KEGG   Canis familiaris (dog): 478232Help
Entry
478232            CDS       T01007                                 

Gene name
MTOR, FRAP1
Definition
mechanistic target of rapamycin (serine/threonine kinase)
Orthology
K07203  
FKBP12-rapamycin complex-associated protein
Organism
cfa  Canis familiaris (dog)
Pathway
ErbB signaling pathway
HIF-1 signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Insulin signaling pathway
Thyroid hormone signaling pathway
Adipocytokine signaling pathway
Type II diabetes mellitus
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Glioma
Prostate cancer
Acute myeloid leukemia
Brite
KEGG Orthology (KO) [BR:cfa00001]
 Environmental Information Processing
  Signal transduction
   04012 ErbB signaling pathway
    478232 (MTOR)
   04066 HIF-1 signaling pathway
    478232 (MTOR)
   04151 PI3K-Akt signaling pathway
    478232 (MTOR)
   04152 AMPK signaling pathway
    478232 (MTOR)
   04150 mTOR signaling pathway
    478232 (MTOR)
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    478232 (MTOR)
   04920 Adipocytokine signaling pathway
    478232 (MTOR)
   04919 Thyroid hormone signaling pathway
    478232 (MTOR)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    478232 (MTOR)
   05206 MicroRNAs in cancer
    478232 (MTOR)
   05205 Proteoglycans in cancer
    478232 (MTOR)
   05214 Glioma
    478232 (MTOR)
   05221 Acute myeloid leukemia
    478232 (MTOR)
   05215 Prostate cancer
    478232 (MTOR)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    478232 (MTOR)
Protein kinases [BR:cfa01001]
 Serine/threonine protein kinases: Atypical group
  PIKK family [Table]
   478232 (MTOR)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Ensembl: 
UniProt: 
Position
2
AA seq 2550 aa AA seqDB search
MLGTGPAAATAATTTSSNVSVLQQFASGLKSRNEETRAKAAKELQHYVTMELREMSQEES
TRFYDQLNHHIFELVSSSDANERKGGILAIASLIGVEGGNATRIGRFANYLRNLLPSNDP
VVMEMASKAIGRLAMAGDTFTAEYVEFEVKRALEWLGADRNEGRRHAAVLVLRELAVSVP
TFFFQQVQPFFDNIFVAVWDPKQAIREGAVAALRACLILTTQREPKEMQKPQWYRHTFEE
AEKGFDETLAKEKGMNRDDRIHGALLILNELVRISSMEGERLREEMEEITQQQLVHDKYC
KDLMGFGTKPRHITPFTSFQAVQPPQSNALVGLLGYSSHQGLMGFGASPSPAKSTLVESR
CCRDLMEEKFDQVCQWVLKCRNSKNSLIQMTILNLLPRLAAFRPSAFTDTQYLQDTMNHV
LSCVKKEKERTAAFQALGLLSVAVRSEFKVYLPRVLDIIRAALPPKDFAHKRQKAMQVDA
TVFTCISMLARAMGPGIQQDIKELLEPMLAVGLSPALTAVLYDLSRQIPQLKKDIQDGLL
KMLSLVLMHKPLRHPGMPKGLAHQLASPGLTALPEASDVGSITLALRTLGSFEFEGHSLT
QFVRHCADHFLNSEHKEIRMEAARTCSRLLTPSVHLISGHAHVVSQTAVQVVADVLSKLL
VVGITDPDPDIRYCVLASLDERFDAHLAQAENLQALFVALNDQVFEIRELAICTVGRLSS
MNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALI
LKLKDPDPDPNPGVINNVLATIGELAQVSGLEMRKWVDELFIIIMDMLQDSSLLAKRQVA
LWTLGQLVASTGYVVEPYRKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHK
VNIGMIDQSRDASAVSLSESKSSQDSSDYSTSEMLVNMGNLPLDEFYPAVSMVALMRIFR
DQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNVIRVCDGAIREFLFQQLGMLV
SFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIILLIEQIVVALGGEFKLYLPQLIPHMLR
VFMHDNSPGRIVSIKLLAAIQLFGANLDDYLHLLLPPIVKLFDAPEVPLPSRKAALETVD
RLTESLDFTDYASRIIHPIVRTLDQSPELRPTAMDTLSSLVFQLGKKYQIFIPMVNKVLV
RHRINHQRYDVLICRIVKGYTLADEEEDPLIYQHRMLRSGQGDALASGPVETGPMKKLHV
