KEGG   Canis familiaris (dog): 486808Help
Entry
486808            CDS       T01007                                 

Gene name
PLCE1
Definition
phospholipase C, epsilon 1 (EC:3.1.4.11)
Orthology
K05860  
phosphatidylinositol phospholipase C, epsilon [EC:3.1.4.11]
Organism
cfa  Canis familiaris (dog)
Pathway
Inositol phosphate metabolism
Metabolic pathways
Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
cAMP signaling pathway
Phosphatidylinositol signaling system
Thyroid hormone signaling pathway
Proteoglycans in cancer
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:cfa00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    486808 (PLCE1)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    486808 (PLCE1)
   04015 Rap1 signaling pathway
    486808 (PLCE1)
   04020 Calcium signaling pathway
    486808 (PLCE1)
   04070 Phosphatidylinositol signaling system
    486808 (PLCE1)
   04024 cAMP signaling pathway
    486808 (PLCE1)
 Organismal Systems
  Endocrine system
   04919 Thyroid hormone signaling pathway
    486808 (PLCE1)
 Human Diseases
  Cancers
   05205 Proteoglycans in cancer
    486808 (PLCE1)
Enzymes [BR:cfa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     486808 (PLCE1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Ensembl: 
UniProt: 
Position
28
AA seq 2309 aa AA seqDB search
MTSEGMAASVLTPVTQRKVTFAPSAVDESSEKVSDISVPKAHSVKQSEQTSTIPWMNKLK
EESSGSNLPKILSIAREKIASDENSNEECWTESTPVSVKNLNINHNNILTNRQCVLPQSQ
SYDTCNSVMEEDPCLETGISSSLERKVFPGIQLEVNRPPMDFRPPGLMDFSTLGSQSAIV
DTGQAHPDSNKAAFQIFNYKVDRRMSDTFCTLSGDLILDDCGNCVPLSSGFGGEQKKNYV
AYTCKLMELAENCDNENGQLQCDDYDALDDKYLCFEDSCQRDSVVCSSDSFRREDLTNSP
PAKTFLSHFEDFPDNGEDVEDFLKNKKERSTLLVRRFCKNDREVKKSVYTGTRAIMRTLP
SGHIGLEAYSYIDQKRSGPLLPRGRVLEQLPVVAIRQDGSQCLSEAQWYRIYNAVRREEE
IENTIGSLLHYFTKLPASKTAHERISVGPCLKQCVRDTICEYRATLQRTSISQYITGSLL
EATTSLGARSGLLSTFGGSTGRMMLKERQPGTSMANSSALPSSSAGISKELIDLQPLIQF
PEEVASILMEQEQNIYRRVLPVDYLYFLTRDLGTPECQTPLPCLKASISASILSSQNGEH
NALEDLVMRFNEVSSWVTWLILTAGSMEEKREVFSYLVHVAKCCWNMGNYNAVMEFLAGL
RSRKVLKMWQFMDQSDLETMRSLKDAMAQHESSCEYRKVITRALHIPGCKVVPFCGVFLK
ELCEVLDGASGLMKLCPRYNSQEETLEFVADYSGQDNFLQRVGHNGLKNSEKESTVNSIF
QIIRSCSRSLEAEEEDSPSEGNSSRKNSLRDKARWQFIIGDLLDSENDIFEQSKEWDSPS
SEEPQKAFDHGTELIPWYVLSIRADVHQFLLQGATVLRYDQDTHLSARCFLQLQPDNSTL
TWIKPTAASPASARAKLGVLSNTSEPGKFPSPGSAGLSGLAEGVLDLFSAKAVYMGHPSI
DIHTVCVQNKLGSMFLSETGVTLLYGLQTTDNRLLHFVAPKHTAKMLFSGLLELTRAVRK
MRKFPDQRQQWLRKQYVSLYQEDGRYEGPTLAHAVELFGGRRWSTRNPSPGTSAKSAEKP
SVQRNNTLGISTTKKKKKILIRGESGEAADDEMATRKAKMHRECRSRSGSDPQDMNEQEE
SEANAIMSPPNTLPSRRAHSLTTAGSPNLSAGTSSPIRPVSSPVLSSSNKSPSSAWSSSS
WHGRIKGGMKGFQSFMVSDSNMSFVEFVELFKSFSVRSRKDLKDLFDIYAVPCNRAGSES
APLYTNLTIDENTSDLQPDLDLLTRNVSDLGLFIKSKQQLSDNQRQISDAIAAASIVTNG
