KEGG   Canis familiaris (dog): 477575Help
Entry
477575            CDS       T01007                                 

Gene name
MAPK1, ERK2
Definition
mitogen-activated protein kinase 1 (EC:2.7.11.24)
Orthology
K04371  
mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
Organism
cfa  Canis familiaris (dog)
Pathway
MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Oocyte meiosis
mTOR signaling pathway
PI3K-Akt signaling pathway
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Dorso-ventral axis formation
TGF-beta signaling pathway
Axon guidance
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Adherens junction
Gap junction
Platelet activation
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Circadian entrainment
Long-term potentiation
Neurotrophin signaling pathway
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Long-term depression
Regulation of actin cytoskeleton
Insulin signaling pathway
GnRH signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Melanogenesis
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Aldosterone-regulated sodium reabsorption
Alzheimer's disease
Prion diseases
Alcoholism
Salmonella infection
Pertussis
Leishmaniasis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Tuberculosis
Hepatitis C
Hepatitis B
Influenza A
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Thyroid cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Brite
KEGG Orthology (KO) [BR:cfa00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    477575 (MAPK1)
   04015 Rap1 signaling pathway
    477575 (MAPK1)
   04010 MAPK signaling pathway
    477575 (MAPK1)
   04012 ErbB signaling pathway
    477575 (MAPK1)
   04350 TGF-beta signaling pathway
    477575 (MAPK1)
   04370 VEGF signaling pathway
    477575 (MAPK1)
   04668 TNF signaling pathway
    477575 (MAPK1)
   04066 HIF-1 signaling pathway
    477575 (MAPK1)
   04068 FoxO signaling pathway
    477575 (MAPK1)
   04022 cGMP - PKG signaling pathway
    477575 (MAPK1)
   04151 PI3K-Akt signaling pathway
    477575 (MAPK1)
   04150 mTOR signaling pathway
    477575 (MAPK1)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    477575 (MAPK1)
  Cell growth and death
   04114 Oocyte meiosis
    477575 (MAPK1)
  Cell communication
   04510 Focal adhesion
    477575 (MAPK1)
   04520 Adherens junction
    477575 (MAPK1)
   04540 Gap junction
    477575 (MAPK1)
 Organismal Systems
  Immune system
   04611 Platelet activation
    477575 (MAPK1)
   04620 Toll-like receptor signaling pathway
    477575 (MAPK1)
   04621 NOD-like receptor signaling pathway
    477575 (MAPK1)
   04650 Natural killer cell mediated cytotoxicity
    477575 (MAPK1)
   04660 T cell receptor signaling pathway
    477575 (MAPK1)
   04662 B cell receptor signaling pathway
    477575 (MAPK1)
   04664 Fc epsilon RI signaling pathway
    477575 (MAPK1)
   04666 Fc gamma R-mediated phagocytosis
    477575 (MAPK1)
   04062 Chemokine signaling pathway
    477575 (MAPK1)
  Endocrine system
   04910 Insulin signaling pathway
    477575 (MAPK1)
   04912 GnRH signaling pathway
    477575 (MAPK1)
   04915 Estrogen signaling pathway
    477575 (MAPK1)
   04914 Progesterone-mediated oocyte maturation
    477575 (MAPK1)
   04917 Prolactin signaling pathway
    477575 (MAPK1)
   04921 Oxytocin signaling pathway
    477575 (MAPK1)
   04919 Thyroid hormone signaling pathway
    477575 (MAPK1)
   04916 Melanogenesis
    477575 (MAPK1)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    477575 (MAPK1)
   04270 Vascular smooth muscle contraction
    477575 (MAPK1)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    477575 (MAPK1)
  Nervous system
