KEGG   Canis familiaris (dog): 485874Help
Entry
485874            CDS       T01007                                 

Gene name
PLCG1
Definition
phospholipase C, gamma 1
Orthology
K01116  
phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Organism
cfa  Canis familiaris (dog)
Pathway
Inositol phosphate metabolism
Metabolic pathways
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
NF-kappa B signaling pathway
HIF-1 signaling pathway
Phosphatidylinositol signaling system
VEGF signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Inflammatory mediator regulation of TRP channels
Thyroid hormone signaling pathway
Epstein-Barr virus infection
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Glioma
Non-small cell lung cancer
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:cfa00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    485874 (PLCG1)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    485874 (PLCG1)
   04015 Rap1 signaling pathway
    485874 (PLCG1)
   04012 ErbB signaling pathway
    485874 (PLCG1)
   04370 VEGF signaling pathway
    485874 (PLCG1)
   04064 NF-kappa B signaling pathway
    485874 (PLCG1)
   04066 HIF-1 signaling pathway
    485874 (PLCG1)
   04020 Calcium signaling pathway
    485874 (PLCG1)
   04070 Phosphatidylinositol signaling system
    485874 (PLCG1)
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    485874 (PLCG1)
   04660 T cell receptor signaling pathway
    485874 (PLCG1)
   04664 Fc epsilon RI signaling pathway
    485874 (PLCG1)
   04666 Fc gamma R-mediated phagocytosis
    485874 (PLCG1)
   04670 Leukocyte transendothelial migration
    485874 (PLCG1)
  Endocrine system
   04919 Thyroid hormone signaling pathway
    485874 (PLCG1)
  Nervous system
   04722 Neurotrophin signaling pathway
    485874 (PLCG1)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    485874 (PLCG1)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    485874 (PLCG1)
   05206 MicroRNAs in cancer
    485874 (PLCG1)
   05205 Proteoglycans in cancer
    485874 (PLCG1)
   05214 Glioma
    485874 (PLCG1)
   05223 Non-small cell lung cancer
    485874 (PLCG1)
  Infectious diseases
   05169 Epstein-Barr virus infection
    485874 (PLCG1)
Enzymes [BR:cfa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     485874 (PLCG1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Ensembl: 
Position
24
AA seq 1177 aa AA seqDB search
MEFRLKTLSLQATSEDEVNMWIKGLTWLMEDTLQAATPLQIERWLRKQFYSVDRNREDRI
SAKDLKNMLSQVNYRVPNMRFLRERLTDLEQRSSDITYGQFAQLYRSLMYSAQKTMDLPF
LEASALRAGERPELCRVSLPEFQQFLLEYQGELWAVDRLQVQEFMLSFLRDPLREIEEPY
FFLDEFVTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEA
YARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILS
IEDHCSIAQQRNMAQYFKKVLGDTLLTKPVDIAADGLPSPNQLKRKILIKHKKLAEGSAY
EEVPTSVMYSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDE
EEPKEASGSTELHSSEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFV
GDYTLSFWRNGKVQHCRIHSRQDAGAPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMR
LSEPVPQTNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKI
KHCRVQQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYG
ALYEGRNPGFYVEANPMPTFKCAVKALFDYKAQRDDELTFTKSAIIQNVEKQEGGWWRGD
YGGKKQLWFPSNYVEEMVSPAALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNN
RLFVFSISMASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALE
LSELVVYCRPVPFDEDKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIY
PKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMAGGHCGYVLQPSTMRDE
AFDPFDKSSLRGLEPYAICIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSIKQKTEFVV
DNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPL
KNNYSEDLELASLLVKIDVFPAKENGDLSPFGMSLRERGSDASGQLFHGRAREGSFEARY
QQPFEDFRISQEHLADHFDSRERRAPRRTRVNGDNRL
