KEGG   Canis familiaris (dog): 485773Help
Entry
485773            CDS       T01007                                 

Gene name
PLCB1
Definition
phospholipase C, beta 1 (phosphoinositide-specific)
Orthology
K05858  
phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
cfa  Canis familiaris (dog)
Pathway
Inositol phosphate metabolism
Metabolic pathways
Rap1 signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
Phosphatidylinositol signaling system
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Wnt signaling pathway
Gap junction
Platelet activation
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Dopaminergic synapse
Long-term depression
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Alzheimer's disease
Huntington's disease
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Amoebiasis
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:cfa00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    485773 (PLCB1)
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    485773 (PLCB1)
   04310 Wnt signaling pathway
    485773 (PLCB1)
   04020 Calcium signaling pathway
    485773 (PLCB1)
   04070 Phosphatidylinositol signaling system
    485773 (PLCB1)
   04022 cGMP - PKG signaling pathway
    485773 (PLCB1)
 Cellular Processes
  Cellular commiunity
   04540 Gap junction
    485773 (PLCB1)
 Organismal Systems
  Immune system
   04611 Platelet activation
    485773 (PLCB1)
   04062 Chemokine signaling pathway
    485773 (PLCB1)
  Endocrine system
   04911 Insulin secretion
    485773 (PLCB1)
   04912 GnRH signaling pathway
    485773 (PLCB1)
   04915 Estrogen signaling pathway
    485773 (PLCB1)
   04921 Oxytocin signaling pathway
    485773 (PLCB1)
   04918 Thyroid hormone synthesis
    485773 (PLCB1)
   04919 Thyroid hormone signaling pathway
    485773 (PLCB1)
   04916 Melanogenesis
    485773 (PLCB1)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    485773 (PLCB1)
   04270 Vascular smooth muscle contraction
    485773 (PLCB1)
  Digestive system
   04970 Salivary secretion
    485773 (PLCB1)
   04971 Gastric acid secretion
    485773 (PLCB1)
   04972 Pancreatic secretion
    485773 (PLCB1)
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    485773 (PLCB1)
  Nervous system
   04724 Glutamatergic synapse
    485773 (PLCB1)
   04725 Cholinergic synapse
    485773 (PLCB1)
   04728 Dopaminergic synapse
    485773 (PLCB1)
   04726 Serotonergic synapse
    485773 (PLCB1)
   04720 Long-term potentiation
    485773 (PLCB1)
   04730 Long-term depression
    485773 (PLCB1)
   04723 Retrograde endocannabinoid signaling
    485773 (PLCB1)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    485773 (PLCB1)
  Environmental adaptation
   04713 Circadian entrainment
    485773 (PLCB1)
 Human Diseases
  Neurodegenerative diseases
   05010 Alzheimer's disease
    485773 (PLCB1)
   05016 Huntington's disease
    485773 (PLCB1)
  Infectious diseases
   05146 Amoebiasis
    485773 (PLCB1)
   05142 Chagas disease (American trypanosomiasis)
    485773 (PLCB1)
   05143 African trypanosomiasis
    485773 (PLCB1)
Enzymes [BR:cfa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     485773 (PLCB1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Ensembl: 
Position
24
AA seq 1115 aa AA seqDB search
MITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKL
QVTPEGRIPLKNIYRLFSADRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCP
RPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPN
NSLAKKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLA
GNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFK
TSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYK
ILVKNKKKSHKSSEGSGKKKLSEQVSNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCK
KSSMDEGTAGSEAMATEEMSNLVNYIQPVKFESFEISKSKNRSFEMSSFVETKGLEQLTK
SPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYE
YNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDM
FGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPSLACLRIAVYEEGGKFIGHRI
