KEGG T01007: 485073

Canis familiaris (dog): 485073

Entry

485073 CDS T01007

Gene name

DOT1L

Definition

DOT1-like, histone H3 methyltransferase (S. cerevisiae)

Orthology

K11427

histone-lysine N-methyltransferase, H3 lysine-79 specific [EC:2.1.1.43]

Organism

cfa Canis familiaris (dog)

Pathway

cfa00310	Lysine degradation
cfa05202	Transcriptional misregulation in cancer

Class

Metabolism; Amino acid metabolism; Lysine degradation [PATH:cfa00310]
Human Diseases; Cancers; Transcriptional misregulation in cancers [PATH:cfa05202]

SSDB

Motif

Pfam:

DOT1

Other DBs

NCBI-GI:

359322276

NCBI-GeneID:

485073

Position

AA seq 2003 aa
MAPACLTKPSGTDSTRMRIPTGRRAEARGGHSHVVIGRTHLYEGAMGSPGGGEGWRLMDQ
TRGARPPDAPLQSKEAPDCGRADAAARARRPPHRASGNPAPPAHAPPSSARGGRPGPAGV
AAAPGARREGPPLLRGGARACHPRPAGSPQVPASGRRGRPTSAEDVRCLQGYANLGKSDK
RNQQLAAFDSGCFGCAEPCCRGYNLCQSLTIKGKLVPVMTCPPCRGPLCGAGGHRAMVGV
PQAGRCLLGDPLRLLASIRLTADALDPAMRPRSWLLRRAPSRGGPWLLCGRVELHWKPGG
ELWAARASPRLGGPVSPRGGWHGGPPPASPRVMGSEVQGLGAEPAGIPRSQLPLLLGLLP
FHDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVLIDYDTKSFESMQRLCDKYNRAIDSI
HQLWKGTTQPMKLNTRPSNGLLRHILQQVYNHSVTDPEKLNNYEPFSPEVYGETSFDLVA
QMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCKHHYGVEKADIPAKYAETMDREFRKW
MKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFVNNFAFGPEVDHQLKERFANMKEGGR
IVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLKGSVSWTGKPVSYYLHTIDRTILENY
FSSLKNPKLREEQEAARRRQQRENKSNTTTPTKVPENKAAVPADTPMDSGAEEEKAGATT
IKKPSPSKARKKKLNKKGRKMAGRKRGRPKKMSTANPERKPKKSQTALDLLHAQAASQTA
APSPQDAYKSPHSPFYQLPPSVQRHPPDQLLLAPTPPALQKLLESFKIQYLQFLAYTKTA
QYKASLQQLLDQEKEKNARLLGAAQQLFGHCQAQKEEIKRLFQQKLDELGVKALTYNDLI
QAQKEISAHNQQLREQTEQLQKDNRELRSQSLQLLKARCEELKLDWSTLSLENLLKEKQA
LRSQISEKQRHCLELQISIVELEKSQRQQELLQLKSCVPPDEALSAHLRGKGALGRELEA
DPSRLHLDLDCSKFSLPHFSSASPELSMNGHAANYELCSALSRPSSKQNTPQYLASPLDQ
EVVPCTPSHSSRSRLEKMSGLALPDYTRLSPAKLVLRRHLSQDHATSGKPAASELHPRAE
HTKENGLPYQSPGIANGIKLSPQDPRPSSPVALQMTGERGSEKGLKERAYASSGEAITSL
PVSIPLSTVQPSKLPVSIPLASVVLPSRAEKVRSTPSPVPQTRESSSTLEKQMGTNTHSA
GSKSLASTPAGFYTGSVAVSGALAGSPAPLAPGAEPSAFDEVSGSGSLFASMGSCSSTPQ
HPPLLPQSRGSGAASPAHPLCASPRLSSVAQGPLPDANKGDLPSEAGFSDPEGEAKRRIV
FTISAGGSSAKQSPPSKPSPLPTGARGDSSQGHGSDSRKRGRRKRASAGTPSLSSGVSPK
RRALPSVAGLFTQSSGSPLNLNSMVSNINQPLEITAISSPESLKSSPVPYQDNDQPPILK
KEKPLSQTNGAHYSPLTSDEEQGSEDEPGSARIERKIATISLESKSPPKTLESGGGLAGR
KPTPASEPTNSSKWKSTFSPISDLGLAKCADSPLQAGSALSQNSLFTFRPPLDDPGSADT
KLAAHPRKSFPGALSGAGGLSPSSNPPNGFAFGGGLAADLSLHSFSDGASLSHKVPEAAS
LGAPLSFPAPRGKEGGATEPGTFVNKRQLDGLGGPKGREAGELGLPVCGPPDKASLTHSK
PTKGRDREPDLKNGHNLFISAATVPPAGLLSGPGLATVASSAVSAAPSAQTHRPFLGTFA
PGPQFALGPMSLQANLGSSVLQSLFSSVPAAAGLVHVSSAATRLTNSHAMGSFSSGVAGG
AVGGPPKGREAVPTCPLGSTLHLPPRSFSRAGATTRALFPPRGGHLSDLTQPTGSGQPWG
LALGKSERPQRLLHGGTVPLQLAPCWAQAAKALSRGWEPGWACPQGVRPGAALQVSLTTR
CLPPPLIRLEPVSAAGLRVAAPR

