KEGG   Canis familiaris (dog): 484990Help
Entry
484990            CDS       T01007                                 

Gene name
INSR
Definition
(RefSeq) insulin receptor
  KO
K04527  
insulin receptor [EC:2.7.10.1]
Organism
cfa  Canis familiaris (dog)
Pathway
MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phospholipase D signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Longevity regulating pathway
Longevity regulating pathway - multiple species
Adherens junction
Insulin signaling pathway
Ovarian steroidogenesis
Regulation of lipolysis in adipocytes
Type II diabetes mellitus
Insulin resistance
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Module
PI3K-Akt signaling
Brite
KEGG Orthology (KO) [BR:cfa00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    484990 (INSR)
   04015 Rap1 signaling pathway
    484990 (INSR)
   04010 MAPK signaling pathway
    484990 (INSR)
   04066 HIF-1 signaling pathway
    484990 (INSR)
   04068 FoxO signaling pathway
    484990 (INSR)
   04072 Phospholipase D signaling pathway
    484990 (INSR)
   04022 cGMP - PKG signaling pathway
    484990 (INSR)
   04151 PI3K-Akt signaling pathway
    484990 (INSR)
   04152 AMPK signaling pathway
    484990 (INSR)
   04150 mTOR signaling pathway
    484990 (INSR)
 Cellular Processes
  Cellular community - eukaryotes
   04520 Adherens junction
    484990 (INSR)
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    484990 (INSR)
   04923 Regulation of lipolysis in adipocyte
    484990 (INSR)
   04913 Ovarian Steroidogenesis
    484990 (INSR)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    484990 (INSR)
  Aging
   04211 Longevity regulating pathway - mammal
    484990 (INSR)
   04213 Longevity regulating pathway - multiple species
    484990 (INSR)
 Human Diseases
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    484990 (INSR)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    484990 (INSR)
   04931 Insulin resistance
    484990 (INSR)
Enzymes [BR:cfa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     484990 (INSR)
Protein kinases [BR:cfa01001]
 Tyrosine protein kinases
  InsR family [OT]
   484990 (INSR)
Enzyme-linked receptors [BR:cfa01020]
 Receptor tyrosine kinases
  RTK class II (Insulin receptor family)
   484990 (INSR)
Cytokine receptors [BR:cfa04050]
 Receptor tyrosine kinase
  RTK class II (Insulin receptor family)
   484990 (INSR)
CD molecules [BR:cfa04090]
 Proteins
  484990 (INSR)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GeneID: 
NCBI-ProteinID: 
Ensembl: 
Position
20
AA seq 1406 aa AA seqDB search
MIKGFKIDGRAPSPRQGPSEWVSRLRLHTCEAGPATTSSNPSVACLLTCLAFCLFFLPVC
PGMDIRNNLTRLHELANCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYG
LESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYSLMNITRGSVRIEKNNELCYL
ATIDWSRILDSVEDNYIVLNKDDNEECGDICPGTAKGKTNCPATVINGQFVERCWTHSHC
