [KO:K15633] [EC:5.4.2.12]
BcerKBAB4_4927  Phosphopyruvate hydratase [KO:K01689] [EC:4.2.1.11]
BcerKBAB4_4428  pyruvate kinase [KO:K00873] [EC:2.7.1.40]
BcerKBAB4_3056  pyruvate kinase [KO:K00873] [EC:2.7.1.40]
BcerKBAB4_3799  Pyruvate dehydrogenase (acetyl-transferring) [KO:K00161] [EC:1.2.4.1]
BcerKBAB4_3798  Transketolase central region [KO:K00162] [EC:1.2.4.1]
BcerKBAB4_2576  catalytic domain of components of various dehydrogenase complexes [KO:K00627] [EC:2.3.1.12]
BcerKBAB4_3797  Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase [KO:K00627] [EC:2.3.1.12]
BcerKBAB4_4004  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
BcerKBAB4_2575  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
BcerKBAB4_3796  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
BcerKBAB4_3545  pyruvate flavodoxin/ferredoxin oxidoreductase domain protein [KO:K00174] [EC:1.2.7.11 1.2.7.3]
BcerKBAB4_3544  pyruvate ferredoxin/flavodoxin oxidoreductase, beta subunit [KO:K00175] [EC:1.2.7.11 1.2.7.3]
BcerKBAB4_4713  L-lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]
BcerKBAB4_4826  L-lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]
BcerKBAB4_1798  L-lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]
BcerKBAB4_4218  iron-containing alcohol dehydrogenase [KO:K04072] [EC:1.1.1.1 1.2.1.10]
BcerKBAB4_2089  Alcohol dehydrogenase GroES domain protein [KO:K13953] [EC:1.1.1.1]
BcerKBAB4_3257  Aldehyde dehydrogenase (NAD(+)) [KO:K00128] [EC:1.2.1.3]
BcerKBAB4_1200  aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
BcerKBAB4_2634  aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
BcerKBAB4_2361  AMP-dependent synthetase and ligase [KO:K01895] [EC:6.2.1.1]
BcerKBAB4_4493  AMP-dependent synthetase and ligase [KO:K01895] [EC:6.2.1.1]
BcerKBAB4_4476  AMP-dependent synthetase and ligase [KO:K01895] [EC:6.2.1.1]
BcerKBAB4_4741  phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I [KO:K01835] [EC:5.4.2.2]
BcerKBAB4_0756  aldehyde dehydrogenase [KO:K00131] [EC:1.2.1.9]
BcerKBAB4_4595  Phosphoenolpyruvate carboxykinase (ATP) [KO:K01610] [EC:4.1.1.49]
BcerKBAB4_5001  6-phospho-beta-glucosidase [KO:K01222] [EC:3.2.1.86]
BcerKBAB4_3531  Beta-glucosidase [KO:K01223] [EC:3.2.1.86]
BcerKBAB4_5118  PTS system, glucose subfamily, IIA subunit [KO:K02777] [EC:2.7.1.-]
BcerKBAB4_3879  PTS system, glucose-specific IIBC subunit [KO:K20116 K20117 K20118] [EC:2.7.1.199 2.7.1.199]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00031  D-Glucose
C00033  Acetate
C00036  Oxaloacetate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00084  Acetaldehyde
C00103  D-Glucose 1-phosphate
C00111  Glycerone phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00186  (S)-Lactate
C00197  3-Phospho-D-glycerate
C00221  beta-D-Glucose
C00236  3-Phospho-D-glyceroyl phosphate
C00267  alpha-D-Glucose
C00469  Ethanol
C00631  2-Phospho-D-glycerate
C00668  alpha-D-Glucose 6-phosphate
C01159  2,3-Bisphospho-D-glycerate
C01172  beta-D-Glucose 6-phosphate
C01451  Salicin
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C05345  beta-D-Fructose 6-phosphate
C05378  beta-D-Fructose 1,6-bisphosphate
C06186  Arbutin
C06187  Arbutin 6-phosphate
C06188  Salicin 6-phosphate
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
(map 1)
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
(map 1)
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
KO pathway
ko00010   

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