KEGG   Canis familiaris (dog): 486148Help
Entry
486148            CDS       T01007                                 

Gene name
IRS1
Definition
insulin receptor substrate 1
Orthology
K16172  
insulin receptor substrate 1
Organism
cfa  Canis familiaris (dog)
Pathway
cGMP-PKG signaling pathway
FoxO signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Neurotrophin signaling pathway
Insulin signaling pathway
Adipocytokine signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
MicroRNAs in cancer
Brite
KEGG Orthology (KO) [BR:cfa00001]
 Environmental Information Processing
  Signal transduction
   04068 FoxO signaling pathway
    486148 (IRS1)
   04022 cGMP - PKG signaling pathway
    486148 (IRS1)
   04151 PI3K-Akt signaling pathway
    486148 (IRS1)
   04152 AMPK signaling pathway
    486148 (IRS1)
   04150 mTOR signaling pathway
    486148 (IRS1)
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    486148 (IRS1)
   04920 Adipocytokine signaling pathway
    486148 (IRS1)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    486148 (IRS1)
  Nervous system
   04722 Neurotrophin signaling pathway
    486148 (IRS1)
 Human Diseases
  Cancers
   05206 MicroRNAs in cancer
    486148 (IRS1)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    486148 (IRS1)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    486148 (IRS1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Position
25
AA seq 1240 aa AA seqDB search
MASPPETDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP
KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGH
HDGASAPGAGGGGGSCSGSSGLGEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLI
GIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQV
DDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLT
RRSRTESITATSPASMVGGKQGSFRVRASSDGEGTMSRPASVDGSPVSPSTTRTHAHRHR
GSSRLHPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSP
SDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGSSTLTAPN
GHYILPRGGNGHRYIPGAGLGTSPALAADEAAAAADLDNRFRKRTHSAGTSPTISHQKTP
SQSSVASIEEYTEMMPAYPPGGGSGGRLPGYRHSAFVPTHSYPEEGLEMHPLDRRGGHHR
PDAAALHTDDGYMPMSPGVAPVPSSRKGSGDYMPMSPKSVSAPQQIINPIRRHPQRVDPN
GYMMMSPSGSCSPDIGGGPGSSSSGSAAPSGSSYGKLWTNGVGGHHPHALPHPKLPVESG
SGKLLSCTGDYMNMSPVGDSNTSSPSDGYYGPEDPQHKPVLSYYSLPRSFKHTQRPGELE
ESARHXHLRLSSSSGRLLYAATAEDSSSSTSSDSLGPGGYCGVRPDPGLPHIHHQVLQPH
LPRKVDTAAQTNSRLARPTRLSLGDPKASTLPRVREQQHPPPLLHPPEPKSPGEYVNIEF
GSDQPGYLSGPVAARSSPSVRCPPQLQPAPREEETGTEEYMNMDLGPGRRAAWQEGAGVQ
PGRVGPAPPGAASVCRPTRAVPSSRGDYMTMQVGCPGQGYVDTSPVAPISYADMRTGIVV
EEASLPGATAAAPSSASAASASPTAPPKAGELVARSSLLGGPQGPGGMSAFTRVNLSPNR
NQSAKVIRADPQGCRRRHSSETFSSTPSATRAGNAVPFGGGAALGGSGGGSSAEDMKRHS
SASFENVWLRPGELGGAPKEPAPHAGAAGGLENGLNYIDLDLVKDFKQCSQERPPQPQPP
PPPAPHQPLGSSESSSTSRSSEDLSAYASISFQKQPEDLQ
NT seq 3723 nt NT seq  +upstreamnt  +downstreamnt
atggcgagccctccggagaccgacggcttctcggacgtgcgcaaggtgggctacctgcgc
aaacccaagagcatgcacaagcgcttcttcgtgctgcgggcggccagcgaggcggggggc
ccggcgcgcctcgagtactacgagaacgagaagaagtggcggcacaagtcgagcgccccc
aaacgctcgatccccctcgagagctgcttcaacatcaacaagcgggcggactccaagaac
aagcacctggtggccctttacacccgggacgagcactttgccatcgcggcggacagcgag
gccgagcaggacagctggtaccaggccctcctgcagctgcacaaccgggccaagggccac
cacgacggcgcctcggcccccggggcgggaggcggcgggggcagctgcagcggcagctcg
ggcctcggggaggccggcgaggacttgagctacggggacgtgcccccgggacctgcgttc
aaggaggtctggcaggtgatcctgaaacccaagggcctggggcagacaaagaacctgatt
