KEGG   Castor canadensis (American beaver): 109699504
Entry
109699504         CDS       T04791                                 
Symbol
Jak1
Name
(RefSeq) tyrosine-protein kinase JAK1 isoform X1
  KO
K11217  Janus kinase 1 [EC:2.7.10.2]
Organism
ccan  Castor canadensis (American beaver)
Pathway
ccan01521  EGFR tyrosine kinase inhibitor resistance
ccan04151  PI3K-Akt signaling pathway
ccan04217  Necroptosis
ccan04380  Osteoclast differentiation
ccan04550  Signaling pathways regulating pluripotency of stem cells
ccan04620  Toll-like receptor signaling pathway
ccan04621  NOD-like receptor signaling pathway
ccan04630  JAK-STAT signaling pathway
ccan04658  Th1 and Th2 cell differentiation
ccan04659  Th17 cell differentiation
ccan05140  Leishmaniasis
ccan05145  Toxoplasmosis
ccan05152  Tuberculosis
ccan05160  Hepatitis C
ccan05161  Hepatitis B
ccan05162  Measles
ccan05163  Human cytomegalovirus infection
ccan05164  Influenza A
ccan05165  Human papillomavirus infection
ccan05166  Human T-cell leukemia virus 1 infection
ccan05167  Kaposi sarcoma-associated herpesvirus infection
ccan05168  Herpes simplex virus 1 infection
ccan05169  Epstein-Barr virus infection
ccan05171  Coronavirus disease - COVID-19
ccan05200  Pathways in cancer
ccan05203  Viral carcinogenesis
ccan05212  Pancreatic cancer
ccan05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:ccan00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    109699504 (Jak1)
   04151 PI3K-Akt signaling pathway
    109699504 (Jak1)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    109699504 (Jak1)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    109699504 (Jak1)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    109699504 (Jak1)
   04621 NOD-like receptor signaling pathway
    109699504 (Jak1)
   04658 Th1 and Th2 cell differentiation
    109699504 (Jak1)
   04659 Th17 cell differentiation
    109699504 (Jak1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    109699504 (Jak1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    109699504 (Jak1)
   05203 Viral carcinogenesis
    109699504 (Jak1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    109699504 (Jak1)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    109699504 (Jak1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    109699504 (Jak1)
   05161 Hepatitis B
    109699504 (Jak1)
   05160 Hepatitis C
    109699504 (Jak1)
   05171 Coronavirus disease - COVID-19
    109699504 (Jak1)
   05164 Influenza A
    109699504 (Jak1)
   05162 Measles
    109699504 (Jak1)
   05168 Herpes simplex virus 1 infection
    109699504 (Jak1)
   05163 Human cytomegalovirus infection
    109699504 (Jak1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    109699504 (Jak1)
   05169 Epstein-Barr virus infection
    109699504 (Jak1)
   05165 Human papillomavirus infection
    109699504 (Jak1)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    109699504 (Jak1)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    109699504 (Jak1)
   05140 Leishmaniasis
    109699504 (Jak1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    109699504 (Jak1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ccan01001]
    109699504 (Jak1)
Enzymes [BR:ccan01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     109699504 (Jak1)
Protein kinases [BR:ccan01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   109699504 (Jak1)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase Jak1_Phl FERM_F2 FERM_F1 ABC1 FERM_C_FAK1 SH2
Other DBs
NCBI-GeneID: 109699504
NCBI-ProteinID: XP_020039827
UniProt: A0A8B7W768
Position
Unknown
AA seq 1093 aa
MHQGCAGCCISPLCHNLFALYNENTKLWYAPNHIITVDDKMSLRLHYRMRFYFTNWHGTN
DNEQSVWRHSPKKQKNGYEKKKVPDATPLLDASSLEYLFAQGQYDLIKCLAPIRDPKTEQ
DGHDIENECLGMAVLAISHYAMIKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI
NNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMN
WFHSNDSGNVLYYEVMVTGNLGIQWRQKTNAVPVEKEKNKLKRKKLENKHKKDDEKNKAR
EEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLIDGYFRLTADAH
HYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVT
CFEKSEVLGGQKQFKNFQIEVQKGSYRLHGSDCSFPSLGELMSHLKKQILRTDNISFVLK
RCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDIVQGEHLGRGTRTHIYSGT
LVDYKDDEGTAEEKRIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDV
ENIMVEEFVEGGPLDIFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLL
LARDGIDSEIGPFIKLSDPGIPVSVLSRQECIERIPWIAPECVEDAKNLSVAADKWSFGT
TLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAI
MRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNT
GEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPS
GSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGD
FGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDSD
SSPMALFLKMIGPTHGQMTVTRLVNALKEGKRLPCPRNCPDEVYQLMRKCWELQPSNRTT
FQNLIEGFEALLK
NT seq 3282 nt   +upstreamnt  +downstreamnt
atgcatcagggctgcgcaggatgctgtatctctcccctatgccacaacctctttgccctg
tacaatgaaaacaccaagctctggtatgctccaaaccacatcatcactgttgatgacaag
atgtcactccggctccactaccggatgagattctactttaccaactggcatgggactaat
gataacgagcagtctgtgtggcgacattctccaaagaagcagaaaaatggctatgagaag
aaaaaggttccagatgcaacccctctccttgatgccagctctctggagtatctgtttgct
cagggacagtatgatttgatcaaatgcctagctcccattcgggaccccaagactgagcag
gatggtcatgatattgagaatgaatgcctgggaatggctgtcttggccatctcccactat
gccatgataaagaagatgcagttgccggaacttcccaaggacatcagctataagcgatat
attccagaaacattgaataaatccatcagacagagaaaccttctcaccaggatgcgaata
aataatgttttcaaggatttcttaaaggaatttaataataagaccatttgtgacagtagt
gtatctacacatgatctgaaggtgaaatacctggccaccttggaaactttgacaaaacat
tacggggctgagatatttgagacttccatgttactgatttcatcagaaaatgaaatgaat
tggtttcattcgaatgacagtggtaatgttctctactatgaagtgatggtgaccggaaat
cttggaattcagtggcggcaaaaaacaaacgctgttcctgttgaaaaggaaaaaaataaa
ctgaagcggaaaaagctggaaaataaacacaagaaggatgatgagaaaaacaaagcccgg
gaagagtggaacaatttttcatacttccctgaaatcactcacattgtaataaaagagtcc
gtagtcagcattaacaagcaggacaacaaaaaaatggaactgaagctctcttcccatgag
gaggccttgtcctttgtgtccctgatagacggctatttccggctcacagcagatgcccac
cattacctctgcactgacgtggctcccccactgatcgtccacaacatacagaatggctgt
catggtccaatctgcacagaatatgctatcaataagctgcggcaagaagggagtgaagag
gggatgtacgtgcttaggtggagctgcactgactttgacaacatcctcatgactgtcacc
tgctttgaaaaatctgaggtgctgggtggccagaagcaattcaagaactttcagattgag
gttcaaaagggcagctaccgactgcatggctcggactgcagctttcccagcttgggagaa
ctcatgagccacctcaagaagcagatcctgcgcacagacaacatcagctttgtgctgaaa
cgctgctgccagcctaagccccgagaaatctccaatctgcttgtggccactaagaaagcc
caggaatggcagcctgtctaccccatgagccagttgagctttgatcggatcctcaagaag
gacattgtgcaaggagaacaccttggcagaggcacgagaacacacatctactctgggaca
ctggtggattacaaggatgatgaaggaactgctgaagagaagagaataaaagtgatcctc
aaagtcttagaccccagccacagggacatttctttggccttctttgaggcagccagcatg
atgagacaggtctcccacaaacacattgtgtacctttatggtgtttgtgtccgagacgtg
gagaatatcatggtggaagagtttgtggagggaggacccttggatatcttcatgcaccgg
aaaagtgatgtcctcactacaccatggaagttcaaggttgccaaacagctggccagtgcc
ctgagttacttggaggataaagacctggttcatggaaatgtgtgtactaaaaaccttctc
ctggcccgagacggcattgacagcgagataggcccattcatcaaactcagcgatcctggc
atccctgtgtctgtgctgtccaggcaagagtgcatagagcgcatcccgtggattgctcct
gagtgtgttgaagacgccaagaacctgagtgtggctgcggacaaatggagttttggaacc
acactctgggaaatctgctacaatggcgagatccccctgaaagacaagacgctgattgag
aaagagagattctatgaaagccgctgcaggccagtgacaccatcctgcaaggaactggct
gatcttatgacccgctgcatgaactatgaccccaatcagagacccttcttccgagctatc
atgagggacattaacaagcttgaagagcagaatccagacattgtttcagaaaaaaaacca
gcaaccgaggtggatcccacccattttgaaaaacgcttcctgaagaggatccgtgacttg
ggagaggggcactttgggaaggttgagctatgcaggtatgaccctgagggggacaacaca
ggggagcaggtagccgtcaaatccctgaagcctgagagtggaggtaaccacatagctgat
ctgaagaaggaaatagaaatcttaagaaacctctatcatgaaaacattgtgaagtacaaa
ggaatctgcacagaagatggaggaaatggtatcaagctcatcatggaatttctgccttct
ggaagcctgaaggaatatcttccaaagaataaaaacaaaattaacctcaaacagcagcta
aaatatgccgttcagatttgtaagggaatggactatttgggttctcggcagtatgttcac
cgggacctagcagcaagaaatgtgcttgtcgaaagtgaacaccaagtgaaaattggagac
tttggcttaaccaaagcaattgaaactgacaaggagtactacacagtcaaggacgaccgg
gacagccctgtgttttggtacgctccagaatgtttaatacagtgtaaattttatattgcc
tctgacgtttggtcttttggcgtgaccctgcatgaactgcttacttactgtgattcagat
tcaagcccaatggctttgttcctaaaaatgattggcccaactcatggccagatgacagta
acacgacttgtgaatgcattgaaagaaggaaaacgcctgccatgtccacgcaactgtccc
gatgaggtttatcaacttatgagaaaatgctgggaactccaaccatctaatcggacaacc
tttcagaaccttattgaaggatttgaagcacttttaaaataa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (28)   
   KEGG PATHWAY (28)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (15)   
   KEGG ORTHOLOGY (1)   
   RefGene (11)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (5)   
   UniProt (1)   
   RefSeq(pep) (4)   
DNA sequence (6)   
   RefSeq(nuc) (4)   
   GenBank (1)   
   EMBL (1)   
Protein domain (8)   
   Pfam (8)   
All databases (67)   

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