STINLQKAWGAARRVSKDDWLEWLRRLSLELLKDSSSPSLRSCWALAQAYNPMARDLFNA
AFVSCWSELNEDQQDELIRSIELALTSQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGI
VLLGERAAKCRAYAKALHYKELEFQKGPTPAILESLISINNKLQQPEAAAGVLEYAMKHF
GELEIQATWYEKLHEWEDALVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEK
WTLVNDETQAKMARMAAAAAWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLA
QQCIDKARDLLDAELTAMAGESYSRAYGAMVSCHMLSELEEVIQYKLVPERREIIRQIWW
ERLQGCQRIVEDWQKILMVRSLVVSPHEDMRTWLKYASLCGKSGRLALAHKTLVLLLGVD
PSRQLDHPLPTVHPQVTYAYMKNMWKSTRKIDAFQHMQHFVQTMQQQAQHAIATEDQQHK
QELHKLMARCFLKLGEWQLNLQGINESTIPKVLQYYSAATEHDRSWYKAWHAWAVMNFEA
VLHYKHQNQARDEKKKLRHASGANITSTTTAATTAATATATATSTEGSNSESEAESTENS
PTPSPLQKKVTEDLSKTLLMYTVPAVQGFFRSISLSRGNNLQDTLRVLTLWFDYGHWPDV
NEALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVA
SKSTTTARHNAANKILKNMCEHSNTLVQQAMMVSEELIRVAILWHEMWHEGLEEASRLYF
GERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQ
AWDLYYHVFRRISKQLPQLTSLELQYVSPKLLMCRDLELAVPGTYDPNQPIIRIQSIAPS
LQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKN
LSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDYDHLT
LMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDR
HPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRIT
CHTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKGNKRSRTRTDSYSAGQSVEILD
GVELGEPAHKKTGTTVPESIHSFIGDGLVKPEALNKKAIQIINRVRDKLTGRDFSHDETL
DVPTQVELLIKQATSHENLCQCYIGWCPFW
NT seq 7653 nt NT seq  +upstreamnt  +downstreamnt
atgcttggaaccggacctgctgccgccaccgcagccaccaccacgtcgagtaacgtgagc
gtcctacagcagttcgccagcggcctgaagagccggaatgaggagaccagggccaaggct
gccaaggagctccaacactatgtcaccatggagctccgagagatgagtcaagaggagtct
actcgcttctatgaccagctgaaccatcacatttttgaactggtttccagctcagatgcc
aatgaaaggaaaggtggcatcttggccatagccagcctcataggagtggaaggtgggaat
gccactcggattggcagattcgctaactatcttcggaacctcctcccctctaatgaccca
gttgtaatggagatggcatccaaggccattggccgccttgccatggcaggggacactttt
acggctgagtatgtggagtttgaggtgaagcgagccttggagtggctgggcgccgaccgc
aacgagggccggagacacgcagctgttctagttctccgtgagctggctgtcagcgtcccc
accttcttcttccagcaagtgcaacccttctttgacaacatttttgtggctgtatgggac
cccaaacaggccatccgtgagggagctgtggctgcccttcgtgcctgtttgatcctcacc
acccagcgtgagccgaaggagatgcagaagcctcagtggtatcggcacacgtttgaagaa
gcagagaaagggtttgatgagacattggccaaggagaagggcatgaatcgggatgatcgc
atccatggagccttgctgatcctcaacgagttggtccgaatcagcagcatggagggagag
cgcctgagagaagaaatggaggagatcacgcagcagcagctggtgcacgacaagtactgc
aaggacctcatgggcttcgggacgaaacctcgccacatcacgcccttcaccagtttccag
gctgtccagcccccgcagtccaacgccttggtgggactgctggggtacagctctcaccaa
ggcctcatggggttcggggcttcccccagcccagccaagtccaccctggtggagagtcgg
tgttgccgagacctgatggaggagaagttcgatcaggtgtgccagtgggtgctgaagtgc
aggaacagcaagaactcgctgatccaaatgacaatccttaatttgttgccccgcctggcc
gcgttccgaccttctgccttcacagatacccagtacctccaagataccatgaaccatgtg
ttaagctgcgtcaagaaggagaaggaacgtacagcagccttccaagccctggggctgctt
tccgtggctgtgagatctgagtttaaggtctatttacctcgtgtgctggacatcatccgt
gcagccctaccccctaaggactttgcccataagagacagaaggccatgcaggtggatgcc
acagtgttcacctgcatcagcatgctggcccgggcaatggggccgggcatccaacaagat
atcaaggagctgctggagcccatgctggcagtgggactgagccctgccctcactgctgtg
ctctacgacctgagccgtcagattccgcagctgaagaaggacatccaggatgggctcctg
