KEGG   Canis familiaris (dog): 490682Help
Entry
490682            CDS       T01007                                 

Gene name
SOS2
Definition
(RefSeq) SOS Ras/Rho guanine nucleotide exchange factor 2
  KO
K03099  son of sevenless
Organism
cfa  Canis familiaris (dog)
Pathway
cfa01521  EGFR tyrosine kinase inhibitor resistance
cfa01522  Endocrine resistance
cfa04010  MAPK signaling pathway
cfa04012  ErbB signaling pathway
cfa04014  Ras signaling pathway
cfa04062  Chemokine signaling pathway
cfa04068  FoxO signaling pathway
cfa04072  Phospholipase D signaling pathway
cfa04150  mTOR signaling pathway
cfa04151  PI3K-Akt signaling pathway
cfa04510  Focal adhesion
cfa04540  Gap junction
cfa04630  Jak-STAT signaling pathway
cfa04650  Natural killer cell mediated cytotoxicity
cfa04660  T cell receptor signaling pathway
cfa04662  B cell receptor signaling pathway
cfa04664  Fc epsilon RI signaling pathway
cfa04714  Thermogenesis
cfa04722  Neurotrophin signaling pathway
cfa04810  Regulation of actin cytoskeleton
cfa04910  Insulin signaling pathway
cfa04912  GnRH signaling pathway
cfa04915  Estrogen signaling pathway
cfa04917  Prolactin signaling pathway
cfa04926  Relaxin signaling pathway
cfa05034  Alcoholism
cfa05160  Hepatitis C
cfa05165  Human papillomavirus infection
cfa05200  Pathways in cancer
cfa05205  Proteoglycans in cancer
cfa05206  MicroRNAs in cancer
cfa05210  Colorectal cancer
cfa05211  Renal cell carcinoma
cfa05213  Endometrial cancer
cfa05214  Glioma
cfa05215  Prostate cancer
cfa05220  Chronic myeloid leukemia
cfa05221  Acute myeloid leukemia
cfa05223  Non-small cell lung cancer
cfa05224  Breast cancer
cfa05225  Hepatocellular carcinoma
cfa05226  Gastric cancer
cfa05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:cfa00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    490682 (SOS2)
   04010 MAPK signaling pathway
    490682 (SOS2)
   04012 ErbB signaling pathway
    490682 (SOS2)
   04630 Jak-STAT signaling pathway
    490682 (SOS2)
   04068 FoxO signaling pathway
    490682 (SOS2)
   04072 Phospholipase D signaling pathway
    490682 (SOS2)
   04151 PI3K-Akt signaling pathway
    490682 (SOS2)
   04150 mTOR signaling pathway
    490682 (SOS2)
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    490682 (SOS2)
   04540 Gap junction
    490682 (SOS2)
  Cell motility
   04810 Regulation of actin cytoskeleton
    490682 (SOS2)
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    490682 (SOS2)
   04660 T cell receptor signaling pathway
    490682 (SOS2)
   04662 B cell receptor signaling pathway
    490682 (SOS2)
   04664 Fc epsilon RI signaling pathway
    490682 (SOS2)
   04062 Chemokine signaling pathway
    490682 (SOS2)
  Endocrine system
   04910 Insulin signaling pathway
    490682 (SOS2)
   04912 GnRH signaling pathway
    490682 (SOS2)
   04915 Estrogen signaling pathway
    490682 (SOS2)
   04917 Prolactin signaling pathway
    490682 (SOS2)
   04926 Relaxin signaling pathway
    490682 (SOS2)
  Nervous system
   04722 Neurotrophin signaling pathway
    490682 (SOS2)
  Environmental adaptation
   04714 Thermogenesis
    490682 (SOS2)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    490682 (SOS2)
   05231 Choline metabolism in cancer
    490682 (SOS2)