TGIESTSLGIFGVGILQLNDFLVNCQGEHCTYDEILSIIQKFEPSISMCHQGLLSFEGFA
RFLMDKDNFASKNDESQENIKDLQLPLSYYYIESSHNTYLTGHQLKGESSVELYSQVLLQ
GCRSVELDCWDGDDGMPIIYHGHTLTTKIPFKEVVEAIDRSAFINSDLPIIISIENHCSL
PQQRKMAEIFKTVFGEKLVAKFLFESDFSDDPMLPSPDQLRRKVLLKNKKLKAHQTPVDI
LKQKAHQLASMQAQAYNGGNVNPPPANNEEEEDEEDEYDYDYESLSDDNILEDRPENKSC
NDKLQFEYNEEIPKRIKKADNSAFNKGKVYDMELGEEFYLPQNKKESRQIAPELSDLVIY
CQAVKFPGLSTLNASGSNRGKERKSRKSIFGNNPGRMSPGETASFNKASGKSSCEGMRQA
WEESSSPLNPTTSLSAIIRTPKCYHISSLNENAAKRLCRRYSQKLIQHTACQLLRTYPAA
TRIDSSNPNPLLFWLHGIQLVALNYQTDDLPLHLNAAMFEANGGCGYVLKPPVLWDKNCP
MYQKFSPLERDLDNMEPAVYSLTIVSGQNVCPSSSTGSPCIEVDVLGMPLDSCHFRTKPI
HRNTLNPMWNEQFLFRVHFEDLIFLRFAVVENNSSAITAQRIIPLKALKRGYRHLQLRNL
HNEVLEISSLFINSRRMEENSSSSATPASLMFNTEERKCLQTHRVTVHGVPGPEPFTVFS
ISGGTKAKQLLQQILTTEQDTKPIVTDYFLMEEKYFISKEKNECRKQPFQRVIGPEEEIM
QILSSWFPEEGYVGRIVLKTQQENLEERSIVQDEKEVILSSEEESFFVQVHDVSPEQPRT
VIKAPRVSTAQDVIQQTLCKAKYSYSILSNPNPSDYVLLEEVVKDATKKSSTPKSSQRVL
LDQECVFQAQSKWKGAGKFILRLKEQVQASREDKRKGISFASEFKKFTKSTKQPRGLTSS
QVLASESVQNKEEKPTGSLSSSDTTDSRQ
NT seq 6930 nt NT seq  +upstreamnt  +downstreamnt
atgacttctgaaggaatggcagcttctgttctcacacctgtgactcaaagaaaagtgaca
tttgctccatcggctgtagatgaaagtagtgaaaaggtctcagacatcagtgttccaaag
gcacatagtgtcaagcagagtgagcagacttctaccatcccgtggatgaacaagcttaaa
gaagaatcttctggaagcaacttgcccaaaattctctccatagcaagggagaaaatagca
agtgatgagaacagcaatgaagagtgctggacggaaagcacaccagtttctgtgaaaaac
cttaacattaaccataacaacatcctgacaaaccgccagtgcgtccttcctcagagccag
tcttatgacacgtgcaattctgtcatggaggaagacccatgtttagaaactggaatctca
tcctcactggaaagaaaggtattccctggaattcaactggaagtcaacagacctcccatg
gactttaggcctccaggcctaatggactttagtaccttaggaagtcagtcagccattgta
gatactggccaggcgcaccctgacagcaacaaagcagcatttcaaatctttaattataaa
gttgacagaaggatgtctgacactttctgtaccctgtcaggtgacttgatattggatgac
tgtggaaactgtgtgccactgtcatctggttttggcggggagcaaaagaaaaattacgtg
gcatatacctgtaaactcatggaattggctgaaaactgtgataatgagaatggacagctg
cagtgtgatgattatgatgccttggatgacaaatacttgtgctttgaagattcttgccaa
agggacagtgtggtatgttcaagtgacagctttcgcagggaggacctaactaacagtcca
cctgccaagacctttctgagccattttgaagacttccctgataatggtgaagatgtagaa
gattttttaaaaaacaaaaaggagagatccactttgttagtgaggagattttgtaaaaat
gacagagaagtaaagaaatctgtgtatactgggacaagggcaatcatgagaactctgcct
tctggtcacattgggctggaagcttacagttacatcgatcagaagagaagtggtccctta
ttaccccgtgggagagttctggaacagctgccagtggtggcaattaggcaagatgggagc
cagtgcctgtcagaagcccagtggtatcggatctacaatgcagtgagaagggaagaagaa
atagaaaataccattggatctcttctccattactttaccaagctcccagcctccaagaca
gcccatgaaaggattagtgttggtccatgcctaaagcagtgtgtccgagacaccatatgt
gagtatcgtgccaccctccagaggacgtccatatctcagtacatcacgggttcgctccta
gaagcaaccacatctttaggagcgagaagtggcctactcagtacttttggaggatccact
ggacgaatgatgctaaaagaacgccagccaggcacctccatggccaattccagtgccctc
ccttcaagttccgctggaatcagcaaggagctgattgacctgcagcctctcattcagttc
ccagaggaagtcgccagcatcctgatggagcaggaacagaacatttaccgaagggtctta
