KEGG   Cricetulus griseus (Chinese hamster): 100689251Help
Entry
100689251         CDS       T02813                                 

Gene name
Pik3ca
Definition
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Orthology
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
Organism
cge  Cricetulus griseus (Chinese hamster)
Pathway
Inositol phosphate metabolism
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Bacterial invasion of epithelial cells
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Hepatitis C
Hepatitis B
Measles
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Brite
KEGG Orthology (KO) [BR:cge00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100689251 (Pik3ca)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    100689251 (Pik3ca)
   04015 Rap1 signaling pathway
    100689251 (Pik3ca)
   04012 ErbB signaling pathway
    100689251 (Pik3ca)
   04370 VEGF signaling pathway
    100689251 (Pik3ca)
   04630 Jak-STAT signaling pathway
    100689251 (Pik3ca)
   04668 TNF signaling pathway
    100689251 (Pik3ca)
   04066 HIF-1 signaling pathway
    100689251 (Pik3ca)
   04068 FoxO signaling pathway
    100689251 (Pik3ca)
   04070 Phosphatidylinositol signaling system
    100689251 (Pik3ca)
   04024 cAMP signaling pathway
    100689251 (Pik3ca)
   04022 cGMP - PKG signaling pathway
    100689251 (Pik3ca)
   04151 PI3K-Akt signaling pathway
    100689251 (Pik3ca)
   04152 AMPK signaling pathway
    100689251 (Pik3ca)
   04150 mTOR signaling pathway
    100689251 (Pik3ca)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    100689251 (Pik3ca)
  Cell growth and death
   04210 Apoptosis
    100689251 (Pik3ca)
  Cell communication
   04510 Focal adhesion
    100689251 (Pik3ca)
 Organismal Systems
  Immune system
   04611 Platelet activation
    100689251 (Pik3ca)
   04620 Toll-like receptor signaling pathway
    100689251 (Pik3ca)
   04650 Natural killer cell mediated cytotoxicity
    100689251 (Pik3ca)
   04660 T cell receptor signaling pathway
    100689251 (Pik3ca)
   04662 B cell receptor signaling pathway
    100689251 (Pik3ca)
   04664 Fc epsilon RI signaling pathway
    100689251 (Pik3ca)
   04666 Fc gamma R-mediated phagocytosis
    100689251 (Pik3ca)
   04670 Leukocyte transendothelial migration
    100689251 (Pik3ca)
   04062 Chemokine signaling pathway
    100689251 (Pik3ca)
  Endocrine system
   04910 Insulin signaling pathway
    100689251 (Pik3ca)
   04915 Estrogen signaling pathway
    100689251 (Pik3ca)
   04914 Progesterone-mediated oocyte maturation
    100689251 (Pik3ca)
   04917 Prolactin signaling pathway
    100689251 (Pik3ca)
   04921 Oxytocin signaling pathway
    100689251 (Pik3ca)
   04919 Thyroid hormone signaling pathway
    100689251 (Pik3ca)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100689251 (Pik3ca)
  Digestive system
   04973 Carbohydrate digestion and absorption
    100689251 (Pik3ca)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100689251 (Pik3ca)
  Nervous system
   04725 Cholinergic synapse
    100689251 (Pik3ca)
   04722 Neurotrophin signaling pathway
    100689251 (Pik3ca)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100689251 (Pik3ca)
  Development
   04380 Osteoclast differentiation
    100689251 (Pik3ca)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    100689251 (Pik3ca)
   05205 Proteoglycans in cancer
    100689251 (Pik3ca)
   05203 Viral carcinogenesis
    100689251 (Pik3ca)
   05210 Colorectal cancer
    100689251 (Pik3ca)
   05212 Pancreatic cancer
    100689251 (Pik3ca)
   05214 Glioma
    100689251 (Pik3ca)
   05221 Acute myeloid leukemia
    100689251 (Pik3ca)
   05220 Chronic myeloid leukemia
    100689251 (Pik3ca)
   05218 Melanoma
    100689251 (Pik3ca)
   05211 Renal cell carcinoma
    100689251 (Pik3ca)
   05215 Prostate cancer
    100689251 (Pik3ca)
   05213 Endometrial cancer
    100689251 (Pik3ca)
   05222 Small cell lung cancer
    100689251 (Pik3ca)
   05223 Non-small cell lung cancer
    100689251 (Pik3ca)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    100689251 (Pik3ca)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    100689251 (Pik3ca)
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    100689251 (Pik3ca)
   05166 HTLV-I infection
    100689251 (Pik3ca)
   05162 Measles
    100689251 (Pik3ca)
   05164 Influenza A
    100689251 (Pik3ca)
