KEGG   Canis familiaris (dog): 489030Help
Entry
489030            CDS       T01007                                 

Gene name
PRF1
Definition
perforin 1 (pore forming protein)
Orthology
K07818  
perforin 1
Organism
cfa  Canis familiaris (dog)
Pathway
Natural killer cell mediated cytotoxicity
Type I diabetes mellitus
Autoimmune thyroid disease
Allograft rejection
Graft-versus-host disease
Viral myocarditis
Brite
KEGG Orthology (KO) [BR:cfa00001]
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    489030 (PRF1)
 Human Diseases
  Immune diseases
   05320 Autoimmune thyroid disease
    489030 (PRF1)
   05330 Allograft rejection
    489030 (PRF1)
   05332 Graft-versus-host disease
    489030 (PRF1)
  Cardiovascular diseases
   05416 Viral myocarditis
    489030 (PRF1)
  Endocrine and metabolic diseases
   04940 Type I diabetes mellitus
    489030 (PRF1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 
Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Ensembl: 
UniProt: 
Position
4
AA seq 555 aa AA seqDB search
MGARLFLPGLVLLLLPTPTPAPCHTATRNECRRNRWFVPGSMLAGEGMDVTSLKRSGSFP
VDTESFLRPDGTCTLCRNTLRGGALQRLPLALTDWRAQGSGCQRRVVKAKASSTEGVARE
AASNIHNDWRVGLDVSPKPNINVHVSMAGSHSRVADFAAQKTHQDRYSFSTDVVECRFYS
FHLVHSPPLHPNFQRALSDLPPNFNTSTEADYLRLISNYGTHFIRSMELGGRTLALTALR
TCELALEGLTADEVSDCLTVEAQVSISDHANPSSEFKACEEKKKKHKMTTSFHQAYQERF
SEIIGGHHTSMSDLLFGNQAGPEQFSAWMASLLDRPGLVDYTLEPLHVLLESQDPRREAL
RQAVSKYVMDRARWKNCSRPCPPGQQKSPHNPCHCVCHNSGITNQDCCPRQRGLAHLEVM
NFQAMGLWGDYFTATDAYLKVFFGGQEQRTYTVWNNNNPTWVTRLDFGNVLLSTGGPLRV
QVWDQDYGWDDDLLGTCDQKAQSGSHEVRCNLSHGHLRFSYIAKCLPHLTGATCLEYAPH
GRLGEPPGNRSGPVW
NT seq 1668 nt NT seq  +upstreamnt  +downstreamnt
atgggtgcccgcctgttcctcccgggcctcgtcctgctgctgctgcccacgcccacccca
gccccctgccacacggccacgcgcaacgagtgccggcgcaaccgctggttcgtgcctggc
tcgatgctggccggggagggcatggacgtgaccagcctcaagcgctcgggctccttccca
gtcgacacagagagcttcctgcggcccgacggcacctgcaccctctgccgcaacacccta
cgggggggtgccctccagcgcctgcccctggcactgaccgactggcgcgcccagggctcg
ggctgccagcgccgcgtggtcaaggccaaggccagctccaccgagggtgtggccagggaa
gcagccagcaacatccacaacgactggcgcgtggggctggatgtgtctcccaagcccaac
atcaatgtgcatgtgagcatggccggctcgcactccagggtggccgacttcgctgcccag
aagacccaccaggacaggtacagcttcagcactgacgtggtggagtgtcgcttctacagt
ttccacctggtacactctccgccactgcaccccaatttccagagggccctcagcgacctg
ccccccaatttcaacacctccacagaggctgactacctcaggctcatctccaactatggc
acccacttcatccggtccatggagctgggcggccggaccctggccctcactgccctgcgt
acgtgtgagctggccctggaagggctcacagccgatgaggtgtcagactgcctaacagtc
gaggcccaggtcagcataagtgaccacgccaacccttcatcagaattcaaggcctgtgag
gaaaagaagaagaagcacaagatgacaacctccttccaccaggcctaccaggaacgcttt
tccgagataattggtggccaccatacctccatgagtgacctgctgtttgggaaccaggcc
gggccggagcagttctcagcctggatggcctcactgctggacagacccggcctggtggac
tacaccctggagcctctgcatgtgctcctggagagccaggacccacggcgggaggcgctg
aggcaggctgtgagcaagtacgtgatggacagagcccgttggaagaactgcagcaggccc
tgccccccggggcagcagaagagcccccacaacccatgccactgtgtgtgccacaactcg
gggatcaccaaccaggactgctgtccccggcagaggggcctggcccacttagaggttatg
aacttccaggcaatgggcctgtggggagactacttcacggccacagatgcctatctgaaa
gtcttctttggaggccaggagcagagaacctacacggtgtggaacaataataaccccacg
tgggtgacgcggctggacttcgggaacgtgctcctgtccacgggggggcccctgagggtt
caggtctgggaccaagactatggctgggatgatgacctccttggcacctgtgaccagaaa
gcacagtctggctcacatgaggtcaggtgcaacctgtcccacggtcacctgagattctcc
tacattgccaagtgcttgcctcacctgacgggggcaacctgcctggagtatgccccccat
ggtcgtctgggagagcctccaggaaaccggagtgggccagtgtggtga

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