   05206 MicroRNAs in cancer
    490682 (SOS2)
   05205 Proteoglycans in cancer
    490682 (SOS2)
   05210 Colorectal cancer
    490682 (SOS2)
   05225 Hepatocellular carcinoma
    490682 (SOS2)
   05226 Gastric cancer
    490682 (SOS2)
   05214 Glioma
    490682 (SOS2)
   05221 Acute myeloid leukemia
    490682 (SOS2)
   05220 Chronic myeloid leukemia
    490682 (SOS2)
   05211 Renal cell carcinoma
    490682 (SOS2)
   05215 Prostate cancer
    490682 (SOS2)
   05213 Endometrial cancer
    490682 (SOS2)
   05224 Breast cancer
    490682 (SOS2)
   05223 Non-small cell lung cancer
    490682 (SOS2)
  Substance dependence
   05034 Alcoholism
    490682 (SOS2)
  Infectious diseases
   05160 Hepatitis C
    490682 (SOS2)
   05165 Human papillomavirus infection
    490682 (SOS2)
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    490682 (SOS2)
   01522 Endocrine resistance
    490682 (SOS2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: RasGEF RasGEF_N RhoGEF Histone PH IQ_SEC7_PH
Motif
Other DBs
NCBI-GeneID: 490682
NCBI-ProteinID: XP_005623436
Ensembl: ENSCAFG00000014275
Position
8
AA seq 1272 aa AA seqDB search
MAQPRTVQDVEERVQKTFPHPIDKWAIADAQSAIEKRKRRNPLLLPVDKIHPSLKEVLGY
KVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMFDQDD
IGLVCLCEDEPSSSGELNYYDLVRTEIAEERQYLRELNMIIKVFREAFLSDRNLFKPSDI
DRIFSNISDIHELTVKLLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYETLSQDI
LSPKFNEHFSKLMARPAVALHFQSIADGFKEAVRYVLPRLMLVPVYHCWHYFELLKQLKA
CSEEQEDRECLNQAITALMNLQGSMDRIYKQYSPRRRPGDPVCPFYNRQLRSKHLAIKKM
NEIQKNIDGWEGKDIGQCCNEFIMEGPLTRIGAKHERHIFLFDGLMISCKPNHSQSRLPG
YSNAEYRLKEKFIMRKTQICDKEDTCECKHAFELISKDENSIIFAAKSAEEKNNWMAALI
SLHYRSTLDRMLDSVLLKEENEQPLRLPSPEVYRFVVKDSEENIVFEDNLQSRSGIPIIK
GGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPEPTEADKLA
VEKGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFYDFERDLELLERLESFISSVR
GKAMKKWVESIAKIIKRKKQAQANGISHNITFESPPPPIEWHISRPGQFETFDLMTLHPI
EIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEA
ENFEERVAILSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRRILD
EAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRR
KVAEITGEIQQYQNQPYCLRIEPEMRRFFENLNPMGNASEKEFTDYLFNKSLEIEPRNCK
QPPRFPRKSTFSLKSPGIRPNTGRHGSTSGTLRGHPMPLEREPYKISFSRIAETDLESTV
SAPTSPNTPSTPPVSASSDLSVFLDVDLNSSCGSNSIFAPVLLPHSKSFFSSCGSLHKLS
EEPLIPPPLPPRKKFDHDASNSKGNTKSDDDPPAIPPRQPPPPKVKPRVPAPTGAFDGPL
HSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFNLQPPPLGHLHRDPDWFRDVSTCPNSPN
TPPSTPSPRVPRRCYLLSSSHNNLAHPQAPPVPPRQNSSPHLPKLPPKTYKRELSHPPSY
RLPLLENAETPQ
NT seq 3819 nt NT seq  +upstreamnt  +downstreamnt
atggctcaaccaaggactgttcaagatgtggaggaacgtgttcaaaagacctttcctcat
ccaattgataaatgggctattgctgatgcacaatctgccatagaaaaacgaaaacgaaga
aatcctctcttactgcctgtggacaaaatccatccttcattgaaggaagttttagggtac
aaagtggactatcatgtatccctgtatattgtggctgtactagagtatatctcagctgat
attttgaagttggctggtaattatgtttttaatatccgacattatgaaatatctcagcag
gacattaaagtatcaatgtgtgcagataaggttttgatggacatgtttgatcaggatgac
ataggtttggtttgtctttgtgaagatgaacctagttcttcaggtgaattaaactactat
gaccttgtcagaactgaaattgcagaagaaaggcaatatctacgggaactaaatatgatc
ataaaagtgtttcgagaagcctttctttcggacagaaatctgtttaaaccttctgatatt
gacagaattttcagtaacatttcagatatacacgaattgactgtgaaacttctaggtttg
attgaagacacagtggaaatgactgatgaaagcagtcctcatcccttagctggcagctgt