   04724 Glutamatergic synapse
    477575 (MAPK1)
   04725 Cholinergic synapse
    477575 (MAPK1)
   04726 Serotonergic synapse
    477575 (MAPK1)
   04720 Long-term potentiation
    477575 (MAPK1)
   04730 Long-term depression
    477575 (MAPK1)
   04723 Retrograde endocannabinoid signaling
    477575 (MAPK1)
   04722 Neurotrophin signaling pathway
    477575 (MAPK1)
  Development
   04320 Dorso-ventral axis formation
    477575 (MAPK1)
   04360 Axon guidance
    477575 (MAPK1)
   04380 Osteoclast differentiation
    477575 (MAPK1)
  Environmental adaptation
   04713 Circadian entrainment
    477575 (MAPK1)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    477575 (MAPK1)
   05205 Proteoglycans in cancer
    477575 (MAPK1)
   05203 Viral carcinogenesis
    477575 (MAPK1)
   05210 Colorectal cancer
    477575 (MAPK1)
   05212 Pancreatic cancer
    477575 (MAPK1)
   05214 Glioma
    477575 (MAPK1)
   05216 Thyroid cancer
    477575 (MAPK1)
   05221 Acute myeloid leukemia
    477575 (MAPK1)
   05220 Chronic myeloid leukemia
    477575 (MAPK1)
   05218 Melanoma
    477575 (MAPK1)
   05211 Renal cell carcinoma
    477575 (MAPK1)
   05219 Bladder cancer
    477575 (MAPK1)
   05215 Prostate cancer
    477575 (MAPK1)
   05213 Endometrial cancer
    477575 (MAPK1)
   05223 Non-small cell lung cancer
    477575 (MAPK1)
  Neurodegenerative diseases
   05010 Alzheimer's disease
    477575 (MAPK1)
   05020 Prion diseases
    477575 (MAPK1)
  Substance dependence
   05034 Alcoholism
    477575 (MAPK1)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    477575 (MAPK1)
  Infectious diseases
   05132 Salmonella infection
    477575 (MAPK1)
   05133 Pertussis
    477575 (MAPK1)
   05152 Tuberculosis
    477575 (MAPK1)
   05164 Influenza A
    477575 (MAPK1)
   05161 Hepatitis B
    477575 (MAPK1)
   05160 Hepatitis C
    477575 (MAPK1)
   05145 Toxoplasmosis
    477575 (MAPK1)
   05140 Leishmaniasis
    477575 (MAPK1)
   05142 Chagas disease (American trypanosomiasis)
    477575 (MAPK1)
Enzymes [BR:cfa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     477575 (MAPK1)
Protein kinases [BR:cfa01001]
 Serine/threonine protein kinases: CMGC group
  MAPK family [OT]
   477575 (MAPK1)
Exosome [BR:cfa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   477575 (MAPK1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Ensembl: 
UniProt: 
Position
26
AA seq 360 aa AA seqDB search
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
NT seq 1083 nt NT seq  +upstreamnt  +downstreamnt
atggcggcggcggcggcggcgggcgcgggcccggagatggtccgcgggcaggtgttcgac
gtggggccgcgctacaccaacctctcctacatcggcgagggcgcctacggcatggtgtgc
tctgcttatgataatgtcaacaaagttcgagtagccatcaagaaaatcagtccttttgag
caccagacctactgccagagaaccctgagggagataaaaatcttactgcgcttcagacat
gagaacatcattggaatcaatgatattattcgagcaccaaccatcgagcaaatgaaagat
gtatatatagtacaagacctcatggaaacagatctttacaagctcttgaagacgcaacac
ctcagcaacgaccatatctgctattttctttaccagatcctcagagggttaaaatatatc
cattcagctaatgtactgcaccgtgacctcaaaccttccaacctgctgctcaataccacc
tgcgatctcaagatctgtgactttggcttggcccgtgttgcagatccggatcatgatcac
acagggttcctgacggagtatgtagccacacgttggtacagggctccagaaattatgttg
aattccaagggctataccaagtccattgatatttggtctgtaggctgcattctggcagag
atgctgtccaacaggcccatcttcccggggaagcattatctcgaccagctgaaccacatt
ttgggtattcttggatccccatcacaggaagacctgaactgtataataaatttaaaagct
agaaactacttgctttctcttccacacaaaaataaggtgccatggaacaggctgttccca
aatgctgactcgaaagctctggatttactggacaaaatgttgacattcaaccctcacaag
aggattgaagtagaacaggctctggcccatccgtatctggagcagtattatgacccaagt
gatgagcccatcgctgaggcgccattcaagtttgacatggagctagatgacctgcccaag
gaaaagctcaaggagctcatcttcgaagagacagctagattccagccgggatacagatct
taa

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