NT seq 6012 nt +upstreamnt +downstreamnt
atggctcctgcgtgtctcacaaaacccagtggcacggacagcacacgaatgcgcatcccc
acaggcagacgcgcggaggcccggggcgggcactcccacgtggtcatcggtcggacccac
ctttatgagggcgcgatgggctcccccgggggcggcgaggggtggcggctgatggaccag
acacgtggcgcccgccctccagatgcaccattgcagagcaaagaagccccagactgcgga
agagccgacgccgcagccagggcccggaggccgccgcaccgagcgagcggcaacccggcg
ccccccgcacacgctcctccgtccagcgcgcgcggcgggcgtcccggcccggcgggagtc
gcggcggccccgggcgcgcggagggaggggcccccgctcctccggggcggggctcgagcc
tgtcatccccggcccgcggggtctccccaggtccccgcgtcgggtcggcgggggcggccg
acgtcagccgaggacgtgcgctgcctgcagggctatgccaatttgggaaagtccgataaa
cggaatcagcagctggcagcctttgattctggctgcttcggctgcgcagagccgtgttgc
cgtggctacaacctgtgccagtccctcacaattaagggcaagctggtgcctgtcatgacc
tgcccaccctgcagggggcccttgtgtggggctggaggccatcgtgccatggtaggagtc
ccccaggctggacgctgtctcctcggggatcccctgaggctactggcgtccattcggctc
actgcagacgccctggaccccgccatgcgtccgaggagctggctccttcgcagagccccg
tcgaggggaggaccgtggctgctgtgcggtcgcgtggagctgcactggaagccgggcggg
gagctgtgggctgcccgggcctcgccgcggctcggagggccggtgtccccgcgtggtggt
tggcacggaggccccccgcccgcgtctccccgggtgatgggcagcgaggttcagggcctg
ggtgctgagccggctggaatcccacgttcccagctgccgcttctgctggggctgctgcct
ttccacgacaaacaccacgatgctgctcatgaaatcatcgagaccatccgatgggtctgt
gaagagatcccagacctcaagcttgctatggagaattacgttttaatcgactacgacacc
aaaagcttcgaaagcatgcagaggctctgtgacaaatacaaccgtgccatcgacagcatc
caccagctgtggaaggggaccactcagcccatgaaactgaacactcggccgtccaacggg
ctcctgaggcacatcctgcagcaggtgtacaaccactcggtgacggaccccgagaagctc
aacaactatgagcccttctccccggaggtgtacggggagacctcctttgacttggtcgca
cagatgatcgacgagatcaagatgaccgaggatgacctgtttgtggacctgggcagtgga
gtgggccaggttgtgctgcaggtcgccgcggccaccaactgcaaacatcactatggcgtg
gagaaagctgacatcccagccaagtacgcggagaccatggaccgagagttcaggaagtgg
atgaaatggtatggaaaaaagcatgcagaatacacactggaaagaggcgacttcctctca
gaagagtggagagagcggattgccaacacaagtgttatatttgtgaataattttgccttt
ggtcctgaggtggatcaccagctgaaggagcggtttgcgaacatgaaggaaggcggcaga
attgtgtcctcgaagcccttcgcacctctcaacttccggataaacagcagaaacttgagc
gacatcggcaccatcatgcgcgttgtggagctctcgcccctgaaaggctcggtgtcctgg
acggggaagccggtctcctactacctgcacactatcgaccgcaccatacttgaaaactat
ttttctagtctgaaaaacccaaaactcagggaggaacaagaggcagctcggcgccggcag