ccagttgactatctttacttcttgacccgggacttgggcactccagaatgccagacaccc
ctgccctgcctcaaagcatccatctcagcttcaattcttagctcccagaacggagagcac
aatgccctggaagatcttgtgatgagatttaatgaggtgagctcctgggtgacatggctg
atcctcacggcgggctccatggaggagaagcgagaagtcttctcctatttggtgcatgtg
gccaaatgctgctggaacatgggcaactacaatgctgtcatggagttcttggctggtctc
aggtcaagaaaagttttaaaaatgtggcagtttatggaccaatctgacctcgagaccatg
aggagcctgaaggacgccatggctcagcatgaatcttcctgcgaatatcggaaggtgata
acgagggctctgcacatacctggctgtaaagtggttccattctgtggagtgtttctgaag
gagctctgtgaagtactggacggagcctctggcctcatgaagctttgcccgaggtacaat
tcccaagaagaaactctagagtttgtagcagattacagtggacaagataatttcttacaa
cgagtggggcataatggcttaaagaattcagagaaggagtccactgtcaacagcatcttt
caaatcattaggagctgcagccgaagtctggaggctgaggaagaggacagccccagtgaa
gggaacagctctaggaaaaattctttaagggacaaagcccgatggcaatttataatcgga
gatttgttggattccgaaaatgacatctttgagcaatccaaagaatgggactctcccagc
tcagaagagcctcagaaagcctttgaccatgggacagagctgatcccttggtacgtgctg
tccatccgagcagatgtgcaccagttcctgctacagggcgccaccgtcctccgctacgac
caggacacgcacctctctgcccgctgcttcctccagcttcagcctgacaatagcaccttg
acatggataaagcccacagctgcctccccggccagtgctagagcaaaactcggtgtgctg
agcaacacgtctgagcctggcaagttcccgtcaccaggcagtgccggactaagcggcctg
gccgagggggtcctggatctgttttcagcaaaggctgtgtacatgggacaccctagcatt
gatatccacactgtgtgtgtccagaacaaactcggtagcatgtttctctcagagactggc
gtgaccctgctctacgggctccagaccacagacaatagattattgcactttgtggcaccc
aaacacactgctaagatgctcttcagtggattgctagaactcacgagggccgtgaggaag
atgagaaagttccctgaccagaggcagcagtggctgcggaaacagtatgttagcctctat
caggaggacggacggtatgagggcccaactttggctcatgctgtggagttgtttggtggc
cggcgatggagtacacgcaatcccagccctgggacatctgcaaagagtgctgagaagccc
agtgtgcagagaaacaacaccttgggcataagcaccaccaagaaaaagaagaaaatcctt
ataaggggtgagagtggagaggcagccgacgatgagatggccacccggaaggccaaaatg
cacagggagtgtcgcagccggagtggttctgacccacaagacatgaatgagcaagaagaa
tctgaggcaaatgccatcatgagccctcctaacactctgccttccagaagagcccactct
ttgactacagctgggtcccctaatttgtctgccgggacatcatctcccatcaggccagtg
tcctcccctgtgctgtcttcttcaaacaagagcccgtccagtgcttggagcagcagcagc
tggcatggaaggatcaaaggaggaatgaagggttttcagagcttcatggtttcagacagt
aacatgagttttgttgaatttgttgagctgttcaaatcattcagtgtgaggagccgcaag
gacctgaaggatctctttgacatctacgctgtgccctgcaatcgggccggctctgagtcg
gccccgctctacaccaacctaacaatagacgaaaacaccagcgatcttcagcctgaccta
gatttattgaccagaaacgtctcggatttggggttgttcattaagagtaaacagcagctg
tcagacaaccagaggcagatttctgatgccattgctgctgcaagtatcgtgacgaatggc
actgggatcgagagcacatctttgggcatctttggggttggcatactccagctcaatgac
ttcctagtcaactgccagggagaacactgcacttacgatgaaatcctcagcatcatccag
aagttcgagcctagcattagtatgtgtcatcagggcctactgtcctttgaaggatttgca
aggtttctgatggataaagataattttgcctccaaaaatgatgagtcacaggagaacatt
aaagatttgcagctgcctctctcctactattacattgagtcttcacacaatacctacctc
acaggccaccagctcaaaggagagtcatcggtagaactctatagccaggtcctcctgcaa
