KEGG   Canis familiaris (dog): 100856190Help
Entry
100856190         CDS       T01007                                 

Gene name
PLCB2
Definition
(RefSeq) phospholipase C beta 2
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
cfa  Canis familiaris (dog)
Pathway
cfa00562  Inositol phosphate metabolism
cfa01100  Metabolic pathways
cfa04015  Rap1 signaling pathway
cfa04020  Calcium signaling pathway
cfa04022  cGMP-PKG signaling pathway
cfa04062  Chemokine signaling pathway
cfa04070  Phosphatidylinositol signaling system
cfa04071  Sphingolipid signaling pathway
cfa04072  Phospholipase D signaling pathway
cfa04261  Adrenergic signaling in cardiomyocytes
cfa04270  Vascular smooth muscle contraction
cfa04310  Wnt signaling pathway
cfa04371  Apelin signaling pathway
cfa04540  Gap junction
cfa04611  Platelet activation
cfa04621  NOD-like receptor signaling pathway
cfa04713  Circadian entrainment
cfa04720  Long-term potentiation
cfa04723  Retrograde endocannabinoid signaling
cfa04724  Glutamatergic synapse
cfa04725  Cholinergic synapse
cfa04726  Serotonergic synapse
cfa04728  Dopaminergic synapse
cfa04730  Long-term depression
cfa04750  Inflammatory mediator regulation of TRP channels
cfa04911  Insulin secretion
cfa04912  GnRH signaling pathway
cfa04915  Estrogen signaling pathway
cfa04916  Melanogenesis
cfa04918  Thyroid hormone synthesis
cfa04919  Thyroid hormone signaling pathway
cfa04921  Oxytocin signaling pathway
cfa04922  Glucagon signaling pathway
cfa04924  Renin secretion
cfa04925  Aldosterone synthesis and secretion
cfa04926  Relaxin signaling pathway
cfa04927  Cortisol synthesis and secretion
cfa04928  Parathyroid hormone synthesis, secretion and action
cfa04933  AGE-RAGE signaling pathway in diabetic complications
cfa04934  Cushing's syndrome
cfa04961  Endocrine and other factor-regulated calcium reabsorption
cfa04970  Salivary secretion
cfa04971  Gastric acid secretion
cfa04972  Pancreatic secretion
cfa05010  Alzheimer's disease
cfa05016  Huntington's disease
cfa05142  Chagas disease (American trypanosomiasis)
cfa05143  African trypanosomiasis
cfa05146  Amoebiasis
cfa05200  Pathways in cancer
Module
cfa_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:cfa00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100856190 (PLCB2)
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    100856190 (PLCB2)
   04310 Wnt signaling pathway
    100856190 (PLCB2)
   04371 Apelin signaling pathway
    100856190 (PLCB2)
   04020 Calcium signaling pathway
    100856190 (PLCB2)
   04070 Phosphatidylinositol signaling system
    100856190 (PLCB2)
   04072 Phospholipase D signaling pathway
    100856190 (PLCB2)
   04071 Sphingolipid signaling pathway
    100856190 (PLCB2)
   04022 cGMP - PKG signaling pathway
    100856190 (PLCB2)
 Cellular Processes
  Cellular community - eukaryotes
   04540 Gap junction
    100856190 (PLCB2)
 Organismal Systems
  Immune system
   04611 Platelet activation
    100856190 (PLCB2)
   04621 NOD-like receptor signaling pathway
    100856190 (PLCB2)
   04062 Chemokine signaling pathway
    100856190 (PLCB2)
  Endocrine system
   04911 Insulin secretion
    100856190 (PLCB2)
   04922 Glucagon signaling pathway
    100856190 (PLCB2)
   04912 GnRH signaling pathway
    100856190 (PLCB2)
   04915 Estrogen signaling pathway
    100856190 (PLCB2)
   04921 Oxytocin signaling pathway
    100856190 (PLCB2)
   04926 Relaxin signaling pathway
    100856190 (PLCB2)
   04918 Thyroid hormone synthesis
    100856190 (PLCB2)
   04919 Thyroid hormone signaling pathway
    100856190 (PLCB2)
   04928 Parathyroid hormone synthesis, secretion and action