cagcgagagaacaagagcaacacgaccactcccaccaaggtgcccgagaacaaggctgct
gtgcctgccgacacccctatggattctggtgccgaggaagaaaaggctggggcaaccacc
atcaaaaagccgtctccctccaaagcccggaagaagaagctgaataagaaggggcggaag
atggccggccggaagcgtgggcgtcccaagaagatgagcactgcaaaccccgagcgtaag
cccaagaagagccaaactgcactggacctcctgcatgcccaggccgcgtctcagacggca
gcgccctcgccgcaggatgcgtacaagtcacctcatagcccgttttatcagctacctccc
agtgtgcagcggcacccccctgaccagctgctgctggcacccaccccacccgcactgcag
aagctgctagaatccttcaagattcagtacttgcagttcttggcgtacaccaagaccgcc
cagtacaaggccagcctgcagcagctgctggaccaggagaaggagaagaacgcccggttg
ctaggtgctgcgcagcagctgtttggccactgccaggcccagaaagaggagatcaagagg
ctcttccagcagaaactggatgagctgggagtgaaggcgctgacctacaacgacctgatt
caggcacagaaggagatctcggctcataatcagcagctgagggaacagacggagcagctg
cagaaggacaacagggagctgaggagccagagcctacagctgctcaaggctcggtgtgag
gagctaaagctggactggtccacgctgtccctggagaacctgctgaaggagaagcaggcc
ctgaggagccagatctccgagaagcagaggcactgcctggagctgcagatcagcatcgtg
gagctggagaagagccagcggcagcaggagctcctgcagctcaagtcctgtgtgcctcca
gacgaggccctgtcagcgcacctgcgtgggaagggcgccctgggccgggagctggaggcc
gaccccagccgactgcacctcgacctggactgctccaagttctctctgccccacttcagc
agcgcaagcccagagctctccatgaacggccacgcagccaactacgagctctgcagtgcg
ctgagccggccctcatccaagcagaacacgcctcagtacctggcctccccgctggaccag
gaagtcgtaccctgcacccccagccacagcagccggtcgaggctcgagaagatgtctggc
ctggccttgcccgactacaccaggctctccccggccaagctggtgctgcggcgtcacctg
agccaggaccacgcgaccagcggcaagccagccgccagtgagctgcacccgcgagctgag
cataccaaggagaacggccttccataccagagccctggcatcgcaaacggcatcaagctg
agccctcaggaccctcgaccctcgtcccccgtggccttacagatgacaggggagaggggc
agcgagaagggcttgaaggagcgtgcctatgccagcagcggagaggccatcaccagcctg
cccgttagcatcccgctcagcaccgtgcagcccagtaagctgcccgtcagcatccctctg
gccagtgtggtgctgcccagccgcgccgagaaagtgagaagcaccccgagccctgtgccg
cagacccgagagtcctcgtccacacttgaaaagcagatgggcacaaacacccacagcgct
ggaagcaaaagccttgcctcaactcctgcaggcttttacacgggctcggtggctgtcagt
ggggccctggcaggcagcccagcgcccctggctcctggagcagagcccagcgccttcgac
gaggtctctggctcaggaagcctgttcgccagcatggggtcctgcagctccaccccgcag
cacccgcccctgctgccacagtcccgtggctccggtgcagcctcacccgcccatccgctc
tgtgccagtccgcggctcagcagtgtcgcccagggcccgctccccgatgccaacaaaggg
gaccttccgtccgaggcgggcttctcagaccccgagggcgaagccaagaggaggattgtc