ggctgtagaagtgtagagttggactgctgggatggagatgacgggatgcccatcatctat
cacggacacacactaacaaccaagatccccttcaaggaggtggttgaagccatcgaccgc
agtgccttcatcaactctgacctgcccatcatcatatcgattgagaaccactgctcgttg
cctcagcaacgaaaaatggcagaaattttcaagactgtgtttggagaaaaactggtggct
aaattcctgtttgagagcgatttctcagatgatccaatgcttccctcacctgaccaactt
aggaggaaagtgcttcttaaaaataagaagctaaaagcccaccagacaccagtggatatc
ttaaagcaaaaggctcatcagttagcatccatgcaagctcaggcttataatgggggaaat
gtcaaccctccacctgctaataacgaggaagaggaagatgaagaggacgaatatgattat
gactatgaatccctgtctgatgacaacattctagaagacagacctgaaaataaatcatgt
aatgacaagcttcagtttgagtataacgaagaaatccccaagaggataaagaaagcagat
aattctgctttcaacaaaggaaaggtttatgacatggaactgggagaagaattttatctt
cctcagaataaaaaggaaagcagacagattgcaccagagctttctgaccttgtcatctac
tgccaagcggtaaagtttccggggctgtcaactctaaatgcatctggctctaacagagga
aaagagaggaaaagcaggaagtccatttttggcaacaatccgggcagaatgagccctggg
gagacagcatcgtttaacaaagcatctggaaaaagttcctgtgaaggaatgcgacaggcg
tgggaggaatcttcttcccccctcaacccaaccacatccctcagcgctatcattagaact
cccaaatgttaccatatctcatcgctgaatgaaaatgccgccaaacgtctgtgtcgcagg
tattctcagaaactgatccagcacactgcctgtcagctgctgaggacttacccggctgcc
acacgcatcgactcctccaaccccaatcctctcttgttctggctccatgggatacagctc
gtggcactcaactaccagacagatgatctccctttacatttaaatgctgccatgtttgag
gccaacggtggctgtggttatgttttgaaaccccccgttctgtgggacaagaactgtccc
atgtaccagaagttttcacccttggaaagagacctggacaacatggagcctgccgtctat
tccttaactattgtctctggtcaaaacgtgtgcccaagtagcagcacgggaagcccatgt
atcgaagtggacgtgctgggcatgcccctggacagttgccacttccgcacaaaacccatc
caccggaacactttgaaccccatgtggaatgaacagtttctcttccgggttcactttgaa
gatctcatattcctgcgttttgcagttgtggaaaacaatagctcagccataaccgctcag
agaatcatccccctcaaggctttaaaacgaggatatcgacatcttcagctgcgaaacctc
cacaatgaagtcttggaaatctctagtttattcataaacagcagaaggatggaagaaaat
tcctccagcagtgccacgccagcctctttgatgtttaatacagaagaaagaaaatgtttg
cagactcacagagtcacagtgcatggggtcccaggtccagagccctttactgttttctcc
ataagtggaggcacgaaggcaaagcagcttctccaacagattctaactactgaacaagac
accaaacctattgtcacagactattttttgatggaagaaaaatattttatatctaaagaa
aagaatgaatgcaggaaacaaccatttcagagagtcatcggtccagaagaagagatcatg
cagattttaagcagctggtttccagaggaaggatatgttggcaggattgtcttaaaaacc
cagcaggaaaacctagaagagagaagcattgttcaagatgagaaagaggtgatcttgagc
tcggaggaggagagcttctttgtccaagtgcatgacgtttctccagagcaacctcggacg
gtcatcaaagcgccccgtgtcagcaccgctcaggatgtcattcaacagaccttatgcaaa
gccaaatattcctatagcatcctgagtaaccccaacccgagtgactatgtgcttctggaa
gaggtggtgaaagatgctaccaagaagtcctccaccccaaagtcctcccagcgggtcctt
ttggaccaagagtgtgtgtttcaagcccagagcaagtggaaaggtgctggaaaattcatc
ctcaggctaaaggagcaggtgcaggcatcccgagaagataaaagaaaaggcatttctttc
gcaagtgaattcaagaagttcaccaaatcaactaaacagccccgaggactcacatcttct
caggtcttggcctcagaaagtgtccaaaacaaggaggagaagcccacgggcagcttgtcc
tccagtgacaccacagactcccgacaataa

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