    100856190 (PLCB2)
   04916 Melanogenesis
    100856190 (PLCB2)
   04924 Renin secretion
    100856190 (PLCB2)
   04925 Aldosterone synthesis and secretion
    100856190 (PLCB2)
   04927 Cortisol synthesis and secretion
    100856190 (PLCB2)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100856190 (PLCB2)
   04270 Vascular smooth muscle contraction
    100856190 (PLCB2)
  Digestive system
   04970 Salivary secretion
    100856190 (PLCB2)
   04971 Gastric acid secretion
    100856190 (PLCB2)
   04972 Pancreatic secretion
    100856190 (PLCB2)
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    100856190 (PLCB2)
  Nervous system
   04724 Glutamatergic synapse
    100856190 (PLCB2)
   04725 Cholinergic synapse
    100856190 (PLCB2)
   04728 Dopaminergic synapse
    100856190 (PLCB2)
   04726 Serotonergic synapse
    100856190 (PLCB2)
   04720 Long-term potentiation
    100856190 (PLCB2)
   04730 Long-term depression
    100856190 (PLCB2)
   04723 Retrograde endocannabinoid signaling
    100856190 (PLCB2)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100856190 (PLCB2)
  Environmental adaptation
   04713 Circadian entrainment
    100856190 (PLCB2)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    100856190 (PLCB2)
  Neurodegenerative diseases
   05010 Alzheimer's disease
    100856190 (PLCB2)
   05016 Huntington's disease
    100856190 (PLCB2)
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    100856190 (PLCB2)
   04934 Cushing's syndrome
    100856190 (PLCB2)
  Infectious diseases
   05146 Amoebiasis
    100856190 (PLCB2)
   05142 Chagas disease (American trypanosomiasis)
    100856190 (PLCB2)
   05143 African trypanosomiasis
    100856190 (PLCB2)
Enzymes [BR:cfa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     100856190 (PLCB2)
Membrane trafficking [BR:cfa04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    100856190 (PLCB2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    100856190 (PLCB2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: PLC-beta_C PI-PLC-X PI-PLC-Y C2 EF-hand_like Gp58 AAA_13 Lectin_N
Motif
Other DBs
NCBI-GeneID: 100856190
NCBI-ProteinID: XP_003640081
Ensembl: ENSCAFG00000009036
UniProt: E2RT75
Position
30
AA seq 1188 aa AA seqDB search
MSLLSPVLLPPKVEAYLSQGERFIKWDDETTIASPVILRVDPKGYYLYWTYQSKETEFLD
ITSIRDTRFGKFAKIPKSQKLREVFNMDFPDNNFLLKTLTVVSGPDMVDLTFHNFVSYKE
NVGKNWAEDVLALAKHPLTANASRSTFLDKILVKLKMQLNPEGKIPVKNFFQMFPADRKR
VEAALSACHLPKGKNDAINPEDFPESVYKSFLMNLCPRPEIDEIFTSYHAKAKPYMTKEH
LTKFINQKQRDPRLNSLLFPPARPDQVRGLIDKYEPSGINVQRGQLSPEGMVWFLCGPEN
SVLSQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLAGCRCVELDC
WKGKPPDEEPIITHGFTMTTDIYFKEAIEAIAESAFKTSPYPVILSFENHVDSPRQQAKM
AEYCRMMFGDMLLTEPLEKFPLKPGIPLPSPEDLRGKILIKNKKNQFSGPAAPSKESGGD
AEGNCPPNASVGEGTVWPGEEGEELEEEEVEEEEEEESGNLDEEEIKKMQSDEGTAGLEV
TAYEEMSSLVNYIQPTKFISFELSAQKNRSYVISSFTELKAYDLLSKASVKFVDYNKRQM
SRIYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEF
MRRPDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRT
RLSPSANSINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHL
CLHSESNMPLTMPALFVFLEMKDYVPDTWADLTVALANPIKFFSAHDKKSVKLKEAMGAL
PEKPFPTGSPVAGQVNGPLAPVSNGSAAARARAGEEAAKEAAEPQTASPEELQELKGVVK
LQRRHEKELRDLERRGARRREELLQRGAAQLAGLGPPGAGGCGGRRLGPGKGSRKKRTSP
CDEAAGAAPQEDREGPEGADARARELKDRLELELLQQGEEQYECILKRKEQHVAEQIAKM
MELAREKQAAELKTLKETLETDTKEMKKKLEAKRLERIQAMVKVTSDKMAQERLKREINN
SHIQEVVQVIKQMTESLEKHQEKLEEKQAACLEQIREMEKQFQQEALAEYEARMKGLEAE
VKESVRACLRGCFPSEAKDMPERPCEAFRELCEQDPLAAKAGAQESRL
NT seq 3567 nt NT seq  +upstreamnt  +downstreamnt
atgtctctgctcagccctgtcctgctgccccccaaggtggaggcttatctgagccaaggg