LPVQAIRPGYHYICLRNERNQPLMLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLME
QRAKQLAALTLEDEEEVKKEADPGETPSEAPSEAGTNPAENGVNHTTSLAPKPPSQALHS
QPAPGSVKAPAKTEDLIQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKT
TDLIKEHTTKYNEIQNDYLRRRAALEKTAKKDSKKKSDPSSPDHGSSTIEQDLAALDAEM
TQKLIDLKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEIC
EKEKKELKKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQ
EKLVEKHKEIRQQILDEKPKLQMDLEQEYQDKFKRLPLEILEFVQEAMKGKISEESNHSS
APPSLASDPGKLNHKPPSSEELEGDNPGKEFDTPL
NT seq 3348 nt NT seq  +upstreamnt  +downstreamnt
atgataacggtggtgtatgggcctgacttagttaacatctcccatttgaatctcgtggct
ttccaagaagaagtggccaaggaatggacaaatgaggttttcagtttggcaacaaacctg
ctggcccaaaacatgtcaagagatgcatttctggaaaaagcctatactaagcttaagctg
caagtcactccagaagggcgcattcctctcaaaaacatataccgcttgttctcagcagac
cggaagcgagttgaaactgctttagaggcttgtagtcttccatcttcaaggaacgattca
atacctcaagaagatttcactccagaagtgtacagagttttcctgaacaacctttgtcct
cgacctgaaattgataatatcttttccgaatttggtgccaaaagcaaaccataccttacc
gttgatcagatgatggattttatcaaccttaagcagcgagatccccggctaaatgaaata
ctttacccacctttaaagcaagaacaagtccaagtattgattgagaagtatgaacccaac
aatagcctcgccaaaaaaggacagatttcagtggatggctttatgcgctatctgagtgga
gaagaaaatggagtcgtttcacctgagaaactggatttgaatgaagatatgtctcagccc
ctttctcactatttcatcaattcctcacacaacacctacctcacagctggccagttggct
ggaaactcctctgttgagatgtatcgccaagtgctcctgtctggttgtcgctgtgtagag
ttggactgctggaagggtcgaactgctgaagaggaaccagtcatcacccatgggttcacc
atgacaaccgaaatatccttcaaggaagtgatagaagcaattgctgagtgtgcatttaag
acgtcaccttttccaattctgctttcatttgagaaccacgtagattccccaaagcagcaa
gccaagatggcggagtattgccgactgatctttggagatgctcttctcatggaaccactg
gaaaaatacccactggaatctggagttcctcttccaagccctatggatttaatgtacaaa
attttggtgaaaaataagaagaaatcccacaagtcgtcagaaggaagtggcaaaaagaag
ctctcagaacaagtctccaacacgtacagtgactcctccagcatgtttgagccctcatct
ccaggagccggggaagctgataccgagagtgatgatgatgatgatgatgatgactgtaaa
aaatcttctatggatgaggggactgccgggagtgaggccatggccacagaagagatgtct
aacctggtgaactatattcaaccagtcaagtttgagtcatttgaaatttcaaaaagtaaa
aatagaagttttgaaatgtcttctttcgtggaaaccaaaggactagagcaactgacaaag
tctccagtggaatttgtagaatataacaaaatgcagcttagcaggatatatccaaaagga
acccgtgtggattcatctaactacatgcctcagctcttctggaatgcaggttgtcaaatg
gttgcacttaattttcaaactgtggacctggctatgcaaataaatatggggatgtatgaa
tacaatgggaaaagtggctacagattaaagccagagttcatgaggagacctgacaagcat
tttgatccattcaccgaaggcatcgtggatgggatagtggccaatactttatctgtcaag
attatttcaggtcagtttctctctgataagaaagttgggacttacgtggaagtggatatg
tttggtttgcctgtggacacaaggaggaaggcatttaagaccaaaacatcacaaggaaat
gctgtaaatcctgtctgggaagaagagcccattgtgttcaaaaaggtggttcttccttct
ctggcctgtttgaggatagcagtttatgaagaaggaggtaaatttatcggtcaccggatc
ttgccagtacaggcaattcggccaggctatcactacatctgtctgaggaatgagaggaac
cagcctctgatgcttccagctgtgtttgtctacatagaggtgaaagactatgtcccagat
acctatgcagatgtgattgaagctttgtcaaatccaatacgatatgtgaatctgatggaa
cagagagctaaacaactggctgctttgacactggaagatgaagaagaagtaaagaaagag
gctgatcctggggaaacaccgtcagaagctccaagtgaagctgggacaaatccagcagaa
aacggagtgaatcacactacatctctggcacccaaaccaccctcccaggccctccacagc
caaccagctccaggctctgtaaaggcacctgccaaaacagaagatcttattcagagtgtt
ttaacagaagtggaagcacagaccattgaagagctaaagcaacagaaatcgtttgtgaaa
cttcaaaagaaacactacaaagaaatgaaagacctggttaaaagacaccacaagaaaacc
acagaccttatcaaagaacacactacaaaatataatgaaattcagaatgactacttgaga
aggagggcagctttggaaaagacagccaaaaaggacagtaagaaaaaatcagatcccagc
agtcctgaccatggttcatcaacaattgagcaagatcttgctgcccttgatgccgaaatg
acccaaaagttaatagacttgaaggacaaacaacagcagcagctgcttaatcttcgacaa
gagcagtattatagtgaaaaataccagaagcgagaacatattaaactgcttattcaaaaa
ttgacggatgttgctgaagaatgtcagaacaatcagttgaagaagctcaaagaaatctgt
gagaaagagaagaaggaattaaagaagaaaatggataaaaaaaggcaggagaagataaca
gaagctaaatccaaagacaaaagtcaaatggaagaggaaaagacagagatgatccggtca
tatatccaggaggtggtgcagtacatcaagaggttagaagaggcacaaagtaaacggcaa
gaaaaacttgtagagaaacacaaggagatacgtcagcagatcctggatgaaaagcccaag
ctgcagatggacttggagcaagagtaccaagacaagttcaaaagactgcccctggagatc
ttggagtttgtgcaggaagccatgaaagggaagatcagtgaagagagcaatcacagttct
gcccctccatccctggcctcagaccctggaaaactgaaccacaagcctccctccagtgag
gagctagagggagacaacccaggaaaagagtttgatactcctctgtga

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