KEGG   Canis familiaris (dog): 486148Help
Entry
486148            CDS       T01007                                 

Gene name
IRS1
Definition
insulin receptor substrate 1
Orthology
K16172  
insulin receptor substrate 1
Organism
cfa  Canis familiaris (dog)
Pathway
FoxO signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
Neurotrophin signaling pathway
Insulin signaling pathway
Adipocytokine signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
MicroRNAs in cancer
Class
Environmental Information Processing; Signal transduction; FoxO signaling pathway [PATH:cfa04068]
Environmental Information Processing; Signal transduction; PI3K-Akt signaling pathway [PATH:cfa04151]
Environmental Information Processing; Signal transduction; mTOR signaling pathway [PATH:cfa04150]
Organismal Systems; Endocrine system; Insulin signaling pathway [PATH:cfa04910]
Organismal Systems; Endocrine system; Adipocytokine signaling pathway [PATH:cfa04920]
Organismal Systems; Excretory system; Aldosterone-regulated sodium reabsorption [PATH:cfa04960]
Organismal Systems; Nervous system; Neurotrophin signaling pathway [PATH:cfa04722]
Human Diseases; Cancers; MicroRNAs in cancer [PATH:cfa05206]
Human Diseases; Endocrine and metabolic diseases; Type II diabetes mellitus [PATH:cfa04930]
Human Diseases; Endocrine and metabolic diseases; Non-alcoholic fatty liver disease (NAFLD) [PATH:cfa04932]
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Position
25
AA seq 1240 aa AA seqDB search
MASPPETDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP
KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGH
HDGASAPGAGGGGGSCSGSSGLGEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLI
GIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQV
DDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLT
RRSRTESITATSPASMVGGKQGSFRVRASSDGEGTMSRPASVDGSPVSPSTTRTHAHRHR
GSSRLHPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSP
SDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGSSTLTAPN
GHYILPRGGNGHRYIPGAGLGTSPALAADEAAAAADLDNRFRKRTHSAGTSPTISHQKTP
SQSSVASIEEYTEMMPAYPPGGGSGGRLPGYRHSAFVPTHSYPEEGLEMHPLDRRGGHHR
PDAAALHTDDGYMPMSPGVAPVPSSRKGSGDYMPMSPKSVSAPQQIINPIRRHPQRVDPN
GYMMMSPSGSCSPDIGGGPGSSSSGSAAPSGSSYGKLWTNGVGGHHPHALPHPKLPVESG
SGKLLSCTGDYMNMSPVGDSNTSSPSDGYYGPEDPQHKPVLSYYSLPRSFKHTQRPGELE
ESARHXHLRLSSSSGRLLYAATAEDSSSSTSSDSLGPGGYCGVRPDPGLPHIHHQVLQPH
LPRKVDTAAQTNSRLARPTRLSLGDPKASTLPRVREQQHPPPLLHPPEPKSPGEYVNIEF
GSDQPGYLSGPVAARSSPSVRCPPQLQPAPREEETGTEEYMNMDLGPGRRAAWQEGAGVQ
PGRVGPAPPGAASVCRPTRAVPSSRGDYMTMQVGCPGQGYVDTSPVAPISYADMRTGIVV
EEASLPGATAAAPSSASAASASPTAPPKAGELVARSSLLGGPQGPGGMSAFTRVNLSPNR
NQSAKVIRADPQGCRRRHSSETFSSTPSATRAGNAVPFGGGAALGGSGGGSSAEDMKRHS
SASFENVWLRPGELGGAPKEPAPHAGAAGGLENGLNYIDLDLVKDFKQCSQERPPQPQPP
PPPAPHQPLGSSESSSTSRSSEDLSAYASISFQKQPEDLQ
NT seq 3723 nt NT seq  +upstreamnt  +downstreamnt
atggcgagccctccggagaccgacggcttctcggacgtgcgcaaggtgggctacctgcgc
aaacccaagagcatgcacaagcgcttcttcgtgctgcgggcggccagcgaggcggggggc
ccggcgcgcctcgagtactacgagaacgagaagaagtggcggcacaagtcgagcgccccc
aaacgctcgatccccctcgagagctgcttcaacatcaacaagcgggcggactccaagaac
aagcacctggtggccctttacacccgggacgagcactttgccatcgcggcggacagcgag
gccgagcaggacagctggtaccaggccctcctgcagctgcacaaccgggccaagggccac
cacgacggcgcctcggcccccggggcgggaggcggcgggggcagctgcagcggcagctcg
ggcctcggggaggccggcgaggacttgagctacggggacgtgcccccgggacctgcgttc
