KEGG   Canis familiaris (dog): 489644Help
Entry
489644            CDS       T01007                                 

Gene name
PIK3CD
Definition
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
Orthology
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
Organism
cfa  Canis familiaris (dog)
Pathway
Inositol phosphate metabolism
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Bacterial invasion of epithelial cells
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Hepatitis C
Hepatitis B
Measles
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Brite
KEGG Orthology (KO) [BR:cfa00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    489644 (PIK3CD)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    489644 (PIK3CD)
   04015 Rap1 signaling pathway
    489644 (PIK3CD)
   04012 ErbB signaling pathway
    489644 (PIK3CD)
   04370 VEGF signaling pathway
    489644 (PIK3CD)
   04630 Jak-STAT signaling pathway
    489644 (PIK3CD)
   04668 TNF signaling pathway
    489644 (PIK3CD)
   04066 HIF-1 signaling pathway
    489644 (PIK3CD)
   04068 FoxO signaling pathway
    489644 (PIK3CD)
   04070 Phosphatidylinositol signaling system
    489644 (PIK3CD)
   04024 cAMP signaling pathway
    489644 (PIK3CD)
   04022 cGMP - PKG signaling pathway
    489644 (PIK3CD)
   04151 PI3K-Akt signaling pathway
    489644 (PIK3CD)
   04152 AMPK signaling pathway
    489644 (PIK3CD)
   04150 mTOR signaling pathway
    489644 (PIK3CD)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    489644 (PIK3CD)
  Cell growth and death
   04210 Apoptosis
    489644 (PIK3CD)
  Cellular commiunity
   04510 Focal adhesion
    489644 (PIK3CD)
 Organismal Systems
  Immune system
   04611 Platelet activation
    489644 (PIK3CD)
   04620 Toll-like receptor signaling pathway
    489644 (PIK3CD)
   04650 Natural killer cell mediated cytotoxicity
    489644 (PIK3CD)
   04660 T cell receptor signaling pathway
    489644 (PIK3CD)
   04662 B cell receptor signaling pathway
    489644 (PIK3CD)
   04664 Fc epsilon RI signaling pathway
    489644 (PIK3CD)
   04666 Fc gamma R-mediated phagocytosis
    489644 (PIK3CD)
   04670 Leukocyte transendothelial migration
    489644 (PIK3CD)
   04062 Chemokine signaling pathway
    489644 (PIK3CD)
  Endocrine system
   04910 Insulin signaling pathway
    489644 (PIK3CD)
   04915 Estrogen signaling pathway
    489644 (PIK3CD)
   04914 Progesterone-mediated oocyte maturation
    489644 (PIK3CD)
   04917 Prolactin signaling pathway
    489644 (PIK3CD)
   04921 Oxytocin signaling pathway
    489644 (PIK3CD)
   04919 Thyroid hormone signaling pathway
    489644 (PIK3CD)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    489644 (PIK3CD)
  Digestive system
   04973 Carbohydrate digestion and absorption
    489644 (PIK3CD)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    489644 (PIK3CD)
  Nervous system
   04725 Cholinergic synapse
    489644 (PIK3CD)
   04722 Neurotrophin signaling pathway
    489644 (PIK3CD)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    489644 (PIK3CD)