tttaccatctcagctggtggcagcagtgccaaacagtcgcctcccagcaaacccagccct
ctgcccacgggtgcccgcggggacagcagccagggccatgggtcggacagccgcaagcgg
ggcaggagaaagcgggcctcggcggggaccccgagcctgagctcaggcgtatcgcctaag
cgtcgggccttgccgtccgttgccggcctcttcacgcagtcttcagggtccccactgaac
ctcaactctatggtcagcaacattaaccagcctttggaaatcacggccatctcgtccccc
gagagcctgaagagctcccctgtcccttaccaggacaacgaccagccgcccattctcaag
aaggagaagcccctgagccagaccaatggggcccactactccccactgacctcagatgag
gagcagggctccgaggacgagccaggcagtgccagaatcgaaagaaaaattgcaacaatt
tccttagaaagcaaatcccctccaaaaaccttggaaagcggtggtggcctggccgggagg
aagccgacccctgccagcgagcccaccaacagcagcaagtggaagtccaccttctcgccc
atctccgacctcggcctggccaagtgcgccgacagcccgctgcaggccggctccgccctg
agccagaactccctattcactttccggcctcccctcgatgatcccggctcggccgacacc
aagctggctgcccaccccaggaaaagctttcccggcgctctgtcaggggccggtgggctg
agcccaagcagcaaccctcccaatggcttcgccttcggcgggggcctggccgccgacctc
agtttacacagcttcagcgatggtgcttctctctcccacaaggtccccgaggcagccagc
ctgggcgcacccctgagctttcctgccccacggggcaaggagggcggtgccacagagccc
ggcacctttgtgaacaagaggcagctggacggactgggcggcccgaagggcagggaggcg
ggcgagctgggcctgccagtgtgcgggcccccggacaaggcctcgctgacacacagcaag
cccaccaagggccgggaccgcgagcccgacctgaagaatggccacaacctcttcatttct
gctgccaccgtgcctcccgcgggcctcctcagcggccccggcctcgccacggtggcatcc
tcggcagtcagcgcggccccatctgcccagactcaccgccccttcctgggcaccttcgcc
cccgggccgcagttcgccctgggtcccatgtccctgcaggccaacctgggctcatccgtg
ctgcagtccttgttcagctccgtgccggctgctgctggcctggtgcacgtctcgtccgct
gcaaccagactgaccaactcgcacgccatgggcagcttttcctcgggggtggcaggcggc
gcagttggagggccccctaaggggcgagaggctgtgcccacctgtccccttgggtccact
ttgcacctgccacctcgttccttttcgagagctggcgccacgactagggctttgtttcct
ccccgtggaggtcatctgtccgacctgacacagcccacgggttctgggcagccttggggg
ctggcgctgggcaagagtgagcggccacagcgcctgctgcatggtggcaccgtacctctg
cagctggctccttgctgggcacaggcggccaaggccctgtcccgcggctgggagcccggg
tgggcgtgcccacagggggtgcggcccggcgctgccctgcaggtgtctttaaccacgcgg
tgccttccgcctccgctcatccgtttggagccagtttcggcagcggggctgcgtgtcgca
gcgccacgctga

All links

Pathway (2)   
   KEGG PATHWAY (2)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (1)   
   OC (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (1)   
   Pfam (1)   
All databases (20)   

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