KEGG   Canis familiaris (dog): 489692Help
Entry
489692            CDS       T01007                                 

Gene name
PLCG2
Definition
(RefSeq) phospholipase C, gamma 2 (phosphatidylinositol-specific)
  KO
K05859  
phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
Organism
cfa  Canis familiaris (dog)
Pathway
Inositol phosphate metabolism
Metabolic pathways
ErbB signaling pathway
Ras signaling pathway
Calcium signaling pathway
NF-kappa B signaling pathway
HIF-1 signaling pathway
Phosphatidylinositol signaling system
Phospholipase D signaling pathway
Axon guidance
VEGF signaling pathway
Osteoclast differentiation
Platelet activation
Natural killer cell mediated cytotoxicity
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Inflammatory mediator regulation of TRP channels
Thyroid hormone signaling pathway
AGE-RAGE signaling pathway in diabetic complications
Epstein-Barr virus infection
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Glioma
Non-small cell lung cancer
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:cfa00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    489692 (PLCG2)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    489692 (PLCG2)
   04012 ErbB signaling pathway
    489692 (PLCG2)
   04370 VEGF signaling pathway
    489692 (PLCG2)
   04064 NF-kappa B signaling pathway
    489692 (PLCG2)
   04066 HIF-1 signaling pathway
    489692 (PLCG2)
   04020 Calcium signaling pathway
    489692 (PLCG2)
   04070 Phosphatidylinositol signaling system
    489692 (PLCG2)
   04072 Phospholipase D signaling pathway
    489692 (PLCG2)
 Organismal Systems
  Immune system
   04611 Platelet activation
    489692 (PLCG2)
   04650 Natural killer cell mediated cytotoxicity
    489692 (PLCG2)
   04662 B cell receptor signaling pathway
    489692 (PLCG2)
   04664 Fc epsilon RI signaling pathway
    489692 (PLCG2)
   04666 Fc gamma R-mediated phagocytosis
    489692 (PLCG2)
   04670 Leukocyte transendothelial migration
    489692 (PLCG2)
  Endocrine system
   04919 Thyroid hormone signaling pathway
    489692 (PLCG2)
  Nervous system
   04722 Neurotrophin signaling pathway
    489692 (PLCG2)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    489692 (PLCG2)
  Development
   04360 Axon guidance
    489692 (PLCG2)
   04380 Osteoclast differentiation
    489692 (PLCG2)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    489692 (PLCG2)
   05206 MicroRNAs in cancer
    489692 (PLCG2)
   05205 Proteoglycans in cancer
    489692 (PLCG2)
   05214 Glioma
    489692 (PLCG2)
   05223 Non-small cell lung cancer
    489692 (PLCG2)
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    489692 (PLCG2)
  Infectious diseases
   05169 Epstein-Barr virus infection
    489692 (PLCG2)
Enzymes [BR:cfa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     489692 (PLCG2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-ProteinID: 
NCBI-GeneID: 
Ensembl: 
UniProt: 
Position
5
AA seq 1265 aa AA seqDB search
MTALAHVDSLPEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADK
IEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEECCFTILYGTQFVLSTLSLAADSKEDAN
KWLSGLKILHQEAMSASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLVNFKVNSA
KFLKDKFVEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASA
VHLHDFQRFLLHEQQELWAQDLNKVRARMTKFIDDTMRETAEPFLFVDEFLTYLFSRENS
IWDEKYDVVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSTEAYIRCLRMGCRCIELDC
WDGPDGKPIIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCCVEQQRHMARV
FKEVFGDQLLTKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNMEDKKDEHKQQGE
LYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTAEEELPQDTPPTELHFGEEWFHKKVEKR
TSAEKLLQEYCAETGGKDGTFLVRESKTFPNDYTLSFWRSGRVQHCRIRSTVEGGTMKYF
LTDNVMFTSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDGLSRGEAEDML
MRVPRDGAFLIRRREGTDSYAITFRARGKVKHCRIHRDGQHFVLGTSAYFESLVELVSYY
EKHALYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDY
KAKRSDELSFCRGALIHNVSKEPWGWWKGDYGTRIQQYFPSNYVEDISTVDVEELEKQII
EDNPLGSLCRGILDLNTYNVVKAPQGKNQKPFVFILEPKKQGDPPVEFATDKVEELFEWF
QSIREITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVE
TKADSVVRQKPVDLLKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTPDKY
