KEGG   Canis lupus familiaris (dog): 481105
Entry
481105            CDS       T01007                                 
Symbol
ERBB3
Name
(RefSeq) receptor tyrosine-protein kinase erbB-3 isoform X1
  KO
K05084  receptor tyrosine-protein kinase erbB-3 [EC:2.7.10.1]
Organism
cfa  Canis lupus familiaris (dog)
Pathway
cfa01521  EGFR tyrosine kinase inhibitor resistance
cfa04010  MAPK signaling pathway
cfa04012  ErbB signaling pathway
cfa04020  Calcium signaling pathway
cfa04151  PI3K-Akt signaling pathway
cfa05205  Proteoglycans in cancer
cfa05206  MicroRNAs in cancer
Brite
KEGG Orthology (KO) [BR:cfa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    481105 (ERBB3)
   04012 ErbB signaling pathway
    481105 (ERBB3)
   04020 Calcium signaling pathway
    481105 (ERBB3)
   04151 PI3K-Akt signaling pathway
    481105 (ERBB3)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    481105 (ERBB3)
   05205 Proteoglycans in cancer
    481105 (ERBB3)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    481105 (ERBB3)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:cfa01001]
    481105 (ERBB3)
Enzymes [BR:cfa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     481105 (ERBB3)
Protein kinases [BR:cfa01001]
 Receptor tyrosine kinases (RTK)
  EGFR family [OT]
   481105 (ERBB3)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Recep_L_domain GF_recep_IV Furin-like Pkinase Kinase-like TM_ErbB1 DUF4381
Other DBs
NCBI-GeneID: 481105
NCBI-ProteinID: XP_038488454
Ensembl: ENSCAFG00000000097
VGNC: 54147
Position
10:468642..486495
AA seq 1312 aa
MCPGTLNGLSVTGDAENQYQTLYKLYERCEVVMGNLEIVLTGHNADLSFLQWIREVTGYV
LVAMNEFPTLPLPNLRVVRGTQVYDGKFAIFVMLNYNTNSSHALRQLRFTQLTEILAGGV
YIEKNDKLCHMDTIDWRDIVRDRDAEIVVKDNGRSCPPCHETCKGRCWGPRPEDCQTLTK
TICAPQCNGHCFGPNPNQCCHDECAGGCSGPQDTDCFACRLFNDSGACVRQCPQPLVYNK
LTFQLEPNPHTKYQYGGVCVASCPHNFVVDQTSCVRACPPDKMEVDKNGLKMCEPCGGLC
PKACEGTGSGSRFQTVDSSNIDGFVNCTKILGNLDFLITGLNGDPWHKIPALDPEKLNVF
RTVREITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIMKNLNITSLGLRSLK
EISAGRIYISANKQLCYHHSLNWTRLLRGPPEERLDIKHNRPRRDCVAEGKVCDPLCSSG
GCWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEPREFAHEAECFSCHPECQPMEGTATCNG
SGSDACAQCAHFRDGPHCVSSCPNGVLGAKGPIYKYPDTHNECRPCHENCTQGCKGPELQ
DCLGQTLALISKTHLAVGLTVVVGLAVIFLILGGTLLYWRGRRIQNKRAMRRYLERGESI
EPLDPSEKANKVLARIFKETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDK
SGRQSFQDVTDHMLAIGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRGALG
PQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLL
HSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKG
ERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEFTRMARDPPRYLVIKRESGPGIP
PGAEPPALTNKELEEVELEPELELDLDLETEEDGLAATLNSALGLPVGTLNRPRGSQSLL
SPSSGYMPMNQGNLGDTCQESAICGTGERCPRPASLHPMPRGRLASESSEGHVTGSEAEL
QEKASMCRSRSRSPRPRGDSAYHSQRHSLLTPVTPLSPPGLEEEDVNGYVMPDAHLKGTP
SSREGTLSSVGISSVLGTEEEEEDEEYEYMNRRRRHSPPRHPRPSSLEELGYEYMDVGSD
LSASLGSTQSCPLNPVPLMPAAGTTPDEDYEYMNRRHAGGAPGGDYAAMGACPAAEQGYE
EMRAFQGPGNHAPHVHCARLKPLRSLEATDSAFDNPDYWHSRLFPKADAQRT
NT seq 3939 nt   +upstreamnt  +downstreamnt
atgtgtcccgggactctgaacgggctgagcgtgaccggcgacgctgagaaccaataccag
accctgtacaagctctacgagcggtgcgaggtggtgatggggaacctcgagatcgtgctc
acagggcacaatgccgacctctccttcctgcagtggatccgagaagtgaccggctatgtc
ctggtggccatgaacgagttccccaccctgcccctgcccaacctccgggtggtgcggggc
actcaggtgtacgacgggaagttcgccatcttcgtcatgctcaactataacaccaactcc
agccatgccctgcgccagctccgcttcactcagctcacggagattctggcggggggagtg
tatattgagaagaacgacaagctttgtcacatggacacgatcgactggagggacatcgtg
agggaccgagacgcagagatagtggtgaaggacaacggcaggagctgtcccccgtgtcat
gagacctgcaaggggcgatgctggggtcctagaccagaagactgccagacattgaccaag
accatctgtgcccctcagtgtaatggtcattgctttgggcccaaccccaaccagtgctgc
catgatgagtgtgcagggggctgctcaggccctcaggatacagactgctttgcctgccga
ctcttcaatgacagcggggcctgtgtgcgccagtgtccacagcctctggtctacaacaag