gagcgcttcatcaaatgggacgatgaaaccacgatagcttctccggttatccttcgtgtg
gatcccaagggctactacttatattggacatatcagagtaaggagacggagtttctagat
atcaccagcatcagggatacccgctttgggaagtttgccaagatacccaagagccagaag
ctccgagaggtcttcaacatggactttcctgacaacaacttcctgctaaagacactcacc
gtggtatctggccctgacatggtggacctcaccttccacaactttgtctcctacaaggag
aatgtgggcaagaactgggctgaagacgtgctggctctggccaagcacccactgacggcc
aatgcttcccgcagcaccttcttggacaaaatcctggtgaaactcaagatgcagctcaac
cccgaagggaagattcctgtgaaaaattttttccagatgtttcctgctgaccgcaagcgg
gtagaagctgccctcagtgcctgccacctcccaaaaggcaagaatgatgccatcaatcct
gaggacttcccagaatctgtctacaagagtttcctcatgaacctctgtcctcggccagaa
atagacgagatcttcacttcttaccatgccaaggccaaaccctacatgaccaaggagcat
ctgaccaaattcatcaaccagaaacagagggacccccgtctcaactccttgctgtttcca
cctgcgcggcctgaccaggtgcggggcctcatcgacaagtatgaacccagtggcatcaac
gtgcagaggggccagctatcacctgagggcatggtgtggtttctgtgtggcccagagaac
agcgtcctgtcccaggacaagctgctactccaccacgacatgacgcagccactcaaccat
tacttcatcaactcctcacacaacacctacctgacagccggccagttctctggcctctcc
tcggcagagatgtaccgccaggtgctgctggctggctgccgctgtgtggagctggactgc
tggaagggcaagccccctgacgaggagcccatcatcacccatggcttcaccatgaccaca
gacatctatttcaaggaagccattgaagccattgcagaaagtgcctttaagacctccccc
tatcctgtcatcctgtcatttgaaaaccatgtggactcaccccgccaacaggccaagatg
gctgagtactgccggatgatgtttggggatatgctgctcacagagcccttggaaaagttc
ccactgaaaccaggcatccctctgcctagccctgaggatctccgaggcaagatcctcatc
aagaacaaaaagaaccagttttctggcccagcagcccccagcaaggaatccggtggggac
gctgagggcaactgcccacctaatgcctctgtgggtgagggcacagtgtggcctggtgag
gaaggggaagagctggaggaggaagaggtggaggaagaggaggaggaggagtcgggaaac
ctggatgaggaagagatcaagaagatgcagtcggatgagggcacggcgggcctggaggtg
acagcctacgaggagatgtccagcctcgtgaattacatccaacccaccaaattcatctcc
ttcgagctctctgcccagaagaaccgaagttatgtcatctcgtccttcacagagctcaag
gcttatgacctgctctccaaggcctcagtgaagtttgtggactacaacaagcgccagatg
agccgcatttaccctaagggcacccgcatggactcctccaactacatgccccagatgttc
tggaatgctggttgccagatggttgccctcaacttccagactatggacctgcccatgcag
cagaacatggcgctgttcgagttcaatgggcagagtggttacctcctcaagcatgagttc
atgcgccgcccagacaagcagttcaaccccttctcggtggatcgcattgacgtggtggta
gccaccaccctgtccattacggtgatctctgggcagttcctgtctgaacgcagtgtgcgc
acctatgtggaagtagaactctttggccttcctggggaccccaagaggcgctatcgcacc
aggctgtcacccagtgccaactccatcaatcctgtctggaaggaagagccttttgtcttt
gagaagatcttgatgcctgagctggcctctctcagggtggctgtaatggaggaaggcaac
aaatttcttggacaccgcatcatccccattaatgccctgaattctggctaccaccatctg
tgcctgcacagcgagagcaacatgccccttaccatgcctgcgctttttgtcttcttggag
atgaaggactatgtacctgacacctgggcagatctcaccgtggctcttgccaatcccatc
aagttcttcagtgcccacgataagaagtctgtgaagctcaaggaagccatgggagctctg
cctgagaaacccttccccactgggagtccagttgccggccaggtcaatgggccattggcc
ccagtgagcaacggatctgcagcagcccgggccagggccggggaggaggccgccaaagaa
gctgcggagccgcagaccgccagcccggaggagctgcaggagctgaagggcgtcgtgaag
ctgcagcggcggcacgagaaggagctccgggacctggagcggcgcggcgcgcggcgccgg
gaggagctgctgcagaggggcgcggcgcagctggccgggctggggccgccgggcgcgggg
ggctgcgggggccgcaggctcggccccgggaagggctcccgcaagaagaggacttcgccc
tgcgacgaggccgccggggccgcgccccaggaggaccgcgagggccccgagggcgcggac
gcgcgtgcgcgcgagctgaaggaccggctggagctggagttgctgcagcagggcgaggag
cagtacgagtgcatcctgaagcgcaaggagcagcacgtggctgagcaaatcgccaagatg
atggagctggccagagagaagcaggctgcagagctgaagaccctcaaggagaccttggag
actgacactaaagagatgaagaaaaagctggaagccaagaggctggagcggattcaggcc
atggtcaaagtcacctcagacaagatggctcaggaaaggctgaagagagagattaacaac
tcccacatccaggaggtggtgcaagtcattaagcagatgacagagagcctggagaagcac
caggagaagctggaggagaagcaggcagcctgcttggaacagatccgggagatggaaaag
cagttccagcaggaggctctggcagagtacgaggccaggatgaagggcttggaggccgag
gtgaaggagtccgtgagggcctgccttaggggctgcttcccctctgaggccaaggacatg
cctgagaggccctgtgaggccttccgggagctgtgtgagcaggacccactcgcagcaaag
gcaggtgcccaggagagccgcctctga

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