KEGG   Canis familiaris (dog): 477085Help
Entry
477085            CDS       T01007                                 

Gene name
PIK3CB
Definition
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
Orthology
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
Organism
cfa  Canis familiaris (dog)
Pathway
Inositol phosphate metabolism
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Bacterial invasion of epithelial cells
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Hepatitis C
Hepatitis B
Measles
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Brite
KEGG Orthology (KO) [BR:cfa00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    477085 (PIK3CB)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    477085 (PIK3CB)
   04015 Rap1 signaling pathway
    477085 (PIK3CB)
   04012 ErbB signaling pathway
    477085 (PIK3CB)
   04370 VEGF signaling pathway
    477085 (PIK3CB)
   04630 Jak-STAT signaling pathway
    477085 (PIK3CB)
   04668 TNF signaling pathway
    477085 (PIK3CB)
   04066 HIF-1 signaling pathway
    477085 (PIK3CB)
   04068 FoxO signaling pathway
    477085 (PIK3CB)
   04070 Phosphatidylinositol signaling system
    477085 (PIK3CB)
   04024 cAMP signaling pathway
    477085 (PIK3CB)
   04022 cGMP - PKG signaling pathway
    477085 (PIK3CB)
   04151 PI3K-Akt signaling pathway
    477085 (PIK3CB)
   04152 AMPK signaling pathway
    477085 (PIK3CB)
   04150 mTOR signaling pathway
    477085 (PIK3CB)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    477085 (PIK3CB)
  Cell growth and death
   04210 Apoptosis
    477085 (PIK3CB)
  Cell communication
   04510 Focal adhesion
    477085 (PIK3CB)
 Organismal Systems
  Immune system
   04611 Platelet activation
    477085 (PIK3CB)
   04620 Toll-like receptor signaling pathway
    477085 (PIK3CB)
   04650 Natural killer cell mediated cytotoxicity
    477085 (PIK3CB)
   04660 T cell receptor signaling pathway
    477085 (PIK3CB)
   04662 B cell receptor signaling pathway
    477085 (PIK3CB)
   04664 Fc epsilon RI signaling pathway
    477085 (PIK3CB)
   04666 Fc gamma R-mediated phagocytosis
    477085 (PIK3CB)
   04670 Leukocyte transendothelial migration
    477085 (PIK3CB)
   04062 Chemokine signaling pathway
    477085 (PIK3CB)
  Endocrine system
   04910 Insulin signaling pathway
    477085 (PIK3CB)
   04915 Estrogen signaling pathway
    477085 (PIK3CB)
   04914 Progesterone-mediated oocyte maturation
    477085 (PIK3CB)
   04917 Prolactin signaling pathway
    477085 (PIK3CB)
   04921 Oxytocin signaling pathway
    477085 (PIK3CB)
   04919 Thyroid hormone signaling pathway
    477085 (PIK3CB)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    477085 (PIK3CB)
  Digestive system
   04973 Carbohydrate digestion and absorption
    477085 (PIK3CB)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    477085 (PIK3CB)
  Nervous system
   04725 Cholinergic synapse
    477085 (PIK3CB)
   04722 Neurotrophin signaling pathway
    477085 (PIK3CB)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    477085 (PIK3CB)
  Development
