KEGG   PATHWAY: ccr02030Help
Entry
ccr02030                    Pathway                                

Name
Bacterial chemotaxis - Caulobacter crescentus CB15
Description
Chemotaxis is the process by which cells sense chemical gradients in their environment and then move towards more favorable conditions. In chemotaxis, events at the receptors control autophosphorylation of the CheA histidine kinase, and the phosphohistidine is the substrate for the response regulator CheY, which catalyzes the transfer of the phosphoryl group to a conserved aspartate. The resulting CheY-P can interact with the switch mechanism in the motor. This interaction causes a change in behavior, such as in direction or speed of rotation of flagella.
Class
Cellular Processes; Cell motility
BRITE hierarchy
Pathway map
ccr02030  Bacterial chemotaxis
ccr02030

Ortholog table
Other DBs
BSID: 4946
GO: 0006935
Organism
Caulobacter crescentus CB15 [GN:ccr]
Gene
CC_0430  methyl-accepting chemotaxis protein McpA [KO:K03406]
CC_0593  methyl-accepting chemotaxis protein McpK [KO:K03406]
CC_0066  methyl-accepting chemotaxis protein McpQ [KO:K03406]
CC_0343  methyl-accepting chemotaxis protein McpC [KO:K03406]
CC_0428  methyl-accepting chemotaxis protein McpB [KO:K03406]
CC_0504  methyl-accepting chemotaxis protein McpN [KO:K03406]
CC_1399  methyl-accepting chemotaxis protein McpP [KO:K03406]
CC_1655  methyl-accepting chemotaxis protein McpD [KO:K03406]
CC_2317  methyl-accepting chemotaxis protein McpM [KO:K03406]
CC_2842  methyl-accepting chemotaxis protein McpO [KO:K03406]
CC_2847  methyl-accepting chemotaxis protein McpI [KO:K03406]
CC_3349  methyl-accepting chemotaxis protein McpH [KO:K03406]
CC_2281  methyl-accepting chemotaxis protein McpE [KO:K03406]
CC_3145  methyl-accepting chemotaxis protein McpJ [KO:K03406]
CC_0433  chemotaxis protein CheA [KO:K03407] [EC:2.7.13.3]
CC_0594  chemotaxis protein CheA [KO:K03407] [EC:2.7.13.3]
CC_0434  chemotaxis protein CheW [KO:K03408]
CC_0764  chemotaxis protein CheW [KO:K03408]
CC_3025  chemotaxis protein CheW [KO:K03408]
CC_0595  chemotaxis protein CheW [KO:K03408]
CC_0591  chemotaxis protein CheY [KO:K03413]
CC_0432  chemotaxis protein CheY [KO:K03413]
CC_0437  chemotaxis protein CheY [KO:K03413]
CC_0596  chemotaxis protein CheY [KO:K03413]
CC_3471  chemotaxis protein CheY [KO:K03413]
CC_0588  chemotaxis protein CheY [KO:K03413]
CC_0431  CheX protein [KO:K03409]
CC_0597  chemotaxis-specific methylesterase [KO:K03412] [EC:3.5.1.44 3.1.1.61]
CC_0436  chemotaxis-specific methylesterase [KO:K03412] [EC:3.5.1.44 3.1.1.61]
CC_0438  chemotaxis protein CheD [KO:K03411] [EC:3.5.1.44]
CC_0435  chemotaxis protein CheR [KO:K00575] [EC:2.1.1.80]
CC_0598  chemotaxis protein CheR [KO:K00575] [EC:2.1.1.80]
CC_3472  chemotaxis protein CheR [KO:K00575] [EC:2.1.1.80]
CC_0906  fliG; flagellar motor switch protein G [KO:K02410]
CC_0908  flagellar motor switch protein [KO:K02417]
CC_2175  hypothetical protein [KO:K02417]
CC_0750  flagellar motor protein MotA [KO:K02556]
CC_1573  chemotaxis protein MotB [KO:K02557]
Compound
C00049  L-Aspartate
C00107  Dipeptide
C00121  D-Ribose
C00124  D-Galactose
C00208  Maltose
C00716  Serine
Reference
  Authors
Kristich CJ, Ordal GW.
  Title
Bacillus subtilis CheD is a chemoreceptor modification enzyme required for chemotaxis.
  Journal
J Biol Chem 277:25356-62 (2002)
DOI:10.1074/jbc.M201334200
Reference
  Authors
Kirby JR, Kristich CJ, Saulmon MM, Zimmer MA, Garrity LF, Zhulin IB, Ordal GW.
  Title
CheC is related to the family of flagellar switch proteins and acts independently from CheD to control chemotaxis in Bacillus subtilis.
  Journal
Mol Microbiol 42:573-85 (2001)
DOI:10.1046/j.1365-2958.2001.02581.x
Reference
  Authors
Szurmant H, Bunn MW, Cannistraro VJ, Ordal GW.
  Title
Bacillus subtilis hydrolyzes CheY-P at the location of its action, the flagellar switch.
  Journal
J Biol Chem 278:48611-6 (2003)
DOI:10.1074/jbc.M306180200
Reference
  Authors
Szurmant H, Muff TJ, Ordal GW.
  Title
Bacillus subtilis CheC and FliY are members of a novel class of CheY-P-hydrolyzing proteins in the chemotactic signal transduction cascade.
  Journal
J Biol Chem 279:21787-92 (2004)
DOI:10.1074/jbc.M311497200
Reference
  Authors
Yoshihara S, Geng X, Okamoto S, Yura K, Murata T, Go M, Ohmori M, Ikeuchi M.
  Title
Mutational analysis of genes involved in pilus structure, motility and transformation competency in the unicellular motile cyanobacterium Synechocystis sp. PCC 6803.
  Journal
Plant Cell Physiol 42:63-73 (2001)
Reference
PMID:8104179
  Authors
Darzins A.
  Title
The pilG gene product, required for Pseudomonas aeruginosa pilus production and twitching motility, is homologous to the enteric, single-domain response regulator CheY.
  Journal
J Bacteriol 175:5934-44 (1993)
DOI:10.1128/JB.175.18.5934-5944.1993
Reference
  Authors
Szurmant H, Ordal GW
  Title
Diversity in chemotaxis mechanisms among the bacteria and archaea.
  Journal
Microbiol Mol Biol Rev 68:301-19 (2004)
DOI:10.1128/MMBR.68.2.301-319.2004
Reference
  Authors
Rao CV, Glekas GD, Ordal GW
  Title
The three adaptation systems of Bacillus subtilis chemotaxis.
  Journal
Trends Microbiol 16:480-7 (2008)
DOI:10.1016/j.tim.2008.07.003
Reference
  Authors
Muff TJ, Ordal GW
  Title
The diverse CheC-type phosphatases: chemotaxis and beyond.
  Journal
Mol Microbiol 70:1054-61 (2008)
DOI:10.1111/j.1365-2958.2008.06482.x
Reference
  Authors
Miller LD, Russell MH, Alexandre G
  Title
Diversity in bacterial chemotactic responses and niche adaptation.
  Journal
Adv Appl Microbiol 66:53-75 (2009)
DOI:10.1016/S0065-2164(08)00803-4
KO pathway
ko02030   

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