KEGG   Canis familiaris (dog): 489692Help
Entry
489692            CDS       T01007                                 

Gene name
PLCG2
Definition
phospholipase C, gamma 2 (phosphatidylinositol-specific)
Orthology
K05859  
phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
Organism
cfa  Canis familiaris (dog)
Pathway
Inositol phosphate metabolism
Metabolic pathways
ErbB signaling pathway
Ras signaling pathway
Calcium signaling pathway
NF-kappa B signaling pathway
HIF-1 signaling pathway
Phosphatidylinositol signaling system
VEGF signaling pathway
Osteoclast differentiation
Natural killer cell mediated cytotoxicity
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Inflammatory mediator regulation of TRP channels
Thyroid hormone signaling pathway
Epstein-Barr virus infection
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Glioma
Non-small cell lung cancer
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Class
Metabolism; Carbohydrate metabolism; Inositol phosphate metabolism [PATH:cfa00562]
Environmental Information Processing; Signal transduction; Ras signaling pathway [PATH:cfa04014]
Environmental Information Processing; Signal transduction; ErbB signaling pathway [PATH:cfa04012]
Environmental Information Processing; Signal transduction; VEGF signaling pathway [PATH:cfa04370]
Environmental Information Processing; Signal transduction; NF-kappa B signaling pathway [PATH:cfa04064]
Environmental Information Processing; Signal transduction; HIF-1 signaling pathway [PATH:cfa04066]
Environmental Information Processing; Signal transduction; Calcium signaling pathway [PATH:cfa04020]
Environmental Information Processing; Signal transduction; Phosphatidylinositol signaling system [PATH:cfa04070]
Organismal Systems; Immune system; Natural killer cell mediated cytotoxicity [PATH:cfa04650]
Organismal Systems; Immune system; B cell receptor signaling pathway [PATH:cfa04662]
Organismal Systems; Immune system; Fc epsilon RI signaling pathway [PATH:cfa04664]
Organismal Systems; Immune system; Fc gamma R-mediated phagocytosis [PATH:cfa04666]
Organismal Systems; Immune system; Leukocyte transendothelial migration [PATH:cfa04670]
Organismal Systems; Endocrine system; Thyroid hormone signaling pathway [PATH:cfa04919]
Organismal Systems; Nervous system; Neurotrophin signaling pathway [PATH:cfa04722]
Organismal Systems; Sensory system; Inflammatory mediator regulation of TRP channels [PATH:cfa04750]
Organismal Systems; Development; Osteoclast differentiation [PATH:cfa04380]
Human Diseases; Cancers; Pathways in cancer [PATH:cfa05200]
Human Diseases; Cancers; MicroRNAs in cancer [PATH:cfa05206]
Human Diseases; Cancers; Proteoglycans in cancer [PATH:cfa05205]
Human Diseases; Cancers; Glioma [PATH:cfa05214]
Human Diseases; Cancers; Non-small cell lung cancer [PATH:cfa05223]
Human Diseases; Infectious diseases; Epstein-Barr virus infection [PATH:cfa05169]