   04380 Osteoclast differentiation
    477085 (PIK3CB)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    477085 (PIK3CB)
   05205 Proteoglycans in cancer
    477085 (PIK3CB)
   05203 Viral carcinogenesis
    477085 (PIK3CB)
   05210 Colorectal cancer
    477085 (PIK3CB)
   05212 Pancreatic cancer
    477085 (PIK3CB)
   05214 Glioma
    477085 (PIK3CB)
   05221 Acute myeloid leukemia
    477085 (PIK3CB)
   05220 Chronic myeloid leukemia
    477085 (PIK3CB)
   05218 Melanoma
    477085 (PIK3CB)
   05211 Renal cell carcinoma
    477085 (PIK3CB)
   05215 Prostate cancer
    477085 (PIK3CB)
   05213 Endometrial cancer
    477085 (PIK3CB)
   05222 Small cell lung cancer
    477085 (PIK3CB)
   05223 Non-small cell lung cancer
    477085 (PIK3CB)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    477085 (PIK3CB)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    477085 (PIK3CB)
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    477085 (PIK3CB)
   05166 HTLV-I infection
    477085 (PIK3CB)
   05162 Measles
    477085 (PIK3CB)
   05164 Influenza A
    477085 (PIK3CB)
   05161 Hepatitis B
    477085 (PIK3CB)
   05160 Hepatitis C
    477085 (PIK3CB)
   05169 Epstein-Barr virus infection
    477085 (PIK3CB)
   05146 Amoebiasis
    477085 (PIK3CB)
   05145 Toxoplasmosis
    477085 (PIK3CB)
   05142 Chagas disease (American trypanosomiasis)
    477085 (PIK3CB)
Enzymes [BR:cfa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     477085 (PIK3CB)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
UniProt: 
Position
23
AA seq 1070 aa AA seqDB search
MCFNFIMPPAMADILDIWAVDSQLASDGSIPVDFLLPTGIYIQLEVPREATISYIKQILW
KQVHNYPMFNLLMEIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGE
KLDSKIGVLIGKGLHEFDALKDPEVNDFRIKMRKFSEEKIQSLVGLSWMDWLKQTYPPEH
EPSILENLEDKLYGGKLIVAVHFENCQDVFSFQISPNMNPIKINELAIQKRLTIHGKEDE
VSPNDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNRTLPHFMLVECCKIKKMYEQEMIAI
EAAINRNASNLPLPLPPKKMRIISHVWENNNPFQIVLVKGNKLNTEESVKVHVRAGLFHG
TELLCKTIVSSEISGKNDHIWNEPLEFDINTCDLPRMARLCFAVYAVLDKVKTKKSTKNI
NPCKYQTIRKSGKVHYPVAWVNTMVFDFKGQLRSGDIILHSWSSFPDELEEMLNPMGTVQ
TNPYTENATALHIKFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLAVLKE
ILDRDPLSQLCENEMDLIWTLRQDCRENFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPK
LPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFL
LERALANRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLK
TLNSLIKLNAVKLNKAKGKEAMHTCLKQNAYREALSDLQSPLNPCVILSELYVEKCKYMD
SKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYG
CLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEE
FTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFIL
TYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKD
IQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS
NT seq 3213 nt NT seq  +upstreamnt  +downstreamnt
atgtgcttcaatttcataatgcctcctgctatggcagacatccttgacatctgggcagtg
gattcacagttagcatctgatggctccatacctgtggatttccttttgcccactgggatt
tatattcagttggaggttcctcgggaagctaccatttcctatattaagcagattttatgg
aaacaagttcacaattatccaatgtttaacctccttatggaaattgactcctatatgttt