   05161 Hepatitis B
    100689251 (Pik3ca)
   05160 Hepatitis C
    100689251 (Pik3ca)
   05169 Epstein-Barr virus infection
    100689251 (Pik3ca)
   05146 Amoebiasis
    100689251 (Pik3ca)
   05145 Toxoplasmosis
    100689251 (Pik3ca)
   05142 Chagas disease (American trypanosomiasis)
    100689251 (Pik3ca)
Enzymes [BR:cge01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     100689251 (Pik3ca)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Position
Un
AA seq 1068 aa AA seqDB search
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFV
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
SFTMPSYSRRISTATPYMNGETTTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHTGLSNRLARDNELRENDKEQLRALCTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRSFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRQPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQEYTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFTKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt NT seq  +upstreamnt  +downstreamnt
atgcctccacgaccatcgtcgggtgaactgtggggcatccacttgatgcccccacgaatc
ctagtggaatgtttactcccaaatggaatgatagtgactttagaatgcctccgtgaggct
acactaatcaccataaaacacgaactgtttaaagaagccagaaaataccctctgcatcag
cttctgcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacaagacggctttgtgaccttcggctttttcaaccctttttaaaa
gtaattgaaccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggttttgtt
atcggcatgccagtgtgtgaatttgatatggttaaagatccagaagtccaggacttccga
aggaacattctgaatgtttgcaaagaagctgtggatctgcgggatctcaactcccctcat
agcagagcaatgtatgtctaccctcccaacgtagagtcttccccagaattgccaaagcac
atctacaacaagttagataaaggacaaatcatagtggtgatttgggtaattgtctctcca
aacaatgacaagcagaagtataccctgaagatcaaccacgactgtgtgccagagcaagtc
attgctgaagccatcaggaagaagactcggagcatgctgctctcgtctgagcagctgaaa
ctctgtgttttagaataccagggcaagtatattctgaaagtgtgtggctgtgatgaatac
ttcctagaaaaataccctctgagtcagtacaagtacataagaagctgtataatgctgggg
aggatgcccaacttgatgttgatggccaaagaaagcctttactctcagctgccaatggat
agcttcacaatgccgtcatactccaggcgcatctccacagccacgccctatatgaatgga
gagacaactacgaaatccctctgggttataaatagtgcgcttagaatcaaaattctttgt
gcaacttatgtaaatgtaaatattcgagacattgataagatctatgttcgaacaggtatc
taccacggaggagaacccttatgtgacaatgtgaacactcaaagagtaccttgttccaat
cctaggtggaatgaatggctgaattatgacatatacattcctgatcttcctcgcgctgct
cgcctttgcctttccatttgctctgttaaaggccgaaagggtgctaaggaggagcactgt
ccattggcctggggaaatataaacttgtttgattacacagacaccctagtatctgggaaa
atggctttgaatctctggcctgtaccacatgggttagaagatctgctgaaccctattggt
gttactgggtcaaatccaaataaagaaactccatgcttagagttggagtttgattggttc
agcagtgtggtgaagtttccagacatgtctgtgatcgaagagcatgctaattggtctgtg
tcccgagaagctggattcagttactctcatacaggactgagtaacagactcgccagagac
aatgaactaagagaaaatgacaaagaacagctccgagcactttgcacccgggacccactg
tctgaaatcactgaacaagagaaagatttcctatggagccacagacactactgtgtaact
attcctgaaatcctacccaaattgcttttgtctgtcaagtggaattccagagatgaagta
gcccagatgtactgcttagtcaaagattggcctccaatcaagcctgagcaggccatggag
cttctggactgtaattatccagatcctatggttcggagttttgccgttcggtgcttggaa
aaatacttaacagatgacaaactttctcagtacctcattcagcttgtccaggtcttaaaa
tatgaacaatatttggataacctgcttgtgagatttttactcaagaaagcgttgacaaat
caaaggattggccattttttcttttggcatttaaaatctgagatgcacaataagaccgtc
agtcaaaggtttggcctcctgttggagtcctactgccgtgcctgtgggatgtatctgaaa
cacctgaacagacaggtagaggccatggagaagctcatcaacctaactgacatcctcaaa
caggagaagaaggatgaaacacaaaaggtacagatgaagtttttggttgagcagatgaga
cagccagatttcatggatgctctgcagggttttctgtctcctctaaaccctgctcatcag
ctagggaacctcagacttgaagagtgtcgaattatgtcctctgcaaaaagaccactgtgg
ttgaattgggagaacccagacatcatgtcagagctactgtttcagaacaatgagatcatc
tttaaaaatggcgatgatttacggcaagatatgttaacacttcagatcatccggattatg
gagaacatctggcaaaaccaaggccttgaccttcgaatgctaccttatggctgtctgtcc
attggggactgtgtggggctcatcgaagtggtgagaaactctcacactatcatgcagatc
cagtgcaaaggaggcctaaagggggcactgcagttcaacagtcacacactgcaccagtgg
ctcaaggacaagaataagggagaaatatatgatgcagccattgacctattcacaaggtca
tgtgctggctactgtgtggcaaccttcatcttggggattggagaccggcacaatagcaac
atcatggtgaaagatgatggacagctgtttcatatagattttgggcactttttggatcac
aagaagaagaaatttggttataaacgggaacgtgtgccatttgttttgacacaagatttc
ttaatagtgattagtaaaggagcccaagaatatacaaagaccagagagtttgagagattt
caggagatgtgttacaaggcttacctagcaattcggcagcatgccaatctcttcatcaac
ctgttttcaatgatgcttggctctggaatgccggaactgcagtcttttgatgacattgca
tatattcgaaagactctggccttagacaaaactgagcaagaggctttggaatatttcaca
aaacaaatgaatgatgcacatcatggcggctggacgacaaaaatggattggatcttccac
accatcaagcagcatgcattgaactga

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