ctaactttccagctggaacccaatccccacaccaagtatcagtatggtggagtttgtgta
gccagctgtccccataactttgtggtcgatcaaacgtcttgtgtccgggcctgtcctcct
gacaagatggaagtagataaaaatggactcaagatgtgtgaaccttgtggggggctgtgc
cccaaagcctgtgaggggacaggctccgggagccgcttccagactgtggactcgagcaac
attgatggatttgtgaactgcaccaagatcctgggcaacctggactttctgatcactggc
ctcaatggagacccctggcacaagatccctgccttggaccctgagaagctcaatgtcttc
cggacagtacgggagatcacaggttacctgaacatccagtcctggcctccccacatgcac
aacttcagtgtcttttccaacctgacaaccattgggggcagaagcctatacaaccggggt
ttctctttgctgatcatgaagaacttgaatataacatctttgggcctccgatctttgaaa
gaaattagtgctgggcgtatttacataagtgccaacaagcaactctgctaccaccattct
ctgaactggaccaggctgcttcgggggcctccagaagagaggctggacatcaagcataat
cggccccgcagagactgcgtggcagagggcaaagtgtgtgatcccctgtgctcctctggg
ggatgctggggcccaggtcctggtcagtgcctgtcctgtcgaaactacagccgaggaggt
gtctgtgtgacccactgcaactttctaaatggggagcctcgtgagtttgcccatgaagct
gaatgcttctcctgccacccggagtgccaacccatggaggggactgccacatgcaatggc
tcgggctctgatgcctgtgctcagtgtgcccattttcgagatgggccgcactgtgtgagc
agctgccccaatggagtcctcggtgccaagggccccatctacaagtacccagacactcac
aatgaatgtcggccctgccacgagaattgcacccaggggtgtaagggaccagagctacaa
gactgtttaggtcaaacactggcactgatcagcaaaacccatctggcagtgggcttaaca
gtggtagtgggattggcagtgattttcctgatcctgggaggcactttactctattggcgt
gggcgccggattcagaataagagggctatgcggcgctacttggaacggggtgagagcata
gagcctctggatcccagtgagaaggctaacaaagtcttggccagaatcttcaaagaaaca
gagctgaggaagcttaaagtccttggctcaggcgtctttggaaccgtgcacaaaggagta
tggattcctgagggtgaatcaatcaagattccagtctgcattaaagtcatcgaggacaag
agtggacggcagagttttcaagatgtgacggatcatatgctggccattggcagcctagac
catgcccacattgtacggctgctgggactgtgcccagggtcatctctgcagctcgtcact
cagtacttgcctctgggttccctgctggatcatgtgagacaacaccgtggagcactgggg
ccccagctgctgctcaattggggagtacagattgccaaggggatgtactaccttgaggag
catggtatggtgcataggaacctggcggcccgaaatgtgctactgaagtcaccaagtcag
gtccaggtggcagattttggggtggctgacctgctgccccccgatgataagcaactacta
cacagtgaggccaagactccaattaagtggatggccctggagagtatccactttggaaaa
tacacacatcagagtgacgtctggagttatggagtgacagtttgggagctgatgaccttt
ggggcagagccctatgctgggctacgattggccgaagtaccagatctgctagagaagggg
gagcgattggcacagccccagatctgtaccattgatgtctacatggtcatggtcaagtgc
tggatgattgatgagaacatccgtccaacctttaaagaactagccaatgagttcaccagg
atggcccgagaccccccacggtatctggtcataaagagagagagtgggcctggaattccc
cccggggcagagccccctgctctgacaaacaaggaactggaggaggtggagctggagcca
gaactggagctagatctggacttggagacggaggaggatggcctggcggccacactaaac
tctgccctcggtttgccagttggaacacttaatcggccccgtgggagccagagcctctta
agcccatcatctggatatatgcctatgaaccagggtaaccttggggacacctgccaggag
tctgccatttgtgggactggtgagcggtgcccccgtccagcctctttgcacccaatgcca
cggggacgcctggcatcagagtcctcagagggccatgtgacagggtccgaggctgagctc
caggagaaggcatcaatgtgtagaagccggagccggagcccacggccacgaggagacagt
gcctaccattcccagcgccacagcctgctcactcctgtcaccccactctccccaccaggg
ttggaggaagaggatgtcaatggatatgtcatgccagatgcacacctcaaaggtactccc
tcctcccgggaaggcaccctttcttcagtgggcatcagttctgtcctgggtactgaagaa
gaggaggaagatgaggagtatgaatatatgaaccggaggagaagacacagtccacctcgt
caccctaggcccagttctctcgaggagctgggttatgagtacatggatgtgggatcagac
ctcagcgcttccctgggcagcacacagagttgcccactcaaccctgtgcccctcatgccc
gctgctggcacaaccccagatgaggactatgaatatatgaatcggcgacatgctggagga
gctcctgggggagactatgcagccatgggggcctgcccagccgctgagcaagggtatgaa
gagatgagagctttccaggggcctggaaaccatgctccgcatgtccactgtgcccgcctc
aaacctctacgtagtttagaagccactgactccgctttcgataatcctgattactggcat
agcaggcttttccccaaggctgatgctcagagaacataa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (7)   
   KEGG PATHWAY (7)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (36)   
   KEGG ORTHOLOGY (1)   
   RefGene (30)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   VGNC (1)   
Protein sequence (9)   
   RefSeq(pep) (9)   
DNA sequence (9)   
   RefSeq(nuc) (9)   
Protein domain (8)   
   Pfam (8)   
All databases (74)   

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