KEGG   Canis familiaris (dog): 483042Help
Entry
483042            CDS       T01007                                 

Gene name
SOS1
Definition
(RefSeq) SOS Ras/Rac guanine nucleotide exchange factor 1
  KO
K03099  
son of sevenless
Organism
cfa  Canis familiaris (dog)
Pathway
EGFR tyrosine kinase inhibitor resistance
Endocrine resistance
MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Chemokine signaling pathway
FoxO signaling pathway
Phospholipase D signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
Dorso-ventral axis formation
Focal adhesion
Gap junction
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Neurotrophin signaling pathway
Regulation of actin cytoskeleton
Insulin signaling pathway
GnRH signaling pathway
Estrogen signaling pathway
Prolactin signaling pathway
Alcoholism
Hepatitis C
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Renal cell carcinoma
Endometrial cancer
Glioma
Prostate cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Breast cancer
Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:cfa00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    483042 (SOS1)
   04010 MAPK signaling pathway
    483042 (SOS1)
   04012 ErbB signaling pathway
    483042 (SOS1)
   04630 Jak-STAT signaling pathway
    483042 (SOS1)
   04068 FoxO signaling pathway
    483042 (SOS1)
   04072 Phospholipase D signaling pathway
    483042 (SOS1)
   04151 PI3K-Akt signaling pathway
    483042 (SOS1)
   04150 mTOR signaling pathway
    483042 (SOS1)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    483042 (SOS1)
  Cellular community - eukaryotes
   04510 Focal adhesion
    483042 (SOS1)
   04540 Gap junction
    483042 (SOS1)
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    483042 (SOS1)
   04660 T cell receptor signaling pathway
    483042 (SOS1)
   04662 B cell receptor signaling pathway
    483042 (SOS1)
   04664 Fc epsilon RI signaling pathway
    483042 (SOS1)
   04062 Chemokine signaling pathway
    483042 (SOS1)
  Endocrine system
   04910 Insulin signaling pathway
    483042 (SOS1)
   04912 GnRH signaling pathway
    483042 (SOS1)
   04915 Estrogen signaling pathway
    483042 (SOS1)
   04917 Prolactin signaling pathway
    483042 (SOS1)
  Nervous system
   04722 Neurotrophin signaling pathway
    483042 (SOS1)
  Development
   04320 Dorso-ventral axis formation
    483042 (SOS1)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    483042 (SOS1)
   05231 Choline metabolism in cancer
    483042 (SOS1)
   05206 MicroRNAs in cancer
    483042 (SOS1)
   05205 Proteoglycans in cancer
    483042 (SOS1)
   05214 Glioma
    483042 (SOS1)
   05221 Acute myeloid leukemia
    483042 (SOS1)
   05220 Chronic myeloid leukemia
    483042 (SOS1)
   05211 Renal cell carcinoma
    483042 (SOS1)
   05215 Prostate cancer
    483042 (SOS1)
   05213 Endometrial cancer
    483042 (SOS1)
   05224 Breast cancer
    483042 (SOS1)
   05223 Non-small cell lung cancer
    483042 (SOS1)
  Substance dependence
   05034 Alcoholism