tttgaagatttggcagaggagcaagcatttgatccttatgaaacattatcacaggacatt
ctttctccaaaatttaatgaacatttcagtaagctgatggccagacctgcagtggctcta
cactttcagtccattgctgatggttttaaagaggcagttcgttatgtccttccacgcctt
atgctagtgcctgtttatcattgttggcactattttgaattattaaagcaattgaaagca
tgtagtgaagagcaggaagacagagaatgtttgaaccaagctattacagctcttatgaat
ctccagggtagcatggaccgaatttataagcagtattcacctagacgccgacctggggat
cctgtttgccctttttataatcgtcaattaagaagcaagcatctagctattaaaaaaatg
aatgaaattcagaaaaacatagatgggtgggaaggcaaagatattggacagtgttgtaat
gaattcattatggaaggtccattgacacgaattggtgctaaacatgaacgacatattttt
ctctttgatggcttaatgattagctgtaagcccaatcatagccagtcacgccttccaggt
tacagtaatgcagaatacagattaaaagaaaaatttatcatgaggaagacacagatatgt
gataaagaagatacttgtgagtgcaaacacgcttttgagttgatatccaaggatgaaaac
agcataatatttgctgctaaatcggctgaagagaaaaataattggatggccgcacttatt
tctcttcactatcgtagtacactagatcgaatgctagattcagtgttattgaaagaagaa
aatgagcaaccattgagattaccaagtcctgaagtatatcgttttgtggtaaaagactct
gaggaaaacattgtttttgaagacaacttgcaaagtagaagtggaattcccattattaaa
ggaggaactgtggtgaaattaattgaaagattaacatatcatatgtatgcagatcccaat
tttgttcgtacttttcttactacataccgttcattttgtaaaccacaggaattgctaagc
ttactgattgaacgatttgaaatcccagagccggaacctactgaagcagataaattggct
gtagagaaaggcgaacagccaatcagtgcagaccttaaaaggtttcgcaaggaatatgtc
caaccagtacaacttaggatcttaaatgtatttcggcactgggttgaacaccacttttat
gactttgaaagggatttggagttgcttgaaagactagaatccttcatttcaagtgtaaga
ggaaaagctatgaagaaatgggtagagtcaattgctaagatcatcaagaggaagaaacaa
gctcaggcaaatggaataagccataatattacctttgaaagtccacctccaccaattgaa
tggcatatcagcagaccaggacagtttgaaacatttgatctcatgacactgcatccaata
gaaattgcacgtcagctgacacttttggaatctgatctctacaggaaagtccaaccttct
gaacttgtagggagtgtatggaccaaagaagataaagaaataaattctccaaatttatta
aaaatgattcgccataccacgaatctcaccctttggtttgaaaagtgcattgtggaagca
gaaaattttgaagaacgggtggcaatactaagcagaattatagaaattctgcaagttttt
caagatttgaataatttcaatggtgtattggagatagtcagtgcagtaaattcagtatca
gtgtacagactagaccatacttttgaggcattgcaggaaagaaaaaggagaattttggat
gaagctgtggaattaagtcaagatcactttaaaaaatacctagtaaaacttaagtcaatc
aatccaccttgtgtgcctttttttggaatatatttaacaaatattctgaaaactgaagaa
gggaataatgattttttaaaaaagaaagggaaagatttaatcaatttcagtaagaggagg
aaagtagctgaaattactggagaaattcagcagtatcagaatcaaccttactgtttacgg
atagaaccagaaatgaggagattctttgaaaaccttaaccccatgggaaatgcttctgaa
aaggagtttacagattatttgttcaacaagtcactagaaattgagccccgaaactgcaaa
cagccacctcgatttcctaggaaatcaactttctctttaaaatctcctggaatacggccg
aatacaggccgacatggctctacctcaggcactttacgaggtcatccaatgccgttagaa
agagaaccatataaaataagctttagtcggattgctgaaactgatcttgaatcaactgtg
tcagcaccaacctctccaaatacaccatctactccaccagtatctgcttcttcagacctt
agtgtgtttttagatgtggatctcaacagttcctgtggcagcaatagcatctttgctcca
gtcctcttgccgcattcaaagtctttcttcagttcatgtggtagtttacataaactaagt
gaagagccactgattcctcctcctcttcctcctcgaaaaaagtttgatcatgatgcttca
aattccaagggaaatacgaaatctgatgatgacccccctgctattccaccaagacaacct
cctcctccaaaggtaaaaccgagagttcctgctcctactggtgcatttgatgggcctctg
catagtccacctccaccgccaccaagagatcctcttcctgatacccctccgccagttccc
cttcgtcctccagaacactttataaactgtccatttaatcttcagccacctccactagga
catctgcacagagatccagactggttcagagacgttagtacctgcccaaattcgccaaat
actcctcccagcacgccctctccaagagtaccacgtcgatgctacctgctcagttctagt
cacaacaaccttgctcatcctcaagctccccctgtgccaccgaggcagaactcaagcccg
cacctaccaaaactgccaccaaagacttataaacgggagctttcacaccccccgtcatac
agactgcctttactagaaaatgcagaaactcctcaatga

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