MQMNHALFSLNGRTGYVLQPESMRTEKYDPMPPESQRKILMTLSVKVLGARHLPKLGRSI
ACPFVEVEICGAEYDNNKFKTTVVNDNGLSPVWAPTQEKVTFEIYDPNLAFLRFVVYEED
MFSDPNFLAHATYPIKGIKSGFRSVPLKNGYSEDIELASLLVFCEMQPVLESEEELYSSC
RQLRRRQEELNNQLFLYDTHQNLRNANRDALVKEFNVNENQLQLYQEKCNRRLREKRVSN
SRFYS
NT seq 3798 nt NT seq  +upstreamnt  +downstreamnt
atgactgccctggcccacgtggacagccttccggaatacgagaagagtcagatcaagaga
gccctggagctgggcacggtgatgacggtgttcagcttccgcaagtccaccccagagcgg
aggactgtccaggtgatcatggagacacgccaggtggcctggagcaagacagccgacaag
atcgagggcttcttggatatcatggaaatcaaggaaatccgcccagggaagaactccaag
gattttgagcgtgcaaaagcagtccgccagaaggaagagtgctgttttaccatcttgtac
ggcacccagtttgttctgagcacactcagtctggcagctgactctaaagaagatgcgaat
aagtggctctctggcttgaaaatcttacaccaggaagcgatgagtgcatctacacccacc
attattgagagttggctgagaaagcagatttattcagtggaccaaaccagaagaaacagc
atcagcctccgagagttgaagaccatcttacccctggtcaactttaaggtgaacagtgcc
aagttcctcaaagataagtttgtggaaattggtgcacacaaagatgagctcagctttgag
cagttccacctgttctataaaaaacttatgtttgagcagcaaaagtcgattcttgatgaa
ttcaaaaaagattcttccgtgttcatcttgggcaacactgaccggccggacgcctctgct
gttcacctgcacgacttccagcgctttctcttacatgagcaacaggagctttgggctcag
gatctgaacaaagtccgtgcgcggatgacaaagtttatcgatgacaccatgagggaaaca
gccgagcccttcttgtttgtcgatgagttcctcacatatctgttttcgcgggagaacagc
atctgggatgagaagtatgacgtggtggacatgcaggacatgaacaaccccttgtcccat
tactggatctcctcttcgcataacacgtacctcaccggtgaccagctacggagtgagtca
tccacagaagcgtacattcgctgcctgcggatgggctgtcgctgcattgagttggactgc
tgggacgggcccgatgggaagcccatcatctaccacggctggacacggaccaccaagata
aagtttgacgacgtcgtgcaggccatcaaagaccatgcctttgtcacttcaagcttcccc
gtgatcctgtccatcgaggagcactgttgcgtggagcagcagcgccacatggccagggtg
ttcaaggaggtgtttggcgaccagctgctgacgaagcccacggaggccagtgctgaccag
ctgccctcgcccagccagttgcgggagaagatcatcatcaagcataagaagctgggtccc
cgaggggacgtggatgtcaacatggaggacaagaaagatgagcacaagcaacagggtgaa
ctgtatatgtgggattccatcgaccagaaatggactcggcactactgtgccatcgccgat
gccaaactgtctttcagcgatgacattgagcagactgcagaagaggagctgccccaggac
acaccccccacggagctgcattttggggaggagtggttccacaagaaagtagagaagagg
acgagtgccgagaagctgctgcaggaatactgtgcagagaccgggggcaaggatgggact
ttccttgtgcgggagagcaagaccttccccaatgactacaccctgtccttctggcggtcc
ggccgcgtccagcactgccggatccgttccaccgtggaggggggcaccatgaagtacttc
ctgactgacaacgtcatgttcaccagcatctacgccctcatccagcactaccgcgagacc
cacctgcgctgcgccgagttcgagctgcggctcaccgaccctgtgcccaaccccaacccc
cacgagtccaagccgtggtactacgacgggctgagccgtggggaggcagaggacatgcta
atgagggtgccccgggacggcgccttcctgatccggaggcgagaaggtaccgattcctac
gccatcaccttcagggccaggggcaaggtgaagcactgccgcattcaccgggatggccag
cactttgtgctggggacctctgcctacttcgagagcctcgtggagctagtcagctactac
gaaaagcacgcgctctaccgaaaaatgcgactgcgctaccccgtgacgcctgagctcctg
gagcgctacaatatggaaagagatataaactccctctatgacgtcagcagaatgtatgtg
gatcccagtgagatcaatccttctatgcctcagagaaccgtgaaagctctgtatgactac
aaagccaagcgaagcgatgagctgagtttctgccgtggggccctcattcacaacgtctcg
aaggagccctggggctggtggaagggggactatggaaccagaatccagcagtacttccca
tccaattacgtcgaggacatttcaacggtcgacgtggaggagctggagaagcagattatt
gaagacaatcccttagggtctctttgtaggggaatactggatctcaatacctataacgtt
gtgaaagccccccaggggaaaaaccagaagccattcgtgtttatcctggagcccaagaag
caaggtgaccccccggtggagtttgccacggacaaggtggaggagctctttgagtggttt
cagagcatccgggagatcacctggaagatagacaccaaggagaacaacatgaagtactgg
gagaagaaccagtccatcgccatcgagctctcggacctggtcgtctactgcaagccaacc
agcaagaccaaggacaatttagaaaaccctgacttccgagaaatccggtcctttgtggag
acaaaggcagacagtgtcgtcagacagaaacccgttgacctcctgaagtacaatcagaag
ggcctgacccgtgtttacccgaagggacagagggtggactcctccaactacgaccccttt
cgcctctggctgtgcggctcccagatggtggcactcaatttccagactccagacaagtat
atgcagatgaatcacgccttgttctcactcaatgggcgaacgggctacgtcctacagcct
gagagcatgaggacggagaagtatgaccccatgccacctgagtcccagaggaagatcctg
atgactctgtcagtcaaggttcttggggctcgccatctccccaaacttggacgaagtatc
gcgtgtccctttgtggaggtggaaatttgtggagctgaatatgacaacaacaagtttaag
acaacagtcgtgaatgacaatggcctaagccctgtttgggctccaacacaggagaaagtg
acctttgaaatttacgaccccaacctggcgtttctgcgctttgtggtctatgaggaagat
atgttcagtgaccccaatttccttgctcacgccacttaccccatcaaaggaatcaaatca
ggattcagatctgttcctctgaagaacgggtacagtgaagacattgagctggcttccctc
ctggttttctgtgagatgcagccagtcctggagagcgaagaggaactttattcctcctgt
cgccagctgcgaaggcggcaggaagagctcaacaatcagctctttctgtacgacacacac
cagaacttgcgcaacgccaaccgggatgccctcgttaaagagttcaatgtcaacgagaac
cagctccagctgtaccaggagaagtgcaaccggaggttgagagagaagcgagtcagcaac
agcaggttttactcctag

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