aaggaggtctggcaggtgatcctgaaacccaagggcctggggcagacaaagaacctgatt
ggcatctaccgcctctgcctgaccagcaagaccatcagcttcgtgaagctgaactccgag
gcggcggccgtggtgctgcagctgatgaacatccgacgttgcggccactcggagaacttc
ttcttcatcgaagtgggccgttccgcagtgacgggacccggcgagttctggatgcaggtg
gatgactccgtggtggcccagaacatgcacgagaccatcctggaggccatgcgggccatg
agcgacgagttccgccctcggagtaagagccagtcctcctccaactgctccaaccccatc
agcgtccccctgcgccggcaccacctcaacaacccccctcccagccaggtggggctgacg
cgccgctcgcgcaccgagagcatcaccgccacctctccggccagcatggtgggcgggaag
cagggctccttccgtgtgcgcgcgtccagcgacggcgagggcaccatgtcccgcccggcc
tcggtggacggcagccccgtgagcccgagcaccaccaggacccacgcgcaccggcatcgc
ggcagctcccggctgcaccccccgctcaaccacagccgctccatccccatgccttcctct
cgctgctcgccttccgccaccagcccggtcagcctgtcgtccagcagcaccagtggccac
ggctccacctcggactgcctcttcccccggcgctctagtgcctctgtgtcgggttccccc
agcgacggtggtttcatctcctctgacgagtacggctcgagtccctgcgatttccgaagt
tccttccgcagtgtcaccccggattccctgggccacacccccccggcccgcggcgaggag
gagctgagcaactacatctgcatgggaggcaaagggtcctccaccctcaccgcccccaac
ggtcactacattttgcctcggggtggcaatggccaccgctacatcccgggggctggcttg
ggcaccagcccggccctggctgcggatgaagcggccgctgcggccgacctggataaccgg
ttccgaaagcggactcactccgcgggcacatcccctaccatttcccaccagaagaccccg
tcccagtcttctgtggcttccattgaggagtacacggagatgatgcctgcctacccgcca
ggaggtggcagtggaggccgactgcctggctaccggcactctgccttcgtgcccacccac
tcctaccccgaggagggtctggaaatgcaccctctggacaggcgtgggggccaccaccgg
ccggacgccgccgccctccacacggatgatggctacatgcccatgtccccgggagtggca
ccggtgcccagcagccggaagggcagtggggactatatgcccatgagccccaagagcgtg
tccgcgccgcagcagatcatcaaccccattagacgccatccccagagggtggaccccaat
ggctacatgatgatgtccccaagcggcagctgctctcctgacattggaggtgggcccggc
agcagcagcagcggcagcgccgccccttctgggagcagctatggcaagctgtggacaaac
ggggtagggggccaccaccctcacgccctgccgcaccccaaactccccgtggagagcggg
agtggcaagctcctgtcttgtaccggcgactacatgaacatgtcgccggtgggggactcc
aacaccagcagcccctccgacggctactacggcccagaggacccccagcacaagccagtt
ctctcctactactcattgccaaggtcctttaagcacacccagcgccctggggagctggag
gagagcgcccggcacnagcacctccgcctctcctccagctcgggtcgtcttctctacgcc
gcgacggcggaagattcctcctcctccaccagcagcgacagcctgggcccagggggatac
tgtggggtcaggccggatcccggcctcccgcatatccaccatcaggtcctgcagcctcac
ctgcctcggaaggtggacacggccgcgcagaccaacagccgcctggctcggcccacgagg
ctgtccctgggggaccccaaggccagcaccttacctcgggttcgagagcagcagcacccg
ccgcccctgctgcaccctccggagcccaagagccccggggaatatgtgaatattgagttc
gggagcgatcagccgggctacttatcggggccggtggctgcccgcagctcgccttctgtc
aggtgcccaccccagctccagccagctccccgcgaggaagagactggcaccgaggagtac
atgaacatggacctggggcctggccggagggcagcctggcaggagggtgctggggtccag
cccggcagggtgggccccgcgccccccggggccgctagcgtgtgcaggcccacccgggca
gtgcccagcagccggggcgactacatgaccatgcaggtgggctgtcccggccagggctac
gtggacacctcgccagtggcccccatcagctacgctgacatgcggacaggcattgtcgtg
gaggaggccagcctgccgggggccacagcggccgccccctcctcggcctcggcagcctcg
gcttcccccacggcgcctccaaaagcgggggagctggtggcccgctcctccctgctgggg
ggcccgcagggacccgggggcatgagcgccttcacccgggtgaacctcagccccaaccgc
aaccagagtgccaaagtgatccgcgccgacccgcaggggtgccggaggcggcatagctct
gagaccttctcctccacgcccagtgccacccgggcgggcaacgcagtgcccttcggcggg
ggggcggccctggggggcagcggtggcggcagcagcgcggaggatatgaaacgccacagt
tcggcttcctttgagaacgtgtggctgaggcctggggagctcgggggagcccccaaggag
ccggccccgcacgctggggccgccgggggtttggagaatgggcttaactacatagacctg
gatttggtcaaggacttcaaacagtgctctcaggagcgcccccctcaaccgcagccgccc
ccgcccccggcccctcatcagcctctgggcagcagtgagagcagttcaaccagccgctcc
agcgaggatctaagcgcctatgccagcatcagtttccagaagcagccagaggacctccag
tag

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