  Development
   04380 Osteoclast differentiation
    489644 (PIK3CD)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    489644 (PIK3CD)
   05205 Proteoglycans in cancer
    489644 (PIK3CD)
   05203 Viral carcinogenesis
    489644 (PIK3CD)
   05210 Colorectal cancer
    489644 (PIK3CD)
   05212 Pancreatic cancer
    489644 (PIK3CD)
   05214 Glioma
    489644 (PIK3CD)
   05221 Acute myeloid leukemia
    489644 (PIK3CD)
   05220 Chronic myeloid leukemia
    489644 (PIK3CD)
   05218 Melanoma
    489644 (PIK3CD)
   05211 Renal cell carcinoma
    489644 (PIK3CD)
   05215 Prostate cancer
    489644 (PIK3CD)
   05213 Endometrial cancer
    489644 (PIK3CD)
   05222 Small cell lung cancer
    489644 (PIK3CD)
   05223 Non-small cell lung cancer
    489644 (PIK3CD)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    489644 (PIK3CD)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    489644 (PIK3CD)
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    489644 (PIK3CD)
   05166 HTLV-I infection
    489644 (PIK3CD)
   05162 Measles
    489644 (PIK3CD)
   05164 Influenza A
    489644 (PIK3CD)
   05161 Hepatitis B
    489644 (PIK3CD)
   05160 Hepatitis C
    489644 (PIK3CD)
   05169 Epstein-Barr virus infection
    489644 (PIK3CD)
   05146 Amoebiasis
    489644 (PIK3CD)
   05145 Toxoplasmosis
    489644 (PIK3CD)
   05142 Chagas disease (American trypanosomiasis)
    489644 (PIK3CD)
Enzymes [BR:cfa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     489644 (PIK3CD)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Ensembl: 
UniProt: 
Position
5
AA seq 1044 aa AA seqDB search
MPPGVDCPMEFWTKEENQSVAVDFLLPTGVYLNFPVSRNANLSTIKKVLWHRAQYEPLFH
MLSDPEAYVFTCVNQTAEQQELEDEQRRLCDIQPFLPVLRLVAREGDRVKKLVNSQISLL
IGKGLHEFDSLRDPEVNDFRTKMRQFCEEAAARRQQLGWEAWLQYCFPLQLEPSARSWGP
GTLRVPSRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYT
LQVNGKHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPR
TKPPPIPMKKPSSLSLWSLEQPFCVELIQGSKVNADERMKLVVQAGLFHGNETLCKTVSS
SEVSVCSEPVWKQRLEFDINVCDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAW
ANLMLFDYKDQLKTGECCLYMWPSVPDEKGELLNPTGTVRSNPNTESAAALVICLPEVAP
YPVYYPTLDKILELGRHGEHGRFSEEEQLQLREILERRGSGELYEHEKDLVWKMRHEVQE
RFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDRHVGSFAIKSL
RKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSV
ALRFGLIMEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKVSSQKTTKPQTKELMHLCMR
QEAYLEALSNLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWVMYSNEEAGSDGSVGIIFKN
GDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLSTGDRTGLIEVVLHSDTIANIQLN
KSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIM
IRENGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYC
ERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFN
EALRESWKTKVNWLAHNVSKDNRQ
NT seq 3135 nt NT seq  +upstreamnt  +downstreamnt
atgccccctggggttgactgccccatggaattctggaccaaggaggagaatcagagtgtg
gctgttgacttcctgttgcccactggggtctatctgaatttccctgtgtcccggaatgcc
aacctcagcaccatcaagaaggtgttgtggcaccgagcccagtatgagccactcttccac
