KEGG   Canis familiaris (dog): 477160Help
Entry
477160            CDS       T01007                                 

Gene name
PLCB4
Definition
phospholipase C, beta 4
Orthology
K05858  
phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
cfa  Canis familiaris (dog)
Pathway
Inositol phosphate metabolism
Metabolic pathways
Rap1 signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
Phosphatidylinositol signaling system
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Wnt signaling pathway
Gap junction
Platelet activation
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Dopaminergic synapse
Long-term depression
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Alzheimer's disease
Huntington's disease
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Amoebiasis
Pathways in cancer
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:cfa00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    477160 (PLCB4)
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    477160 (PLCB4)
   04310 Wnt signaling pathway
    477160 (PLCB4)
   04020 Calcium signaling pathway
    477160 (PLCB4)
   04070 Phosphatidylinositol signaling system
    477160 (PLCB4)
   04022 cGMP - PKG signaling pathway
    477160 (PLCB4)
 Cellular Processes
  Cellular commiunity
   04540 Gap junction
    477160 (PLCB4)
 Organismal Systems
  Immune system
   04611 Platelet activation
    477160 (PLCB4)
   04062 Chemokine signaling pathway
    477160 (PLCB4)
  Endocrine system
   04911 Insulin secretion
    477160 (PLCB4)
   04912 GnRH signaling pathway
    477160 (PLCB4)
   04915 Estrogen signaling pathway
    477160 (PLCB4)
   04921 Oxytocin signaling pathway
    477160 (PLCB4)
   04918 Thyroid hormone synthesis
    477160 (PLCB4)
   04919 Thyroid hormone signaling pathway
    477160 (PLCB4)
   04916 Melanogenesis
    477160 (PLCB4)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    477160 (PLCB4)
   04270 Vascular smooth muscle contraction
    477160 (PLCB4)
  Digestive system
   04970 Salivary secretion
    477160 (PLCB4)
   04971 Gastric acid secretion
    477160 (PLCB4)
   04972 Pancreatic secretion
    477160 (PLCB4)
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    477160 (PLCB4)
  Nervous system
   04724 Glutamatergic synapse
    477160 (PLCB4)
   04725 Cholinergic synapse
    477160 (PLCB4)
   04728 Dopaminergic synapse
    477160 (PLCB4)
   04726 Serotonergic synapse
    477160 (PLCB4)
   04720 Long-term potentiation
    477160 (PLCB4)
   04730 Long-term depression
    477160 (PLCB4)
   04723 Retrograde endocannabinoid signaling
    477160 (PLCB4)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    477160 (PLCB4)
  Environmental adaptation
   04713 Circadian entrainment
    477160 (PLCB4)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    477160 (PLCB4)
  Neurodegenerative diseases
   05010 Alzheimer's disease
    477160 (PLCB4)
   05016 Huntington's disease
    477160 (PLCB4)
  Infectious diseases
   05146 Amoebiasis
    477160 (PLCB4)
   05142 Chagas disease (American trypanosomiasis)
    477160 (PLCB4)
   05143 African trypanosomiasis
    477160 (PLCB4)
Enzymes [BR:cfa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     477160 (PLCB4)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Ensembl: 
Position
24
AA seq 1187 aa AA seqDB search
MAKPYEFNWQKEVPSFLQEGAIFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVL
ECSLINSIRLGATPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPE
VTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
SKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEKKQLEALKSM
MEAGESAAPVSILEDDNEEEIESADQEEEAHPEYKFGNELSADDLGHKEAVANSVKKASD
DLEHEINKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNI
HYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVS
LNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVI
SGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLA
VLRIAVYDDNNRLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGF
GDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKANVTPQ
SSSELRPTTTAAMGSGVEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAK
EHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSD
HKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLRKLLISAHEQQTQQLKLS
HDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMK
QSKEMDQLKKVQLEHLEFLEKQNEQAKEMQQMVKLEAEMDRRPATVV
NT seq 3564 nt NT seq  +upstreamnt  +downstreamnt
atggccaaaccttatgaatttaattggcagaaggaagttccttcctttttgcaagaagga
gccatttttgacagatatgaagaggaatcctttgtgtttgaacccaactgcctcttcaaa
gtggatgaatttggcttctttctgacctggaggagtgaaggcaaggaaggacaagtgcta
gaatgctccctcatcaacagtattcgattgggagccaccccaaaggatcccaaaatcttg
gccgctcttgaggctgttggaaagtcagagaatgatctggaagggcggatagtttgtgtc
tgcagtggcacagatctggtgaacatcagtttcacatacatggtggctgagaatccagaa
gtaactaagcaatgggtagaaggattgagatcaatcatacataacttcagagccaacaat
gttagtccaatgacctgcctcaagaaacactggatgaaattggcatttatgaccaacaca
aatggtaaaattccagtcaggagtattactagaacgtttgcgtcggggaaaacagaaaaa
gtgatctttcaagcactcaaggagttaggtcttcccagtggaaagaatgatgaaattgag
cctgcagcatttacttatgagaagttctatgaactgacacaaaagatttgtcctcggaca
gatatagaggatctttttaaaaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaatgaacatcagcgagaccctcgactgaatgaaattttattc
ccattttatgatgcaaaaagggcaatgcagatcatcgagatgtatgagcctgatgaagat
ttgaagaaaaaaggcctcatatcaagtgatgggttttgcagatatctgatgtcagatgaa
aatgccccagtcttcctggatcgtttagaactttaccaagaaatggaccaccctctggcc
cactacttcatcagttcttcacataacacctatctcactggccgacagtttggtgggaaa
tcttcagtagaaatgtacagacaggttctcctggctggttgcagatgtgttgaacttgac
tgttgggacggaaaaggtgaagaccaagaaccaataataactcatggaaaagctatgtgt
acagatatcctttttaaggatgttattcaagccatcaaggaaactgcatttgtcacatcc
gaatatcctgtaattctctcctttgaaaatcactgcagcaaatatcaacagtacaagatg
tccaaatattgtgaagatctatttggggatctcctgttgaaacaagcacttgaatcacat
ccacttgaaccaggcaggcccttaccatcccccaatgacctcaaaagaaaaatactcatc
aaaaataaacggctgaaacctgaggttgaaaaaaaacagctcgaggctttgaaaagcatg
atggaagctggagaatctgctgccccagttagcatcctagaggatgataatgaagaggaa
atagaaagtgctgaccaagaggaggaagctcaccctgaatacaaatttggaaatgaactt
tctgctgatgacttgggtcacaaggaggctgttgcaaatagtgtcaagaaggcgtcggat
gaccttgaacatgaaatcaacaaaaagggcctggttactgtagaagatgagcaggcatgg
atggcatcatataagtatgtaggtgctaccactaatatccatccatatttgtctacaatg
atcaactatgcacagcctgtaaagtttcaaggtttccatgtggctgaagagcgcaatatt
cattataacatgtcttcttttaacgagtccgttggtctaggctacttgaagacacatgca
attgaatttgtgaattataacaaacggcaaatgagtcgcatttaccccaagggaggccgg
gttgattccagtaattacatgcctcaaattttctggaatgctggctgccagatggtttcg
ctgaactatcaaaccccagatttagcgatgcaattgaatcagggaaaatttgagtataat
ggatcatgtgggtacctcctcaaaccagatttcatgagacggcccgatcgaacctttgat
ccattctctgaaacgcctgtcgatggggttattgcagccacttgctcagtgcaggtcata
tcaggtcagtttttatcagataagaagattggtacgtacgtagaagtggatatgtatggg
ttgcccaccgacactatccgtaaggaattccgaactcgcatggtgatgaacaatggactc
aatccagtttacaatgaagaatcatttgtgtttcggaaggtaatcctccctgacctggca
gtcttgagaatagcagtgtatgacgacaacaataggctgataggccagaggattcttcca
ctggatggcctccaagcaggctatcgacacatttcccttcgaaacgagggaaataaacca
ttatcactgccaacaattttctgcaatattgttcttaaaacatatgtgcctgatggattt
ggagatattgtggatgctttatcagatccaaagaaatttctttccattacagaaaagaga
gcagaccaaatgagagctatgggcattgaaactagtgacatagcagatgtgcccagcgat
acttctaagaatgacaagaaaggaaaagccaacactgccaaagcaaatgtgaccccacag
agcagctccgagctcagaccaaccaccacagcagccatggggtctggtgtggaagccaag
aaaggtatcgaacttatccctcaagtgaggatagaagatttaaagcagatgaaggcttac
ctgaagcacttaaagaagcaacagaaggagctaaattctttaaagaagaaacatgcgaag
gaacacagcaccatgcagaagttgcactgcacacaagttgacaaaattgtggcacagtat
gacaaagagaagtcgacacatgagaaaatcctagagaaggcgatgaagaagaagggggga
agtaattgtctcgaaatgaaaaaagaaacagaaattaaaattcagacactgacatcagat
cacaaatctaaggtcaaagagatagtggcccagcacacaaaggagtggtcagaaatgatc
aacacccacagtgctgaggagcaagaaatccgggacctgcaccttagccagcagtgtgag
ctcctgagaaagctactgatcagtgcccatgagcagcagacccagcagctgaaactgtcc
catgacagggaaagcaaggaaatgcgagcacaccaggctaagatttctatggaaaacagc
aaagccatcagccaagataaatctatcaagaacaaagcagaacgggaaaggcgagtcagg
gagttaaatagcagcaacaccaaaaagtttctggaagaaagaaagagacttgcaatgaaa
cagtccaaagaaatggatcagttgaaaaaagtccagcttgaacacctagagttcctagag
aaacagaatgagcaggcgaaggagatgcagcagatggtgaaattggaagccgagatggac
cgcagaccagcaacagtagtgtga

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