QKVCPTICKSHGCTAEGLCCHSECLGNCSEPDDPTKCVACRNFYLDGRCVETCPPPYYHF
QDWRCVNFSFCQDLHNKCKNSRRQGCHQYVIHNNKCIPECPSGYTMNSSNLMCTPCLGPC
PKVCHILEGEKTIDSVTSAQELRGCTVVNGSLIINIRGGNNLAAELEANLGLIEEISGYL
KIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFF
HYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELLKFSYIRTSYDKILLK
WEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNH
PGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSS
SQIILKWKPPSDPNGNITHYLVFWERQAEDSELYELDYCLKGLKLPSRTWSPPFEAEGSQ
KHNQSEYEESAGECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVPRKSSSSPGAEDT
RPSRKRRALSDAGNVTAAIPTVPGFPNTSTSTPTSPEEHKPFEKVVNKESLVISGLRHFT
GYRIELQACNQDSPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKE
PNGLIVLYEVSYRRYGDEELHLCVSRRHFALERGCRLRGLPPGNYSVRVRATSLAGNGSW
TEATYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSN
PEYLSASDVFPCSVYVPDEWEVPREKITLLRELGQGSFGMVYEGNARDIVKGEPETRVAV
KTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVFKGQPTLVVMELMAHGDLKSYLR
SLRPEAENNPGRPPPTKQEMIQMAAEIADGMVYLNAKKFVHRDLAARNCMVAHDYTVKIG
DFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQP
YQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVDLLKDDLHP
SFPEVSFFHSEENKAPESEELEMEFEDMESVPLDRASHSQREEAGGRDAGSSLGLKRSYE
EHIPYTHMNGGKKNGRILTLPRSNPS
NT seq 4221 nt NT seq  +upstreamnt  +downstreamnt
atgattaagggtttcaagatagatggaagagccccgagccccaggcagggcccttctgag
tgggtctcgcgactcaggttgcacacctgcgaagctggccctgccactacttcttctaac
ccatccgtggcatgtttgctcacctgtcttgctttctgcttgtttttccttccagtgtgt
cctggcatggatatccggaacaacctaacgaggctgcatgagctggccaactgctcggtc
attgaaggacatttgcagatactgttaatgttcaaaacgaggcccgaggatttccgagac
ctcagtttccccaaactcatcatgatcactgattacttgctgctcttccgggtctatggg
ctggagagcctgaaggacctgttccccaacctcacggtcatccgaggctcgcgcctcttc
ttcaactacgcgctggtcatcttcgagatggtccacctgaaggagcttggcctctacagc
ttgatgaacatcacccggggctccgtccgcatcgagaagaacaatgagctctgctacctg
gccaccatcgactggtcccgcatcctggattctgtggaggataattatattgtgctgaac
aaagacgacaacgaggagtgtggggacatctgtccaggcactgccaagggcaagaccaac
tgccctgccactgtcatcaatgggcagtttgtcgagcggtgttggacacacagccactgc
cagaaagtttgtccgaccatctgcaagtcgcatggctgcaccgccgagggcctctgctgc
cacagcgagtgtttaggcaactgctccgagcccgacgaccccaccaagtgcgtggcctgt
cgcaacttctacctggatggcaggtgcgtggagacctgcccacccccgtactaccacttc
caagactggcgctgcgtgaacttcagcttctgccaggacctgcacaacaaatgcaagaac
tcccggagacagggctgccaccagtacgtcatccacaataacaagtgcatccccgagtgc
ccctctggctacacgatgaattccagcaacctgatgtgcactccgtgcctgggcccctgt
cccaaggtctgccacattctggaaggcgagaagaccatcgactcagtgacgtctgcccag
gagcttcgaggctgcactgttgtcaacggaagtctaatcatcaacattcgagggggcaac
aacctggcggccgagctggaggccaacctcggactcattgaagagatttccgggtacctg
aaaatccggagatcctatgctcttgtgtctctttcctttttccggaagttgcggctgatt
cgaggggagaccttggagatcgggaactactctttctatgccttggacaaccagaaccta
aggcagctatgggactggagcaaacacaacctcaccatcactcaggggaaactcttcttc
cactataatcccaaactctgcttgtctgagatccacaagatggaggaagtctcaggaacc