gcatgtgtgaatcaaactgctgtatatgaggagcttgaagatgaaacaagaagactctgt
gatgtcagaccttttcttccagttctcaaattagtgacaagaagttgtgatccaggggaa
aaattagactcaaaaattggagtccttataggaaaaggtctacatgaatttgatgcactg
aaggatcctgaagtgaatgatttccgaataaaaatgcgcaaattcagtgaggaaaagatt
cagtcacttgtgggattgtcttggatggattggctgaagcagacatatccaccagaacat
gaaccatcgatccttgaaaacttagaagataaactttatggaggaaagctcattgtggct
gttcattttgaaaattgtcaggacgtgtttagctttcaaatatctcctaatatgaatcct
atcaaaataaatgaactggcaatccaaaaacgtttgactattcatgggaaagaagatgaa
gttagccccaatgattatgtgttgcaagtcagtgggagagtagaatatgtatttggtgat
cacccactaattcaattccagtatatccggaactgtgtaatgaacaggactttgccccat
tttatgcttgtggaatgttgcaagattaagaagatgtatgaacaggaaatgattgccata
gaggctgccataaatcgaaatgcatcaaaccttcctcttcctttacccccaaagaaaatg
cgaattatttctcatgtttgggaaaataacaatcctttccaaattgtcttggttaaggga
aataaacttaacacagaagaaagtgtaaaagttcatgtcagggccggcctttttcatggt
actgaactcctctgtaaaaccatcgtaagctcagagatatcagggaaaaatgatcacatt
tggaatgaaccactggaatttgatataaatacttgtgacctgccacgaatggctcgatta
tgttttgctgtttatgcagttttggataaagtgaaaacaaaaaagtcaactaaaaatatt
aatccctgtaaatatcagaccatccggaaatctgggaaagtgcattatcctgtggcatgg
gtaaatacgatggtttttgactttaaaggacagttgagatctggagacataatattgcac
agctggtcttcatttcctgatgaacttgaagaaatgttgaatccaatgggaactgttcaa
acaaatccatatactgaaaatgcaacagctttgcatatcaaattcccagagaataaaaaa
caaccttattattatcctccctttgataagataatcgagaaggcagctgagattgcaagc
agtgacagtgctaatgtatcaagtcgaggtggaaaaaagtttcttgctgtactgaaagaa
atcttggacagggatcctttgtctcaactttgtgagaatgaaatggatcttatatggact
ttgagacaagattgcagagagaattttccacagtcactgccaaaattactgctgtcgatc
aagtggaataagcttgaggatgttgctcagcttcaggcactacttcagatttggcctaaa
ctgcccccccgggaggccttagagcttctagatttcaactatccagatcagtacgtgcga
gaatatgctgtgggctgcctgcgacagatgagtgatgaagaactctctcagtatctttta
caactggtgcaagttttaaaatatgagccttttcttgattgtgccctgtctagattccta
ttagaaagagcgcttgctaatcggaggatagggcagtttctattttggcaccttaggtca
gaagtgcatatccctgctgtctcagtacagtttggtgtcatccttgaagcatattgccgg
ggaagcgtagggcacatgaaagtgctttccaagcaggttgaagcactcaataagttaaaa
actttaaatagtttaatcaaactgaatgcagtgaagctaaacaaagccaaagggaaggag
gccatgcatacttgtttaaaacagaatgcttaccgggaagccctctctgacctgcagtcg
cctctgaatccatgtgttatactttcagaactctatgttgaaaagtgtaaatacatggat
tccaaaatgaagcctttgtggctcgtgtacaacaacaaagtgtttggtgaggattcagtt
ggagtgatttttaaaaatggtgatgatttacgacaagatatgttgacactccagatgctg
cgcttgatggatttactttggaaagaagctggtctggatcttcggatgctgccttatggc
tgtttagcgacaggagaccgctctggcctcattgaagttgtgagcacctctgaaacaatt
gctgacattcagctgaacagtagcaatgtggctgccgcagcagccttcaacaaagatgcc
cttctgaactggcttaaagaatataattctggggatgacctagaccgagccattgaagag
tttaccttgtcctgtgccggctactgtgtagcttcttatgtccttgggattggtgataga
catagtgacaacatcatggtcaaaaaaactggccagctcttccacattgactttggacat
attcttggaaatttcaagtctaaatttggcattaaaagggaacgggtgccttttattctt
acctatgatttcattcatgtgattcaacaaggaaaaacaggaaacacagaaaagtttggc
cgcttccgccagtgttgtgaggatgcatatctgatattacgacggcacgggaatctcttc
atcaccctttttgcactgatgttgactgcagggcttcctgagctcacatcagtcaaggat
atacagtatcttaaggactctcttgccttagggaagagtgaagaagaagcactcaagcaa
tttaagcaaaaatttgatgaggcactcagggaaagctggactactaaagtgaactggatg
gcgcacacagttcggaaagactacagatcttaa

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