KEGG   PATHWAY: bwe00010Help
Entry
bwe00010                    Pathway                                

Name
Glycolysis / Gluconeogenesis - Bacillus weihenstephanensis KBAB4
Description
Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003].
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
Glycolysis / Gluconeogenesis
bwe00010

All organismsOrtholog table
Module
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate [PATH:bwe00010]
Glycolysis, core module involving three-carbon compounds [PATH:bwe00010]
Gluconeogenesis, oxaloacetate => fructose-6P [PATH:bwe00010]
Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:bwe00010]
PTS system, glucose-specific II component [PATH:bwe00010]
Other DBs
BSID: 
GO: 
Organism
Bacillus weihenstephanensis KBAB4 [GN:bwe]
Gene
putative glucokinase, ROK family [KO:K00845] [EC:2.7.1.2]
Glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]
6-phosphofructokinase [KO:K00850] [EC:2.7.1.11]
fructose-1,6-bisphosphatase, class II [KO:K02446] [EC:3.1.3.11]
fructose-1,6-bisphosphatase, class II [KO:K02446] [EC:3.1.3.11]
fructose-1,6-bisphosphate aldolase, class II [KO:K01624] [EC:4.1.2.13]
Triose-phosphate isomerase [KO:K01803] [EC:5.3.1.1]
glyceraldehyde-3-phosphate dehydrogenase, type I [KO:K00134] [EC:1.2.1.12]
glyceraldehyde-3-phosphate dehydrogenase, type I [KO:K00134] [EC:1.2.1.12]
Phosphoglycerate kinase [KO:K00927] [EC:2.7.2.3]
phosphoglycerate mutase 1 family [KO:K01834] [EC:5.4.2.11]
Phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
Phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
Phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
Phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [KO:K15633] [EC:5.4.2.12]
Phosphoglycerate mutase [KO:K15634] [EC:5.4.2.12]
Phosphoglycerate mutase [KO:K15634] [EC:5.4.2.12]
Phosphopyruvate hydratase [KO:K01689] [EC:4.2.1.11]
pyruvate kinase [KO:K00873] [EC:2.7.1.40]
pyruvate kinase [KO:K00873] [EC:2.7.1.40]
Pyruvate dehydrogenase (acetyl-transferring) [KO:K00161] [EC:1.2.4.1]
Pyruvate dehydrogenase (acetyl-transferring) [KO:K00161] [EC:1.2.4.1]
Transketolase central region [KO:K00162] [EC:1.2.4.1]
Transketolase central region [KO:K00162] [EC:1.2.4.1]
catalytic domain of components of various dehydrogenase complexes [KO:K00627] [EC:2.3.1.12]
Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase [KO:K00627] [EC:2.3.1.12]
dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
pyruvate flavodoxin/ferredoxin oxidoreductase domain protein [KO:K00174] [EC:1.2.7.11 1.2.7.3]
pyruvate ferredoxin/flavodoxin oxidoreductase, beta subunit [KO:K00175] [EC:1.2.7.11 1.2.7.3]
L-lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]
L-lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]
L-lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]
iron-containing alcohol dehydrogenase [KO:K04072] [EC:1.1.1.1 1.2.1.10]
Alcohol dehydrogenase GroES domain protein [KO:K13953] [EC:1.1.1.1]
Aldehyde dehydrogenase (NAD(+)) [KO:K00128] [EC:1.2.1.3]
aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
AMP-dependent synthetase and ligase [KO:K01895] [EC:6.2.1.1]
AMP-dependent synthetase and ligase [KO:K01895] [EC:6.2.1.1]
AMP-dependent synthetase and ligase [KO:K01895] [EC:6.2.1.1]
phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I [KO:K01835] [EC:5.4.2.2]
aldehyde dehydrogenase [KO:K00131] [EC:1.2.1.9]
Phosphoenolpyruvate carboxykinase (ATP) [KO:K01610] [EC:4.1.1.49]
6-phospho-beta-glucosidase [KO:K01222] [EC:3.2.1.86]
Beta-glucosidase [KO:K01223] [EC:3.2.1.86]
PTS system, glucose subfamily, IIA subunit [KO:K02777] [EC:2.7.1.-]
PTS system, glucose-specific IIBC subunit [KO:K20116 K20117 K20118] [EC:2.7.1.199 2.7.1.199]
Compound
C00022  
Pyruvate
C00024  
Acetyl-CoA
C00031  
D-Glucose
C00033  
Acetate
C00036  
Oxaloacetate
C00068  
Thiamin diphosphate
C00074  
Phosphoenolpyruvate
C00084  
Acetaldehyde
C00103  
D-Glucose 1-phosphate
C00111  
Glycerone phosphate
C00118  
D-Glyceraldehyde 3-phosphate
C00186  
(S)-Lactate
C00197  
3-Phospho-D-glycerate
C00221  
beta-D-Glucose
C00236  
3-Phospho-D-glyceroyl phosphate
C00267  
alpha-D-Glucose
C00469  
Ethanol
C00631  
2-Phospho-D-glycerate
C00668  
alpha-D-Glucose 6-phosphate
C01159  
2,3-Bisphospho-D-glycerate
C01172  
beta-D-Glucose 6-phosphate
C01451  
Salicin
C05125  
2-(alpha-Hydroxyethyl)thiamine diphosphate
C05345  
beta-D-Fructose 6-phosphate
C05378  
beta-D-Fructose 1,6-bisphosphate
C06186  
Arbutin
C06187  
Arbutin 6-phosphate
C06188  
Salicin 6-phosphate
C15972  
Enzyme N6-(lipoyl)lysine
C15973  
Enzyme N6-(dihydrolipoyl)lysine
C16255  
[Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
(map 1)
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
(map 1)
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
KO pathway
 

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