aaggggcgccaggagaggaacgacattgccctgaagaccaacggggaccaggcgtcttgt
gaaaacgaactacttaaattttcttacattcggacgtcttatgacaagatcttgctgaaa
tgggagccctactggccccccgacttccgagacctcctggggttcatgctcttctacaaa
gaggccccttatcagaatgtgaccgagtttgatgggcaggacgcgtgtggctccaacagc
tggacggtggtggacattgacccacctctgcggtccaacgaccccaaatcgcagaaccac
ccggggtggctgatgcggggtctcaagccctggacccaatatgccatctttgtcaagacc
ttggtcaccttttctgatgaacgccgcacgtatggagccaagagtgacatcatctatgtg
cagacagatgccactaatccttccgtccccctggatccaatctcggtttcgaattcctcg
tcccagattattctgaagtggaagcctccctctgaccccaatggcaatatcacgcactac
ctggttttctgggagaggcaggccgaagacagtgagctctatgagttggattattgcctc
aaagggttgaagctgccctcccggacctggtctccgccgttcgaggccgagggctcccag
aagcacaaccagagtgaatacgaggagtctgccggcgaatgctgctcctgccccaaaacg
gactctcagatcctcaaggagctagaggagtcctcttttaggaagacgtttgaggattac
ctgcacaacgtggtgtttgtccccagaaaatcctcttcgagccctggtgctgaggacact
aggccatcgaggaaacgcagggcgctcagtgatgctggcaacgtgacagcagctataccc
acagttcccggtttccccaacacctcgaccagcacgcccacgagcccggaggagcacaag
cccttcgagaaagtggtgaacaaagaatctctggtcatctccggtctgcgccacttcact
ggctaccgcatcgagctgcaggcttgcaaccaagactcccccgaggagaggtgcagcgtg
gcggcctatgtcagcgccaggaccatgcccgaagccaaggcagacgacatcgttggcccc
gtgacccacgaaatcttcgagaacaatgtcgttcacttgatgtggcaggagccaaaggaa
cccaatggtctgatcgtgctttatgaagtgagttaccgacggtatggcgatgaggagctg
cacctgtgtgtctcccggaggcattttgctctggagcgtggctgcaggctacgcgggctg
cctccggggaattacagcgtgcgagtccgggccacctccctggcgggtaatggctcctgg
acagaagccacctatttctacgtgacagactatttagatgtcccatcgaatattgcaaaa
attatcatcggccccctcatctttgtctttctcttcagtgttgtgattggaagtatttac
ctgttcctgagaaagaggcagccggatgggccactgggaccgctgtatgcttcttcaaac
cctgagtacctcagtgccagtgatgtgtttccatgttctgtgtatgtgccggacgagtgg
gaggtgccgcgggagaagatcaccctcctgcgcgagctggggcaaggctccttcggcatg
gtgtacgagggcaacgccagggacatcgtcaagggtgagcccgagacccgcgtggccgtc
aagaccgtcaacgagtccgccagcctgcgagagaggatcgagtttctcaatgaggcatca
gtcatgaagggcttcacctgtcaccacgtggtccgcctcctgggggtggtgttcaaaggc
caaccgacgctggtggtgatggagctgatggctcatggagacctgaagagctacctccgc
tccctgcggccggaggctgagaataaccccggccgccctccgcctaccaagcaagagatg
attcagatggcggcggagatcgccgacgggatggtctacctgaacgccaagaagtttgtg
caccgggatctagcagcccgaaactgcatggttgcccacgattacactgtcaaaattgga
gactttgggatgaccagagacatctatgagacggattactatcggaaaggaggcaagggt
ctgctccccgtgcggtggatggcaccggagtccctgaaggacggggtctttaccacttct
tctgacatgtggtcctttggcgtggtcctttgggaaatcaccagcttggcagagcagcct
taccaaggcctgtctaatgaacaggtgttgaaatttgtcatggacggagggtatctggat
caacccgacaattgtccagagagagtcactgacctgatgcgcatgtgctggcagttcaat
cccaagatgcggcccaccttcctggagattgtcgacctgctcaaggatgatctgcacccc
agctttccagaagtttccttcttccacagcgaggagaacaaggcacccgagagcgaggag
ttggagatggagtttgaggacatggagagtgtccctctggatcgggcctcacactctcag
agggaggaggccgggggccgggatgcagggtcctcgctgggcctaaagcggagctacgag
gagcacatcccctacactcacatgaacgggggcaagaaaaatggacggattctgactctg
ccaaggtcgaatccttcctaa

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