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
UniProt: 
Position
5
AA seq 1336 aa AA seqDB search
MGKLRLSVGTRRAQGRERWPERGAASVALPVPARERPPPGGSPALAACTGRSGVQGAPPS
SSLTAPPILPTMTALAHVDSLPEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMET
RQVAWSKTADKIEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEECCFTILYGTQFVLSTL
SLAADSKEDANKWLSGLKILHQEAMSASTPTIIESWLRKQIYSVDQTRRNSISLRELKTI
LPLVNFKVNSAKFLKDKFVEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFI
LGNTDRPDASAVHLHDFQRFLLHEQQELWAQDLNKVRARMTKFIDDTMRETAEPFLFVDE
FLTYLFSRENSIWDEKYDVVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSTEAYIRCL
RMGCRCIELDCWDGPDGKPIIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHC
CVEQQRHMARVFKEVFGDQLLTKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNME
DKKDEHKQQGELYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTAEEELPQDTPPTELHFG
EEWFHKKVEKRTSAEKLLQEYCAETGGKDGTFLVRESKTFPNDYTLSFWRSGRVQHCRIR
STVEGGTMKYFLTDNVMFTSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYD
GLSRGEAEDMLMRVPRDGAFLIRRREGTDSYAITFRARGKVKHCRIHRDGQHFVLGTSAY
FESLVELVSYYEKHALYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSM
PQRTVKALYDYKAKRSDELSFCRGALIHNVSKEPWGWWKGDYGTRIQQYFPSNYVEDIST
VDVEELEKQIIEDNPLGSLCRGILDLNTYNVVKAPQGKNQKPFVFILEPKKQGDPPVEFA
TDKVEELFEWFQSIREITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLEN
PDFREIRSFVETKADSVVRQKPVDLLKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQM
VALNFQTPDKYMQMNHALFSLNGRTGYVLQPESMRTEKYDPMPPESQRKILMTLSVKVLG
ARHLPKLGRSIACPFVEVEICGAEYDNNKFKTTVVNDNGLSPVWAPTQEKVTFEIYDPNL
AFLRFVVYEEDMFSDPNFLAHATYPIKGIKSGFRSVPLKNGYSEDIELASLLVFCEMQPV
LESEEELYSSCRQLRRRQEELNNQLFLYDTHQNLRNANRDALVKEFNVNENQLQLYQEKC
NRRLREKRVSNSRFYS
NT seq 4011 nt NT seq  +upstreamnt  +downstreamnt
atggggaaactgaggctgagcgtaggtacgcggcgtgcccaaggtcgcgagcggtggcct
gagcgcggcgcggcctcagtggcccttcccgttccggcccgagagcggccacctccaggt
ggttctccggcgctcgcggcctgcacggggcgcagcggggtgcagggggcgcccccgtcc
tcttccctcactgctccccccattctgccaacaatgactgccctggcccacgtggacagc
cttccggaatacgagaagagtcagatcaagagagccctggagctgggcacggtgatgacg
gtgttcagcttccgcaagtccaccccagagcggaggactgtccaggtgatcatggagaca
cgccaggtggcctggagcaagacagccgacaagatcgagggcttcttggatatcatggaa
atcaaggaaatccgcccagggaagaactccaaggattttgagcgtgcaaaagcagtccgc
cagaaggaagagtgctgttttaccatcttgtacggcacccagtttgttctgagcacactc
agtctggcagctgactctaaagaagatgcgaataagtggctctctggcttgaaaatctta
caccaggaagcgatgagtgcatctacacccaccattattgagagttggctgagaaagcag
atttattcagtggaccaaaccagaagaaacagcatcagcctccgagagttgaagaccatc
ttacccctggtcaactttaaggtgaacagtgccaagttcctcaaagataagtttgtggaa
attggtgcacacaaagatgagctcagctttgagcagttccacctgttctataaaaaactt
atgtttgagcagcaaaagtcgattcttgatgaattcaaaaaagattcttccgtgttcatc
ttgggcaacactgaccggccggacgcctctgctgttcacctgcacgacttccagcgcttt
ctcttacatgagcaacaggagctttgggctcaggatctgaacaaagtccgtgcgcggatg
acaaagtttatcgatgacaccatgagggaaacagccgagcccttcttgtttgtcgatgag
ttcctcacatatctgttttcgcgggagaacagcatctgggatgagaagtatgacgtggtg
gacatgcaggacatgaacaaccccttgtcccattactggatctcctcttcgcataacacg
