KEGG   Canis familiaris (dog): 415128Help
Entry
415128            CDS       T01007                                 

Gene name
CYP2E1
Definition
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7)
Orthology
K07415  
cytochrome P450, family 2, subfamily E, polypeptide 1 [EC:1.14.13.-]
Organism
cfa  Canis familiaris (dog)
Pathway
Steroid hormone biosynthesis
Arachidonic acid metabolism
Linoleic acid metabolism
Metabolism of xenobiotics by cytochrome P450
Drug metabolism - cytochrome P450
Metabolic pathways
Non-alcoholic fatty liver disease (NAFLD)
Chemical carcinogenesis
Brite
KEGG Orthology (KO) [BR:cfa00001]
 Metabolism
  Lipid metabolism
   00140 Steroid hormone biosynthesis
    415128 (CYP2E1)
   00590 Arachidonic acid metabolism
    415128 (CYP2E1)
   00591 Linoleic acid metabolism
    415128 (CYP2E1)
  Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    415128 (CYP2E1)
   00982 Drug metabolism - cytochrome P450
    415128 (CYP2E1)
 Human Diseases
  Cancers
   05204 Chemical carcinogenesis
    415128 (CYP2E1)
  Endocrine and metabolic diseases
   04932 Non-alcoholic fatty liver disease (NAFLD)
    415128 (CYP2E1)
Enzymes [BR:cfa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors with incorporation of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.-  
     415128 (CYP2E1)
Cytochrome P450 [BR:cfa00199]
 Cytochrome P450, animal type
  CYP2 family
   415128 (CYP2E1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 
Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
UniProt: 
Position
28
AA seq 494 aa AA seqDB search
MAALGITVALLVWMATLMLISIWKQIYSRWKLPPGPFPLPIIGNILQVDIKNVPKSLAKL
AEQYGPVFTLYLGSQRTVVLHGYKAVKEVLLDHKNDLSGRGEVFAFQSHKDRGITFNNGP
GWKDTRRLSLSTLRDYGMGKRGNEERIQREIPFLLEALRGTRGQPFDPTFLLGFAPFNVI
ADILFHKHFDYSDQTGLRIQKLFNENFHLLSTGWLQLYNIFPSYLHYLPGSHRKVLRNVA
ELKDYSLERVKEHQESLDPTCSRDFTDCLLQELQKERYGTEPWYTLDNIAVTVADLFFAG
TETTSTTLRYGLLILMKYPEVEEKLHEEIDRVIGPSRVPAIKDRLEMPYMDAVVHEIQRF
IDLLPSNLPHVANQDTMFRGYVIPKGTVVIPTLDSVLFDKQEFPDPEKFKPEHFLNENGK
FKYSDYFKAFSAGKRVCVGEGLARMELFLFLSAILQHFNLKSLVDPKDIDLSPCTIGFAK
IPPHYKLCVVPRSG
NT seq 1485 nt NT seq  +upstreamnt  +downstreamnt
atggccgccttgggcatcacagtggccctgctggtgtggatggccaccttaatgcttatc
tctatctggaagcagatctacagccgctggaaactgccccctggcccttttccactgccc
atcattgggaatattctgcaggtggatatcaagaatgttcccaaatctctcgccaagctg
gcagagcagtacgggccagtgttcaccttgtacctgggctcccagcgcacagtggtcctg
catggctacaaggcggtgaaggaagttctgcttgaccacaagaatgacctttctggcaga
ggagaagtcttcgcattccagtcgcacaaggacagagggatcacgttcaacaatgggccc
ggctggaaggacacgcggcgactctccctgagcaccctccgggactacggcatggggaag
cgcggcaacgaggagcggatccagagggagatccccttcctgctggaggcgctcaggggc
acccggggccagcccttcgaccccacctttctcctgggcttcgcccccttcaacgtcatc
gctgacatcctcttccacaagcactttgactactcggatcagactgggctgcggatacag
aagctgttcaacgagaacttccacctgctcagcaccggctggctccagctttataacatt
ttcccaagctatctgcactacctgcccggaagccatagaaaagtcttaagaaatgtggct
gaactaaaggattacagcttagaaagggtgaaggagcaccaggagtcgctggaccccacc
tgctcccgggacttcactgactgcttgctccaggagctgcagaaggagagatacggtacg
gagccttggtataccttggacaacattgccgtgaccgtggctgacctgttctttgcgggc
acggagaccaccagcaccaccctgagatacgggctcctgattctcatgaaatacccagag
gtcgaagagaaacttcatgaagaaatcgacagggtgatcggcccaagccgagtccctgcc
atcaaggacaggctggagatgccctacatggatgccgtggtgcacgagattcagcgattc
atcgacctgctgccctccaacctgccccatgtagcaaaccaggacacgatgttcagagga
tatgtcatccccaagggcacagtggtaattcccacactggactccgtcttgtttgacaaa
caagaattccctgatccagagaagttcaagccagagcactttctgaatgaaaacggaaaa
ttcaaatatagtgactacttcaaggcattctccgcaggaaagcgggtgtgtgttggagaa
ggcctggctcgcatggagctcttcctgttcttgtccgccattttgcagcactttaacctg
aagtctctcgtcgaccccaaggatattgacctcagtccctgcacaatcgggtttgccaag
atccccccccattacaaactctgtgtcgttccccgctcgggctga

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