    483042 (SOS1)
  Infectious diseases
   05160 Hepatitis C
    483042 (SOS1)
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    483042 (SOS1)
   01522 Endocrine resistance
    483042 (SOS1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-ProteinID: 
NCBI-GeneID: 
Ensembl: 
Position
17
AA seq 1358 aa AA seqDB search
MQICNDSPIPVGSSRAKLARLTVRILNPGRGGGGGPERPEREGGARTWKRVSSSVQGQVH
PTLESSDDALQYVEELILQLLNMLCQAQPRSASDVEERVQKSFPHPIDKWAIADAQSAIE
KRKRRNPLSLPVEKIHPLLKEVLGYKIDHQVSVYIVAVLEYISADILKLVGNYVRNIRHY
EITKQDIKVAMCADKVLMDMFHQDVEDINILSLTDEEPSTSGEQTYYDLVKAFMAEIRQY
IRELNLIIKVFREPFVSNSKLFSANDVENIFSRIVDIHELSVKLLGHIEDTVEMTDEGSP
HPLVGSCFEDLAEELAFDPYESYARDILRPGFHDRFLSQLSKPGAALYLQSIGEGFKEAV
QYVLPRLLLAPVYHCLHYFELLKQLEEKSEDQEDKECLKQAITALLNVQSGMEKICSKSL
AKRRLSESACRFYSQQMKGKQLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGTLTRVGA
KHERHIFLFDGLMICCKSNHGQPRLPGASNAEYRLKEKFFMRKVQINDKDDTSEYKHAFE
IILKDENSVIFSAKSAEEKNNWMAALISLQYRSTLERMLDVTMLQEEKEEQMRLPSADVY
RFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFC
KPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRH
WVEHHFYDFERDADLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQ
SSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKE
INSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVV
SAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLT
NILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLN
PMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGTMRHPTP
LQQEPRKISYSRIPESETESTASAPNSPRTPLTPPPASGASSTTDVCSVFDSDHSSPFHS
SSDTVFIQVSLPHGPRSASVSSISLTKGTDEVPVPPPVPPRRRPESAPAESSPSKIMSKH
LDSPPAIPPRQPTSKAYSPRYSISDRTSISDPPESPPLLPPREPVRTPDVFSSSPLHLQP
PPLGKKSDHGNAFFPNSPSPFTPPPPQTPSPHGTRRHLPSPPLTQEADLPSVTGPPVPPR
QSTSQHIPKLPPKTYKREHTHPSVHRDGPPLLENAHSS
NT seq 4077 nt NT seq  +upstreamnt  +downstreamnt
atgcagatctgcaatgactctcccatcccagtggggagttccagagcaaagcttgcccgc
ttaacggtaagaatcctgaacccggggcggggcgggggggggggtccggaaagacctgag
agagaagggggcgcaagaacgtggaaaagagttagttcctcggtccagggacaagttcat
ccgactcttgagtctagtgacgatgctcttcaatatgttgaagaattaattttgcagtta
ttaaatatgctatgccaagctcagccccgaagtgcttcagatgtagaggaacgtgttcaa
aaaagtttccctcatccaattgataagtgggcaatagctgatgcccaatcggctattgaa
aagaggaagcgaagaaaccctttatctctcccagtagaaaaaattcatcctttattaaag
gaggtcctaggttataaaattgaccaccaagtttctgtttacatagtagcagtattagaa
tacatttctgcagacattttaaagctggtggggaattatgtacggaatatacggcattat
gaaattacaaaacaagatattaaagtggcaatgtgtgctgataaggtattaatggacatg
tttcatcaagatgtagaagatataaatatattatctttgactgatgaagagccttccacc
tcaggagagcaaacttattatgatttggtaaaagcatttatggcagaaattcgacagtac
ataagggaactaaatttaattataaaagtttttagagagccctttgtctccaattcaaaa
ttgttttcagctaatgatgtagaaaatatatttagtcgtatagtagatatacatgaactt
agtgtaaagttactgggccatatagaagatactgtggaaatgactgatgaagggagcccc
catcccttagtaggaagctgctttgaagacttagcagaggaactggcatttgatccatat
gaatcatatgctcgagatattttacggcctggttttcatgatcgtttccttagtcagtta
tcaaagcctggagcagcactctatttacagtcaataggcgaaggtttcaaagaagctgtt
cagtatgttttacccaggctacttctagcccctgtttaccactgtctacattactttgaa
cttttgaagcagttagaagaaaagagtgaagatcaagaggacaaggagtgtttgaaacaa