aagatgctgtccctggtcctgatgcacaaacccctccggcacccgggcatgcccaagggc
ctggcccaccagctagcttcccccggcctcacagccctccccgaggccagcgatgtgggc
agcattactcttgccctgcgaactcttggcagctttgagtttgaaggccactctctgacc
cagtttgtccgccactgtgcggatcatttcctaaacagcgagcacaaggagatccgcatg
gaagctgcccgcacctgctcccgcctgctcacgccctccgtccacctcatcagtggccac
gctcatgtggtcagccagactgcagtgcaagtggtggcagacgtgctcagcaaactgctt
gtggttgggataacagatcctgaccctgacatccgctactgtgtcttggcgtccctggat
gagcgctttgatgcacacctggcccaggcagagaatttgcaggccctgtttgtggccctg
aacgaccaggtgtttgagatccgggagctggccatctgcaccgtgggccggctcagtagc
atgaacccggccttcgtcatgcctttcctgcgcaagatgctcatccagattctgacagag
ctggagcacagcggtattggaagaatcaaagagcagagtgcccgcatgctggggcacctg
gtctccaatgccccccggctcatccgcccctacatggagcccatcctgaaggctttaatt
ttgaaactgaaagatccagaccctgatccaaacccaggtgtgatcaacaatgtcttggct
acaattggagaattggctcaggttagtggcctagagatgaggaagtgggtggatgaactc
tttattatcatcatggacatgctccaggactcctctctgttggccaaaaggcaggtggct
ctgtggaccctgggacagttggtggccagcactggctacgtggtggagccctaccggaag
taccccactttgcttgaggtcctgctgaattttctgaagactgagcagaaccagggtaca
cggagagaggctatccgtgtgttagggcttttgggggccctggatccctacaagcacaaa
gtgaacatcggcatgattgaccagtcccgcgacgcttctgctgtcagcctgtctgaatcc
aagtcaagtcaggattcctccgactacagcaccagtgagatgctggtcaacatgggcaac
ctgcccctggacgagttctaccccgccgtgtccatggtggcgctgatgcggatcttccga
gaccagtccctctcgcaccatcacaccatggttgtccaggccatcaccttcatcttcaag
tccctgggcctcaagtgtgtgcagtttctgccgcaggtcatgcccacattcctcaatgtc
attcgggtctgcgatggggccatccgggaattcctgttccagcagctgggaatgttggtg
tcctttgtgaagagccacatcagaccttacatggatgaaatagtcaccctcatgagagaa
ttctgggtcatgaacacctcgatccagagcacaatcattcttctcattgagcaaattgtg
gtagctcttgggggtgaatttaagctctacctgccccagctgatcccacacatgctccgc
gtcttcatgcatgataacagcccaggccgcatcgtctccatcaagctgttggctgccatc
cagctgtttggtgccaacctggatgactatctgcatttgttgttgcctcctatcgtgaag
ctgtttgacgccccggaagttcccctgccgtctcggaaggcagcgctagagaccgtagac
cgcctgacagagtccctggacttcactgactatgcctcccgtatcattcatccgattgtt
cggacgctagaccagagcccggagctgcgtcccacagccatggacacattgtcttcactg
gtcttccaactggggaagaagtaccaaattttcattccaatggtgaataaagtcctggtg
cgacaccgaatcaaccatcagcgctacgacgtcctcatctgcagaatcgtcaagggatac
acccttgctgacgaggaagaggaccctttgatttatcagcatcgaatgctgaggagcggc
caaggggatgcgttggctagtgggccagtagaaacgggacccatgaagaaactgcacgtc
agcaccatcaacctccaaaaggcctggggagctgccagaagggtctccaaagacgactgg
ctggaatggctgaggcggctgagtctggagctcctgaaggactcctcgtcgccttccctg
cgctcgtgctgggccctggctcaggcctacaacccgatggccagggatctctttaatgct
gcatttgtgtcctgctggtctgaactgaatgaagaccagcaggatgaactcatcagaagc
atcgagttggccctcacctcacaggacattgccgaagtcacgcagaccctcttaaacttg
gctgaattcatggaacacagtgacaagggccccctgccattgagagacgacaatggcatt
gtcctgctgggtgagagggcagccaagtgccgagcatatgccaaagcgctgcactacaaa
gaactggagttccagaaaggtcccacccccgccatcctagagtctctcatcagcattaat
aataagctacagcagccagaggcagcggccggggtgttggaatatgccatgaaacacttc
ggagagctggagatccaggctacctggtacgagaaactgcatgagtgggaggatgcgctg
gtggcctatgataagaagatggacacgaacaaggatgaccccgagctgatgctgggccgc
atgcgctgcctcgaggccttgggggaatgggggcagctccaccagcagtgctgtgaaaag
tggaccctggttaatgacgagacccaagccaagatggcccgcatggctgctgcagctgcg
tggggcttaggccagtgggacagcatggaggagtacacctgtatgatccctcgggacacc
cacgatggggcattttatagagccgtgctggcgctgcatcaggacctcttctccttggct
