KEGG   Canis familiaris (dog): 488084Help
Entry
488084            CDS       T01007                                 

Gene name
PIK3CA
Definition
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Orthology
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
Organism
cfa  Canis familiaris (dog)
Pathway
Inositol phosphate metabolism
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Bacterial invasion of epithelial cells
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Hepatitis C
Hepatitis B
Measles
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Brite
KEGG Orthology (KO) [BR:cfa00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    488084 (PIK3CA)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    488084 (PIK3CA)
   04015 Rap1 signaling pathway
    488084 (PIK3CA)
   04012 ErbB signaling pathway
    488084 (PIK3CA)
   04370 VEGF signaling pathway
    488084 (PIK3CA)
   04630 Jak-STAT signaling pathway
    488084 (PIK3CA)
   04668 TNF signaling pathway
    488084 (PIK3CA)
   04066 HIF-1 signaling pathway
    488084 (PIK3CA)
   04068 FoxO signaling pathway
    488084 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    488084 (PIK3CA)
   04022 cGMP - PKG signaling pathway
    488084 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    488084 (PIK3CA)
   04152 AMPK signaling pathway
    488084 (PIK3CA)
   04150 mTOR signaling pathway
    488084 (PIK3CA)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    488084 (PIK3CA)
  Cell growth and death
   04210 Apoptosis
    488084 (PIK3CA)
  Cell communication
   04510 Focal adhesion
    488084 (PIK3CA)
 Organismal Systems
  Immune system
   04611 Platelet activation
    488084 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    488084 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    488084 (PIK3CA)
   04660 T cell receptor signaling pathway
    488084 (PIK3CA)
   04662 B cell receptor signaling pathway
    488084 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    488084 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    488084 (PIK3CA)
   04670 Leukocyte transendothelial migration
    488084 (PIK3CA)
   04062 Chemokine signaling pathway
    488084 (PIK3CA)
  Endocrine system
   04910 Insulin signaling pathway
    488084 (PIK3CA)
   04915 Estrogen signaling pathway
    488084 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    488084 (PIK3CA)
   04917 Prolactin signaling pathway
    488084 (PIK3CA)
   04921 Oxytocin signaling pathway
    488084 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    488084 (PIK3CA)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    488084 (PIK3CA)
  Digestive system
   04973 Carbohydrate digestion and absorption
    488084 (PIK3CA)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    488084 (PIK3CA)
  Nervous system
   04725 Cholinergic synapse
    488084 (PIK3CA)
   04722 Neurotrophin signaling pathway
    488084 (PIK3CA)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    488084 (PIK3CA)
  Development
   04380 Osteoclast differentiation
    488084 (PIK3CA)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    488084 (PIK3CA)
   05205 Proteoglycans in cancer
    488084 (PIK3CA)
   05203 Viral carcinogenesis
    488084 (PIK3CA)
   05210 Colorectal cancer
    488084 (PIK3CA)
   05212 Pancreatic cancer
    488084 (PIK3CA)
   05214 Glioma
    488084 (PIK3CA)
   05221 Acute myeloid leukemia
    488084 (PIK3CA)
   05220 Chronic myeloid leukemia
    488084 (PIK3CA)
   05218 Melanoma
    488084 (PIK3CA)
   05211 Renal cell carcinoma
    488084 (PIK3CA)
   05215 Prostate cancer
    488084 (PIK3CA)
   05213 Endometrial cancer
    488084 (PIK3CA)
   05222 Small cell lung cancer
    488084 (PIK3CA)
   05223 Non-small cell lung cancer
    488084 (PIK3CA)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    488084 (PIK3CA)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    488084 (PIK3CA)
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    488084 (PIK3CA)