NT seq 3534 nt NT seq  +upstreamnt  +downstreamnt
atggaattccgcctgaagactctgagcctgcaagctacatctgaggatgaagtgaacatg
tggatcaagggtttaacttggctgatggaggatacattgcaggcagccacacctctgcag
attgagaggtggctgcggaagcagttctactcagtggatcggaatcgtgaggatcgtata
tcagccaaggacttgaagaacatgctgtcccaggtcaactaccgggttcccaacatgcgc
ttcctccgagagcgtctgacggacctggagcagcgcagcagtgacatcacctacgggcag
tttgctcagctgtaccgcagcctcatgtacagcgcccagaagacgatggacctccccttc
ttggaagccagtgccctgagggcaggggagcgcccggagctctgtcgtgtgtcccttcct
gagtttcagcagttcctcctcgagtaccagggggagctgtgggctgttgatcggcttcag
gtgcaggagttcatgctcagcttccttcgagatcctttacgagaaattgaagagccttac
ttcttcctggacgagtttgtcaccttcttgttctccaaagagaacagcgtgtggaattca
cagctggatgcagtgtgcccggacaccatgaacaaccctctgtcccactactggatctcc
tcctcccacaacacgtacctgactggggaccagttctccagcgagtcctctctggaagcc
tatgctcgctgcctgcggatgggctgtcgctgcattgagttggactgctgggatggccca
gatgggatgccagtcatttaccatgggcacacccttaccaccaagatcaagttctcagat
gttctacataccatcaaggagcatgccttcgtggcttcagagtatccggtcatcctgtcc
atcgaggaccactgcagcatcgcccagcagagaaacatggcgcagtacttcaagaaggtg
cttggggacacactcctcaccaagcctgtggacatcgccgctgacgggctcccctcaccc
aaccagctcaagaggaagatcctcatcaagcacaagaagctggcagagggcagtgcctac
gaagaggtgcctacgtcagtgatgtactccgagaacgatatcagcaactccatcaagaat
ggcatcctctacctggaggacccggtgaaccatgagtggtacccccactacttcgttctg
accagcagcaagatctactactctgaggagaccagcagtgaccagggcaatgaggatgag
gaggaacccaaggaggccagtggcagcacagagctgcactccagtgagaagtggttccac
gggaagcttggagcaggacgggatggacggcacattgccgagcgcctgctcaccgagtat
tgcattgagaccggggcccctgatggctccttcctcgtgcgggagagcgagaccttcgtg
ggcgactataccctctctttctggaggaacgggaaagtccagcactgtcggatccattcc
cggcaggatgctggggcccccaagttcttcttgacagacaacctggtctttgattcgctc
tatgacctcatcacgcactaccagcaagtgcccctgcgctgcaacgaatttgagatgcgc
ctttcagagccggtcccacagaccaatgcccacgagagcaaagagtggtaccacgccagc
ctgaccagagctcaggccgagcacatgctgatgcgtgttccccgggatggggccttcctg
gtgaggaaacggaatgagcccaactcctatgccatctctttccgggccgagggcaagatc
aaacattgccgcgtccagcaggagggccagactgtgatgctgggcaactctgagtttgac
agcctcgtggacctcatcagctactatgagaagcacccgctataccgcaaaatgaagctg
cgctatcccatcaatgaggaagcgctggagaagataggcacagctgagcctgactatgga
gccctgtatgagggacgcaaccctggcttctatgtggaggcaaatcctatgccgactttt
aagtgtgccgtcaaagccctctttgactacaaggctcagagggatgacgagctgacattc
acgaagagcgccatcatccagaatgtggagaagcaagaaggtggctggtggcggggggac
tacggggggaaaaagcagctctggttcccgtcaaactacgtagaagagatggtcagccct
gcagccctggagcctgagagggagcacttggatgagaacagccccctgggggatttgctc
cgtggggtcttggatgtgccagcctgtcagattgctatccgtcctgagggcaagaacaac
cggctcttcgtcttctccatcagcatggcttcagtggcacactggtccttggatgtcgct
gctgattcacaggaagagctgcaggactgggtgaagaagatccgagaagtggcccagacg
gcagacgccaggctcacggaggggaagatgatggagcgcaggaagaagatcgccctggag
ctctccgagctggttgtctactgcaggccggttcccttcgatgaagacaagattggcaca
gaacgtgcctgctaccgggacatgtcatcctttccggaaaccaaggctgagaaatatgtg
aacaaggccaaaggcaagaagttcctccagtacaaccggctgcagctctcacgcatctac
cccaagggccagcggctagactcctccaattatgaccccctgcccatgtggatctgtggc
agtcagctcgtagccctcaacttccagaccccagacaagcccatgcagatgaaccaggcc
ctcttcatggccggcggccactgcggctacgtgctgcagccgagcaccatgcgggacgag
gcctttgatccctttgacaagagcagcctccgaggcctggaaccatatgccatctgcatt
gaggtgctgggggctcggcacctgccaaagaatggccgaggcatcgtgtgtcctttcgtg
gagattgaagtggccggagcagagtacgacagcatcaagcagaagacagagttcgtggtg
gacaatggactgaaccctgtgtggcctgctaagcccttccacttccagatcagtaaccca
gaattcgcctttttgcgctttgtggtgtatgaggaagacatgtttagtgaccagaacttc
ctggctcaggctacattcccggtgaaaggcctgaagacaggatacagagctgtgcctttg
aagaacaactacagtgaggacctagagctggcctccctgctcgtcaagatcgacgtgttc
cctgccaaggagaatggggacctcagtcccttcgggatgtctcttcgggagcgaggctct
gatgcctcaggccagctgttccatggccgggcccgtgaaggttcctttgaggcccgctac
cagcagccatttgaggactttcgtatctcccaggagcacctggcagaccattttgacagt
cgggaacggagggccccacggaggacacgggtcaacggagacaaccgcctctag

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