caacagtgcatcgacaaagccagagacctgctggatgcggagttaactgctatggcagga
gagagctacagtcgggcatatggggccatggtttcttgccacatgctgtccgagctggag
gaggttatccagtacaaacttgtccccgagcgacgggagatcatccgccagatctggtgg
gagagactgcagggctgccagcgcatcgtggaagactggcagaaaatcctcatggtgcgg
tcgctggtggtcagccctcacgaggacatgaggacctggctcaagtatgccagcctgtgt
gggaagagcggtaggctggcccttgctcataaaaccttagtgttgctcctgggagtcgac
ccatctcggcagcttgaccatcctctgccaacagtgcaccctcaggtgacctacgcctac
atgaaaaacatgtggaagagcactcgcaagatcgatgccttccagcacatgcagcacttc
gtgcagaccatgcagcagcaagcgcagcatgccatcgcgaccgaggaccagcagcacaag
caagagctgcacaaactcatggcccggtgtttcctgaaactcggggagtggcagctgaac
cttcagggcatcaacgagagcacaatccccaaggtgctgcagtactacagcgctgccacg
gagcatgaccgcagctggtacaaggcctggcatgcgtgggcggtgatgaactttgaagct
gtgctgcactacaaacaccagaaccaagcccgggacgagaagaagaagctgcgtcacgcc
agcggggccaacatcaccagcacgaccaccgccgccaccacagcagccacggccacggcc
acggccaccagcaccgagggcagcaacagcgagagtgaggccgagagcaccgagaacagc
cccaccccgtctcctctgcagaagaaggtcactgaggatttgtccaagaccctcttgatg
tacacggtccccgccgtccagggcttcttccgttccatctccttgtcacgaggcaacaac
ctccaggacacactgagagtcctcaccttatggtttgactatggtcactggccggatgta
aacgaagccttggtggagggggtgaaagcgatccagatcgacacctggttacaggttata
cctcagctcattgcgagaatcgatacgcctcggcccttggtgggccgcctcattcaccag
cttctcacagacattggccggtaccacccccaggccctcatctaccccctgaccgtggcc
tctaaatccaccacgacggcccgccacaacgcagccaacaagattctgaagaacatgtgc
gagcacagcaacaccctggtccagcaggccatgatggtgagtgaggagctcatccgcgtg
gccatcctctggcacgagatgtggcacgaaggcctggaagaagcgtcacgtttgtacttt
ggggagaggaacgtgaaaggcatgtttgaggtgctggagcccctgcatgctatgatggaa
cggggcccccagactctgaaggaaacatcttttaatcaggcatatggtcgagacttaatg
gaggcccaggagtggtgcaggaagtacatgaaatccgggaacgtcaaggacctcacccag
gcctgggacctctattaccacgtgttcagacggatctccaagcagctgcctcagctcacc
tccctggaactgcagtatgtttcccccaaacttctgatgtgccgggaccttgagttggcc
gtgccgggaacgtacgaccccaaccagcccatcattcgcattcagtccatagcaccgtcc
ctgcaggtcatcacctccaagcagaggccccggaagctgacgctcatgggcagcaacggg
catgagtttgttttcctcctgaagggccacgaagacctgcggcaggatgagcgggtgatg
cagctcttcggcctggtgaacacccttctggccaatgacccaacgtctcttcgcaagaac
ctcagcatccagaggtacgctgtcatccccttatcaaccaactcgggcctcattggctgg
gtcccccactgcgacacgctgcacgccctcatccgggactacagagagaaaaagaagatc
cttctcaacatcgagcatcgcatcatgttgcggatggctccagactacgatcacctgacg
ctgatgcagaaggtggaggtgtttgagcacgccgtcaacaacacagccggggacgacctg
gccaagctgctgtggctgaaaagccctagctccgaggtatggtttgaccgaagaaccaac
tacacccgctctttagcggtcatgtccatggttgggtatattttgggcctgggagataga
cacccatccaatctgatgcttgaccggctgagtgggaagatcctgcacatcgactttggg
gactgctttgaggttgctatgaccagagagaaattcccagagaagattccatttagacta
acgagaatgctgaccaatgctatggaggttacgggtctggacggcaactacagaatcacg
tgccacacggtgatggaggtgcttcgggaacacaaggacagcgtcatggccgtgctggaa
gcctttgtctacgaccccttgctgaactggaggctgatggacacaaataccaaaggcaac
aagcggtcccgaacaaggacagattcctactctgctggccagtcagtagaaattttggat
ggtgtggaacttggggaacccgcccacaagaaaacagggaccacagtgccggaatctatc
cattctttcattggagacggtttggtgaagccagaggccctaaataagaaagctatccag
ataattaacagggttcgagataagctcactgggcgggacttttctcacgatgaaaccctg
gatgtcccgacacaagtcgagctgctcatcaaacaggccacatcccacgagaacctgtgt
cagtgctacatcggctggtgtcctttctggtaa

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