tacctcaccggtgaccagctacggagtgagtcatccacagaagcgtacattcgctgcctg
cggatgggctgtcgctgcattgagttggactgctgggacgggcccgatgggaagcccatc
atctaccacggctggacacggaccaccaagataaagtttgacgacgtcgtgcaggccatc
aaagaccatgcctttgtcacttcaagcttccccgtgatcctgtccatcgaggagcactgt
tgcgtggagcagcagcgccacatggccagggtgttcaaggaggtgtttggcgaccagctg
ctgacgaagcccacggaggccagtgctgaccagctgccctcgcccagccagttgcgggag
aagatcatcatcaagcataagaagctgggtccccgaggggacgtggatgtcaacatggag
gacaagaaagatgagcacaagcaacagggtgaactgtatatgtgggattccatcgaccag
aaatggactcggcactactgtgccatcgccgatgccaaactgtctttcagcgatgacatt
gagcagactgcagaagaggagctgccccaggacacaccccccacggagctgcattttggg
gaggagtggttccacaagaaagtagagaagaggacgagtgccgagaagctgctgcaggaa
tactgtgcagagaccgggggcaaggatgggactttccttgtgcgggagagcaagaccttc
cccaatgactacaccctgtccttctggcggtccggccgcgtccagcactgccggatccgt
tccaccgtggaggggggcaccatgaagtacttcctgactgacaacgtcatgttcaccagc
atctacgccctcatccagcactaccgcgagacccacctgcgctgcgccgagttcgagctg
cggctcaccgaccctgtgcccaaccccaacccccacgagtccaagccgtggtactacgac
gggctgagccgtggggaggcagaggacatgctaatgagggtgccccgggacggcgccttc
ctgatccggaggcgagaaggtaccgattcctacgccatcaccttcagggccaggggcaag
gtgaagcactgccgcattcaccgggatggccagcactttgtgctggggacctctgcctac
ttcgagagcctcgtggagctagtcagctactacgaaaagcacgcgctctaccgaaaaatg
cgactgcgctaccccgtgacgcctgagctcctggagcgctacaatatggaaagagatata
aactccctctatgacgtcagcagaatgtatgtggatcccagtgagatcaatccttctatg
cctcagagaaccgtgaaagctctgtatgactacaaagccaagcgaagcgatgagctgagt
ttctgccgtggggccctcattcacaacgtctcgaaggagccctggggctggtggaagggg
gactatggaaccagaatccagcagtacttcccatccaattacgtcgaggacatttcaacg
gtcgacgtggaggagctggagaagcagattattgaagacaatcccttagggtctctttgt
aggggaatactggatctcaatacctataacgttgtgaaagccccccaggggaaaaaccag
aagccattcgtgtttatcctggagcccaagaagcaaggtgaccccccggtggagtttgcc
acggacaaggtggaggagctctttgagtggtttcagagcatccgggagatcacctggaag
atagacaccaaggagaacaacatgaagtactgggagaagaaccagtccatcgccatcgag
ctctcggacctggtcgtctactgcaagccaaccagcaagaccaaggacaatttagaaaac
cctgacttccgagaaatccggtcctttgtggagacaaaggcagacagtgtcgtcagacag
aaacccgttgacctcctgaagtacaatcagaagggcctgacccgtgtttacccgaaggga
cagagggtggactcctccaactacgacccctttcgcctctggctgtgcggctcccagatg
gtggcactcaatttccagactccagacaagtatatgcagatgaatcacgccttgttctca
ctcaatgggcgaacgggctacgtcctacagcctgagagcatgaggacggagaagtatgac
cccatgccacctgagtcccagaggaagatcctgatgactctgtcagtcaaggttcttggg
gctcgccatctccccaaacttggacgaagtatcgcgtgtccctttgtggaggtggaaatt
tgtggagctgaatatgacaacaacaagtttaagacaacagtcgtgaatgacaatggccta
agccctgtttgggctccaacacaggagaaagtgacctttgaaatttacgaccccaacctg
gcgtttctgcgctttgtggtctatgaggaagatatgttcagtgaccccaatttccttgct
cacgccacttaccccatcaaaggaatcaaatcaggattcagatctgttcctctgaagaac
gggtacagtgaagacattgagctggcttccctcctggttttctgtgagatgcagccagtc
ctggagagcgaagaggaactttattcctcctgtcgccagctgcgaaggcggcaggaagag
ctcaacaatcagctctttctgtacgacacacaccagaacttgcgcaacgccaaccgggat
gccctcgttaaagagttcaatgtcaacgagaaccagctccagctgtaccaggagaagtgc
aaccggaggttgagagagaagcgagtcagcaacagcaggttttactcctag

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