KEGG   Canis familiaris (dog): 485773Help
Entry
485773            CDS       T01007                                 

Gene name
PLCB1
Definition
(RefSeq) phospholipase C beta 1
  KO
K05858  
phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
cfa  Canis familiaris (dog)
Pathway
Inositol phosphate metabolism
Metabolic pathways
Rap1 signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
Phosphatidylinositol signaling system
Sphingolipid signaling pathway
Phospholipase D signaling pathway
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Wnt signaling pathway
Apelin signaling pathway
Gap junction
Platelet activation
NOD-like receptor signaling pathway
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Dopaminergic synapse
Long-term depression
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Glucagon signaling pathway
Renin secretion
Aldosterone synthesis and secretion
AGE-RAGE signaling pathway in diabetic complications
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Alzheimer's disease
Huntington's disease
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Amoebiasis
Pathways in cancer
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:cfa00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    485773 (PLCB1)
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    485773 (PLCB1)
   04310 Wnt signaling pathway
    485773 (PLCB1)
   04371 Apelin signaling pathway
    485773 (PLCB1)
   04020 Calcium signaling pathway
    485773 (PLCB1)
   04070 Phosphatidylinositol signaling system
    485773 (PLCB1)
   04072 Phospholipase D signaling pathway
    485773 (PLCB1)
   04071 Sphingolipid signaling pathway
    485773 (PLCB1)
   04022 cGMP - PKG signaling pathway
    485773 (PLCB1)
 Cellular Processes
  Cellular community - eukaryotes
   04540 Gap junction
    485773 (PLCB1)
 Organismal Systems
  Immune system
   04611 Platelet activation
    485773 (PLCB1)
   04621 NOD-like receptor signaling pathway
    485773 (PLCB1)
   04062 Chemokine signaling pathway
    485773 (PLCB1)
  Endocrine system
   04911 Insulin secretion
    485773 (PLCB1)
   04922 Glucagon signaling pathway
    485773 (PLCB1)
   04912 GnRH signaling pathway
    485773 (PLCB1)
   04915 Estrogen signaling pathway
    485773 (PLCB1)
   04921 Oxytocin signaling pathway
    485773 (PLCB1)
   04918 Thyroid hormone synthesis
    485773 (PLCB1)
   04919 Thyroid hormone signaling pathway
    485773 (PLCB1)
   04916 Melanogenesis
    485773 (PLCB1)
   04924 Renin secretion
    485773 (PLCB1)
   04925 Aldosterone synthesis and secretion
    485773 (PLCB1)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    485773 (PLCB1)
   04270 Vascular smooth muscle contraction
    485773 (PLCB1)
  Digestive system
   04970 Salivary secretion
    485773 (PLCB1)
   04971 Gastric acid secretion
    485773 (PLCB1)
   04972 Pancreatic secretion
    485773 (PLCB1)
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    485773 (PLCB1)
  Nervous system
   04724 Glutamatergic synapse
    485773 (PLCB1)
   04725 Cholinergic synapse
    485773 (PLCB1)
   04728 Dopaminergic synapse
    485773 (PLCB1)
   04726 Serotonergic synapse
    485773 (PLCB1)
   04720 Long-term potentiation
    485773 (PLCB1)
   04730 Long-term depression
    485773 (PLCB1)
   04723 Retrograde endocannabinoid signaling
    485773 (PLCB1)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    485773 (PLCB1)
  Environmental adaptation
   04713 Circadian entrainment
    485773 (PLCB1)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    485773 (PLCB1)
  Neurodegenerative diseases
   05010 Alzheimer's disease
    485773 (PLCB1)
   05016 Huntington's disease
    485773 (PLCB1)
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    485773 (PLCB1)
  Infectious diseases
   05146 Amoebiasis
    485773 (PLCB1)
   05142 Chagas disease (American trypanosomiasis)
    485773 (PLCB1)
   05143 African trypanosomiasis
    485773 (PLCB1)
Enzymes [BR:cfa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     485773 (PLCB1)
Membrane trafficking [BR:cfa04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    485773 (PLCB1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    485773 (PLCB1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-ProteinID: 
NCBI-GeneID: 
Ensembl: 
Position
24
AA seq 1190 aa AA seqDB search
MCFLVQMDSTIVTPIILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGKHAKAPKDPKL
RELLDVGNIGRLEHRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLATNLLAQNM
SRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSADRKRVETALEACSLPSSRNDSIPQED
FTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPL
KQEQVQVLIEKYEPNNSLAKKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYF
INSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEI
SFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPL
ESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQVSNTYSDSSSMFEPSSPGAGE
ADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEMSNLVNYIQPVKFESFEISKKRNRSFE
MSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNF
QTVDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQ
FLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPSLACLR
IAVYEEGGKFIGHRILPVQAIRPGYHYICLRNERNQPLMLPAVFVYIEVKDYVPDTYADV
IEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKKEADPGETPSEAPSEAGTNPAENGVNH
TTSLAPKPPSQALHSQPAPGSVKAPAKTEDLIQSVLTEVEAQTIEELKQQKSFVKLQKKH
YKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLRRRAALEKTAKKDSKKKSDPSSPDHG
SSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVA
EECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEV
VQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKPKLQMDLEQEYQDKFKRLPLEILEFVQ
EAMKGKISEESNHSSAPPSLASDPGKLNHKPPSSEELEGDNPGKEFDTPL
NT seq 3573 nt NT seq  +upstreamnt  +downstreamnt
atgtgttttcttgtgcagatggactccactattgtgactccaattattttgaggactgac
cctcagggatttttcttttactggacagatcaaaataaggagacggagctgttagatctc
agccttgtcaaggatgccagatgtgggaaacatgccaaagctcccaaggaccccaaatta
cgtgaacttttggatgtggggaacatcggacgcctggagcatcgcatgataacggtggtg
tatgggcctgacttagttaacatctcccatttgaatctcgtggctttccaagaagaagtg
gccaaggaatggacaaatgaggttttcagtttggcaacaaacctgctggcccaaaacatg
tcaagagatgcatttctggaaaaagcctatactaagcttaagctgcaagtcactccagaa
gggcgcattcctctcaaaaacatataccgcttgttctcagcagaccggaagcgagttgaa
actgctttagaggcttgtagtcttccatcttcaaggaacgattcaatacctcaagaagat
ttcactccagaagtgtacagagttttcctgaacaacctttgtcctcgacctgaaattgat
aatatcttttccgaatttggtgccaaaagcaaaccataccttaccgttgatcagatgatg
gattttatcaaccttaagcagcgagatccccggctaaatgaaatactttacccaccttta
aagcaagaacaagtccaagtattgattgagaagtatgaacccaacaatagcctcgccaaa
aaaggacagatttcagtggatggctttatgcgctatctgagtggagaagaaaatggagtc
gtttcacctgagaaactggatttgaatgaagatatgtctcagcccctttctcactatttc
atcaattcctcacacaacacctacctcacagctggccagttggctggaaactcctctgtt
gagatgtatcgccaagtgctcctgtctggttgtcgctgtgtagagttggactgctggaag
ggtcgaactgctgaagaggaaccagtcatcacccatgggttcaccatgacaaccgaaata
tccttcaaggaagtgatagaagcaattgctgagtgtgcatttaagacgtcaccttttcca
attctgctttcatttgagaaccacgtagattccccaaagcagcaagccaagatggcggag
tattgccgactgatctttggagatgctcttctcatggaaccactggaaaaatacccactg
gaatctggagttcctcttccaagccctatggatttaatgtacaaaattttggtgaaaaat
aagaagaaatcccacaagtcgtcagaaggaagtggcaaaaagaagctctcagaacaagtc
tccaacacgtacagtgactcctccagcatgtttgagccctcatctccaggagccggggaa
gctgataccgagagtgatgatgatgatgatgatgatgactgtaaaaaatcttctatggat
gaggggactgccgggagtgaggccatggccacagaagagatgtctaacctggtgaactat
attcaaccagtcaagtttgagtcatttgaaatttcaaaaaaaagaaatagaagttttgaa
atgtcttctttcgtggaaaccaaaggactagagcaactgacaaagtctccagtggaattt
gtagaatataacaaaatgcagcttagcaggatatatccaaaaggaacccgtgtggattca
tctaactacatgcctcagctcttctggaatgcaggttgtcaaatggttgcacttaatttt
caaactgtggacctggctatgcaaataaatatggggatgtatgaatacaatgggaaaagt
ggctacagattaaagccagagttcatgaggagacctgacaagcattttgatccattcacc
gaaggcatcgtggatgggatagtggccaatactttatctgtcaagattatttcaggtcag
tttctctctgataagaaagttgggacttacgtggaagtggatatgtttggtttgcctgtg
gacacaaggaggaaggcatttaagaccaaaacatcacaaggaaatgctgtaaatcctgtc
tgggaagaagagcccattgtgttcaaaaaggtggttcttccttctctggcctgtttgagg
atagcagtttatgaagaaggaggtaaatttatcggtcaccggatcttgccagtacaggca
attcggccaggctatcactacatctgtctgaggaatgagaggaaccagcctctgatgctt
ccagctgtgtttgtctacatagaggtgaaagactatgtcccagatacctatgcagatgtg
attgaagctttgtcaaatccaatacgatatgtgaatctgatggaacagagagctaaacaa
ctggctgctttgacactggaagatgaagaagaagtaaagaaagaggctgatcctggggaa
acaccgtcagaagctccaagtgaagctgggacaaatccagcagaaaacggagtgaatcac
actacatctctggcacccaaaccaccctcccaggccctccacagccaaccagctccaggc
tctgtaaaggcacctgccaaaacagaagatcttattcagagtgttttaacagaagtggaa
gcacagaccattgaagagctaaagcaacagaaatcgtttgtgaaacttcaaaagaaacac
tacaaagaaatgaaagacctggttaaaagacaccacaagaaaaccacagaccttatcaaa
gaacacactacaaaatataatgaaattcagaatgactacttgagaaggagggcagctttg
gaaaagacagccaaaaaggacagtaagaaaaaatcagatcccagcagtcctgaccatggt
tcatcaacaattgagcaagatcttgctgcccttgatgccgaaatgacccaaaagttaata
gacttgaaggacaaacaacagcagcagctgcttaatcttcgacaagagcagtattatagt
gaaaaataccagaagcgagaacatattaaactgcttattcaaaaattgacggatgttgct
gaagaatgtcagaacaatcagttgaagaagctcaaagaaatctgtgagaaagagaagaag
gaattaaagaagaaaatggataaaaaaaggcaggagaagataacagaagctaaatccaaa
gacaaaagtcaaatggaagaggaaaagacagagatgatccggtcatatatccaggaggtg
gtgcagtacatcaagaggttagaagaggcacaaagtaaacggcaagaaaaacttgtagag
aaacacaaggagatacgtcagcagatcctggatgaaaagcccaagctgcagatggacttg
gagcaagagtaccaagacaagttcaaaagactgcccctggagatcttggagtttgtgcag
gaagccatgaaagggaagatcagtgaagagagcaatcacagttctgcccctccatccctg
gcctcagaccctggaaaactgaaccacaagcctccctccagtgaggagctagagggagac
aacccaggaaaagagtttgatactcctctgtga

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