atgctcagcgaccctgaggcctatgtgttcacctgcgtcaaccagactgcggagcagcag
gagctggaagatgagcagcggcggctatgtgacatccaacccttcctgccagtgctgcgc
ctggtggcccgagagggtgacagggtgaagaagcttgtcaactcacagatcagcctcctc
atcggcaaaggcctccatgagttcgactccttgcgggaccctgaggtgaatgactttcgc
accaagatgcgccagttctgtgaggaggcggccgcccggcggcagcaactgggctgggag
gcctggcttcagtattgcttccccctgcagctggagccctccgcccggagctgggggcct
ggcaccctgcgggtccccagccgggccctcctggtcaacgtcaagttcgagggcagcgag
gagagcttcaccttccaggtgtccaccaaggatgtgccgctggcgctgatggcctgtgcc
ctccggaagaaggccacggtgttccggcagccgctggtggagcagccggaggactacacg
ctgcaggtgaacgggaagcacgagtacctgtatggcagctaccccctctgccagttccag
tacatctgcagctgcctgcacagcgggctgaccccccacctgaccatggtgcactcttcc
tccatcctcgccatgcgggacgagcagagcaaccctgccccccaagtccaaaaaccacgc
accaaaccaccccccattcccatgaagaagccttcttccttgtccctgtggtccctggag
cagcctttctgcgtggagctgatccagggcagcaaagtgaatgccgatgagcggatgaag
ctggtggtgcaggctgggcttttccacggcaatgagacgctgtgcaagacggtgtcgagc
tcggaggtgagcgtgtgctcagagcctgtgtggaaacagcgactggagttcgacatcaac
gtgtgtgacctgcctcgcatggcccgtctctgctttgcactttatgctgtgatcgagaag
gccaagaaggctcgctcgaccaagaagaagtccaagaaggcggactgccccatcgcctgg
gccaacctcatgctgtttgactataaggaccagctcaagaccggtgaatgctgcctgtac
atgtggccctccgtcccagacgagaaaggggagctgctgaaccccacaggaacagtgcgg
agtaaccccaacacagagagcgcagcggccctggtcatctgcctgcctgaggtggctccc
taccccgtctactaccccaccctggacaagattctggagctggggcgacacggcgagcat
gggcgcttcagtgaggaggagcagctacagctgcgggaaatcctggagcggcgggggtcc
ggggagctgtatgagcacgagaaggacctggtgtggaagatgcggcacgaggtccaggag
cgcttccccgaggcgctggcccgcctgctgctggtcaccaagtggaacaagcatgaggat
gtggcccagatgctctacctgctgtgctcgtggcctgagctgcccgtcctgagcgccctg
gagctgctggacttcagcttcccggaccgccacgtgggctccttcgccatcaagtctctg
cggaagctgacggacgatgagcttttccagtacctgctgcagctggtgcaggtgctcaag
tacgaatcctacctcgactgcgaactgaccaagttcctgctggaccgggccctggccaac
cgcaagattggccacttcctcttctggcacctccgctccgagatgcacgtgccatccgtg
gctctgcgcttcggcctcatcatggaggcctactgcaggggcagcacccaccacatgaag
gtgctcatgaagcagggggaggcgctgagcaaactgaaggctctaaacgactttgtcaaa
gtgagctcccagaagaccaccaagccccagaccaaggagctgatgcacctgtgcatgcgc
caggaggcctacctggaggccctctccaacctgcagtccccactggaccccagtaccctg
ctggctgaagtctgcgtggagcagtgcaccttcatggactctaagatgaagcccctgtgg
gtcatgtacagcaacgaggaggcaggcagtgatggcagcgtgggcatcatcttcaagaat
ggggacgacctccgccaggacatgctgactttacagatgatccagctcatggacgtcctg
tggaagcaggagggattggacctgaggatgaccccctatggctgcctctccaccggggac
cgcacaggcctcatcgaggtggtgcttcactcggacaccatcgccaacatccagctaaac
aaaagcaacatggcggccacagctgccttcaacaaggatgccctgctcaactggctcaag
tccaagaacccaggggaggccttggatcgagccattgaggagttcaccctctcctgtgcc
ggctactgtgtggccacttacgtgctgggcatcggtgatcggcacagcgacaacatcatg
atccgcgagaatgggcagctgttccacatcgattttggccactttctgggtaatttcaag
accaagtttggaatcaaccgtgagcgagtcccgttcatcctcacatatgactttgtgcac
gtgatccagcaagggaagacgaataacagtgagaaatttgaaagattccgaggttactgt
gagcgagcctacaccatcctgcggcgccatgggctgctcttcctccacctctttgccctg
atgcgggctgccggcctgcctgagctcagctgctccaaagacatccagtacctcaaggac
tctctggcgttgggaaagacagaggaggaggctctaaagcacttccgagtgaagtttaac
gaagccctccgggagagctggaagaccaaagtgaactggctggcccacaatgtgtccaaa
gataacaggcaatag

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