ggcatctaccgcctctgcctgaccagcaagaccatcagcttcgtgaagctgaactccgag
gcggcggccgtggtgctgcagctgatgaacatccgacgttgcggccactcggagaacttc
ttcttcatcgaagtgggccgttccgcagtgacgggacccggcgagttctggatgcaggtg
gatgactccgtggtggcccagaacatgcacgagaccatcctggaggccatgcgggccatg
agcgacgagttccgccctcggagtaagagccagtcctcctccaactgctccaaccccatc
agcgtccccctgcgccggcaccacctcaacaacccccctcccagccaggtggggctgacg
cgccgctcgcgcaccgagagcatcaccgccacctctccggccagcatggtgggcgggaag
cagggctccttccgtgtgcgcgcgtccagcgacggcgagggcaccatgtcccgcccggcc
tcggtggacggcagccccgtgagcccgagcaccaccaggacccacgcgcaccggcatcgc
ggcagctcccggctgcaccccccgctcaaccacagccgctccatccccatgccttcctct
cgctgctcgccttccgccaccagcccggtcagcctgtcgtccagcagcaccagtggccac
ggctccacctcggactgcctcttcccccggcgctctagtgcctctgtgtcgggttccccc
agcgacggtggtttcatctcctctgacgagtacggctcgagtccctgcgatttccgaagt
tccttccgcagtgtcaccccggattccctgggccacacccccccggcccgcggcgaggag
gagctgagcaactacatctgcatgggaggcaaagggtcctccaccctcaccgcccccaac
ggtcactacattttgcctcggggtggcaatggccaccgctacatcccgggggctggcttg
ggcaccagcccggccctggctgcggatgaagcggccgctgcggccgacctggataaccgg
ttccgaaagcggactcactccgcgggcacatcccctaccatttcccaccagaagaccccg
tcccagtcttctgtggcttccattgaggagtacacggagatgatgcctgcctacccgcca
ggaggtggcagtggaggccgactgcctggctaccggcactctgccttcgtgcccacccac
tcctaccccgaggagggtctggaaatgcaccctctggacaggcgtgggggccaccaccgg
ccggacgccgccgccctccacacggatgatggctacatgcccatgtccccgggagtggca
ccggtgcccagcagccggaagggcagtggggactatatgcccatgagccccaagagcgtg
tccgcgccgcagcagatcatcaaccccattagacgccatccccagagggtggaccccaat
ggctacatgatgatgtccccaagcggcagctgctctcctgacattggaggtgggcccggc
agcagcagcagcggcagcgccgccccttctgggagcagctatggcaagctgtggacaaac
ggggtagggggccaccaccctcacgccctgccgcaccccaaactccccgtggagagcggg
agtggcaagctcctgtcttgtaccggcgactacatgaacatgtcgccggtgggggactcc
aacaccagcagcccctccgacggctactacggcccagaggacccccagcacaagccagtt
ctctcctactactcattgccaaggtcctttaagcacacccagcgccctggggagctggag
gagagcgcccggcacnagcacctccgcctctcctccagctcgggtcgtcttctctacgcc
gcgacggcggaagattcctcctcctccaccagcagcgacagcctgggcccagggggatac
tgtggggtcaggccggatcccggcctcccgcatatccaccatcaggtcctgcagcctcac
ctgcctcggaaggtggacacggccgcgcagaccaacagccgcctggctcggcccacgagg
ctgtccctgggggaccccaaggccagcaccttacctcgggttcgagagcagcagcacccg
ccgcccctgctgcaccctccggagcccaagagccccggggaatatgtgaatattgagttc
gggagcgatcagccgggctacttatcggggccggtggctgcccgcagctcgccttctgtc
aggtgcccaccccagctccagccagctccccgcgaggaagagactggcaccgaggagtac
atgaacatggacctggggcctggccggagggcagcctggcaggagggtgctggggtccag
cccggcagggtgggccccgcgccccccggggccgctagcgtgtgcaggcccacccgggca
gtgcccagcagccggggcgactacatgaccatgcaggtgggctgtcccggccagggctac
gtggacacctcgccagtggcccccatcagctacgctgacatgcggacaggcattgtcgtg
gaggaggccagcctgccgggggccacagcggccgccccctcctcggcctcggcagcctcg
gcttcccccacggcgcctccaaaagcgggggagctggtggcccgctcctccctgctgggg
ggcccgcagggacccgggggcatgagcgccttcacccgggtgaacctcagccccaaccgc
aaccagagtgccaaagtgatccgcgccgacccgcaggggtgccggaggcggcatagctct
gagaccttctcctccacgcccagtgccacccgggcgggcaacgcagtgcccttcggcggg
ggggcggccctggggggcagcggtggcggcagcagcgcggaggatatgaaacgccacagt
tcggcttcctttgagaacgtgtggctgaggcctggggagctcgggggagcccccaaggag
ccggccccgcacgctggggccgccgggggtttggagaatgggcttaactacatagacctg
gatttggtcaaggacttcaaacagtgctctcaggagcgcccccctcaaccgcagccgccc
ccgcccccggcccctcatcagcctctgggcagcagtgagagcagttcaaccagccgctcc
agcgaggatctaagcgcctatgccagcatcagtttccagaagcagccagaggacctccag
tag

DBGET integrated database retrieval system