   05166 HTLV-I infection
    488084 (PIK3CA)
   05162 Measles
    488084 (PIK3CA)
   05164 Influenza A
    488084 (PIK3CA)
   05161 Hepatitis B
    488084 (PIK3CA)
   05160 Hepatitis C
    488084 (PIK3CA)
   05169 Epstein-Barr virus infection
    488084 (PIK3CA)
   05146 Amoebiasis
    488084 (PIK3CA)
   05145 Toxoplasmosis
    488084 (PIK3CA)
   05142 Chagas disease (American trypanosomiasis)
    488084 (PIK3CA)
Enzymes [BR:cfa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     488084 (PIK3CA)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
UniProt: 
Position
34
AA seq 1068 aa AA seqDB search
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt NT seq  +upstreamnt  +downstreamnt
atgcctccaagaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatggaatgatagtgacgttagaatgcctccgtgaggct
acattaataactataaagcatgaattatttaaagaagcaagaaagtaccctctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacaagacggctttgtgaccttcggctttttcaaccctttttaaaa
gtaattgagccagtaggcaaccgagaagaaaagatcctcaatcgagaaattggttttgct
attggcatgccagtgtgtgaatttgatatggttaaagatccagaagtacaggacttccga
agaaatattctgaatgtttgtaaagaagctgtggatcttcgggatcttaattcacctcat
agtagagcaatgtatgtctatcctccaaatgtagaatcttcaccagaactgccaaagcac
atatataataaattagataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgacaaacagaagtatactctgaaaatcaaccatgactgtgttccagaacaagta
attgctgaagcaatcagaaaaaaaactagaagtatgttgctatcatctgaacaactaaaa
ctctgtgttttagaatatcagggcaagtatattttaaaagtatgtggatgtgatgaatac
ttccttgaaaaatatcctctaagtcagtataagtacataagaagctgtataatgcttgga
aggatgcccaatttgatgttgatggctaaagaaagcctttactcccaattgccaatggac
tgtttcacaatgccatcttattccagacgcatctccacagctacaccatatatgaatgga
gaaacatctacaaaatccctttgggttataaatagcgcactcagaataaaaatcctttgt
gcaacctatgtaaatgtaaatattcgagacattgacaagatttatgttcgaacaggtatc
tatcatggaggagaacccttatgtgataatgttaacactcaaagagtaccttgttctaat
cccaggtggaatgaatggctaaattacgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttccatttgttctgttaaaggccgaaagggtgctaaagaggaacactgt
ccattggcctggggaaatataaacttgtttgattacacagatactctagtatctggaaaa
atggctctgaatctttggccagtacctcatggattagaagatttgctgaaccctattggt
gttactgggtcaaatccaaataaagaaactccatgcttagagttggagtttgactggttc
agcagtgtggtaaagttcccagatatgtcagtgattgaagagcatgccaactggtcggtg
tctcgggaagcaggatttagttattcccatgcaggactgagtaacagactggctagagac
aacgaattaagagaaaatgataaagaacagctccgagcaatttgtacccgagatcctctc
tctgaaatcactgagcaagagaaagattttctgtggagccacagacactattgtgtaact
atccctgaaattctacccaaactgcttctgtccgttaaatggaattctagagatgaagta
gctcagatgtactgcttagtaaaagattggcctccaatcaaacctgaacaagctatggag
cttctggactgtaattacccagatcctatggttcgaggttttgctgttcggtgcttggaa
aaatacttaacagatgacaagctttctcagtacctaattcagctagtacaggtcctaaaa
tacgaacaatatttggataacctgcttgtgagatttttactcaagaaagcattgactaat
caaaggattgggcattttttcttttggcatttaaaatctgagatgcacaataaaacggtt
agtcagaggtttggcctgcttttggagtcctattgccgtgcttgtgggatgtatttgaag
cacctaaataggcaagttgaggctatggaaaagctcattaacttaactgacattctcaaa
caagagaagaaggatgaaacacaaaaggtacagatgaagtttttagttgagcaaatgcgg
cgaccagatttcatggatgctctacaaggttttctatctcctctaaatcctgctcatcaa
ctaggaaatctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagagttactctttcagaacaatgagatcatc
tttaaaaatggggatgatttacgacaagatatgctaacacttcaaataattcgcattatg
gaaaatatctggcaaaatcaaggtcttgatcttcgaatgttaccttatggttgtctgtca
atcggtgactgtgtgggacttattgaggtggtgcgaaattctcacactattatgcagatt
cagtgcaaaggtggcctgaaaggtgcactgcagttcaacagccacacactacaccagtgg
ctcaaagacaagaacaaaggagaaatatatgatgcagccattgacctgttcacacgttca
tgtgctggatattgtgttgctaccttcattttgggaattggagatcgtcacaatagtaac
atcatggttaaagatgatggacaactgtttcatatagattttggacactttttggaccat
aagaagaaaaaatttggttataaacgggaacgtgtgccatttgttttgacacaggatttc
ttaatagtgattagtaaaggagcccaggaatgcacaaaaacaagagaatttgagaggttt
caggagatgtgttacaaggcttacctagctattcggcagcatgccaatctcttcataaat
cttttctcaatgatgcttggctctggaatgccagaactacaatcttttgatgatattgca
tacattcgaaagaccctagctttagataaaactgaacaagaggctttggaatatttcatg
aaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttccac
accattaagcagcatgctttgaactga

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