gcaataacagctttgcttaatgttcagagtggtatggaaaaaatatgttctaaaagtctt
gcaaaacgaagactgagtgaatctgcatgtcggttttatagtcagcaaatgaaggggaaa
caactagcaatcaagaaaatgaacgagattcaaaagaatattgatggttgggagggaaaa
gacattggacaatgttgcaatgaatttataatggaaggaactcttacacgtgtaggagcc
aaacatgagagacacatatttctctttgatggcttaatgatttgctgtaaatcaaatcat
gggcagccaagacttcctggtgctagcaatgcagaatatcgtcttaaagaaaagtttttc
atgagaaaggtacaaattaatgacaaagatgacaccagtgagtacaagcatgcttttgaa
ataattttaaaagatgaaaatagtgttatattttctgccaagtcagctgaagagaaaaac
aattggatggcagcattgatatctttacagtaccggagtacactggaaaggatgcttgat
gtgacgatgctacaggaagagaaggaggagcagatgaggctccctagtgccgatgtttat
agatttgcagagcctgactctgaagagaatataatatttgaagaaaacatgcagcccaag
gctggaattccaattatcaaagcaggaactgttattaaacttatagagaggctcacgtac
catatgtacgcagatcccaattttgttcggacatttcttacaacatacagatccttttgt
aaacctcaagaactactgagtcttataatagaaaggtttgaaattccagagcctgagcca
acagaagctgatcgcatagctatagagaatggagatcagcccttgagtgcagaactaaaa
aggtttagaaaagaatacatacagcctgtacaactgcgagtattaaatgtatgtcggcat
tgggtggagcaccacttctatgattttgaaagagatgcagatcttttgcagcgaatggaa
gaatttattggaacagtgagaggtaaagcaatgaaaaaatgggttgaatccatcactaaa
ataatccaaaggaaaaaaattgcaagagacaatggaccaggtcataatattacatttcag
agttcacctcccacagtcgagtggcatataagcaggcctgggcacatagagacttttgac
ctgctcaccttacacccaatagaaattgctcgacaactcactttacttgaatcagatctg
tatcgagctgtacagccatcagaattagttggaagtgtgtggacaaaagaagacaaagaa
attaattctcccaatcttctaaaaatgatccggcacaccactaatctcactctgtggttt
gagaaatgtattgtagaaactgaaaacttagaagaaagagtagctgtggtgagtcgaata
attgagattctacaagtctttcaagagctgaacaacttcaatggtgttcttgaggttgtc
agtgctatgaactcatcacctgtttacagactagaccacacatttgagcaaataccaagt
cgccaaaagaaaattttagaagaagctcatgaattaagtgaagatcactataagaaatat
ttggcaaaactcaggtctattaatccaccatgtgtgcctttctttggaatttatctaact
aatatcttgaaaacagaagaaggcaaccctgaggtcctaaaaaggcatggaaaagagctt
ataaactttagcaaaaggaggaaagtagcagaaataacaggagagatccagcagtaccaa
aatcagccttattgtttacgagtagaatcagatatcaaaaggttttttgaaaatttgaat
ccaatgggaaatagcatggaaaaagaatttacagattatcttttcaacaaatccctagag
atagaaccacgaaaccctaagcctctgccaagatttccaaaaaaatatagctatccccta
aaatctcctggtgttcgtccatcaaacccaagaccaggtaccatgagacatcctacacct
ctgcagcaggagccaaggaaaattagttatagtagaatccctgaaagtgaaacagaaagt
acagcatctgcaccaaattctccaagaacaccgttaacacctcctcctgcttctggtgct
tctagtaccacagatgtttgcagcgtttttgattccgaccattcgagcccttttcactca
agcagcgataccgtctttatccaagtttcactgccccatggcccaagatctgcttcagta
tcatctataagtttaaccaagggcactgatgaagtacctgtcccccctcctgttcctcca
cgaagaaggccggaatctgcccccgccgaatcttcaccgtctaagattatgtctaagcat
ttggacagccccccagcaattcctcctaggcagcccacatcaaaagcctattcaccgcga
tattcaatatcagaccggacctctatatcagaccctcctgagagccctcccttattacca
ccacgagaacctgtgaggacacctgatgttttctccagctcaccactacatctccagcct
ccccctctgggcaaaaaaagtgatcatggcaatgccttcttcccaaacagcccttcccct
tttacaccacctcctcctcaaacaccttctccccatggcacgagaaggcatctgccatca
ccaccattgacacaagaagcggaccttccttcagtcactgggccgcctgttcctccacga
caaagcacttcccaacatatccctaaactccctccgaaaacttataaaagggagcacaca
cacccatctgtgcacagagatggaccacccctgttggagaatgcccattcttcctga

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